LOCUS       NM_010795               4682 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus mannoside acetylglucosaminyltransferase 3 (Mgat3),
            mRNA.
ACCESSION   NM_010795 XM_001473411
VERSION     NM_010795.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4682)
  AUTHORS   Huang,H., Liu,Y., Yu,P., Qu,J., Guo,Y., Li,W., Wang,S. and Zhang,J.
  TITLE     MiR-23a transcriptional activated by Runx2 increases metastatic
            potential of mouse hepatoma cell via directly targeting Mgat3
  JOURNAL   Sci Rep 8 (1), 7366 (2018)
   PUBMED   29743543
  REMARK    GeneRIF: MiR-23a transcriptional activated by Runx2 increases
            metastatic potential of mouse hepatoma cell via directly targeting
            Mgat3
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4682)
  AUTHORS   Kizuka,Y., Nakano,M., Kitazume,S., Saito,T., Saido,T.C. and
            Taniguchi,N.
  TITLE     Bisecting GlcNAc modification stabilizes BACE1 protein under
            oxidative stress conditions
  JOURNAL   Biochem J 473 (1), 21-30 (2016)
   PUBMED   26467158
REFERENCE   3  (bases 1 to 4682)
  AUTHORS   Kizuka,Y., Kitazume,S., Fujinawa,R., Saito,T., Iwata,N.,
            Saido,T.C., Nakano,M., Yamaguchi,Y., Hashimoto,Y., Staufenbiel,M.,
            Hatsuta,H., Murayama,S., Manya,H., Endo,T. and Taniguchi,N.
  TITLE     An aberrant sugar modification of BACE1 blocks its lysosomal
            targeting in Alzheimer's disease
  JOURNAL   EMBO Mol Med 7 (2), 175-189 (2015)
   PUBMED   25592972
REFERENCE   4  (bases 1 to 4682)
  AUTHORS   Kurimoto,A., Kitazume,S., Kizuka,Y., Nakajima,K., Oka,R.,
            Fujinawa,R., Korekane,H., Yamaguchi,Y., Wada,Y. and Taniguchi,N.
  TITLE     The absence of core fucose up-regulates GnT-III and Wnt target
            genes: a possible mechanism for an adaptive response in terms of
            glycan function
  JOURNAL   J Biol Chem 289 (17), 11704-11714 (2014)
   PUBMED   24619415
  REMARK    GeneRIF: data suggest that Fut8(-/-) mice adapted to oxidative
            stress, both ex vivo and in vivo, by inducing various genes
            including GnT-III, which may compensate for the loss of core fucose
            functions
REFERENCE   5  (bases 1 to 4682)
  AUTHORS   Miwa,H.E., Koba,W.R., Fine,E.J., Giricz,O., Kenny,P.A. and
            Stanley,P.
  TITLE     Bisected, complex N-glycans and galectins in mouse mammary tumor
            progression and human breast cancer
  JOURNAL   Glycobiology 23 (12), 1477-1490 (2013)
   PUBMED   24037315
  REMARK    GeneRIF: The MGAT3 and bisected complex N-glycans retard mouse
            mammary tumor progression; identification of key galectins that
            promote mammary tumor progression in mice is not straightforward
            because the galectin genes are expressed; and high levels of MGAT3.
REFERENCE   6  (bases 1 to 4682)
  AUTHORS   Bhaumik,M., Harris,T., Sundaram,S., Johnson,L., Guttenplan,J.,
            Rogler,C. and Stanley,P.
  TITLE     Progression of hepatic neoplasms is severely retarded in mice
            lacking the bisecting N-acetylglucosamine on N-glycans: evidence
            for a glycoprotein factor that facilitates hepatic tumor
            progression
  JOURNAL   Cancer Res 58 (13), 2881-2887 (1998)
   PUBMED   9661906
REFERENCE   7  (bases 1 to 4682)
  AUTHORS   Yoshimura,M., Ihara,Y., Nishiura,T., Okajima,Y., Ogawa,M.,
            Yoshida,H., Suzuki,M., Yamamura,K., Kanakura,Y., Matsuzawa,Y. and
            Taniguchi,N.
