LOCUS       NM_013720              13931 bp    mRNA    linear   ROD 27-MAY-2024
DEFINITION  Mus musculus MAX gene associated (Mga), transcript variant 1, mRNA.
ACCESSION   NM_013720
VERSION     NM_013720.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13931)
  AUTHORS   Thomas,M.E. 3rd, Qi,W., Walsh,M.P., Ma,J., Westover,T.,
            Abdelhamed,S., Ezzell,L.J., Rolle,C., Xiong,E., Rosikiewicz,W.,
            Xu,B., Loughran,A.J., Pruett-Miller,S.M., Janke,L.J. and Klco,J.M.
  TITLE     Functional characterization of cooperating MGA mutations in
            RUNX1::RUNX1T1 acute myeloid leukemia
  JOURNAL   Leukemia 38 (5), 991-1002 (2024)
   PUBMED   38454121
  REMARK    GeneRIF: Functional characterization of cooperating MGA mutations
            in RUNX1::RUNX1T1 acute myeloid leukemia.
REFERENCE   2  (bases 1 to 13931)
  AUTHORS   Zhu,J.Y., Wang,G., Huang,X., Lee,H., Lee,J.G., Yang,P., van de
            Leemput,J., Huang,W., Kane,M.A., Yang,P. and Han,Z.
  TITLE     SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes
            through MGA/MAX complex-mediated increased glycolysis
  JOURNAL   Commun Biol 5 (1), 1039 (2022)
   PUBMED   36180527
  REMARK    GeneRIF: SARS-CoV-2 Nsp6 damages Drosophila heart and mouse
            cardiomyocytes through MGA/MAX complex-mediated increased
            glycolysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13931)
  AUTHORS   Tanaskovic,N., Dalsass,M., Filipuzzi,M., Ceccotti,G.,
            Verrecchia,A., Nicoli,P., Doni,M., Olivero,D., Pasini,D.,
            Koseki,H., Sabo,A., Bisso,A. and Amati,B.
  TITLE     Polycomb group ring finger protein 6 suppresses Myc-induced
            lymphomagenesis
  JOURNAL   Life Sci Alliance 5 (8), e202101344 (2022)
   PUBMED   35422437
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13931)
  AUTHORS   Mochizuki,K., Sharif,J., Shirane,K., Uranishi,K., Bogutz,A.B.,
            Janssen,S.M., Suzuki,A., Okuda,A., Koseki,H. and Lorincz,M.C.
  TITLE     Repression of germline genes by PRC1.6 and SETDB1 in the early
            embryo precedes DNA methylation-mediated silencing
  JOURNAL   Nat Commun 12 (1), 7020 (2021)
   PUBMED   34857746
  REMARK    GeneRIF: Repression of germline genes by PRC1.6 and SETDB1 in the
            early embryo precedes DNA methylation-mediated silencing.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 13931)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13931)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 13931)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 13931)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   9  (bases 1 to 13931)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 13931)
  AUTHORS   Hurlin,P.J., Steingrimsson,E., Copeland,N.G., Jenkins,N.A. and
            Eisenman,R.N.
  TITLE     Mga, a dual-specificity transcription factor that interacts with
            Max and contains a T-domain DNA-binding motif
  JOURNAL   EMBO J 18 (24), 7019-7028 (1999)
   PUBMED   10601024
  REMARK    Erratum:[EMBO J 2000 Jul 17;19(14):3841]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046252.1, AK172962.1, CD539587.1, AF205935.1, BQ552371.1,
            CN725372.1 and AL954662.13.
