LOCUS       NM_001081279            6417 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus malignant fibrous histiocytoma amplified sequence 1
            (Mfhas1), transcript variant 1, mRNA.
ACCESSION   NM_001081279 XM_884423
VERSION     NM_001081279.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6417)
  AUTHORS   Chen,W., Xu,Y., Zhong,J., Wang,H., Weng,M., Cheng,Q., Wu,Q.,
            Sun,Z., Jiang,H., Zhu,M., Ren,Y., Xu,P., Chen,J. and Miao,C.
  TITLE     MFHAS1 promotes colorectal cancer progress by regulating
            polarization of tumor-associated macrophages via STAT6 signaling
            pathway
  JOURNAL   Oncotarget 7 (48), 78726-78735 (2016)
   PUBMED   27783989
  REMARK    GeneRIF: Colorectal carcinoma cells induce M2 polarization of
            tumor-associated macrophagess through MFHAS1 induction and
            subsequent STAT6 and KLF4 activation to promote CRC progression.
REFERENCE   2  (bases 1 to 6417)
  AUTHORS   Zhong,J., Shi,Q.Q., Zhu,M.M., Shen,J., Wang,H.H., Ma,D. and
            Miao,C.H.
  TITLE     MFHAS1 Is Associated with Sepsis and Stimulates TLR2/NF-kappaB
            Signaling Pathway Following Negative Regulation
  JOURNAL   PLoS One 10 (11), e0143662 (2015)
   PUBMED   26599367
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6417)
  AUTHORS   Ng,A.C., Eisenberg,J.M., Heath,R.J., Huett,A., Robinson,C.M.,
            Nau,G.J. and Xavier,R.J.
  TITLE     Human leucine-rich repeat proteins: a genome-wide bioinformatic
            categorization and functional analysis in innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 108 Suppl 1 (Suppl 1), 4631-4638 (2011)
   PUBMED   20616063
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC129082.6 and AC129211.3.
            
            On Jun 12, 2018 this sequence version replaced NM_001081279.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082308.1, AK081646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3570              AC129082.6         70096-73665
            3571-3697           AC129211.3         146190-146316       c
            3698-6417           AC129211.3         131535-134254       c
FEATURES             Location/Qualifiers
     source          1..6417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 21.16 cM"
     gene            1..6417
                     /gene="Mfhas1"
                     /gene_synonym="2310066G09Rik; D8Ertd91e"
                     /note="malignant fibrous histiocytoma amplified sequence
                     1"
                     /db_xref="GeneID:52065"
                     /db_xref="MGI:MGI:1098644"
     exon            1..3570
                     /gene="Mfhas1"
                     /gene_synonym="2310066G09Rik; D8Ertd91e"
                     /inference="alignment:Splign:2.1.0"
     CDS             585..3731
                     /gene="Mfhas1"
                     /gene_synonym="2310066G09Rik; D8Ertd91e"
                     /note="isoform 1 is encoded by transcript variant 1;
                     malignant fibrous histiocytoma-amplified sequence 1
                     homolog"
                     /codon_start=1
                     /product="malignant fibrous histiocytoma-amplified
                     sequence 1 homolog isoform 1"
                     /protein_id="NP_001074748.1"
                     /db_xref="CCDS:CCDS40319.1"
                     /db_xref="GeneID:52065"
                     /db_xref="MGI:MGI:1098644"
