LOCUS       NM_001110150            2695 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus mannoside acetylglucosaminyltransferase 1 (Mgat1),
            transcript variant 4, mRNA.
ACCESSION   NM_001110150
VERSION     NM_001110150.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2695)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2695)
  AUTHORS   Sheikh,S., Lo,B.K.M., Kaune,H., Bansal,J., Deleva,A. and
            Williams,S.A.
  TITLE     Rescue of follicle development after oocyte-induced ovary
            dysfunction and infertility in a model of POI
  JOURNAL   Front Cell Dev Biol 11, 1202411 (2023)
   PUBMED   37614224
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2695)
  AUTHORS   Sy,M., Brandt,A.U., Lee,S.U., Newton,B.L., Pawling,J., Golzar,A.,
            Rahman,A.M.A., Yu,Z., Cooper,G., Scheel,M., Paul,F., Dennis,J.W.
            and Demetriou,M.
  TITLE     N-acetylglucosamine drives myelination by triggering
            oligodendrocyte precursor cell differentiation
  JOURNAL   J Biol Chem 295 (51), 17413-17424 (2020)
   PUBMED   33453988
REFERENCE   4  (bases 1 to 2695)
  AUTHORS   Mortales,C.L., Lee,S.U., Manousadjian,A., Hayama,K.L. and
            Demetriou,M.
  TITLE     N-Glycan Branching Decouples B Cell Innate and Adaptive Immunity to
            Control Inflammatory Demyelination
  JOURNAL   iScience 23 (8), 101380 (2020)
   PUBMED   32745987
REFERENCE   5  (bases 1 to 2695)
  AUTHORS   Biswas,B., Batista,F., Akintayo,A., Aguilan,J. and Stanley,P.
  TITLE     Transgenic Rescue of Spermatogenesis in Males With Mgat1 Deleted in
            Germ Cells
  JOURNAL   Front Cell Dev Biol 8, 212 (2020)
   PUBMED   32300591
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2695)
  AUTHORS   Danciger,M., Brady,J., Adamson,M.C., Farber,D.B., Piatigorsky,J.
            and Kozak,C.A.
  TITLE     Chromosomal localization of the genes for five zinc finger proteins
            expressed in mouse lens
  JOURNAL   Genomics 28 (1), 39-43 (1995)
   PUBMED   7590745
REFERENCE   7  (bases 1 to 2695)
  AUTHORS   Miyazaki,S., Kozak,C.A., Marchetti,A., Buttitta,F., Gallahan,D. and
            Callahan,R.
  TITLE     The chromosomal location of the mouse mammary tumor gene Int6 and
            related pseudogenes in the mouse genome
  JOURNAL   Genomics 27 (3), 420-424 (1995)
   PUBMED   7558022
REFERENCE   8  (bases 1 to 2695)
  AUTHORS   Kumar,R., Yang,J., Eddy,R.L., Byers,M.G., Shows,T.B. and Stanley,P.
  TITLE     Cloning and expression of the murine gene and chromosomal location
            of the human gene encoding N-acetylglucosaminyltransferase I
  JOURNAL   Glycobiology 2 (4), 383-393 (1992)
   PUBMED   1421759
  REMARK    Erratum:[Glycobiology 1999 Aug;9(8):ix]
REFERENCE   9  (bases 1 to 2695)
  AUTHORS   Pownall,S., Kozak,C.A., Schappert,K., Sarkar,M., Hull,E.,
            Schachter,H. and Marth,J.D.
  TITLE     Molecular cloning and characterization of the mouse
            UDP-N-acetylglucosamine:alpha-3-D-mannoside
            beta-1,2-N-acetylglucosaminyltransferase I gene
  JOURNAL   Genomics 12 (4), 699-704 (1992)
   PUBMED   1533386
REFERENCE   10 (bases 1 to 2695)
  AUTHORS   Lo,C.W.
