LOCUS       NM_028657               3987 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus major facilitator superfamily domain containing 12
            (Mfsd12), mRNA.
ACCESSION   NM_028657
VERSION     NM_028657.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3987)
  AUTHORS   Watkins-Chow,D.E., Incao,A.A., Rivas,C., Elliott,G., Garrett,L.J.
            and Pavan,W.J.
  TITLE     The MFSD12 p.Tyr182His common variant is sufficient to alter mouse
            agouti coat color
  JOURNAL   Pigment Cell Melanoma Res 37 (2), 259-264 (2024)
   PUBMED   37874775
  REMARK    GeneRIF: The MFSD12 p.Tyr182His common variant is sufficient to
            alter mouse agouti coat color.
REFERENCE   2  (bases 1 to 3987)
  AUTHORS   Adelmann,C.H., Traunbauer,A.K., Chen,B., Condon,K.J., Chan,S.H.,
            Kunchok,T., Lewis,C.A. and Sabatini,D.M.
  TITLE     MFSD12 mediates the import of cysteine into melanosomes and
            lysosomes
  JOURNAL   Nature 588 (7839), 699-704 (2020)
   PUBMED   33208952
REFERENCE   3  (bases 1 to 3987)
  AUTHORS   Crawford,N.G., Kelly,D.E., Hansen,M.E.B., Beltrame,M.H., Fan,S.,
            Bowman,S.L., Jewett,E., Ranciaro,A., Thompson,S., Lo,Y.,
            Pfeifer,S.P., Jensen,J.D., Campbell,M.C., Beggs,W., Hormozdiari,F.,
            Mpoloka,S.W., Mokone,G.G., Nyambo,T., Meskel,D.W., Belay,G.,
            Haut,J., Rothschild,H., Zon,L., Zhou,Y., Kovacs,M.A., Xu,M.,
            Zhang,T., Bishop,K., Sinclair,J., Rivas,C., Elliot,E., Choi,J.,
            Li,S.A., Hicks,B., Burgess,S., Abnet,C., Watkins-Chow,D.E.,
            Oceana,E., Song,Y.S., Eskin,E., Brown,K.M., Marks,M.S.,
            Loftus,S.K., Pavan,W.J., Yeager,M., Chanock,S. and Tishkoff,S.A.
  CONSRTM   NISC Comparative Sequencing Program
  TITLE     Loci associated with skin pigmentation identified in African
            populations
  JOURNAL   Science 358 (6365) (2017)
   PUBMED   29025994
  REMARK    Erratum:[Science. 2020 Jan 17;367(6475):eaba7178. doi:
            10.1126/science.aba7178.. PMID: 31949055]
REFERENCE   4  (bases 1 to 3987)
  AUTHORS   Sikora,K.M., Nosavanh,L.M., Kantheti,P., Burmeister,M. and
            Hortsch,M.
  TITLE     Expression of Caytaxin protein in Cayman Ataxia mouse models
            correlates with phenotype severity
  JOURNAL   PLoS One 7 (11), e50570 (2012)
   PUBMED   23226316
REFERENCE   5  (bases 1 to 3987)
  AUTHORS   Bendor,J., Lizardi-Ortiz,J.E., Westphalen,R.I., Brandstetter,M.,
            Hemmings,H.C. Jr., Sulzer,D., Flajolet,M. and Greengard,P.
  TITLE     AGAP1/AP-3-dependent endocytic recycling of M5 muscarinic receptors
            promotes dopamine release
  JOURNAL   EMBO J 29 (16), 2813-2826 (2010)
   PUBMED   20664521
REFERENCE   6  (bases 1 to 3987)
  AUTHORS   Beier,D.R., Chaillet,J.R., Schmidt,E.V. and Leder,P.