                     /translation="MAGQDSGNLKTVRLWRDAALRARKLRSNLRQLTLSCPGAGGDPL
                     ESPDAPQLVLPANIGDIEVLNLGNNGLEDVPEGLGSALGSLRVLVLRRNRFARLPPAV
                     AELGHHLTELDVSHNRLTILGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD
                     VSFNRLAHLPDSFSCLNHLRTLDVDHNQLTAFPQQLLQLAALEELDVSSNRLRGLPED
                     ISALRALKILWLSGAELGTLPRGFCELASLESLMLDNNGLQALPDEFSRLQRLKMLNL
                     SSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLIAGLGRLLTLWLDNNRIRYLPDSI
                     VELTGLEELVLQGNQIAVLPDNFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQ
                     KELAHSQPAVQPRLKLLLMGHKAAGKTLLRHCLTEDKVEGGQGGGDKEKSYLPFPPLG
                     SKGIEVTSWTADASRGLRFIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRCF
                     PTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQIALQEKNDAEGLS
                     HLAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVS
                     CRDPLQLQRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDS
                     ARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSPALKEHVFHNLTRLIDILNVFFQRD
                     ASLLLHKLLLGTNGEGEGEGESFPTIAVPSPGQDPLRATQLHHYVEGFLLHGLLPAHI
                     IRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKPLNGSAAWYKFPCYVQNEVPH
                     AEAWINGTNLAGQSFVAEQLQIEYSFPFTFPPGLFARYSVQINSHVVHRSDGKFQIFA
                     YRGKVPVVVSYRPAKGVLQPDTLSIASHASLPNIWTAWQAITPLVEELNVLLQEWPGL
                     HYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNGSERVNVALVYPPTP
                     TVISPCSKKNVGEKHRNQ"
     exon            3571..3697
                     /gene="Mfhas1"
                     /gene_synonym="2310066G09Rik; D8Ertd91e"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..6417
                     /gene="Mfhas1"
                     /gene_synonym="2310066G09Rik; D8Ertd91e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6393..6398
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mfhas1"
                     /gene_synonym="2310066G09Rik; D8Ertd91e"
                     /note="hexamer: AATAAA"
     polyA_site      6417
                     /gene="Mfhas1"
                     /gene_synonym="2310066G09Rik; D8Ertd91e"
                     /note="major polyA site"
ORIGIN      
        1 gtagcttccc gatcgcgctc tccaagcgcc ggggacgcgg cgctcgcgct cccgcccgag
       61 ccgcggggaa acggagacaa ggagacgcct tcacctccgg ctccccggcc ctgcgcccgc
      121 agcatgcccg ccgcggagcc gagcgccgcc ctcctcctgc agctcgcgga ggtgacgccg
      181 ccggcctccg gaccgccgct gcgagggtag cggggctgga gtcggctacc gaggctcggc
      241 gaggcgggcg gagctggagg aggagcaggc atcctccgcg gcgcggcggg cggcggccct
      301 gctgcccggc gcgcccatgg cccaggagca cggagaatgc gagccgcgct gcgcggccgc
      361 agcccagctc cgagccgctt gcccggagcc cctcaaacct gcctgcgtcg ctgccgcccg
      421 ccaccggctg cgctaggacc cacggccgcc ggccgcgcag gggtggtggc ccgggagcag
      481 cgggagctag agggcccggg ggctgggcgc ccgccggagt ccagcgcggc atgcagctgc
      541 gggctccggt accggcgtga gggttgtcgg cgcggggccc cgccatggct ggccaggaca
      601 gtggcaacct gaagacggtg aggctgtggc gggacgccgc cctgagagcc aggaagctgc
      661 ggagcaacct gcgccagctc acgctcagct gcccaggggc cggaggcgac ccactggagt
      721 cccccgacgc cccccagctg gtgctgccgg ccaacatcgg ggacattgag gtgctgaacc
      781 tggggaacaa cggcctcgag gatgtgcctg aaggtctggg gtcagctctg ggcagccttc
      841 gcgtcttggt cttgcgcagg aaccgttttg cccggctgcc ccctgcggtg gcggagctag