            
            On Dec 30, 2006 this sequence version replaced NM_013720.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AK046252.1         2-78
            78-3591             AK172962.1         1-3514
            3592-3994           CD539587.1         191-593
            3995-4963           AF205935.1         3812-4780
            4964-5016           BQ552371.1         271-323
            5017-5444           AF205935.1         4834-5261
            5445-7699           AK172962.1         4741-6995
            7700-8207           CN725372.1         151-658
            8208-13931          AL954662.13        100300-106023
FEATURES             Location/Qualifiers
     source          1..13931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 59.97 cM"
     gene            1..13931
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="MAX gene associated"
                     /db_xref="GeneID:29808"
                     /db_xref="MGI:MGI:1352483"
     exon            1..119
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            120..1247
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..9315
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MAX-interacting protein; MAX gene-associated protein; Max
                     dimerization protein 5"
                     /codon_start=1
                     /product="MAX gene-associated protein isoform 1"
                     /protein_id="NP_038748.2"
                     /db_xref="CCDS:CCDS38208.1"
                     /db_xref="GeneID:29808"
                     /db_xref="MGI:MGI:1352483"
                     /translation="MEEKQQIILANQDGGTVTGGAPTFFVILKQPGNGKTDQGILVTN
                     RDARALLSRESSPGKSKEKICLPADCTVGKITVTLDNNSMWNEFHNRSTEMILTKQGR
                     RMFPYCRYWITGLDSNLKYILVMDISPVDSHRYKWNGRWWEPSGKAEPHILGRVFIHP
                     ESPSTGHYWMHQPVSFYKLKLTNNTLDQEGHIILHSMHRYLPRLHLVPAEKATEVIQL
                     NGPGVHTFTFPQTEFFAVTAYQNIQITQLKIDYNPFAKGFRDDGLSSKPQREGKQRNS
                     SDQEGNSVSSSPAHRVRLTEGEGSEIHSGDFDPVLRGHEASSLSLEKAPHNVKQDFLG
                     FMNTDSTHEVPQLKHEISESRIVNSFEDDSQISSPSNPNGNFNVVIKEEPLDDYDYEL
                     GECPEGITVKQEETDEETDVYSNSDDDPILEKQLKRHNKVDNLEADHPSYKWLPNSPG
                     VAKAKMFKLDAGKMPVVYLEPCAVTKSTVKISELPDNMLSTSRKDKSMLAELEYLPAY
                     IENSDGTDFCLSKDSENSLRKHSPDLRIVQKYTLLKEPNWKYPDILDNSSTERIHDSS
                     KGSTAESFSGKEDLGKKRTTMLKMAIPSKTVTASHSASPNTPGKRGRPRKLRLSKAGR
                     PPKNTGKSLTAAKNIPVGPGSTFPDVKPDLEDVDGVLFVSFESKEALDIHAVDGTTEE
                     PSSLQTTTTNDSGCRTRISQLEKELIEDLKSLRHKQVIHPALQEVGLKLNSVDPTVSI
                     DLKYLGVQLPLAPATSFPLWNVTGTNPASPDAGFPFVSRTGKTNDFTKIKGWRGKFQN
                     ASASRNEGGNSEASLKNRSAFCSDKLDEYLENEGKLMETNIGFSSNAPTSPVVYQLPT
                     KSTSYVRTLDSVLKKQSTISPSTSHSVKPQSVTTASRKTKAQNKQTTLSGRTKSSYKS
                     ILPYPVSPKQKNSHVSQGDKITKNSLSSTSDNQVTNLVVPSVDENAFPKQISLRQAQQ
                     QHLQQQGTRPPGLSKSQVKLMDLEDCALWEGKPRTYITEERADVSLTTLLTAQASLKT
                     KPIHTIIRKRAPPCNNDFCRLGCVCSSLALEKRQPAHCRRPDCMFGCTCLKRKVVLVK
                     GGSKTKHFHKKAANRDPLFYDTLGEEGREGGGVREDEEQLKEKKKRKKLEYTVCEAEP
                     EQPVRHYPLWVKVEGEVDPEPVYIPTPSVIEPIKPLVLPQPDLSSTTKGKLTPGIKPA
                     RTYTPKPNPVIREEDKDPVYLYFESMMTCARVRVYERKKEEQRQLSPPLSPSSSFQQQ
                     SSCYSSPENRVTKELDSEQTLKQLICDLEDDSDKSQEKSWKSSCNEGESSSTSYVHQR
                     SPGGPTKLIEIISDCNWEEDRNKILSILSQHINSNMPQSLKVGSFIIELASQRKCRGE
                     KTPPVYSSRVKISMPSSQDQDDMAEKSGSETPDGPLSPGKMDDISPVQTDALDSVRER
                     LHGGKGLPFYAGLSPSGKLVAYKRKPSSTTSGLIQVASNAKVAASRKPRTLLPSTSNS
                     KMASSGPATNRSGKNLKAFVPAKRPIAARPSPGGVFTQFVMSKVGALQQKIPGVRTPQ