  TITLE     Localization of low abundance DNA sequences in tissue sections by
            in situ hybridization
  JOURNAL   J Cell Sci 81, 143-162 (1986)
   PUBMED   3733894
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK004760.1 and AI118268.1.
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 1. All variants encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004760.1, AK155322.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2345              AK004760.1         1-2345
            2346-2695           AI118268.1         1-350               c
FEATURES             Location/Qualifiers
     source          1..2695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 29.27 cM"
     gene            1..2695
                     /gene="Mgat1"
                     /gene_synonym="Mgat-1"
                     /note="mannoside acetylglucosaminyltransferase 1"
                     /db_xref="GeneID:17308"
                     /db_xref="MGI:MGI:96973"
     exon            1..104
                     /gene="Mgat1"
                     /gene_synonym="Mgat-1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..229
                     /gene="Mgat1"
                     /gene_synonym="Mgat-1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..2686
                     /gene="Mgat1"
                     /gene_synonym="Mgat-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..1694
                     /gene="Mgat1"
                     /gene_synonym="Mgat-1"
                     /EC_number="2.4.1.101"
                     /note="GNT-I; glcNAc-T I;
                     N-glycosyl-oligosaccharide-glycoprotein
                     N-acetylglucosaminyltransferase I"
                     /codon_start=1
                     /product="alpha-1,3-mannosyl-glycoprotein
                     2-beta-N-acetylglucosaminyltransferase"
                     /protein_id="NP_001103620.1"
                     /db_xref="CCDS:CCDS24602.1"
                     /db_xref="GeneID:17308"
                     /db_xref="MGI:MGI:96973"
                     /translation="MLKKQTAGLVLWGAIIFVGWNALLLLFFWTRPAPGRLPSDSALG
                     DDPASLTREVIHLAEDAEAELERQRGLLQQIKEHYALWRQRWRVPTVAPPAWPRVPVT
                     PSPVQIPILVIACDRSTVRRCLDKLLHYRPSAERFPIIVSQDCGHEETAQVIASYGTA
                     VTHIRQPDLSNIAVQPDHRKFQGYYKIARHYRWALGQIFNKFKFPAAVVVEDDLEVAP
                     DFFEYFQATYPLLRTDPSLWCVSAWNDNGKEQMVDSSKPELLYRTDFFPGLGWLLLAD
                     LWAELEPKWPKAFWDDWMRRPEQRKGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFI
                     KLNQQFVPFTQLDLSYLQQEAYDRDFLAQVYGAPQLQVEKVRTNDQKELGEVRVQYTS
                     RDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPQTWTGYDPSWN"
     regulatory      2663..2668
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgat1"
                     /gene_synonym="Mgat-1"
                     /note="hexamer: AGTAAA"
     polyA_site      2686
                     /gene="Mgat1"
                     /gene_synonym="Mgat-1"
                     /note="major polyA site"
ORIGIN      
        1 ggggaaggac cacattgccg gctagcagga aggccaacca gaccggacga ggccgctcca
       61 gcgctgggtg ttgccggtcc ggggcgagcc tggttccagg cggggttaaa ctcactttct
