LOCUS       NM_133829               4788 bp    mRNA    linear   ROD 31-JUL-2024
DEFINITION  Mus musculus major facilitator superfamily domain containing 6
            (Mfsd6), transcript variant 1, mRNA.
ACCESSION   NM_133829
VERSION     NM_133829.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4788)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4788)
  AUTHORS   Knupp,D., Cooper,D.A., Saito,Y., Darnell,R.B. and Miura,P.
  TITLE     NOVA2 regulates neural circRNA biogenesis
  JOURNAL   Nucleic Acids Res 49 (12), 6849-6862 (2021)
   PUBMED   34157123
REFERENCE   3  (bases 1 to 4788)
  AUTHORS   Bagchi,S., Perland,E., Hosseini,K., Lundgren,J., Al-Walai,N.,
            Kheder,S. and Fredriksson,R.
  TITLE     Probable role for major facilitator superfamily domain containing 6
            (MFSD6) in the brain during variable energy consumption
  JOURNAL   Int J Neurosci 130 (5), 476-489 (2020)
   PUBMED   31906755
  REMARK    GeneRIF: Probable role for major facilitator superfamily domain
            containing 6 (MFSD6) in the brain during variable energy
            consumption.
REFERENCE   4  (bases 1 to 4788)
  AUTHORS   Tashiro-Yamaji,J., Maeda,S., Ikawa,M., Okabe,M., Kubota,T. and
            Yoshida,R.
  TITLE     Macrophage MHC and T-cell receptors essential for rejection of
            allografted skin and lymphoma
  JOURNAL   Transplantation 96 (3), 251-257 (2013)
   PUBMED   23836286
  REMARK    GeneRIF: MMRs on monocytes/macrophages and TCRs on cytotoxic T
            lymphocytes in mice were essential for recognition and rejection of
            allografted skin and lymphoma, respectively.
REFERENCE   5  (bases 1 to 4788)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   6  (bases 1 to 4788)
  AUTHORS   Shimizu,T., Tashiro-Yamaji,J., Hayashi,M., Inoue,Y., Ibata,M.,
            Kubota,T., Tanigawa,N. and Yoshida,R.
  TITLE     HLA-B62 as a possible ligand for the human homologue of mouse
            macrophage MHC receptor 2 (MMR2) on monocytes
  JOURNAL   Gene 454 (1-2), 31-38 (2010)
   PUBMED   20123006
REFERENCE   7  (bases 1 to 4788)
  AUTHORS   Tashiro-Yamaji,J., Kubota,T. and Yoshida,R.
  TITLE     Macrophage MHC receptor 2: a novel receptor on allograft
            (H-2D(d)K(d))-induced macrophage (H-2D(b)K(b)) recognizing an MHC
            class I molecule, H-2K(d), in mice
  JOURNAL   Gene 384, 1-8 (2006)
   PUBMED   17010536
  REMARK    GeneRIF: isolation of a cDNA clone encoding a novel receptor (MMR2)
            on allograft (H-2D(d)K(d))-induced macrophages (AIM) recognizing
            another MHC class I molecule, H-2K(d), by the expression cloning
            method
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139299.3 and AC161876.3.