      901 gccaccacct taccgaactg gacgtcagcc acaaccggtt gaccatcctg ggagccgagg
      961 tggtgagcgc cctgagggag ctgcgcaaac tcaacctgag ccacaaccag ttgccagccc
     1021 tgcctgccca gctgggtgcc ctcgcccacc tggaggagct ggatgtcagc ttcaaccggc
     1081 tggcgcatct gccagattcc ttctcctgcc tcaaccacct tcggaccctt gacgtggacc
     1141 acaaccagct caccgccttt ccccagcagc tgctgcagct ggctgccctg gaggagctcg
     1201 acgtctccag caaccggctg cgaggcctac ctgaggatat cagtgccctg cgtgccctca
     1261 agatcctctg gcttagcggg gccgagcttg gcacgctgcc cagaggcttc tgcgagctgg
     1321 ccagtttgga gagcctcatg ttagataaca acgggctcca ggctctgccc gacgagttca
     1381 gccgtctgca gaggctcaaa atgctcaacc tctcttccaa cctcttcgag gagttccctg
     1441 ctgcgctgct gcccctggct ggtctggagg agctctatct tagtcgcaat cagctcacct
     1501 cagtgccctc tcttatcgcc gggctgggtc ggcttctcac cttgtggctg gataataacc
     1561 gcatccggta cctgccagac tccattgtgg agctgactgg cctggaggag ctggtgctcc
     1621 agggcaacca gatcgctgtg ctgccggaca actttggcca gctctcccgg gtaggcttgt
     1681 ggaaaatcaa ggacaaccca ctgattcagc ccccttacga agtctgcatg aaggggatcc
     1741 cttacatcgc agcctaccag aaggaactgg cgcattcgca gccagccgtg cagccccggc
     1801 tcaagctgct cctgatgggc cacaaggctg caggaaagac cctgcttcga cattgcctca
     1861 ccgaggacaa agtggaggga gggcaaggtg gaggggacaa ggagaagagc tacctacctt
     1921 tccctcccct tggtagtaag ggcatcgagg tgaccagctg gacagcggat gcttcccggg
     1981 gcttgcggtt cattgtgtat gacttagccg gtgatgaaag ctatgaggtg atacagccct
     2041 tcttcctctc ccctggagcc ctgtatgtgc tcgtggtcaa cttggccacc tatgaacctc
     2101 gctgcttccc taccaccgtg ggctccttct tgcatcgggt gggggcccgg gtgcctcacg
     2161 ctgtggtgtg tattgtaggc acgcatgcgg acctgtgtgg ggagcgggag cttgaggaga
     2221 aatgtctgga cattcaccga cagattgccc tgcaggagaa gaacgatgca gagggcctta
     2281 gccatctagc caaggtggtg gatgaggccc tggctcggga cttcgagctg cgctctgcca
     2341 gccctcacgc agcctactac ggtgtttcag acaagaacct tcggaggcgc aaggcccatt
     2401 ttcaatactt gcttaaccac cggttgcaga tcctctctcc cgtgttgccc gtaagctgcc
     2461 gggaccccct ccaattgcaa cgccttcgag acaagctgct ctctgtagct gagcaccgag
     2521 aaatctttcc caacttacac cgagtcctgc ctcgatcctg gcaggtactg gaggaactgc
     2581 acttccagcc acctcaggca caacgactgt ggctgagctg gtgggactct gcccgcctgg
     2641 gcctgcaggc aggtctgact gaggaccggc tccagagtgc tctttcctac ctgcacgaga
     2701 gcggcaaact gctctatttt gaggatagcc cagccctcaa ggagcatgtc ttccacaacc
     2761 tcacccgcct cattgacatc ctcaatgtct ttttccagag agatgcttca ttgctgctgc
     2821 ataaactgct cttagggacc aatggagagg gggaggggga gggggaaagt ttccccacta
     2881 tagcagtgcc cagcccgggt caggacccac tccgggccac ccagcttcat cattatgtgg
     2941 aaggcttttt gctgcatggg cttctgccag cccacatcat tcggttgctg cttaagcctc
     3001 atgtccaggc ccaacaggac ttgcagctcc tgctggagct gttggagaag atgggactct
     3061 gttactgcct caataaaccc aaaggcaagc ctttgaatgg ctccgcggca tggtacaagt
     3121 tcccatgcta cgtgcagaat gaggtgcccc atgcagaggc ctggattaat ggcaccaacc
     3181 tagccgggca gtcttttgtg gctgaacagt tacagatcga atatagtttt cccttcacct
     3241 ttccacctgg attgttcgca cgttacagtg tccagatcaa cagtcacgtg gtgcacaggt
     3301 cggatgggaa atttcagatc tttgcatata gagggaaagt tcccgtggtg gtgagttaca
     3361 gacctgccaa gggggttctg cagcccgaca ccctgtccat tgccagccat gcgtcactac
     3421 caaatatatg gaccgcatgg caagccatca cccctttggt agaggaactg aatgtcctac
     3481 ttcaggaatg gcctggactg cactacactg tgcacatcct ctgttctaag tgccttaaga
     3541 gagggtcgcc aaatccacac gctttcccag gggagttgct gagccagccc aggccagaag
     3601 gggtggcaga gatcatctgc cccaagaatg gcagcgagcg agtgaatgtg gctttggttt
