LOCUS       NM_026358               1245 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mitochondria localized glutamic acid rich protein
            (Mgarp), transcript variant 1, mRNA.
ACCESSION   NM_026358
VERSION     NM_026358.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1245)
  AUTHORS   Li,H., Jiang,Y., Liu,M., Yu,J., Feng,X., Xu,X., Wang,H., Zhang,J.,
            Sun,X. and Yu,Y.
  TITLE     DNA methylation-mediated inhibition of MGARP is involved in
            impaired progeny testosterone synthesis in mice exposed to DBP in
            utero
  JOURNAL   Environ Toxicol 38 (4), 914-925 (2023)
   PUBMED   36602389
  REMARK    GeneRIF: DNA methylation-mediated inhibition of MGARP is involved
            in impaired progeny testosterone synthesis in mice exposed to DBP
            in utero.
REFERENCE   2  (bases 1 to 1245)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   3  (bases 1 to 1245)
  AUTHORS   Zhang,S.
  TITLE     MGARP is ultrastructurally located in the inner faces of
            mitochondrial membranes
  JOURNAL   Biochem Biophys Res Commun 516 (1), 138-143 (2019)
   PUBMED   31202457
REFERENCE   4  (bases 1 to 1245)
  AUTHORS   Menendez-Montes,I., Escobar,B., Palacios,B., Gomez,M.J.,
            Izquierdo-Garcia,J.L., Flores,L., Jimenez-Borreguero,L.J.,
            Aragones,J., Ruiz-Cabello,J., Torres,M. and Martin-Puig,S.
  TITLE     Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch
            Essential for Cardiac Maturation
  JOURNAL   Dev Cell 39 (6), 724-739 (2016)
   PUBMED   27997827
REFERENCE   5  (bases 1 to 1245)
  AUTHORS   Jia,L., Liang,T., Yu,X., Ma,C. and Zhang,S.
  TITLE     MGARP regulates mouse neocortical development via mitochondrial
            positioning
  JOURNAL   Mol Neurobiol 49 (3), 1293-1308 (2014)
   PUBMED   24323429
  REMARK    GeneRIF: The ratio of motile mitochondria was remarkably decreased
            in the axons of MGARP-overexpressing cells.
REFERENCE   6  (bases 1 to 1245)
  AUTHORS   Matsumoto,T., Minegishi,K., Ishimoto,H., Tanaka,M., Hennebold,J.D.,
            Teranishi,T., Hattori,Y., Furuya,M., Higuchi,T., Asai,S., Kim,S.H.,
            Miyakoshi,K. and Yoshimura,Y.
  TITLE     Expression of ovary-specific acidic protein in steroidogenic
            tissues: a possible role in steroidogenesis
  JOURNAL   Endocrinology 150 (7), 3353-3359 (2009)
   PUBMED   19325000
  REMARK    GeneRIF: OSAP is prominently expressed in steroidogenic tissues;
            results suggest that OSAP is involved in steroidogenesis,
            potentially through its ability to maintain mitochondrial abundance
            and morphology
REFERENCE   7  (bases 1 to 1245)
  AUTHORS   Kinouchi,R., Kinouchi,T., Hamamoto,T., Saito,T., Tavares,A.,
            Tsuru,T. and Yamagami,S.
  TITLE     Distribution of CESP-1 protein in the corneal endothelium and other
            tissues
  JOURNAL   Invest Ophthalmol Vis Sci 47 (4), 1397-1403 (2006)
   PUBMED   16565373
REFERENCE   8  (bases 1 to 1245)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   9  (bases 1 to 1245)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1245)
  AUTHORS   Hennebold,J.D., Tanaka,M., Saito,J., Hanson,B.R. and Adashi,E.Y.
  TITLE     Ovary-selective genes I: the generation and characterization of an
            ovary-selective complementary deoxyribonucleic acid library
  JOURNAL   Endocrinology 141 (8), 2725-2734 (2000)
   PUBMED   10919256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY328038.1 and BC012511.1.