            
            On Apr 1, 2022 this sequence version replaced NM_133829.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861890.167857.1,
                                           SRR7974084.7833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               AC139299.3         184445-184758       c
            315-1906            AC139299.3         165586-167177       c
            1907-2004           AC161876.3         4976-5073
            2005-2166           AC161876.3         18105-18266
            2167-2265           AC161876.3         19063-19161
            2266-2546           AC161876.3         20464-20744
            2547-4788           AC161876.3         23006-25247
FEATURES             Location/Qualifiers
     source          1..4788
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 26.99 cM"
     gene            1..4788
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /note="major facilitator superfamily domain containing 6"
                     /db_xref="GeneID:98682"
                     /db_xref="MGI:MGI:1922925"
     exon            1..314
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /inference="alignment:Splign:2.1.0"
     exon            315..1906
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2750
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /note="isoform 1 is encoded by transcript variant 1; major
                     facilitator superfamily domain-containing protein 6;
                     macrophage MHC receptor 2; macrophage MHC class I receptor
                     2"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 6 isoform 1"
                     /protein_id="NP_598590.2"
                     /db_xref="CCDS:CCDS14945.2"
                     /db_xref="GeneID:98682"
                     /db_xref="MGI:MGI:1922925"
                     /translation="MAADDKVAILTDDEEEQKRKYVLADPFNGICREPEPPSNETPSS
                     TETSAIPEEEIDWIEKHCVKVNNDLLISKVFYFFFYSAYGSLYPLLPVYYKQLGMSPS
                     QSGLLVGIRYFIEFCSAPFWGVVADRFRKGKIVLLFSLLCWVLFNLGIGFVKPATLRC
                     LPKIPPTAHPTNVSHPVTVLPMNSSTVAFFSTPPKLLQKRDVQLSETEPNISDIDLVS
                     TALTLTSEPTRRPQTEAITHPVTGLILNTSTVTLPPTGNVTRETTIAVVTTTKSLPSD
                     QVTLVYDQQEVEAIFLIILVVVIIGEFFSASSVTIVDTVTLQYLGKHRDRYGLQRMWG
                     SLGWGLAMLSVGIGIDYTHIDVLIDGKGCKPPEYRNYQIVFIVFGVLMTMALIVATQF
                     RFRYNHFNNSDGKGKEVEIPQVERDNSTESSEETPTAATHSQAFNFWDLIKLLCSVQY
                     GSVLFVAWFMGFGYGFVFTFLYWHLEDLNGTTTLFGVCSVLSHVSELTAYFFSHKLIE
                     LIGHIRVLYIGLACNTARYIYISYLENAWTVLPMEVLQGVTHAAIWAACISYLSAAVP
                     PELRTSAQGILQGLHLGLGRGCGAMIGGVLVNYFGAAATFRGIGMACLVILLLFALIQ
                     WLAVPDEEEDKTMLAERIPVPSSPVPIATIDLVQQQTEDVMPRVEARLPPKKTKHQEE
                     QEDVNKPAWGVSSSPWVTFVYALYQVKELIQLTRESRASEIQPLQGTSENREASPAGG
                     AQRAPRETHSASPRNQPSPDTAASQTQSSPAHPSATPHGQESGEKQAQPTVGEH"
     exon            1907..2004
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2166
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2265
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2546
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..4788