                     PLTGPQKFSIRPSPVMVVTPVVSSEQVQVCSTVAAAVTTSPQVFLENVTAVPSLTANS
                     DMGAKEATYSSSASTAGVVEISETNNTTLVTSTQSTATVNLTKTTGITTSPVASVSFA
                     KPLVASPTITLPVASTASTSIVMVTTAASSSVVTTPTSSLSSVPIILSGINGSPPVSQ
                     RPENAPQIPVTTPQISSNNVKRTGPRLLLIPVQQGSPTLRPIQNPQLQGQRMVLQPVR
                     GPSGMNLFRHPNGQIVQLLPLHQIRGSNAQPSLQPVVFRNPGSMVGIRLPAPCKSSET
                     PSSSASSSAFSVMSPVIQAVGSSPTVNVISQAPSLLSSGSSFVSQAGTLTLRISPPET
                     QNLASKTGSESKITPSTGGQPVGTASLIPLQSGSFALLQLPGQKPIPSSVLQHVASLQ
                     IKKESQSTDQKDETNSIKREEETKKALPSKDKALDSEANIMKQNSGIIASENTSNNSL
                     DDGGDLLDEETLREDARPYEYSYSTGSHTDEDKDGDEDSGNKNQNSPKEKQTVPEVRA
                     GSKNIDIMALQSIRSIRPQKCVKVKVEPQEGSDNPENPDDFLVLSKDSKFELSGNQVK
                     EQQSNSQAEAKKDCEDSLGKDSLRERWRKHLKGPLTQKYIGISQNFNKEANVQFFTEM
                     KPCQENSEQDISELLGKSGTIESGGVLKTEDGSWSGISSSAAFSIIPRRATKGRRGSR
                     HFQGHLLLPREQMKPKQQTKDGRSSAADFTVLDLEDEDEEDEKTDDSLDEIVDVVSGY
                     QSEEVDVEKNNYVDYLEDDEQVDVETIEELSEEINFPYKKTTATHTQSFKQQCHSHIS
                     ADEKASEKSRKVSLISSKLKDDCWGDKPHKETEAFAYYRRTHTANERRRRGEMRDLFE
                     KLKITLGLLHSSKVSKSLILNRAFSEIQGLTDQADKLIGQKNLLSRKRSILIRKVSSL
                     SGKTEEVVLKKLEYIYAKQQALEAQKRKKKLGSDEFCVSPRIGTQLEGSSASSVDLGQ
                     MLMNNRRGKPLILSRKRDQATENASPSDTPHSSANLVMTPQGQLLTLKGPLFSGPVVA
                     VSPALLEGGLKPQVASSTMSQSENDDLFMMPRIVNVTSLAAEEDLGGMSGNKYRHEVP
                     DGKPLDHLRDIAGSEASSLKDTERISSRGNHRDSRKALGPTQVLLANKDSGFPHVADV
                     STMQAAQEFIPKNMSGDVRGHRYKWKECELRGERLKSKESQFHKLKMKDLKDSSIEME
                     LRKVASAIEEAALHPSELLTNMEDEDDTDETLTSLLNEIAFLNQQLNDDSGLAELSGS
                     MDTEFSGDAQRAFISKLAPGNRSAFQVGHLGAGVKELPDVQEESESISPLLLHLEDDD
                     FSENEKQLGDTASEPDVLKIVIDPEIKDSLVSHRKSSDGGQSTSGLPAEPESVSSPPI
                     LHMKTGPENSNTDTLWRPMPKLAPLGLKVANPPSDADGQSLKVMPALAPIAAKVGSIG
                     HKMNLAGIDQEGRGSKVMPTLAPVVPKLGNSGAPSSSSGK"
     exon            1248..2190
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2269
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            2270..2365
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2497
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            2498..2602
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..3261
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            3262..3604
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            3605..3828
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..4011
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            4012..4081
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            4082..4599
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            4600..4747
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            4748..5371
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            5372..5662
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            5663..7131
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            7132..7259
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            7260..7311
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            7312..7518
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            7519..7630
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            7631..7864
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            7865..8041
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     exon            8042..13931
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      11974..11979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="hexamer: ATTAAA"