  TITLE     Bisecting GlcNAc structure is implicated in suppression of
            stroma-dependent haemopoiesis in transgenic mice expressing
            N-acetylglucosaminyltransferase III
  JOURNAL   Biochem J 331 (Pt 3) (Pt 3), 733-742 (1998)
   PUBMED   9560299
REFERENCE   8  (bases 1 to 4682)
  AUTHORS   Ihara,Y., Yoshimura,M., Miyoshi,E., Nishikawa,A., Sultan,A.S.,
            Toyosawa,S., Ohnishi,A., Suzuki,M., Yamamura,K., Ijuhin,N. and
            Taniguchi,N.
  TITLE     Ectopic expression of N-acetylglucosaminyltransferase III in
            transgenic hepatocytes disrupts apolipoprotein B secretion and
            induces aberrant cellular morphology with lipid storage
  JOURNAL   Proc Natl Acad Sci U S A 95 (5), 2526-2530 (1998)
   PUBMED   9482919
REFERENCE   9  (bases 1 to 4682)
  AUTHORS   Priatel,J.J., Sarkar,M., Schachter,H. and Marth,J.D.
  TITLE     Isolation, characterization and inactivation of the mouse Mgat3
            gene: the bisecting N-acetylglucosamine in asparagine-linked
            oligosaccharides appears dispensable for viability and reproduction
  JOURNAL   Glycobiology 7 (1), 45-56 (1997)
   PUBMED   9061364
REFERENCE   10 (bases 1 to 4682)
  AUTHORS   Bhaumik,M., Seldin,M.F. and Stanley,P.
  TITLE     Cloning and chromosomal mapping of the mouse Mgat3 gene encoding
            N-acetylglucosaminyltransferase III
  JOURNAL   Gene 164 (2), 295-300 (1995)
   PUBMED   7590346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ174488.1 and BC053040.1.
            
            On Nov 10, 2012 this sequence version replaced NM_010795.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053040.1, SRR1660813.95518.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                CJ174488.1         1-90
            91-4682             BC053040.1         1-4592
FEATURES             Location/Qualifiers
     source          1..4682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.85 cM"
     gene            1..4682
                     /gene="Mgat3"
                     /gene_synonym="1110038J12Rik; GnT-III"
                     /note="mannoside acetylglucosaminyltransferase 3"
                     /db_xref="GeneID:17309"
                     /db_xref="MGI:MGI:104532"
     exon            1..118
                     /gene="Mgat3"
                     /gene_synonym="1110038J12Rik; GnT-III"
                     /inference="alignment:Splign:2.1.0"
     exon            119..4665
                     /gene="Mgat3"
                     /gene_synonym="1110038J12Rik; GnT-III"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1736
                     /gene="Mgat3"
                     /gene_synonym="1110038J12Rik; GnT-III"
                     /EC_number="2.4.1.144"
                     /note="glcNAc-T III;
                     N-glycosyl-oligosaccharide-glycoprotein
                     N-acetylglucosaminyltransferase III"
                     /codon_start=1
                     /product="beta-1,4-mannosyl-glycoprotein
                     4-beta-N-acetylglucosaminyltransferase"
                     /protein_id="NP_034925.2"
                     /db_xref="CCDS:CCDS27660.1"
                     /db_xref="GeneID:17309"
                     /db_xref="MGI:MGI:104532"
                     /translation="MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPN
                     LVSSFFWNNAPVTPQASPEPGGPDLLRTPLYSHSPLLQPLSPSKATEELHRVDFVLPE