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4767..4772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /note="hexamer: ATTAAA"
     polyA_site      4788
                     /gene="Mfsd6"
                     /gene_synonym="2210010L05Rik; 9630025I22Rik; MMR2"
                     /note="major polyA site"
ORIGIN      
        1 gttctccagc tcagccctga aacgggtcca gccggtcggg agcgaaggcg gcggcagcga
       61 ggccaggcct gggaccaaag cggcgaggag gagcggacag aggggttgcg ccggactgcg
      121 ccgggccagc gccatcgctc gccccacccg gcttgcatcc agccgtcgcg cccgccgcac
      181 ccccgggaga ggagctagcc acccaaccga catgcggcgc tctggcctgc ccgccgccgc
      241 cccggcgccc cgagcggccg ccccgcaccc cggggacagg gctccccgcg cctcgcgcag
      301 ctgagcgcct ccagatcacc attcagaatt ttgaaggtca ctgaccctaa tggtggtggt
      361 aagccatggc tgctgatgat aaagttgcta tcctaactga tgatgaagag gagcagaaga
      421 gaaaatatgt gcttgctgat cccttcaatg gcatctgcag ggaaccagaa ccaccttcta
      481 atgaaacccc ctcctccaca gagacctcag ccattcccga ggaggaaata gactggatag
      541 agaaacattg tgtgaaagtc aacaatgacc ttctcatctc caaggtgttt tattttttct
      601 tttactctgc ctatggctct ctttaccctc tcttacctgt atattataaa cagctgggaa
      661 tgtcacctag ccagagtgga ctgttggtgg gcattcgata cttcattgaa ttctgcagtg
      721 cccccttctg gggtgtagtt gcagatcgtt tcagaaaggg caaaattgtc ctcctctttt
      781 cgcttctgtg ttgggttttg ttcaacctgg gcattggatt tgtcaaacct gctaccttga
      841 gatgtctacc aaagatcccc ccaacagctc accccaccaa tgtaagtcac ccagtaactg
      901 ttctgccaat gaactcctcc actgtcgctt tctttagcac accaccaaaa ttgctccaga
      961 aaagggacgt gcaattgtct gaaacagagc ccaatatctc agacatagat ctcgtgtcaa
     1021 cagcattgac cttgaccagt gaacccacac ggaggcccca gacagaggca attacccacc
     1081 ctgttacagg cttgattttg aacacaagca cagtgactct gccccccaca ggaaatgtca
     1141 ccagggagac aaccattgct gtggtcacca ccaccaaatc tttaccatct gatcaagtca
     1201 cccttgtgta tgaccaacag gaagttgagg cgatattctt aattatctta gtggttgtca
     1261 taataggaga atttttcagt gcctcttctg tcacgattgt agatacagta accctccagt
     1321 acctgggaaa acaccgagac cgatatgggc tacagcgcat gtggggctcc ctgggctggg
     1381 gcctggccat gctgtctgtg ggtattggaa tcgactatac tcatatagat gtgctcattg
     1441 atgggaaggg gtgtaagccc cctgagtacc ggaactacca gattgtcttc atcgtctttg
     1501 gagttctcat gaccatggcc ctgatcgttg ccactcagtt ccggttccgc tacaaccact
     1561 tcaacaatag tgatggtaaa gggaaagagg tggagatccc acaggtggaa agggacaact
     1621 ccacagagtc ctctgaagag actccaactg ccgcgactca ctcacaggcc ttcaacttct
     1681 gggacttgat caagttgcta tgcagtgtgc agtatggctc ggttctgttt gtggcctggt
     1741 tcatgggttt tggatacggc ttcgtgttca cctttctcta ctggcatctg gaagacctaa
     1801 atggaactac aaccctcttt ggggtctgtt cagtcctgag tcatgtgtcc gagttgaccg
     1861 cttacttctt cagccacaag cttattgagt tgattggcca tatcagggtt ttatacattg
     1921 gcctggcctg taatacagct cgctatattt acatttccta cctggaaaat gcctggactg
     1981 tcctccctat ggaagttctt caaggtgtca cacacgcagc catctgggca gcgtgcatct
     2041 cttacctcag tgcagctgtc ccccctgagc tgaggacttc tgcacaggga atcctgcaag
     2101 gccttcatct gggtctgggg cgaggatgtg gtgccatgat cggaggcgtg ttagtcaatt
     2161 attttggggc tgctgcaact ttccgaggga ttggcatggc ttgcctggtg atccttctcc
     2221 tctttgccct gatccagtgg ctggcagtac cagatgaaga agaagacaag acaatgttgg