     polyA_site      11992
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="major polyA site"
     regulatory      12070..12075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="hexamer: AATAAA"
     regulatory      12079..12084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="hexamer: ATTATA"
     regulatory      12088..12093
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="hexamer: ATTAAA"
     polyA_site      12096
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="major polyA site"
     polyA_site      12099
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="major polyA site"
     polyA_site      12112
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
     regulatory      13493..13498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
                     /note="hexamer: ATTAAA"
     polyA_site      13514
                     /gene="Mga"
                     /gene_synonym="C130042M01Rik; D030062C11Rik; Mad5"
ORIGIN      
        1 atccggtgcg tgcgcaggct cttcagctga agcggacaca cggtgtgcga acccttcaga
       61 ataaccctcc cctagaggga tgtgaaggac tcggggtgag gccggccacg ccccgcacgg
      121 atgaaaaagc atttgtaact atgaattgac tacagttttc ttactactga atttctcact
      181 ggaatcatgg aagagaaaca gcaaatcata ttggccaatc aagatggagg gacagtgaca
      241 ggaggagcac ctaccttctt tgtcatccta aagcagccag gaaatggcaa aactgatcaa
      301 ggaattttag ttactaatcg agatgcccgt gctttgttga gtagggagtc atcaccagga
      361 aaatctaaag agaaaatttg ccttccggct gattgtactg tgggaaaaat cacggttacc
      421 cttgataaca atagtatgtg gaatgagttc cataatcgaa gcacagagat gattctgacc
      481 aaacagggaa gacgcatgtt tccttattgt cgatattgga taacaggctt agattcaaat
      541 ttaaagtata tccttgtaat ggacatatct cctgtggata gtcatcggta taagtggaat
      601 ggtcgttggt gggaacccag tgggaaggct gaaccccata ttttggggag agttttcatt
      661 catccagaat ctccttctac aggtcattat tggatgcatc aaccagtgtc tttctataaa
      721 ctcaaactta ctaacaatac actggaccag gaaggacata ttatcttgca ctctatgcat
      781 cgttatctgc caaggcttca tttggtgcca gcagaaaagg ctacagaagt gatacagtta
      841 aatggccccg gtgttcatac ttttactttc ccccagactg aattctttgc agtaacagct
      901 tatcagaaca ttcagattac tcagttgaaa atagattaca atccttttgc caaaggcttt
      961 cgggatgatg ggttgagcag taagcctcag agagaaggaa aacagaggaa tagctccgat
     1021 caagaaggga atagtgtttc tagttctcct gctcatcgtg ttcgtcttac agaaggtgaa
     1081 gggtcagaga tacattcagg tgattttgat cctgtgttaa ggggtcatga agcatcaagc
     1141 ttaagtttag agaaggctcc ccataatgta aaacaagact ttcttggatt tatgaatact
     1201 gattcgacac atgaagttcc tcagttgaaa catgagattt ctgaaagtcg tattgtgaac
     1261 agttttgaag atgattccca gatttcctca ccatcaaacc cgaatggaaa ctttaatgtc
     1321 gtcattaaag aagagcctct agatgattat gattatgaac ttggtgaatg cccagaaggg
     1381 ataacagtga aacaagaaga gacagatgag gaaacggatg tatactcaaa cagcgatgac
     1441 gatcctatac tagagaaaca actaaagagg cacaataaag ttgataattt agaagctgac
     1501 catccatctt ataaatggct accaaatagc ccaggtgttg ctaaagctaa aatgtttaaa
     1561 ttagatgctg ggaaaatgcc agtagtttac ttggagccct gtgctgtcac gaaaagcaca
     1621 gtgaaaattt ctgaattgcc tgataatatg ctctccactt ctcgaaaaga taaatctatg
     1681 ttagcagaat tagaatattt gcctgcgtat attgaaaatt ctgatgggac tgacttttgc
     1741 ttaagcaagg attcagaaaa tagtctcaga aaacattcac cagatctcag aattgtacaa
     1801 aaatatactt tacttaaaga gcctaattgg aaatacccgg acatacttga caacagtagc
     1861 acggaaagaa tacatgacag ttccaaagga tcaactgcag agtcattttc aggaaaagag
     1921 gacttaggca aaaagcgaac aacaatgctt aaaatggcaa taccatcaaa gactgtgact
     1981 gctagtcata gtgcctctcc aaatactcct gggaaaagag gaagaccgag aaagttgaga
     2041 ctctctaagg cagggcgacc acctaaaaac acagggaaat ctttaactgc tgccaagaat
     2101 attcctgtag gccctggaag cacctttcct gatgtgaaac ctgatctaga agatgtggat