  TITLE     Close linkage of a transgene insertion site to the steel (Sl) locus
            on mouse chromosome 10
  JOURNAL   Genomics 10 (4), 1003-1008 (1991)
   PUBMED   1655629
REFERENCE   7  (bases 1 to 3987)
  AUTHORS   Noebels,J.L. and Sidman,R.L.
  TITLE     Persistent hypersynchronization of neocortical neurons in the mocha
            mutant of mouse
  JOURNAL   J Neurogenet 6 (1), 53-56 (1989)
   PUBMED   2778559
REFERENCE   8  (bases 1 to 3987)
  AUTHORS   Womack,J.E. and Auerbach,S.B.
  TITLE     An acid phosphatase locus expressed in mouse kidney (Apk) and its
            genetic location on chromosome 10
  JOURNAL   Biochem Genet 16 (3-4), 239-245 (1978)
   PUBMED   678292
REFERENCE   9  (bases 1 to 3987)
  AUTHORS   Cacheiro,N.L. and Russell,L.B.
  TITLE     Evidence that Linkage Group IV as well as linkage Group X of the
            mouse are in chromosome 10
  JOURNAL   Genet Res 25 (2), 193-195 (1975)
   PUBMED   1183807
REFERENCE   10 (bases 1 to 3987)
  AUTHORS   Lane,P.W. and Deol,M.S.
  TITLE     Mocha, a new coat color and behavior mutation on chromosome 10 of
            the mouse
  JOURNAL   J Hered 65 (6), 362-364 (1974)
   PUBMED   4448900
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155937.4, BC119790.1, AK149678.1 and AI852143.1.
            
            On Feb 13, 2018 this sequence version replaced NM_028657.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154902.1, AK149678.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC155937.4         82282-82360
            80-1781             BC119790.1         1-1702
            1782-2149           AK149678.1         1709-2076
            2150-3962           AK149678.1         2078-3890
            3963-3987           AI852143.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..3987
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3987
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /note="major facilitator superfamily domain containing 12"
                     /db_xref="GeneID:73822"
                     /db_xref="MGI:MGI:3604804"
     exon            1..396
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1538
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /note="protein grizzled"
                     /codon_start=1
                     /product="major facilitator superfamily domain-containing
                     protein 12"
                     /protein_id="NP_082933.2"
                     /db_xref="CCDS:CCDS35996.1"
                     /db_xref="GeneID:73822"
                     /db_xref="MGI:MGI:3604804"
                     /translation="MSPPSDDAGPGPPRTLSLAARLSFAVGHFLNDLCAGMWFTYLLL
                     FLHSVRGYSSRGAGLLLLLGQVADGLCTPLVGYEADRASCVRCGPRKAWHLAGTVCVL
                     LSFPFIFSPCLGCGEATPEWAALLYYGPFIVVFQFGWAATQIAHLSLIPELVTSDHEK
                     VELTALRYAFTVVANITVYGAAWLLLHLQGSAHGEQDISVGDQLGVQDVPVFRNLALL
                     VVGVGAIFSLLFHLGTKEGHRSQHWGNEPNEHTPLVAPAAQPLLLWKHWLREPAFYQV
                     GMLYMTTRLIVNLSQTYIAMYLTYSLSLPKKFIATIPLVMYLSGFFSSFLMKPVNRRI