     2281 cagaaaggat cccagttccc tctagtcccg ttcccatagc aaccattgac ctggtacagc
     2341 aacagacaga agatgtcatg ccacgcgttg aggccagact tccgcccaag aaaaccaagc
     2401 accaggaaga gcaggaagat gtaaataaac cggcctgggg ggtcagctcc tcgccttggg
     2461 tgacctttgt ctatgctctc taccaagtta aagagctaat tcaactgaca agagagagcc
     2521 gtgcttctga gatacaacct ttacagggga ccagtgagaa tcgggaagcc tctccagctg
     2581 gtggagccca gcgtgcccca cgtgaaactc actccgcctc acctagaaac cagccatccc
     2641 ctgacacagc agcatctcaa acgcagtcca gccctgctca ccccagtgct accccgcatg
     2701 gacaggagag tggagagaag caggctcagc ccactgtggg agaacactga gggtcagctc
     2761 ataccctgca tggcactagg cacctcagcc aggacagggg gcgaggcccc aaccctgacc
     2821 atgcctctac aagggggtca ctgcaatgca tatgcttcta aatatctaaa ctcattactg
     2881 tggaacaaca cacacacaca cacacacaca cacacacact cactcacaca cacacactca
     2941 ctcacacaca cacactcaca cgcacgcaga tgcacaaatg cacaggcaca catgagtaaa
     3001 tgttggcagg aaaacagaga ctgccacagt ccagtagaga cacagaacaa cgtctcttgg
     3061 ttagttaggt ctgacctaac ttctccacca agatgaaagg gtgagaagca gaactcacac
     3121 caagttgggt gaatgaaagg gccacaaagt gaacaaggac ttcatctccc tcttctgatt
     3181 atttattctg aatattgggt tcttagtgaa aagtgagagg gaaaaaagta tatctatagt
     3241 tttattcgtc ttgaagaaaa gaactttaaa aaatataaga catattgaaa agggaaccag
     3301 atggaactta gtagaacata tgcttttttt gttgtttaga aaagttcact gaactttgta
     3361 catctctagc aaatctattt ttatatgcat atagtatata gtgagcatag ttctttggga
     3421 cgcaaagctg ttgctgacta ctgcatactg agttgagctt taaaatgtct ttgatgcaat
     3481 gggctgtgag aatgagcaga agtgagaggc tatttcaaag actccaagca actcagtatc
     3541 ctaagacatg acagacaagg ccttcctaag cagacccttc tatagcagcc tctgatgctg
     3601 gattttaatt agacttgggt tctaattagc taatggaatt aaaaaaaaaa aagacaactc
     3661 accagattcc taagtgttaa gctaaagagt actatttaca aacagcagga taagatttaa
     3721 gtgcctgggg gagggacatg atgtttaaaa cttacatagt aggtctgttt tgtttgtgaa
     3781 ggagtaagta gggaaccagg aatgggaatt ctgggaataa gaatgacttt ctaaagactt
     3841 aagacaagaa tcttagaata ttcttctccc ccaaaccata gtcatacact gaaaactttt
     3901 gggtttgagc tacaaactac accaggtacc accccagata gagggtgtct tgggtgactg
     3961 catgtagagc ttgctcctag aaggaaagca gaggctgtaa gaagccaagg gatgcctgcc
     4021 tatatggaag ggggatgctg ctgtggttga atgggggtca gtcatattgt ggatggacac
     4081 cagaatggtt cgaaatggaa gctcacccta gcctctaaca taggagacag gatcagctgt
     4141 acagtgaagg cctctgtgtg accgttctgc ctgcccctgc ctcgggagga aacattctac
     4201 acctggatgc ctagcttcac tacaaaacac agcttggaat gatgggaaca attaagctga
     4261 tggttacttt tgcacttgaa tggtactgca ctgtcaaccc ccaaggctca ttttaagtga
     4321 cctttaaaat cagatgtatt tattatgctc gtgcaattac agaaatgaag tgggagacag
     4381 gctgagcccc acctatgaat gtacagtatg tggattgtga aagtgactgt agggaatcag
     4441 agcgttgtat cttgtgttta caattctggt tgatttcttt gaaaagctgc tggtttggga
     4501 aatgcacagt gggtgtattg aaataaaagg taaataccat ttttaaatat ttcgtaaatg
     4561 aaaaacacgt gaccaaacaa gagaacatcc tctgctctgt aatgaatgac accaaattca
     4621 atatgccttc gttacaaaat gtttactgtg agcgtcgatc caacagtgca gtaatttcta
     4681 gccttttgag ctgacacctt cacgagtttg tggactttgt gactttttct tcctgttctt
     4741 acagtgccat atgtcacttg aaaaatatta aagtgaattc caattaaa
//
