LOCUS       NM_008595               1868 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus MFNG O-fucosylpeptide
            3-beta-N-acetylglucosaminyltransferase (Mfng), transcript variant
            1, mRNA.
ACCESSION   NM_008595 XM_912004
VERSION     NM_008595.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1868)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 1868)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1868)
  AUTHORS   Maunsell,H.R., Ellis,K., Kelley,M.W. and Driver,E.C.
  TITLE     Lrrn1 Regulates Medial Boundary Formation in the Developing Mouse
            Organ of Corti
  JOURNAL   J Neurosci 43 (29), 5305-5318 (2023)
   PUBMED   37369584
REFERENCE   4  (bases 1 to 1868)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1868)
  AUTHORS   Ulmke,P.A., Sakib,M.S., Ditte,P., Sokpor,G., Kerimoglu,C., Pham,L.,
            Xie,Y., Mao,X., Rosenbusch,J., Teichmann,U., Nguyen,H.P.,
            Fischer,A., Eichele,G., Staiger,J.F. and Tuoc,T.
  TITLE     Molecular Profiling Reveals Involvement of ESCO2 in Intermediate
            Progenitor Cell Maintenance in the Developing Mouse Cortex
  JOURNAL   Stem Cell Reports 16 (4), 968-984 (2021)
   PUBMED   33798452
REFERENCE   6  (bases 1 to 1868)
  AUTHORS   Ishii,Y., Nakamura,S. and Osumi,N.
  TITLE     Demarcation of early mammalian cortical development by differential
            expression of fringe genes
  JOURNAL   Brain Res Dev Brain Res 119 (2), 307-320 (2000)
   PUBMED   10675782
REFERENCE   7  (bases 1 to 1868)
  AUTHORS   Moran,J.L., Johnston,S.H., Rauskolb,C., Bhalerao,J., Bowcock,A.M.
            and Vogt,T.F.
  TITLE     Genomic structure, mapping, and expression analysis of the
            mammalian Lunatic, Manic, and Radical fringe genes
  JOURNAL   Mamm Genome 10 (6), 535-541 (1999)
   PUBMED   10341080
REFERENCE   8  (bases 1 to 1868)
  AUTHORS   Thelu,J., Viallet,J.P. and Dhouailly,D.
  TITLE     Differential expression pattern of the three Fringe genes is
            associated with epidermal differentiation
  JOURNAL   J Invest Dermatol 111 (5), 903-906 (1998)
   PUBMED   9804358
REFERENCE   9  (bases 1 to 1868)
  AUTHORS   Cohen,B., Bashirullah,A., Dagnino,L., Campbell,C., Fisher,W.W.,
            Leow,C.C., Whiting,E., Ryan,D., Zinyk,D., Boulianne,G., Hui,C.C.,
            Gallie,B., Phillips,R.A., Lipshitz,H.D. and Egan,S.E.
  TITLE     Fringe boundaries coincide with Notch-dependent patterning centres
            in mammals and alter Notch-dependent development in Drosophila
  JOURNAL   Nat Genet 16 (3), 283-288 (1997)
   PUBMED   9207795
REFERENCE   10 (bases 1 to 1868)
  AUTHORS   Johnston,S.H., Rauskolb,C., Wilson,R., Prabhakaran,B., Irvine,K.D.
            and Vogt,T.F.
  TITLE     A family of mammalian Fringe genes implicated in boundary
            determination and the Notch pathway
  JOURNAL   Development 124 (11), 2245-2254 (1997)
   PUBMED   9187150
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592169.14 and AL591946.14.