      121 gcttcggacg tcaaggtatt gccattctaa tccagacatc aagggcggtg gagaagacaa
      181 aagtcggttg tctgtttaca gaagaggaac tgaggcagtg gttcttcagg tacatggctt
      241 cttcctactc tcagcctaga agaataaacc cttagtgtgg ggacctgagc caggcaagcc
      301 aaaggcagcc ttgagccctc cctcccctgc cctcccctgc gggggccagg atgctgaaga
      361 agcagactgc agggcttgtg ctttggggtg ctatcatctt tgtgggctgg aatgccctgc
      421 tgcttctctt cttctggaca cgcccagcac ctggcaggct gccctcagac agcgcccttg
      481 gtgatgaccc tgccagcctc acccgtgagg tcatccacct ggccgaggac gctgaggcgg
      541 agttggagcg gcagagggga ctgttgcagc aaatcaagga gcattatgct ttgtggaggc
      601 agaggtggag agttcccact gtggcccctc cagcctggcc ccgtgtgcct gtgaccccct
      661 caccagtgca gatccccatc ctggtcattg cctgtgaccg cagcactgtc cggcgctgct
      721 tggataagtt gttgcactat cggccctcag ctgagcgttt ccccattatt gtcagtcagg
      781 actgtgggca tgaagagaca gcacaggtca ttgcttccta tggcactgca gtcacacaca
      841 tccggcagcc ggacctgagt aacattgccg tgcagccaga ccaccgcaag ttccagggtt
      901 actacaagat tgccaggcac taccgctggg cactaggcca gatcttcaac aagttcaagt
      961 tcccggccgc tgtggtagtg gaggatgatc tggaagtggc accagacttc tttgagtact
     1021 tccaggccac ctacccactg ctgagaacag acccctccct ttggtgtgtg tctgcttgga
     1081 atgacaatgg caaggagcag atggtagact caagcaaacc tgagctgctc tatcgaacag
     1141 acttttttcc tggccttgga tggctgctgt tggctgatct gtgggcagag ctggagccca
     1201 agtggcccaa ggccttttgg gacgactgga tgcgccgacc tgagcagcgg aaaggacggg
     1261 cttgtattcg tccagaaatt tcaagaacta tgacctttgg tcgcaagggt gtgagccacg
     1321 ggcagttctt tgaccagcat cttaagttca tcaagctgaa ccagcagttc gtccccttca
     1381 cccagttgga cctgtcgtac ctgcagcagg aggcctatga ccgggacttc ctcgcccagg
     1441 tctatggtgc cccccagcta caggtggaga aagtaaggac caatgatcag aaggagctgg
     1501 gggaggtgcg ggtacagtac actagcagag acagcttcaa ggcctttgct aaggccctgg
     1561 gtgtcatgga tgacctcaag tctggtgtcc ccagggctgg ctaccgtggc attgtcactt
     1621 tccagtttcg gggccggcgt gtgcacctgg cacccccaca gacatggact ggctatgatc
     1681 ctagctggaa ttagcagcac ctgcctttcc ctcctgggtc tccttgccgc gtgctgagcc
     1741 gaggcaggcc tgcagggcct gggctacacc atcctgccag tgtctccctc tcagtgtctc
     1801 cctcttggat ctgtagatct tccctttgtg tcctggccag cccccaaatg gcattctagt
     1861 gcacaaatca taggatgaga gttatactcc tgttgtcaag ggagtattgt gtggtatgtt
     1921 cggggcatat tgaacaagaa accactgtgt ggtatgggga gggttgggcc tgttggggcc
     1981 aggtttgtaa tgtctccaag ggcatctgca gagagcttgg cagctccagc tctcctcagc
     2041 aggcctctcc accctgatct ggcccctgtt agcccatgag ccctctttat gtacccatcc
     2101 tccctttctg aaccttccct cagggtgggg ctggattatg gaggaaggaa tggatctttg
     2161 gtcagatgag actaacagag ggactcactg tcagagttag cgtggattgc tgctgccggg
     2221 gcactacctc ctggcttctc tccctgctga cgtggctctt gtcctggagc agagcagtgc
     2281 gttgttggga gatggaaagt ctatgcgtgg gtaccctgtc ttcttgcctg tggcccccct
     2341 cctttctgaa agttagttct ctccgcattc tttaggagga ttcaggggcg gcctagtgga
     2401 agacagtggg ctccatgcct ctttcccctg gggtttgctt caggggctcc tccccgaggg
     2461 cttgctcctg gtggcagcag ctgagatcag gacatctgtg gccctgagcc ggctctggtc
     2521 ctcggccttt cccagccttc ccacatcttc ccaggccaag atgcaggggg caggctgaag
     2581 agaaatttgt gtgtccttgt ttgttgcctg atcttagttt catggaagaa aatggaatct
     2641 acagaattat tttcaaaaat aaagtaaagg ctgaattgct gaaaaaaaaa aaaaa
//