     2161 ggggtgctct ttgtttcctt tgaatcaaag gaggctcttg atattcatgc agttgatggg
     2221 acaacagaag aaccttctag tcttcagacc acaaccacaa atgattcagg ttgcagaaca
     2281 agaatttccc agttggaaaa ggaattaata gaagatttga agtctttgag gcataagcag
     2341 gtgatacatc ctgctcttca agaagtgggc ttaaaactga attcagtgga tccaacagtg
     2401 agcattgatc ttaaatactt gggagtacaa ttgcctttgg ctccagccac cagctttccc
     2461 ctatggaatg ttacaggtac caaccctgcc tcacctgatg ctgggtttcc ttttgtttct
     2521 aggacgggga agaccaatga ctttaccaaa atcaagggat ggagaggaaa atttcaaaat
     2581 gcttctgcat ctaggaatga aggtggaaat tcagaggctt cactgaaaaa ccgttctgct
     2641 ttctgtagtg ataagctaga tgagtacttg gaaaatgaag gcaaattgat ggaaacaaac
     2701 ataggtttct cttcaaatgc tcccacatct ccagtagtgt accagctacc caccaagagt
     2761 accagctatg ttcgaactct tgatagtgta ctaaagaagc aatctaccat ttccccttct
     2821 acctctcact ctgtgaagcc tcagtctgta accactgcct ctcgaaaaac aaaggctcag
     2881 aacaaacaga caacactcag tggccgaact aaatcatctt ataagtctat tttaccatac
     2941 cctgtttcac caaagcagaa aaactctcat gtgagccaag gagataaaat taccaagaat
     3001 tccttgagtt cgacctcaga taatcaggtg actaacttgg ttgtgccatc tgtagatgaa
     3061 aatgcatttc caaagcagat tagtttgcgg caggcccagc aacagcacct tcagcagcaa
     3121 ggaactcgcc ctccaggctt gtcgaaatct caagtaaagc ttatggacct ggaagactgt
     3181 gcactctggg aaggaaaacc aaggacctat attactgaag agcgagcaga tgtctccttg
     3241 acaactctgc ttactgctca ggcatctctc aaaactaaac ctatccacac aatcataagg
     3301 aaacgagctc ctccatgcaa caatgacttc tgtcgcctgg gttgtgtgtg ctctagtcta
     3361 gctttggaaa agcgccaacc tgctcactgc cgtcgaccag actgcatgtt tggttgcact
     3421 tgtttgaaaa gaaaagttgt gttggttaaa gggggatcta aaacaaagca tttccataag
     3481 aaggctgcta atcgagatcc attattttat gatacgctgg gagaggaagg aagggaagga
     3541 ggaggagtca gagaagatga ggaacaattg aaggagaaaa agaagagaaa gaagctcgaa
     3601 tacactgtat gtgaagcaga acctgagcag ccggttcgac attacccact gtgggtgaag
     3661 gtagaaggtg aagtagatcc agagccggtt tatattccaa ctccttctgt cattgaacct
     3721 ataaaaccat tggtgttgcc tcagccggat ttatcttcta ctacgaaggg caaactaacc
     3781 cctggaatta aaccagcacg aacatatact cccaagccca atcctgtgat acgagaagag
     3841 gacaaagatc cagtctattt gtactttgaa agtatgatga cttgtgcccg agttcgagta
     3901 tatgaacgaa agaaagagga acagagacaa ctgtctccac ccctgtctcc atcctcatca
     3961 tttcagcagc agagttcctg ttactctagt cctgagaacc gtgttacaaa ggaacttgat
     4021 tctgaacaga ccttaaagca gctcatttgt gacttggagg atgattctga taaatcacaa
     4081 gaaaagagct ggaaatcctc ctgcaatgaa ggagagtcct cttctacctc gtatgtacat
     4141 cagaggtcac ctggtggtcc taccaaattg atagagatca tctcagactg caactgggaa
     4201 gaagatcgaa acaagatctt gagcatttta tctcagcaca tcaatagcaa catgccacag
     4261 tcacttaagg tgggcagctt catcattgag ttggcttctc agcggaagtg tcggggtgag
     4321 aagacccctc ctgtttattc ttctcgtgtg aaaatctcta tgccatcaag tcaagaccaa
     4381 gatgatatgg ctgagaaatc tggatcagag actcctgatg gtccattgtc ccctgggaaa
     4441 atggatgata tctctcctgt gcagacagat gccctggatt cagtgaggga gagattacat
     4501 ggaggcaaag gtctaccttt ttatgcaggg ctttctcctt cggggaagct tgtggcctat
     4561 aaacgtaaac ccagttcaac tacatctggg cttatccagg tagcatccaa tgccaaggtg
     4621 gctgcatcca ggaaaccacg caccctgttg ccttcaacat ccaattccaa aatggcatcc
     4681 tctggcccag caacaaatcg ctctgggaag aatctgaagg catttgttcc agcaaaaagg
     4741 ccaattgcag cgcggccctc tcctggtggt gtgttcacac agtttgtgat gagcaaagtt
     4801 ggtgccttac agcagaagat acccggagtt cgcacacctc aaccccttac agggccacag
     4861 aagttcagta tcaggccttc tccagtaatg gtcgtcacac ctgtggtttc ttctgagcaa
     4921 gttcaggtgt gcagcactgt agctgctgct gtcactactt cccctcaagt gtttctagaa
     4981 aatgttactg ctgtgccatc tctgactgct aattctgata tgggagctaa agaagctaca
     5041 tattcttcta gtgcctccac tgctggggtt gttgagatct ctgaaactaa taacactacc