            
            On Aug 24, 2022 this sequence version replaced NM_008595.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143523.1, BC010983.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-461               AL592169.14        151508-151968
            462-510             AL592169.14        157796-157844
            511-613             AL592169.14        158066-158168
            614-767             AL591946.14        533-686
            768-853             AL591946.14        4110-4195
            854-1019            AL591946.14        5643-5808
            1020-1105           AL591946.14        7619-7704
            1106-1868           AL591946.14        8357-9119
FEATURES             Location/Qualifiers
     source          1..1868
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.69 cM"
     gene            1..1868
                     /gene="Mfng"
                     /note="MFNG O-fucosylpeptide
                     3-beta-N-acetylglucosaminyltransferase"
                     /db_xref="GeneID:17305"
                     /db_xref="MGI:MGI:1095404"
     exon            1..461
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..1172
                     /gene="Mfng"
                     /EC_number="2.4.1.222"
                     /note="isoform 1 is encoded by transcript variant 1;
                     beta-1,3-N-acetylglucosaminyltransferase manic fringe;
                     O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase;
                     manic fringe homolog"
                     /codon_start=1
                     /product="beta-1,3-N-acetylglucosaminyltransferase manic
                     fringe isoform 1"
                     /protein_id="NP_032621.1"
                     /db_xref="CCDS:CCDS27622.1"
                     /db_xref="GeneID:17305"
                     /db_xref="MGI:MGI:1095404"
                     /translation="MHCRLFRGMAGALFTLLCVGLLSLRYHSSLSQRMIQGALRLNQR
                     NPGPLELQLGDIFIAVKTTWAFHRSRLDLLLDTWVSRIRQQTFIFTDSPDERLQERLG
                     PHLVVTNCSAEHSHPALSCKMAAEFDAFLVSGLRWFCHVDDDNYVNPKALLQLLKTFP
                     QDRDVYVGKPSLNRPIHASELQSKNRTKLVRFWFATGGAGFCINRQLALKMVPWASGS
                     HFVDTSALIRLPDDCTVGYIIECKLGGRLQPSPLFHSHLETLQLLGAAQLPEQVTLSY
                     GVFEGKLNVIKLPGPFSHEEDPSRFRSLHCLLYPDTPWCPLLAAP"
     exon            462..510
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            511..613
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            614..767
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            768..853
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1019
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1105
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1868
                     /gene="Mfng"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1847..1852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mfng"
                     /note="hexamer: ATTAAA"
     polyA_site      1868
                     /gene="Mfng"
                     /note="major polyA site"
ORIGIN      
        1 aggtggcggg ctggtggcct ctgccggctg gcaggacggt ggtggctcag tctctgggtc
       61 cagagaccca gcttcctcct ttcccgttgg tgtgtgcccc cgatgcctgc cagacttttg
      121 cctgtaccag ggccccctcc tgaccagcct cccaccccag actgattggg gagtcggggg
      181 ctgaactgtc tgggggcctg ctaccaatgc actgccgact ttttcggggc atggcgggag
      241 ccctctttac cctcctgtgc gtggggctcc tgtctctacg ataccactca agtttgtccc
      301 agaggatgat acagggcgcg ctcaggctga accaacggaa cccaggaccc ctggagctgc
      361 agctaggcga catcttcatc gcagtcaaga ctacctgggc cttccatcgc tcccgcctgg
      421 acctgctact agacacgtgg gtctccagga tcaggcaaca gacattcatc ttcactgaca
      481 gcccagatga acgcctccag gagagactag gcccgcacct cgtggtcacc aactgttctg
      541 cagagcacag tcatcctgct ctgtcctgca agatggctgc agagttcgat gccttcttgg
      601 tcagtggcct caggtggttc tgccacgtgg atgatgacaa ctatgtgaac cccaaggctc
      661 tgctgcagct gttgaaaaca ttcccgcagg accgtgatgt ctatgtgggc aagcccagcc
      721 tgaaccggcc catccacgcc tctgagctgc agtcaaaaaa ccgcacgaag ctggtgcggt
      781 tctggtttgc cacagggggt gctggtttct gcatcaaccg ccaactggct ttgaagatgg
      841 tgccatgggc cagcggctcc cactttgtgg acacttctgc tctcatccgg ctccccgatg
      901 actgcactgt gggctacatc atcgagtgca agctgggggg tcgcctgcag cccagccccc
      961 tcttccactc acacctggaa accctgcagc tgctgggggc cgcccagctt ccggagcagg
     1021 tcaccctcag ctacggtgtc tttgagggga aactgaatgt catcaagcta ccgggcccct
     1081 tctcccatga agaggacccc tccagattcc gctccctcca ttgtctcctc tacccagaca
     1141 caccctggtg tccgctgctg gcagcgccct gagctctgaa ctgccgcaaa ggatgatgga
     1201 tgctactgcc tgaccactcc ctcacctccc aagcagtcct gagggctctc agtccagtgc
     1261 acactggcag atggtccctg gcagggcctc tgggtgacag gaaaggctac gatatggaca
     1321 ctgcttggtg ttgagggtgt cttgggctgg tcataccaca gaggcggcag gaacgcttga
     1381 gttggtgtgt gggaggggat aggggtcctc accctcctga gggtgacatg tgccctgcat
     1441 ggaatctagc ctctggcttt ggcctcagtc attccttaga gactagagtc attgggagaa
     1501 ggccagggtc tgtgacctgc ggctgtggaa ctggtctcag ctgctcctgg cgctgctcag
     1561 ctggccaatg gacctagact ttagaagccc agaaggctca ggtgccaatt gcaaccgacc
     1621 tttggtcact gtcccagcct tctctgctgt gaggagctgc catgtgaccc agtggaactg
     1681 agcaaagcca atagaagggt ttctggaata cattcccagc ccaagacccc atcttcctac
     1741 tatgaatgtg ggtgtgacgg ctgaatctgg ggaaactact ttggcaccat gaaggaaagg
     1801 ccaagacaat ctaaagttgt tctccctaac acctcatctg taagaaatta aacctttatt
     1861 taagtctc
//
