LOCUS       NM_029662               2166 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus MFSD2 lysolipid transporter A, lysophospholipid
            (Mfsd2a), mRNA.
ACCESSION   NM_029662 XM_131683
VERSION     NM_029662.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2166)
  AUTHORS   Pfau,S.J., Langen,U.H., Fisher,T.M., Prakash,I., Nagpurwala,F.,
            Lozoya,R.A., Lee,W.A., Wu,Z. and Gu,C.
  TITLE     Characteristics of blood-brain barrier heterogeneity between brain
            regions revealed by profiling vascular and perivascular cells
  JOURNAL   Nat Neurosci 27 (10), 1892-1903 (2024)
   PUBMED   39210068
REFERENCE   2  (bases 1 to 2166)
  AUTHORS   Xu,X., Xu,K., Chen,F., Yu,D. and Wang,X.
  TITLE     Mfsd2a regulates the blood-labyrinth-barrier formation and function
            through tight junctions and transcytosis
  JOURNAL   Hear Res 450, 109048 (2024)
   PUBMED   38852535
  REMARK    GeneRIF: Mfsd2a regulates the blood-labyrinth-barrier formation and
            function through tight junctions and transcytosis.
REFERENCE   3  (bases 1 to 2166)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2166)
  AUTHORS   Chin,C.F., Galam,D., Gao,L., Tan,B.C., Wong,B.H., Chua,G.L.,
            Loke,R.Y., Lim,Y.C., Wenk,M.R., Lim,M.S., Leow,W.Q., Goh,G.B.,
            Torta,F. and Silver,D.L.
  TITLE     Blood-derived lysophospholipid sustains hepatic phospholipids and
            fat storage necessary for hepatoprotection in overnutrition
  JOURNAL   J Clin Invest 133 (17), e171267 (2023)
   PUBMED   37463052
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2166)
  AUTHORS   Loke,R.Y.J., Chin,C.F., Liang,G., Wong,B.H., Galam,D.L.A.,
            Tan,B.C., Chua,G.L., Minegishi,S., Morisawa,N., Sidorov,I.,
            Heijs,B., Titze,J., Wenk,M.R., Torta,F. and Silver,D.L.
  TITLE     Mfsd2a-mediated lysolipid transport is important for renal recovery
            after acute kidney injury
  JOURNAL   J Lipid Res 64 (8), 100416 (2023)
   PUBMED   37467896
  REMARK    GeneRIF: Mfsd2a-mediated lysolipid transport is important for renal
            recovery after acute kidney injury.
REFERENCE   6  (bases 1 to 2166)
  AUTHORS   Berger,J.H., Charron,M.J. and Silver,D.L.
  TITLE     Major facilitator superfamily domain-containing protein 2a (MFSD2A)
            has roles in body growth, motor function, and lipid metabolism
  JOURNAL   PLoS One 7 (11), e50629 (2012)
   PUBMED   23209793
  REMARK    GeneRIF: Data suggest that the ligand(s) that are transported by
            MFSD2A play important roles in these physiological processes and
            await future identification.
REFERENCE   7  (bases 1 to 2166)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   8  (bases 1 to 2166)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   9  (bases 1 to 2166)
  AUTHORS   Angers,M., Uldry,M., Kong,D., Gimble,J.M. and Jetten,A.M.
  TITLE     Mfsd2a encodes a novel major facilitator superfamily
            domain-containing protein highly induced in brown adipose tissue
            during fasting and adaptive thermogenesis
  JOURNAL   Biochem J 416 (3), 347-355 (2008)
   PUBMED   18694395
  REMARK    GeneRIF: Results identify Mfsd2a (major facilitator superfamily
            domain-containing protein 2a) and an additional closely related
            protein Mfsd2b, and suggest that Mfsd2a plays a role in adaptive
            thermogenesis.
REFERENCE   10 (bases 1 to 2166)
  AUTHORS   Esnault,C., Priet,S., Ribet,D., Vernochet,C., Bruls,T.,
            Lavialle,C., Weissenbach,J. and Heidmann,T.
  TITLE     A placenta-specific receptor for the fusogenic, endogenous
            retrovirus-derived, human syncytin-2
  JOURNAL   Proc Natl Acad Sci U S A 105 (45), 17532-17537 (2008)
   PUBMED   18988732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX525587.1 and BC060526.1.