     5101 cttgtaacat ctacccagtc tacagccact gtgaacctta ccaaaactac tgggataact
     5161 actagccctg tggcttcagt ttcatttgct aaaccattgg tagcatctcc aaccataact
     5221 cttcctgttg cttccactgc ctccacctcc atagtcatgg tgaccacagc tgcatcttcc
     5281 tccgtggtga ccacacctac ttcatcactg agttctgtac ctattatact ctcaggaatt
     5341 aatggaagtc cacccgtgag ccagagacca gaaaatgccc ctcaaattcc agtgactact
     5401 ccacagatct cttctaacaa cgtgaaacgt actggacctc gattgttgtt gattccagtg
     5461 cagcagggtt ctcctacgct tagaccaatc caaaacccac agcttcaggg acagcggatg
     5521 gtcttgcaac ctgttagggg tccaagtgga atgaacctat tcaggcaccc caatgggcag
     5581 attgtccaac tcctaccttt acatcagatt cgaggctcta atgcccagcc cagcttacag
     5641 cctgtggtat ttcggaaccc aggatctatg gtgggaatcc gactaccagc tccttgcaaa
     5701 tcttcagaga ctccatcatc ttctgcttca tcctctgcct tctctgtcat gagtcctgtg
     5761 attcaggctg ttgggtcttc tccaacagta aatgtcattt ctcaggcacc ttcactgctt
     5821 tcctctggat ctagttttgt ctctcaggct ggtacactga ctctgaggat ctctcctcct
     5881 gaaactcaaa accttgcaag taaaacaggc tctgaaagca aaataacacc cagcactgga
     5941 ggacagcctg taggcactgc tagcctcatt cctctgcagt caggtagttt tgccttgttg
     6001 cagctcccag gacaaaagcc tatccctagc tctgttcttc agcatgttgc ttcccttcaa
     6061 ataaaaaagg aatctcagag tacagaccag aaagatgaaa caaactctat caaaagagag
     6121 gaggaaacta agaaagctct accatcaaaa gataaagctc tagactctga ggctaatata
     6181 atgaagcaaa actcaggaat tattgcctca gaaaatacct cgaataattc attggatgat
     6241 gggggtgatc ttttggatga agaaaccctt agggaagatg ccagacctta tgaatactct
     6301 tatagcactg ggtctcatac agatgaagac aaagatggtg atgaggactc tgggaacaag
     6361 aatcagaaca gtccaaaaga aaaacaaact gttccagaag ttagagctgg ctctaaaaac
     6421 attgatatta tggcactcca aagcatcaga agtatacggc ctcaaaagtg tgttaaggtg
     6481 aaggttgaac cgcaggaggg atcagacaat ccagagaacc cagatgactt tctagtcctt
     6541 tctaaggaca gtaaatttga attatcgggg aaccaagtta aggaacagca atctaactca
     6601 caggcagagg ccaagaagga ttgtgaagat tctctgggga aggacagtct tagagagaga
     6661 tggagaaaac acctaaaggg ccccttaact cagaagtaca ttggaatttc acagaacttt
     6721 aacaaagagg caaacgttca gttctttaca gaaatgaagc catgtcaaga aaattctgaa
     6781 caggatatct ctgaattact tggaaaaagt ggaactattg agagtggtgg agttctaaaa
     6841 actgaggatg gttcttggag tggcatttct agttctgcgg ccttctctat tatccctagg
     6901 agagctacaa aaggaagaag agggagcaga cattttcagg gtcatttact gctcccaaga
     6961 gaacagatga aaccaaagca acagacaaag gatgggagaa gcagtgctgc tgacttcaca
     7021 gttttggatc tggaagatga ggatgaggaa gatgagaaaa ctgatgattc tcttgatgag
     7081 attgtggatg ttgtctctgg ctaccagagt gaggaggttg atgtagaaaa gaataactat
     7141 gtagactatc ttgaggatga tgagcaggtg gatgttgaaa caatagaaga gctttcagag
     7201 gaaattaact ttccctacaa gaagaccaca gcaactcaca cacagtcctt caaacagcag
     7261 tgtcatagcc atatctctgc agatgaaaaa gcttctgaaa agagtcgaaa ggtttcatta
     7321 atttcttcaa aattgaaaga tgattgctgg ggtgataaac cacacaaaga aacagaagct
     7381 tttgcatatt accgacggac acacactgcc aatgagcggc gtcggcgtgg tgaaatgaga
     7441 gatctttttg aaaaattgaa gattacatta ggattacttc attcttccaa agtttccaaa
     7501 agtctcattc ttaatcgggc attcagtgaa attcaaggac taacagacca ggcagataaa
     7561 ttgatagggc agaaaaatct cctgagtcga aaacgaagta ttttaatacg gaaggtatcg
     7621 tctctttcag ggaagacaga agaagtggtc ctgaagaagc tagagtatat ttatgcaaaa
     7681 caacaagcac tagaagcaca aaaaagaaaa aagaagctgg ggtcagatga gttttgtgtg
     7741 tcccccagaa ttggcacaca gctggaggga tcttctgcat catctgtaga tcttggacag
     7801 atgctcatga ataacaggag ggggaaacct ttgattcttt ccagaaaaag agaccaggct
     7861 acagaaaatg cctcaccttc tgacactccg cactcttctg ccaacctggt aatgactcca
     7921 caagggcagt tgcttaccct aaaaggcccc ttattctcag gaccagtggt agcggtttct
     7981 cctgctctct tagaaggtgg tctgaagcct caagttgcaa gcagtactat gtctcagtct