                     GRNMTYFTGLLVILAFAAWVALADNLGVAVYGAAVLLGAGCATILVTSLAMTADLIGP
                     HTHSGAFVYGAMSFSDKVANGLAVMAVQSLHPCPSELCCGACISFYHWVMTAVTGGVG
                     VAAALALCSLLIWPIRIRNRDPRDRP"
     exon            397..607
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..746
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            747..932
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1025
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1118
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1289
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1384
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1515
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..3971
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3946..3951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /note="hexamer: AATAAA"
     polyA_site      3961
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
     polyA_site      3969
                     /gene="Mfsd12"
                     /gene_synonym="C19orf28; F630110N24Rik; gr; Wdt1"
                     /note="major polyA site"
ORIGIN      
        1 gttgctccga ggctccgccc tgttgaggcg gctcccggga gcggcggcag cgtagccgcg
       61 cgggtagcgc ggggcggcag tgtggggcgg tggggtttgc ggccgcgatg tcgcctccgt
      121 cggacgacgc aggcccgggg ccgccgcgga cgctgtccct cgccgcgcgg ctgagcttcg
      181 cggtcggcca cttcctcaac gacctgtgcg ccggcatgtg gttcacctac ctgctactat
      241 tcctgcactc cgtgcgcggg tacagctcgc ggggcgcggg gctgctgctg ctgctgggcc
      301 aagtggccga cgggctctgc acgccgctcg tgggctacga ggcggaccgc gcctcctgcg
      361 tgcgctgtgg gccccgcaag gcctggcacc tagcgggcac tgtctgtgtc ctgctctcct
      421 tcccgttcat cttcagcccg tgcctgggct gcggggaagc cacgcctgaa tgggctgcct
      481 tgctgtacta tggacccttc attgtcgtct tccagtttgg ctgggctgcc acgcagattg
      541 cccacctgag cctcatccca gagctggtga ccagtgacca cgagaaggtg gagctcacgg
      601 ccctcaggta tgcgttcact gtggtggcta acatcaccgt gtacggcgca gcctggctgc
      661 tgctgcactt gcagggctct gcacacggcg agcaggacat cagtgtgggt gaccagctag
      721 gagtccagga tgtgcccgtg ttccggaacc tggccctgct tgtggtgggt gtgggagcca
      781 tcttctctct gctcttccac ttgggtacca aggagggcca caggtcccag cactggggga
      841 acgaacccaa tgagcacacc cccctggtgg ccccagcggc ccagccactg ctgctgtgga
      901 aacactggct tcgggagcca gctttttatc aggtaggcat gctgtacatg accacaaggc
      961 tcattgtgaa cctgtctcag acctacattg ccatgtacct gacctattct ctcagcttgc
     1021 ccaagaagtt catcgccacc atccccctgg tgatgtactt gagtggcttc ttctcttcct
     1081 tcctcatgaa gccagtcaac cggcgcatag ggaggaatat gacctacttc accgggctgc
     1141 tggtgatcct ggccttcgca gcttgggtgg ccctggcaga taatctgggt gtggccgtgt
     1201 acggggctgc agtgctgcta ggtgcaggct gtgccaccat ccttgtcacc tccctagcca
     1261 tgacagctga cctcattggc ccacacacgc acagtggagc cttcgtgtat ggtgctatga
     1321 gcttttcgga taaggtggcc aacggactgg cagtcatggc tgtgcagagc ctgcatccct
     1381 gtccctctga gctgtgctgt ggggcctgca tcagcttcta ccactgggtg atgacagcag
     1441 tgacaggcgg cgtgggtgtg gccgcggctc tggctctctg cagcctcctc atctggccca
     1501 tccgcattcg caaccgggac ccgcgagacc ggccttgacc tctggctccc cagggcgacg