            
            On Apr 23, 2009 this sequence version replaced NM_029662.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060526.1, AK006096.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BX525587.1         23-51
            30-2166             BC060526.1         1-2137
FEATURES             Location/Qualifiers
     source          1..2166
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.34 cM"
     gene            1..2166
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /note="MFSD2 lysolipid transporter A, lysophospholipid"
                     /db_xref="GeneID:76574"
                     /db_xref="MGI:MGI:1923824"
     exon            1..248
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1760
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /note="major facilitator superfamily domain containing 2;
                     major facilitator superfamily domain-containing protein
                     2A; major facilitator superfamily domain containing 2A;
                     sodium-dependent LPC symporter 1"
                     /codon_start=1
                     /product="sodium-dependent lysophosphatidylcholine
                     symporter 1"
                     /protein_id="NP_083938.2"
                     /db_xref="CCDS:CCDS18605.1"
                     /db_xref="GeneID:76574"
                     /db_xref="MGI:MGI:1923824"
                     /translation="MAKGEGAESGSAAGLLPTSILQASERPVQVKKEPKKKQQLSICN
                     KLCYAVGGAPYQLTGCALGFFLQIYLLDVAKVEPLPASIILFVGRAWDAFTDPLVGFC
                     ISKSSWTRLGRLMPWIIFSTPLAIIAYFLIWFVPDFPSGTESSHGFLWYLLFYCLFET
                     LVTCFHVPYSALTMFISTEQSERDSATAYRMTVEVLGTVIGTAIQGQIVGQAKAPCLQ
                     DQNGSVVVSEVANRTQSTASLKDTQNAYLLAAGIIASIYVLCAFILILGVREQRELYE
                     SQQAESMPFFQGLRLVMGHGPYVKLIAGFLFTSLAFMLVEGNFALFCTYTLDFRNEFQ
                     NLLLAIMLSATFTIPIWQWFLTRFGKKTAVYIGISSAVPFLILVALMERNLIVTYVVA
                     VAAGVSVAAAFLLPWSMLPDVIDDFHLKHPHSPGTEPIFFSFYVFFTKFASGVSLGVS
                     TLSLDFANYQRQGCSQPEQVKFTLKMLVTMAPIILILLGLLLFKLYPIDEEKRRQNKK
                     ALQALREEASSSGCSDTDSTELASIL"
     exon            249..380
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            381..505
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..644
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            645..723
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            724..881
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            882..972
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1094
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1178
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1262
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1375
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1519
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1696
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..2151
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2131..2136
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /note="hexamer: CATAAA"
     polyA_site      2151
                     /gene="Mfsd2a"
                     /gene_synonym="1700018O18Rik; Mfsd2; NLS1"
                     /note="major polyA site"
ORIGIN      
        1 ggagttttca tcgccggcgt tcctggtttg ctaagtgcta gcgaacgtag tagtggctgg
       61 ggctgcgcct aggatcggag ccacaggcga gtgccggccg gcagaacaca agagcatccc
      121 ggcgtcccgg tcccacgcgg cgtggcccgc gggtcatggc caaaggagaa ggcgccgaga
      181 gcggttccgc ggcggggctg ctccccacca gcatcctcca agccagtgaa cggccggtcc
      241 aggtgaagaa ggaaccaaaa aagaagcagc aactgtccat ttgcaacaag ctttgctatg
      301 cagttggagg ggccccgtac cagttgaccg gctgcgcact gggattcttc ctgcagatct
      361 acctattgga tgtggctaag gtggaaccac ttcctgcttc cattatcctt tttgtgggcc
      421 gagcctggga tgccttcact gaccctctgg tgggcttctg cattagcaag tcctcctgga
      481 cccgcctggg ccgcctcatg ccctggatca tcttctccac tcccctggcc atcattgctt
      541 acttcctcat ctggtttgtg cctgacttcc catcagggac ggaaagttca cacggcttcc
      601 tttggtacct gcttttctat tgcctctttg agacactggt cacgtgcttt catgttccct
      661 actcagcgct caccatgttc atcagcacgg agcagagtga gcgtgactca gccacggcat
      721 acagaatgac tgtggaggtg ctgggcacag tgataggcac agcgattcaa ggacaaattg
      781 tgggccaagc caaggcacct tgtctccagg accagaatgg ctctgtggtg gtctcagaag
      841 ttgccaatcg cacccagagt actgcctccc tcaaagacac gcaaaatgct tacctgctgg
      901 cagcagggat catcgcctcc atctacgtcc tctgtgcctt cattctgatc ctaggcgtgc
      961 gggagcagag agaactctac gagtcccagc aggctgagtc aatgcccttc tttcagggcc
     1021 tccggctggt catgggtcat ggcccctatg tcaagctcat tgccggcttc ctttttacct
     1081 ccctggcttt catgctggtg gagggtaact ttgccttgtt ctgcacctat accttggact
     1141 tccgaaatga gttccagaac ctcctcctgg ccatcatgct ctcggccaca ttcaccatcc
     1201 ctatctggca gtggttccta acccggtttg gcaagaagac agctgtatac atcgggatct
     1261 cttctgcagt tccttttctc atcttggtgg ccctcatgga gcgtaatcta atcgtcactt
     1321 acgtggtggc cgtagcagct ggcgtcagtg tagcagctgc cttcctacta ccatggtcca
     1381 tgctgcctga cgttatcgat gacttccacc tgaaacaccc tcactcccct ggcaccgagc
     1441 ccatattctt ctccttctat gtcttcttca ccaagtttgc ctctggagtc tcactgggtg
     1501 tctctaccct cagtctcgac tttgccaact accagaggca gggatgctcc cagccagaac
     1561 aggtcaagtt tacactgaag atgctggtga ccatggctcc tatcatcctc atcttgctgg
     1621 gcctgctgct cttcaagctc taccccattg atgaggagaa gcggcgacag aataagaaag
     1681 ctctgcaggc tctacgagaa gaagccagca gctcaggttg ctcggataca gactccacag
     1741 agctggccag tattctctag gacttgccag ggtgcctgaa gccaccacac aaaggacctg
     1801 gggcaccagg tagcattaag cacgggatct ctttgccctt gcactgagca gctgttcttc
     1861 ctatgtcaag acagggacca aggagtggag ggtgagcgga ccaggacatc tgtgctcact
     1921 gcaaggctga ccgctctgtc acctcctcac tgcctgccca ctgggccaag ccttagggct
     1981 gctactgtga atatgccaag gactgactgg gcctagctcg gaacactaat gtagaaacgt
     2041 tttatacaga gactaattaa taacttaatg actatgtata tagtgatgtg tgtatgtatg
     2101 tgtctatgag gtattaatgt tattaatttt cataaaaact ggaaacacaa aaaaaaaaaa
     2161 aaaaaa
//