     3661 acccacctac accgactgtg atcagccctt gttccaagaa gaacgttggt gagaagcaca
     3721 gaaaccagtg acatccgcgc ctgtggaatt ttcatggagt taatacaggg catgggaccg
     3781 actgggacat ctcccgcccc tggcgagcct cctgccgtac tcccaagcgc cttccggggc
     3841 ccagagtgaa accgcgcatg cacactgggg tgcttgcaga ggacccttgg aggggttgga
     3901 gggggctggg aagatgggag caaacatgga gcgaatgttt cacaacccga acctcagaac
     3961 tgtgatcctc caaggagaaa gctacttgaa gaaaagaaga aaaaagaaaa aagttaacag
     4021 gcttctcagg gattgtgttt tctgtgtaca catgagccat agctccaggc caggcggcac
     4081 tcagatttca gtttcttgtt caatgtgaag gagggatcaa ctgacgttca ttgccgttcc
     4141 gtaactagtg taagatatgt atatgttaat ctttattttt ataatatgca aaatacattt
     4201 aaatttatac agttggacgc ttctagcatg agtgaacact gggtgcaata ttctgcatga
     4261 gagttgtgcc aagatggggc tggtgtcttt tagtgtcaga ccttgggttc ttctcgtagt
     4321 ccttttgccc acccactcaa ctgcaaagaa cagaaaaagc tagcctctcc ctcggagtcc
     4381 atagctaggt tcaaggttgg ttcctagaac tcttaatact ccccagtggc gttcagccca
     4441 tggagacaga gtcccctccc accttttcat cacacctccc tgcttgctag tcactggaca
     4501 tggtggtaga atgatagctg ttctgtctcc acccatgacc actgaggctg aggggtgcgt
     4561 tcctagaggc cagacgaggt gacgaatctc tgaaaacccg aatcttggaa caacttgaga
     4621 taatctgagt tcagttctaa atcttgcagc tgttctcctg ctatgcaccc ccccgccccc
     4681 cccccctgtc tccctgaccc cgggaacagc gtgcatgatt ttgcagagcc ctctgtgaac
     4741 ctctccatct gattggtagc cttcctgaaa ggagcatcct ctttcagggc tccatccctc
     4801 attggctgtt tattcatgca gagccacttg gaggaagtct gcagccaagg tcctagtaga
     4861 accattgttt tgaaacctct aggaggttaa acacttaaaa acaaactcta caaattgctc
     4921 tccagtgtcc tcctggttag ggccaaacag cacgtgttgc agtagagaca cattctctga
     4981 agactgtaaa ggactgtgtt tacatccgcc tcctccgtgt gttgacagga aacatgtcaa
     5041 actgactgtt ccccacaaga aaagtgtgtc agctcttctt actctgtcac ctgtattcta
     5101 aaatattgac tcctagaatg tcacagcaca ggcagttgcc acgaatcttt aagaggaagg
     5161 aatacaagca ggcgactgca cttcttgagg cgttacaaat aagattcgtg ttgaatctgt
     5221 tcagttgact tccctgcccc ccggagcccg ttatgtggag gcaatttctc agaaatcaga
     5281 atctagtagg gattgtctct ctctctctct ctatgttttg aatacttgaa catgacaagt
     5341 ccagtttaaa atgtcttttt ccttttagga cacagttgca ggatgggtaa gaatctggtt
     5401 gatctcttct gtcataggtc tcatgtgtat gtgtgcaagt gtaaaccaga gggttagcat
     5461 tccccttcct ttgtagacca ctgaattatt gggcaatagt ttattttgtt gttattggct
     5521 ttttgttttt gtttttgttt ttttttaaat tggcaccaaa cagttctgaa actgtcaagt
     5581 cagcaaagtt caatgtccgc tatgattttg ggtttacttc ccagagggcc atgtcaaatc
     5641 agaagaaggc tccttgggag agcataccct gcccatggat gctcttttca taaacacaga
     5701 tgcccatgtt ctgaatatct gttactttct gacaagtgat gttgtgtgtt gtcatctgaa
     5761 ccctagagaa gcatcgtaga tgagggaacc ttggcggtca tgtatcgtgg ctagggtggg
     5821 cacgatcaga gggtcacgtg cccgagaaag ctccagcaaa gcgtgagaac ttgcctcagt
     5881 gtggggggga agggctgaga tacagaagcc accttgcccc agaagaattt cagcggcggc
     5941 tgtatgagaa attctgtttc cttatttcac acctgggaag actcagcagc cagcagctga
     6001 ggggccatcc actaagcaca agaggaattc gttctaccca aggagccccg tgcctctcaa
     6061 atgcgctccg agtttgttat ggtttctatt cttacaacta acggtatcaa aaccacttcc
     6121 tgggattgta caagtgctgc cagaataaat gtttccccct tctaaggaaa aaaaaacaaa
     6181 acaaaacaag acaaaaaatc cgacagtgct catgtttgac gtgtgcgctg gactcttttg
     6241 aatgaataaa gaggaagggc ttgttgggat tccagtggag tgtgtgtttt tcatgctgca
     6301 gtctgtgaat tgtaattgtg gtttcccagt tcattgtcct aacggggcag aagttaaaaa
     6361 acaaaacaaa aacaaaacaa aacaaaaaaa acaataaaaa cacaatgaaa tggttaa
//