                     DTTEYFVRTKAGGVCFKPGTRMLEKPSPGRTEEKPEVSEGSSARGPARRPMRHVLSTR
                     ERLGSRGTRRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAINI
                     NHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYV
                     FLDHFPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFL
                     KLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTMDMLQAVYGLDGIRLRRRQYYT
                     MPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDY
                     EDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLENPYRE
                     PKSTEEGGRRNQGSDGRPSAVRGKLDTVEG"
     regulatory      4642..4647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgat3"
                     /gene_synonym="1110038J12Rik; GnT-III"
                     /note="hexamer: AATAAA"
     polyA_site      4665
                     /gene="Mgat3"
                     /gene_synonym="1110038J12Rik; GnT-III"
                     /note="major polyA site"
ORIGIN      
        1 gatggggcga ggagaggctg cggcggacgc cagcatctcc ccgccgggga ccccgggggc
       61 cccggagccg ccgccgccgc tgcttctacc gccgctgctg agacccagcg gacgatggga
      121 tgaagatgag acgctacaag ctctttctca tgttctgtat ggctggcctg tgcctcatat
      181 ccttcctgca cttctttaag accttatcct atgtcacctt cccgagagaa ctggcctccc
      241 tcagccctaa cctcgtatcc agcttcttct ggaacaatgc ccctgtcact ccccaggcca
      301 gtccggagcc gggtggcccc gacctattgc ggacacccct ctactcccac tctcccctgc
      361 tccagccact gtccccgagc aaggccacag aggaactgca ccgggtggac ttcgtgttgc
      421 cggaggacac cacggagtat tttgtgcgca ccaaagctgg tggtgtgtgc ttcaaaccag
      481 gtaccaggat gctggagaaa ccttcgccag ggcggacaga ggagaagccc gaagtgtctg
      541 agggctcctc agcccgggga cctgctcgga ggcccatgag gcacgtgttg agtacgcggg
      601 agcgcctggg cagccggggc actaggcgca agtgggttga gtgtgtgtgc ctgccaggct
      661 ggcacgggcc cagttgcggg gtgcccacgg tggtgcagta ttccaacctg cccaccaagg
      721 aacgcctggt acccagggag gtaccgaggc gggttatcaa cgccatcaac atcaaccacg
      781 agttcgacct gctggatgtg cgtttccatg agctgggaga tgttgtggac gccttcgtgg
      841 tctgtgaatc taatttcacc gcctacgggg agcctcggcc gctcaagttc cgagagatgc
      901 tgaccaatgg caccttcgag tacatccgcc acaaggtgct ctatgtcttc ctggaccatt
      961 tcccacctgg tggccgtcag gacggctgga ttgcggatga ctacctgcgc accttcctca
     1021 cccaggatgg cgtctcccgc ctgcgcaacc tgcggcccga tgacgtcttt atcatcgacg
     1081 atgcggacga gatccctgcg cgtgatggtg tgctgttcct caaactctac gatggctgga
     1141 cagagccctt cgccttccac atgcggaagt ccctgtatgg tttcttctgg aagcagccgg
     1201 gcacactgga ggtggtgtca ggctgcacca tggacatgct gcaggccgtg tatgggctgg
     1261 atggcatccg cctgcgccgc cgccagtact acaccatgcc caacttccgg cagtatgaga
     1321 accgcaccgg ccacatccta gtgcagtggt ctctcggcag ccccctgcac ttcgcgggct
     1381 ggcattgctc ctggtgcttc acacccgagg gcatctactt taaactcgtg tcagcccaga
     1441 atggcgactt cccccgctgg ggtgactatg aggacaagag ggacctcaat tacatccgca
     1501 gcttgatccg cactggggga tggttcgacg gaacgcagca ggagtaccct cctgcggacc
     1561 ccagtgagca catgtatgct cctaaatacc tgctcaagaa ctatgaccag ttccgctact
     1621 tgctggaaaa tccctaccgg gagcccaaga gcactgaaga gggtgggcgc cggaaccagg
     1681 gctcagatgg aaggccatct gctgtcaggg gcaagttgga tacagtggag ggctagggct
     1741 gtgcactttc acagggctgg gtaggctgaa ataatggcta agccagtgct atcttaggcc
     1801 tcctccttat cccggggcac ttgagagagc caggagtcct tgtagatgga tggtcctctg
     1861 tgctcaggcc tctagaatta agggtcaggc ctttcaccct aaaacagaaa aaattacttt
     1921 ctagtagaga agagcaagcc cggacatcta tgcagcattt ttgttcccaa gagtgctgtg