     8041 gagaatgatg acttatttat gatgccacga attgtcaatg tgacatcatt ggctgcagag
     8101 gaagatttgg gaggtatgag tggcaacaaa taccgtcacg aagttcctga tggcaagcca
     8161 cttgaccacc tgagagacat tgctgggagt gaagccagct ccttaaaaga tacagagaga
     8221 atctcttcca gaggaaacca tcgagatagc agaaaggcac tgggtccaac acaggtgctt
     8281 ttggcaaata aagattctgg gtttccacat gtagctgatg tttccactat gcaggcagca
     8341 caggaattta tacctaaaaa tatgtctggt gatgtgagag ggcatcggta taaatggaag
     8401 gagtgtgagt tgagaggaga gagactaaag tcaaaggagt ctcagtttca taaattaaag
     8461 atgaaagatc tgaaggactc aagcatagag atggaactga ggaaagtagc ctcggctatc
     8521 gaggaagcag ccctccatcc cagtgagctg ctgactaaca tggaagatga ggatgacact
     8581 gatgagactc tgacttcact gctcaatgaa attgcttttc ttaatcaaca gctaaatgat
     8641 gactctggcc tagctgaact gtcaggttct atggatacag aattctcagg agatgctcag
     8701 cgagctttta tcagtaaact tgctcctggg aacagatcag ctttccaagt tggacacttg
     8761 ggagcaggtg tgaaagagtt gcctgatgtc caagaggaga gtgaatccat cagccccctc
     8821 ctcttgcact tggaagatga tgacttttct gagaatgaaa aacagcttgg ggacacagcc
     8881 tctgagccag atgtccttaa gattgttatt gaccctgaaa taaaggattc tcttgtttcc
     8941 cataggaaat ctagtgatgg agggcagagt acttctggtc tccccgcaga gcctgaaagt
     9001 gtatcttcac ctcccatctt acacatgaag actggcccgg agaacagcaa cacagatact
     9061 ttgtggaggc ctatgccaaa gttggcccca ttaggtttaa aagtagctaa tccccccagt
     9121 gatgccgatg gtcagagtct caaggtgatg cctgccttgg cacctatagc tgccaaagtt
     9181 gggtcaattg gacacaaaat gaatttagca ggaattgacc aggaaggccg ggggagcaag
     9241 gtgatgccta cattggcacc tgttgtacct aaattgggca actctggagc tccatcaagt
     9301 tcatcaggga aatgagcttg ttcatcctca tacaaaagcc aggctgtgag gggaaatgaa
     9361 tttcacctcc tttctctgta ggcgtctgtt tgtttgtatt atggaactat tatccttgac
     9421 ttaattatgt gtgaatattg atggagaaag gaggtgtagg gtgctggtcc tggtgtttga
     9481 aattctgatc atgttaaaaa tgtgttacct cacttgtggt gctgggtccc ctcatcttct
     9541 ctaagaaggt gtgattccct cttgcccaag gaattcataa caagattctg gctccatcaa
     9601 ctaccttatt attttcccct gagaaaatgc ttgagacttg gaattactat agactaaagt
     9661 ataagtcata gttgttggct ccaaaatctg agaattatga tacagttgtg tgggaaaaaa
     9721 aaaaaaaaag aacttttagt tactatttca atagtagggc atggtaggac tgggcatggt
     9781 agtgcacact tgtaattcca gcacttagaa gactaaagca gaaggattgc aagtttgtgt
     9841 ctaccctggc ctatcaaggg gacagacaca cacacacaca tacacacttg tgggggccag
     9901 gggagtagga agagagaatg ttatagtagg taggatgaat attatggaat accaaagtga
     9961 agggattttg tcattcagca gactgtttca tatccagaat agttcttccc ttaccctttc
    10021 agtcataatt aaaaacctaa gctttctggt aaagtaggaa tatacttttt acttttacta
    10081 ttaacatact tattttcaga gactaaaaaa gacatacttc tcccttattt cttggggtat
    10141 cacaaagatt cattcataat accagagatt tctactcatt gttttttgga agtagacata
    10201 gaggcagccc ttccctttcc caaatcatgt cactcaagaa acagctaaaa tgaaaagcag
    10261 tttctcccct aaccagagac cgtagccaaa ataaaaattt gtggggctgg gtatttccca
    10321 aatgaaacca gcctctaggt gcttgaaggt tttgttcact gtcacctgca caggatgtaa
    10381 agaaaaggcg agtcagagtg agcaatcttt accagggaag taaggcagta tttgagtcac
    10441 aaagtatatt ttttatctgc tatcatggca tcaatgatct gtagagcttt ttcactcatt
    10501 ggctgtcagg gtatgaagga ctgacaacct gtaaagatga agatatttat atttttgtat
    10561 agttgttttc atagatttct caaaggatga agttttcgac ctagaagaga tttgtattga
    10621 gtatagaaat gtttcctatc tagtttgtaa ataatcatgg tgcatttgag gggtctctcg
    10681 ggaactcgtg aggcaagaat cactgttctg aaaatgtata gactgagatg tagctgctgc
    10741 atttgccttt cttaaataat tatattttgg aatgtaaccc gttctgtctt caatgacagg
    10801 atttgcttgt gttgtaaaaa cactttaaca caagtgcttc cggtgcctgg gctgtgcctg
    10861 ggtgattgta tttcttttac actactgcgt ctttatccta agtcccactc tgtatcctct
    10921 gacctaggtt gtgagaccaa ctttggaatg aatctagcca gtgaattact tctatgtttg
