LOCUS       NP_080509                373 aa            linear   ROD 07-FEB-2025
DEFINITION  alpha-1,3-mannosyl-glycoprotein
            4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
            precursor [Mus musculus].
ACCESSION   NP_080509 XP_912028
VERSION     NP_080509.2
DBSOURCE    REFSEQ: accession NM_026233.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 373)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 373)
  AUTHORS   Akintayo,A., Liang,M., Bartholdy,B., Batista,F., Aguilan,J.,
            Prendergast,J., Sabrin,A., Sundaram,S. and Stanley,P.
  TITLE     The Golgi Glycoprotein MGAT4D is an Intrinsic Protector of
            Testicular Germ Cells From Mild Heat Stress
  JOURNAL   Sci Rep 10 (1), 2135 (2020)
   PUBMED   32034218
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 373)
  AUTHORS   Lu,Y., Oura,S., Matsumura,T., Oji,A., Sakurai,N., Fujihara,Y.,
            Shimada,K., Miyata,H., Tobita,T., Noda,T., Castaneda,J.M.,
            Kiyozumi,D., Zhang,Q., Larasati,T., Young,S.A.M., Kodani,M.,
            Huddleston,C.A., Robertson,M.J., Coarfa,C., Isotani,A.,
            Aitken,R.J., Okabe,M., Matzuk,M.M., Garcia,T.X. and Ikawa,M.
  TITLE     CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched
            genes dispensable for male fertility in micedagger
  JOURNAL   Biol Reprod 101 (2), 501-511 (2019)
   PUBMED   31201419
REFERENCE   4  (residues 1 to 373)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (residues 1 to 373)
  AUTHORS   Huang,H.H. and Stanley,P.
  TITLE     A testis-specific regulator of complex and hybrid N-glycan
            synthesis
  JOURNAL   J Cell Biol 190 (5), 893-910 (2010)
   PUBMED   20805325
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK016272.1 and AC155304.4.
            
            On Dec 27, 2006 this sequence version replaced NP_080509.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK016272.1, SRR5189685.174595.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..373
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 39.84 cM"
     Protein         1..373
                     /product="alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D
                     precursor"
                     /note="GlcNAcT-I inhibitory protein; glycosyltransferase
                     54 domain-containing protein;
                     alpha-1,3-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase-like protein
                     MGAT4D; N-acetylglucosaminyltransferase MGAT1 inhibitory
                     protein"
                     /calculated_mol_wt=40989
     sig_peptide     1..21
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2330
     Site            6..26
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9D4R2.2)"
     Site            29
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D4R2.2)"
     Site            54
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D4R2.2)"
     Region          96..373
                     /region_name="Glyco_transf_54"
                     /note="N-Acetylglucosaminyltransferase-IV (GnT-IV)
                     conserved region; pfam04666"
                     /db_xref="CDD:461384"
     Site            144
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9D4R2.2)"
     CDS             1..373
                     /gene="Mgat4d"
                     /gene_synonym="4933434I20Rik; GnT1IP; GnT1IP-L"
                     /coded_by="NM_026233.2:14..1135"
                     /db_xref="CCDS:CCDS22451.1"
                     /db_xref="GeneID:67555"
                     /db_xref="MGI:MGI:1914805"
ORIGIN      
        1 mkaknvnllf afvavllfgf scfcisrmnq tnnqlincrn hvlefkeiml rlknksenhh
       61 qdlmqvlyqm krkaahttrs sgnflekkgs ilsqhetlpn qfevlkyflp hlrtagklyp
      121 aiatskgrag vsfalgisti nrgnhtylkq tltsvlsrmt peeeedsvvi vsvadtdesy
      181 lksvvrmvkt kfrkqvqsgv levisiptlf ypqtlldkkt ktdseswqik qvldfcilml
      241 yaqpkatyyl qleddivakk myftkmkdfv nsltsknwff iefsvlgfig klfrskdltd
      301 fvhfflmfye tkpidilldd iflirvcisg epvrsclqrk kgfriqyrps lfqhvgtqss
      361 fpgreqhlkd nyy
//
