LOCUS       NP_666147                442 aa            linear   ROD 15-APR-2025
DEFINITION  alpha-1,6-mannosyl-glycoprotein
            2-beta-N-acetylglucosaminyltransferase precursor [Mus musculus].
ACCESSION   NP_666147
VERSION     NP_666147.1
DBSOURCE    REFSEQ: accession NM_146035.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   Asmat,M.S., Zheng,X.Y., Nauman,M., Zheng,D. and Stanley,P.
  TITLE     Deletion of Mgat2 in spermatogonia blocks spermatogenesis
  JOURNAL   Front Cell Dev Biol 12, 1428715 (2024)
   PUBMED   39364139
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Mkhikian,H., Hayama,K.L., Khachikyan,K., Li,C., Zhou,R.W.,
            Pawling,J., Klaus,S., Tran,P.Q.N., Ly,K.M., Gong,A.D., Saryan,H.,
            Hai,J.L., Grigoryan,D., Lee,P.L., Newton,B.L., Raffatellu,M.,
            Dennis,J.W. and Demetriou,M.
  TITLE     Age-associated impairment of T cell immunity is linked to
            sex-dimorphic elevation of N-glycan branching
  JOURNAL   Nat Aging 2 (3), 231-242 (2022)
   PUBMED   35528547
REFERENCE   3  (residues 1 to 442)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 442)
  AUTHORS   Mortales,C.L., Lee,S.U., Manousadjian,A., Hayama,K.L. and
            Demetriou,M.
  TITLE     N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to
            Control Inflammatory Demyelination
  JOURNAL   iScience 23 (8), 101380 (2020)
   PUBMED   32745987
REFERENCE   5  (residues 1 to 442)
  AUTHORS   Mochida,T., Take,K., Maki,T., Nakakariya,M., Adachi,R., Sato,K.,
            Kitazaki,T. and Takekawa,S.
  TITLE     Inhibition of MGAT2 modulates fat-induced gut peptide release and
            fat intake in normal mice and ameliorates obesity and diabetes in
            ob/ob mice fed on a high-fat diet
  JOURNAL   FEBS Open Bio 10 (3), 316-326 (2020)
   PUBMED   31837122
REFERENCE   6  (residues 1 to 442)
  AUTHORS   Yen,C.L. and Farese,R.V. Jr.
  TITLE     MGAT2, a monoacylglycerol acyltransferase expressed in the small
            intestine
  JOURNAL   J Biol Chem 278 (20), 18532-18537 (2003)
   PUBMED   12621063
  REMARK    GeneRIF: MGAT2 is a monoacylglycerol acyltransferase expressed in
            the small intestine
REFERENCE   7  (residues 1 to 442)
  AUTHORS   Cao,J., Lockwood,J., Burn,P. and Shi,Y.
  TITLE     Cloning and functional characterization of a mouse intestinal
            acyl-CoA:monoacylglycerol acyltransferase, MGAT2
  JOURNAL   J Biol Chem 278 (16), 13860-13866 (2003)
   PUBMED   12576479
  REMARK    GeneRIF: MGAT2 may play an important role in dietary fat absorption
REFERENCE   8  (residues 1 to 442)
  AUTHORS   Lowe,J.B. and Marth,J.D.
  TITLE     A genetic approach to Mammalian glycan function
  JOURNAL   Annu Rev Biochem 72, 643-691 (2003)
   PUBMED   12676797
  REMARK    Review article
REFERENCE   9  (residues 1 to 442)
  AUTHORS   Wang,Y., Schachter,H. and Marth,J.D.
  TITLE     Mice with a homozygous deletion of the Mgat2 gene encoding
            UDP-N-acetylglucosamine:alpha-6-D-mannoside
            beta1,2-N-acetylglucosaminyltransferase II: a model for congenital
            disorder of glycosylation type IIa
  JOURNAL   Biochim Biophys Acta 1573 (3), 301-311 (2002)
   PUBMED   12417412
  REMARK    Review article
REFERENCE   10 (residues 1 to 442)
  AUTHORS   Wang,Y., Tan,J., Sutton-Smith,M., Ditto,D., Panico,M.,
            Campbell,R.M., Varki,N.M., Long,J.M., Jaeken,J., Levinson,S.R.,
            Wynshaw-Boris,A., Morris,H.R., Le,D., Dell,A., Schachter,H. and
            Marth,J.D.
  TITLE     Modeling human congenital disorder of glycosylation type IIa in the
            mouse: conservation of asparagine-linked glycan-dependent functions
            in mammalian physiology and insights into disease pathogenesis
  JOURNAL   Glycobiology 11 (12), 1051-1070 (2001)
   PUBMED   11805078
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY101942.1, AK083370.1, AK152925.1 and AI595654.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 28.73 cM"
     Protein         1..442
                     /product="alpha-1,6-mannosyl-glycoprotein
                     2-beta-N-acetylglucosaminyltransferase precursor"
                     /EC_number="2.4.1.143"
                     /note="alpha-1,6-mannosyl-glycoprotein
                     2-beta-N-acetylglucosaminyltransferase; glcNAc-T II;
                     beta-1,2-N-acetylglucosaminyltransferase II;
                     N-glycosyl-oligosaccharide-glycoprotein
                     N-acetylglucosaminyltransferase II"
                     /calculated_mol_wt=48757
     sig_peptide     1..19
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2291
     Site            10..29
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q921V5.1)"
     Site            64
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q921V5.1)"
     Site            81
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q921V5.1)"
     Region          87..435
                     /region_name="MGAT2"
                     /note="N-acetylglucosaminyltransferase II (MGAT2);
                     pfam05060"
                     /db_xref="CDD:461539"
     CDS             1..442
                     /gene="Mgat2"
                     /gene_synonym="CDGS2; GLCNACTII; GNT-II; GNT2"
                     /coded_by="NM_146035.2:497..1825"
                     /db_xref="CCDS:CCDS25947.1"
                     /db_xref="GeneID:217664"
                     /db_xref="MGI:MGI:2384966"
ORIGIN      
        1 mrfriykrkv liltlvvaac gfvlwssngr qrksdalgpp lldaepvrga ghlavsvgir
       61 rvsnesaapl vpavprpevd nltlryrslv yqlnfdqmlr nvgndgtwsp gelvlvvqvh
      121 nrpeylrlli dslrkaqgiq evlvifshdf wsaeinslis rvdfcpvlqv ffpfsiqlyp
      181 nefpgsdprd cprdlkknaa lklgcinaey pdsfghyrea kfsqtkhhww wklhfvwerv
      241 kvlqdytgli lfleedhyla pdfyhvfkkm wklkqqecpg cdvlslgtyt tirsfygiad
      301 kvdvktwkst ehnmglaltr dayqkliect dtfctyddyn wdwtlqyltl aclpkiwkvl
      361 vpqaprifha gdcgmhhkkt crpstqsaqi esllnsnkqy lfpetlvige kfpmaaispp
      421 rknggwgdir dhelcksyrr lq
//