            
            On Jul 23, 2009 this sequence version replaced NM_026358.2.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript for this gene.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012511.1, AF228502.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY328038.1         1-7
            8-1245              BC012511.1         1-1238
FEATURES             Location/Qualifiers
     source          1..1245
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 22.46 cM"
     gene            1..1245
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /note="mitochondria localized glutamic acid rich protein"
                     /db_xref="GeneID:67749"
                     /db_xref="MGI:MGI:1914999"
     exon            1..121
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..891
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /note="corneal endothelium-specific protein 1;
                     ovary-specific acidic protein; hypoxia up-regulated
                     mitochondrial movement regulator protein"
                     /codon_start=1
                     /product="protein MGARP"
                     /protein_id="NP_080634.2"
                     /db_xref="CCDS:CCDS17338.1"
                     /db_xref="GeneID:67749"
                     /db_xref="MGI:MGI:1914999"
                     /translation="MYLRRAVSKTLALPRRAPPGPAPLGKDASLRRMSSRKFPGTSGS
                     NMIYYLVVGVTVSAGGYYTYKALTSKQVRRTEHVAEPKEQTKAELQPLPGEKEEHVAE
                     AEQVCSEPGDTAVTEAESVDAEEVPEAAVVLPEESQASAPSEVPAEAAVVEASLSSSE
                     PELKITEASLVETTESVPESTQEVESAAPDQDDVCNEGADTSQEGADTSQEGADTSQE
                     GADTTKEEADNSKEAEGTTTEDPRSISEESAELEESPPLGSEPPAQPESQEEETQVTE
                     ETASPQG"
     exon            122..225
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /inference="alignment:Splign:2.1.0"
     exon            226..319
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /inference="alignment:Splign:2.1.0"
     exon            320..1231
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1210..1215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /note="hexamer: AATAAA"
     polyA_site      1231
                     /gene="Mgarp"
                     /gene_synonym="4930583H14Rik; CESP-1; HUMMR; Osap; Qsap"
                     /note="major polyA site"
ORIGIN      
        1 ggttgcttga tccgctgctg aatctgagcg catctggcga tgtatctccg cagggctgtg
       61 tccaagactc tggcgctgcc ccggagggcg cccccgggtc ccgcgccgct ggggaaggac
      121 gcatctcttc gccgaatgtc atccaggaaa ttccctggaa catctggctc caatatgatc
      181 tattacctgg ttgtaggtgt gacagtcagt gctggtggat attacactta caaggcttta
      241 acatcaaagc aagtgagacg tacagaacat gtagctgaac cgaaagaaca aacaaaggcg
      301 gagttgcaac cacttccagg tgaaaaggaa gagcatgtgg cagaagccga gcaagtgtgt
      361 tcagagcctg gagacactgc tgtaacggaa gctgaatcgg tagatgctga ggaagtccca
      421 gaggctgcag ttgtgcttcc agaagagtct caggcctccg ccccctccga ggtccctgcc
      481 gaagctgccg tggtggaggc atccttatcg agctcagagc ctgagctgaa gataaccgag
      541 gcttccctgg tggagactac cgagagtgtc cctgagtcta ctcaggaggt ggagagtgca
      601 gccccagacc aggatgacgt ttgcaatgag ggggctgata ctagccagga gggcgctgat
      661 accagccagg agggggctga taccagccag gagggcgctg ataccaccaa ggaggaggct
      721 gataacagca aggaggctga aggtaccact actgaggacc cgcgctcgat ctccgaggag
      781 agtgccgaac tagaagaaag ccctccctta ggctcagaac cccctgccca gcctgagtca
      841 caagaagaag aaacccaggt cacagaggaa acagcatcac cccaaggttg atctgcaaaa
      901 ttctatagtt gcttttgtat ttttagtgac cttagccctt cttcctagaa tattttaata
      961 taccttaaag aatttaactt tactaataga tatttgattg ggagttggta ttttacaagt
     1021 cttaatagtt tttccaccct ctaaaatcag gctgtgttaa gaccttaaat agtgttaagt
     1081 ttggatttaa gttttacgtt ttagaaactg agttatctat gcaaccggtg tcactttgat
     1141 tttcctttgc ctttctctta ctttgttcta tgtaagacca gattactggg tttgctgtga
     1201 actcatttaa ataaaattag aaaatcctaa aaaaaaaaaa aaaaa
//