    10981 atttcctttt tagattaact ctgataatca ctagattgaa atgatgaaaa acttacactg
    11041 caaatggcag tggtagtaaa tctttcattg gttttgcgct gcttgctcta gacaggtcat
    11101 cagcacttaa cctttcctgt ttactacaaa agctgataaa gtaaaaacag tattcctcag
    11161 cttctcctct gtcccttctg tcctttaccc aactgacttt atccaatgcc ttagccaagg
    11221 agtgcagcac ctgtcgccct tgctagcagc tgtcctcaga gacgctagtt ctttagccca
    11281 ggtatagtag tttccagtgg tcttattgcc tgtttctttc ccgagtgttc ttctggcttc
    11341 ccagagccct tttgggtttt gagagtcaga caagaaacaa aacaagggag tgaataatcc
    11401 tcaggaaaca atggaccatt gtggcttccg aatacttttt tctcttttct ttcctttcct
    11461 ttccttttct ttctttcttt ctttctttct ttttttttta aatttgaaaa agcatagaaa
    11521 aaaaacaggt cagggtttat tctttattgg aagatacttg cctgtgttta tgaaagatgt
    11581 acaaagatag agatgagatt tggttcaggg aaagctgcag atgtcattac aaactcccaa
    11641 gatacattgt tcttaagaca aatttaggag ctatcaggcc gaatttgagg agggtttagt
    11701 ctttagaaca atcatgtagt cttgacaaaa ataaaaaatc tccctaaact cctacccttt
    11761 agcatttcat taggagaaac tgatctatta aaattatatg tatgattatg aaaagtgaat
    11821 tcaagtgaga acattggagg aacctggaaa aagctccacc ctgactaaga agcatgatct
    11881 cagtcgacca ataactcgcc ttttatacac ctgtaaatac atggaatgtt tttaaggata
    11941 taattatgtc agatttagca ttttctttta tatattaaat atatatcttt aatttctgct
    12001 tttgaaagtg attatttttt tagaaataac agaagtttgg cagttgaaag gcaagacatg
    12061 tgaacctgaa ataaaccaat tatactaatt aaagcagaat ttggtgttgg gaggtttgtg
    12121 cctggttgaa gaattcttta tgccctcaga catatttgag agagggttcc attgaagaga
    12181 tcttttctga agcttcttga ctggaaagct ttcgatctgt catttgggaa gacctttggt
    12241 attctagtcc ttgtagcatg tctcaattgg aacttcaaga ttatgtacaa tttgatggca
    12301 aatatttgct gttccatagt gagaatagtt tcataatacc actgtcttta tctgctgcct
    12361 tggggaacaa caggacagaa acacaatctt atgtctggag acaataggtg ttctttttaa
    12421 atttgtgtgt atatattggc tgtgtgtgcc ttgttgtgta catggagctt acaggacaac
    12481 tttgtggagt tacttctact tctctcctac cagggatcca actcacattg tcaagcaatc
    12541 acagcaaaca ctttaactta cttgagccat cttgacagct tcattggtct tcttaagaca
    12601 agatgttaag gggtttcata cttaacagag tcttcttatg gaagtctttt aaacattgaa
    12661 ctgtcctgac ttaagggagt tgacagatca agtttagtta gttgtataaa cttcattaaa
    12721 agtgtttacc ttatatactt ttatgataaa agttttttgt gcccccagaa ttgtggataa
    12781 aattaatagt aggccttttt tacagttttg aaaatgtttt gaacagaaaa gacagtagac
    12841 atctatacat ccatttactt gtttgttttt tgagatggtc tcactatgca acctatggcc
    12901 tgggattctg tggagaccaa actggccttg aactcaccaa gatccacctc cctctgcctg
    12961 cagggattga aggcatatgc ccatctttat attttttttt ataaaattcc atacattttt
    13021 cctgactgta ccagttattt ctagtggaat tgtgtgatca gtgcatcttg aagacaagtc
    13081 tgcaaagtag caatgccact tgtctctaat agaattaagc catggacagt gtaggcagct
    13141 tgttttcagg aacttaaagg cttatatcct tatttctttt tcttttttct ttctttcttt
    13201 ctttcttttt tttttttttt tttttggttt ttcgagacag ggtttctctg tatatccctg
    13261 gctgtcctgg aactcactct gtagaccagg ctggcctcga actcagaagt ccgcctgcct
    13321 ctgcctcccg agtgctggga ttaaaggcgt gcgccaccac gcccggctta gatccttatt
    13381 tcatggagag tcactggtac ttaaaggatc agaataaact gtttgcacag aattgttgct
    13441 tttgaagaaa gcacttttaa gggtccttta ataacttaat gtatcattgc taattaaaag
    13501 tccttccctc ccaagtgtga tgactgaagt tgaattctta gaaactatga atgccagctg
    13561 tgtaatctca gcactggaaa ggagcagaca gggaggattc ttggtattct ctggccagct
    13621 agtctagcct aatgggttag ctcaggccaa caagagacct gtcccaacaa cttggcgaca
    13681 ttcattagaa ttcgctagaa gtggtcctct agtctccata cccacataca agtgcagatg
    13741 cacctgcatg tacacagaaa ttaactcatt tatcaatgac tttagtacat agaaaattaa
    13801 agctcgggtt ggtaagatga cttgtaaagg tgcttgtcaa cactgatgac caaagttcaa
    13861 tccccagaaa ccatatagta gggaaaaaaa aaacttgtac catggtaata tgtgtacaac
    13921 ccccccgccg c
//