     1981 ggaaagaggt gttcctggag ggcataaggt ggtgttctgg gactgggagt gctatggaac
     2041 ttcagtctag ttaaagagaa gccccaccgt tgacacctgg gactgttgtc cattacagga
     2101 caaggaggta taccatgcca ggggttccca gaatcttgta aataaatgca tttgggtcca
     2161 ggagcaagaa gagacagtag ggagggacta gaaactgtat ttgctcttga tgtgggccaa
     2221 gaagctaggg aagcattgga aggtaccctg gagagaacac actttgtagc ttcctcagac
     2281 atgcgggacc caagggatga ggtcccgcat ggctgagagg atgaagctcg ttagtcagtc
     2341 ccattgcctc tgtaagaagg catgccgggg gtgatgcgga atcttcctct ggtcccaaat
     2401 atacccttga tagctgttct cacttttcct gttgctgtct tgtgggagcc acttgcaaag
     2461 gactctagga gtctagtttt tggggtggga caggagctgg agaccataag gacagccagt
     2521 atagtaggcg agacaagaga aggagactga cagaggcctc tctacgcctc tctccctccc
     2581 tatcactctc tgccggcatc cagtcccata ttacagcgtc ccaaatgtaa ccagtcctgt
     2641 gccactacgc ctccaccccc acacccgtaa gagcaggcta ggggccagga agggaccaca
     2701 aggttctcct gggtccaaga aagaacatta aggtcagtgg tatatcaacc catccctctt
     2761 aatttgcctt gtgtgtgggg gggtacagga tgtatttcag aagatgctaa gctgctgtag
     2821 aagccccttg gcaaccagca agcaattcaa ataagaccag cttgttacta agtaaatagt
     2881 ccaggaagag atggtccaaa gcctattaga cagtcagctt agcttcacat acaactccca
     2941 ggtctggata gaggggctgc acctgctcac atgataagag gagaaagtgt gaactcttcc
     3001 ctgtgaaggg caggagtcag atgtgtctgt tgcttctgat agtgtcttac tggtctggac
     3061 ttagctgcat ggctataggt agttgcaagg aaaactggga aatgtagttt tgagcaggac
     3121 tgccatatgc ctgcctccat ttgagagttc tgtattacta gcagcaccct taaaggaagg
     3181 gtacaaatga ttgctcatta ccctgctctc ttcctatctg ccctggggtt gaggtacagt
     3241 ggggacttgc aggtgtatag gaagagtggg tgcctcttcc tgaggccctt gacgttccct
     3301 tgatgccagt atgcagggct acctgtggaa tggtccgtgt ttgtgcgtgt atgtatattt
     3361 atgggcatgg gtgcatgctt ggtgtgtatt gtacatgtct gtatccatgt gtccctgtac
     3421 aaagatgata ctcatgtgtg ggcgtaggag cctaggcttg gctgtcctct tccttaggac
     3481 ctggatctta tagtctcatc tcctatggct ccacgagatg cccgagacag gaagtccttg
     3541 ggggaacctt gaaagcaaga ctagaaggga gtacagggtc tgtctgtctg tctgtctttc
     3601 agtctgagaa atggaatctt cctaggtata gggatatgca gctgagagcc caccactccc
     3661 tcagcccctc ttggctctct acatcctccc cctgccacct cagcatctct tggatgtagc
     3721 tctgtctgga gtagtttgcc aggtggtggc tgctctgaca aacaggcatg aagggctcta
     3781 tggcttctct cctcccattg aggaacaccc tccatggaac ctctccttca aagagccttc
     3841 ctctctagtt cctctaggga ttgagaggtg gccacagaag tcagggcatc ccagggactg
     3901 atgggtccat ctgagccagg gctctctcct gagatgtctg tggatgtttc tgtgatacct
     3961 tcccccttga atgaaatcct taccccacac tcttggtacc ctcagctgct tcattgatat
     4021 cctgttccag gcatttcagg gctcctgccc acaagtgacc aattcaggga gggagaagga
     4081 ccctgggaaa gcacaggtct gctgggctgg ccttccttct cagatagtac aatagtttca
     4141 attaggcagg aagaggcctg gccatgggct gagagaccac cctcaagagg tgggagctaa
     4201 agagtttcac atataaccac agcatacact gggaagttga ggggcaggga acccaggacc
     4261 attcccccaa tatgaagaga aaccgaattg aatgtgaaag tgggcacatt ctccaggaac
     4321 cactggcctg tgacctctag acccaaggaa gcctatactg gcgtccagct ggcctcattc
     4381 acccaagggt cacagtggtt aaaagggaca agcttgttga agctttggaa acaaagattc
     4441 agggtgggaa gataggactc acccaagtag aaggaagggc cctgggaaat gtgtaattta
     4501 aggacaccaa taataataat aatagtatta ttttttttgt aaatgaaaat caatatgtac
     4561 attctgaaat cattttctct gtaaatggtt gaatttcatt tcacccttaa agggatgctt
     4621 aaaggagaag ataatattaa taataaaaca gctgagaagt ctggaaaaaa aaaaaaaaaa
     4681 aa
//