     1561 ttatgaagga ccaggcagac accctgcccc ctccccaacc tgctcaggat cagagggcac
     1621 ggcctgcggg tgggtgtacc cggccaagct tgctgagtga gccctagggg cccgttgtgc
     1681 ctcgccccac ttttgacagg gatgcaccag cctaccggga ggctgtaggg gacacatgcc
     1741 cgggctgcac gtgggagaga tcacctggct tacggggaca cggacacacg ggtcggtagc
     1801 acggctttat cagagcgcgg gtgtgaaagc cggaggaggc tggccgatgg ccgggcaggg
     1861 ccgctgcagg ccccgctgtc tgaagtcctg cgcggtgaag cgcggccgct gtggcagcga
     1921 caggagcggc acatagtcgg accgccaggg cagctttgcc ccgaactggt tcctggtgac
     1981 cactgcggac aggaccggac gagctctgca gctgcggggc cgggggtggg gggggggctc
     2041 ccaaatcctt atgctgaccg agcccaccag gccacgccca tcctgcgctc ccgcacctct
     2101 gcccattgct ggcctagccc tccttatttt ttcgtttttt ttttttttta atattgtttt
     2161 cttttgacac tagctagccc aggctgcctc cgggaccaaa aatcccccta tctctgcctc
     2221 cgagagtgga gtgacccacg tgcagtacta cccccggccc cctcctgtcc gcatcccctc
     2281 agctcaccga actccttgcc acggatttgc ctgtccctcc actgcatgca cccccagcgc
     2341 gggcctgagt tgagatactg cgcggttatc gcggggtccc agaaggccat ctcccgcaag
     2401 tgctgtgtgt aggctgcggg gaggcacgga agggagggtg tcagtttgag acccacgggt
     2461 gtgcacgacc ggaggtggga tactcaccgg gcggcaggcc acgctggcga ctctgaaagc
     2521 agccgtgcca acgcgtgtgg gcctcgcggt acggagtgtc aagagcacgg ggcagcttgt
     2581 accaggcatc accaggttct gagttggtca ggccggtgaa ccacacctgg ccggccgcat
     2641 cccgtcccat gggcgtgaat ttccagcgca cggcttgttt gatggccggc gcccaacggg
     2701 gcccctccag ggacacgtag tcattgctga gggagggtgg ggactgagcc agggcgtcct
     2761 gctggtccca gccagctttc ctgtcccaac tctttgccaa ggtgctgggt gagagtcatc
     2821 cccttctacc catctcctct gtgcactttc ccacctgcag tctatatctt gtagccgaga
     2881 atggccctgt ttgaggcagt tgtcagtgtt gacctggcag caatcctgcc tcagccttga
     2941 gccacttatg gctgttgggg gaaggaggga ccaagggtgt gcctagcctg taactcccca
     3001 cagatggtgc atgcatggga ggccatgcag gctgcaggag tggggcttgc aagggaccca
     3061 cgtgaggtgg cctgtcatca gcaccatgga aggcccaagt gtgagcagac ctatgaaatg
     3121 ggacttttct gctaggtgtg ggtggcgaca ctaagtgtgc caaggcagga ggatctctgt
     3181 gggcttatga acagctcggg atacacacaa gaatctaaaa agggagggca ttcaggcaca
     3241 tggctgccac tgcagcacct gtagacagga gaatcaatag acccctctgc ttgggagtat
     3301 gagtggcagc acctgtctgc ttgggagtgg gtgtgtgcaa atgcctaact tacaaccctt
     3361 gcatacctcc atcccagcca cctgagctgc tggtaggggt aggggatctg gggtctgggt
     3421 gaagaaaggg accaagggca ggaacccacc ggtagagatg gtcggggaag tagagttcaa
     3481 gggtgcctga gggaacagag ggccgagtag cctcccgcct cacgttttcc atgtctggcc
     3541 ctgcctgccc agaggctcta gtcaccaagg ccctggggcc attgttgaca gggacaaagg
     3601 tatcccagca acagggaagc gggcagccac agtctaagac ctcagcttac ttcctggtgc
     3661 ggggctggga cccaaagtgt tccctccccc ctccctgccc cacagcggga ggtcatgccc
     3721 tctagagcgt gggtctccac cccatctctg tcctcaagac acatccaagt aagggcacag
     3781 tgacaaaggc cacaaagtat gggccatgat ctagagatcc acagaaggaa gtggatacct
     3841 aagtcttggg ttggggagaa tgctctggga tcactggtgg catcgctgaa catgcagagc
     3901 ccagggcctg ctcattctgc tagtgcatcc tgtgtatctc atgacaataa acagcaacaa
     3961 ccaatctcat aaaaaaaaaa aaaaaaa
//
