LOCUS       NM_001372414            1650 bp    mRNA    linear   ROD 07-JUL-2024
DEFINITION  Mus musculus mitochondrial fission factor (Mff), transcript variant
            13, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001372414 XM_006496572
VERSION     NM_001372414.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Takeichi,Y., Miyazawa,T., Sakamoto,S., Hanada,Y., Wang,L.,
            Gotoh,K., Uchida,K., Katsuhara,S., Sakamoto,R., Ishihara,T.,
            Masuda,K., Ishihara,N., Nomura,M. and Ogawa,Y.
  TITLE     Non-alcoholic fatty liver disease in mice with hepatocyte-specific
            deletion of mitochondrial fission factor
  JOURNAL   Diabetologia 64 (9), 2092-2107 (2021)
   PUBMED   34052855
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Varuzhanyan,G., Chen,H., Rojansky,R., Ladinsky,M.S., McCaffery,J.M.
            and Chan,D.C.
  TITLE     Mitochondrial fission factor (Mff) is required for organization of
            the mitochondrial sheath in spermatids
  JOURNAL   Biochim Biophys Acta Gen Subj 1865 (5), 129845 (2021)
   PUBMED   33476744
  REMARK    GeneRIF: Mitochondrial fission factor (Mff) is required for
            organization of the mitochondrial sheath in spermatids.
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Hanada,Y., Ishihara,N., Wang,L., Otera,H., Ishihara,T., Koshiba,T.,
            Mihara,K., Ogawa,Y. and Nomura,M.
  TITLE     MAVS is energized by Mff which senses mitochondrial metabolism via
            AMPK for acute antiviral immunity
  JOURNAL   Nat Commun 11 (1), 5711 (2020)
   PUBMED   33177519
  REMARK    GeneRIF: MAVS is energized by Mff which senses mitochondrial
            metabolism via AMPK for acute antiviral immunity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Zhao,Y., Sun,X., Hu,D., Prosdocimo,D.A., Hoppel,C., Jain,M.K.,
            Ramachandran,R. and Qi,X.
  TITLE     ATAD3A oligomerization causes neurodegeneration by coupling
            mitochondrial fragmentation and bioenergetics defects
  JOURNAL   Nat Commun 10 (1), 1371 (2019)
   PUBMED   30914652
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Lewis,T.L. Jr., Kwon,S.K., Lee,A., Shaw,R. and Polleux,F.
  TITLE     MFF-dependent mitochondrial fission regulates presynaptic release
            and axon branching by limiting axonal mitochondria size
  JOURNAL   Nat Commun 9 (1), 5008 (2018)
   PUBMED   30479337
  REMARK    GeneRIF: the Drp1 'receptor' Mitochondrial fission factor (MFF) is
            required for determining the size of mitochondria entering the
            axon.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Long,B., Wang,K., Li,N., Murtaza,I., Xiao,J.Y., Fan,Y.Y., Liu,C.Y.,
            Li,W.H., Cheng,Z. and Li,P.
  TITLE     miR-761 regulates the mitochondrial network by targeting
            mitochondrial fission factor
  JOURNAL   Free Radic Biol Med 65, 371-379 (2013)
   PUBMED   23867156
  REMARK    GeneRIF: This study reveals a novel model of mitochondrial fission
            regulation, which is composed of miR-761 and mitochondrial fission
            factor
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Palmer,C.S., Elgass,K.D., Parton,R.G., Osellame,L.D.,
            Stojanovski,D. and Ryan,M.T.
  TITLE     Adaptor proteins MiD49 and MiD51 can act independently of Mff and
            Fis1 in Drp1 recruitment and are specific for mitochondrial fission
  JOURNAL   J Biol Chem 288 (38), 27584-27593 (2013)
   PUBMED   23921378
  REMARK    GeneRIF: MiD49 and MiD51 can act independently of Mff and Fis1 in
            Drp1 recruitment and suggest that they provide specificity to the
            division of mitochondria.
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Loson,O.C., Song,Z., Chen,H. and Chan,D.C.
  TITLE     Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in
            mitochondrial fission
  JOURNAL   Mol Biol Cell 24 (5), 659-667 (2013)
   PUBMED   23283981
  REMARK    GeneRIF: immunofluorescence analysis of Drp1 suggests that Fis1 and
            Mff are important for the number and size of Drp1 puncta on
            mitochondria.
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   Otera,H., Wang,C., Cleland,M.M., Setoguchi,K., Yokota,S.,
            Youle,R.J. and Mihara,K.
  TITLE     Mff is an essential factor for mitochondrial recruitment of Drp1
            during mitochondrial fission in mammalian cells
  JOURNAL   J Cell Biol 191 (6), 1141-1158 (2010)
   PUBMED   21149567
REFERENCE   10 (bases 1 to 1650)
  AUTHORS   Dixit,E., Boulant,S., Zhang,Y., Lee,A.S., Odendall,C., Shum,B.,
            Hacohen,N., Chen,Z.J., Whelan,S.P., Fransen,M., Nibert,M.L.,
            Superti-Furga,G. and Kagan,J.C.
  TITLE     Peroxisomes are signaling platforms for antiviral innate immunity
  JOURNAL   Cell 141 (4), 668-681 (2010)
   PUBMED   20451243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138214.8.
            
            On Aug 30, 2019 this sequence version replaced XM_006496572.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.29000.1,
                                           SRR5286961.76157.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC138214.8         80102-80268
            168-276             AC138214.8         82412-82520
            277-497             AC138214.8         84400-84620
            498-667             AC138214.8         86297-86466
            668-759             AC138214.8         90600-90691
            760-844             AC138214.8         105704-105788
            845-1650            AC138214.8         106769-107574
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 42.45 cM"
     gene            1..1650
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /note="mitochondrial fission factor"
                     /db_xref="GeneID:75734"
                     /db_xref="MGI:MGI:1922984"
     exon            1..167
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            168..276
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            277..497
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..976
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /note="isoform 13 is encoded by transcript variant 13"
                     /codon_start=1
                     /product="mitochondrial fission factor isoform 13"
                     /protein_id="NP_001359343.1"
                     /db_xref="GeneID:75734"
                     /db_xref="MGI:MGI:1922984"
                     /translation="MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQEFQDGV
                     PNASVIMQVPERIVVTGNNEDISFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLD
                     FLDLERPLPTPQSEEQSRAVGRLKRERSMSENAVRQNGQLVRNDSMYGISNLDAAIEG
                     ASDDMTVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFR
                     R"
     exon            498..667
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            668..759
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            760..844
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1650
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1650
                     /gene="Mff"
                     /gene_synonym="5230400G24Rik"
                     /note="major polyA site"
ORIGIN      
        1 agtcctggcc gttctcgcgt ctgtcccggc ccgtcgcggc cgctccgccg cttctttgcc
       61 cgggcgcctc ggtgcgctcg gtcaacggcc tctgcgagcg ctcacccgag tgccccggag
      121 ccggcgggcg gcgaccctct ctccggggac tctccagcag gcccagggga taaaagtggc
      181 tctcacccta gcacatgtgc atcggagcaa tttaaggagt taatatgaag cacagaagca
      241 gatagtgcca aatagcaagc ctgttgtttc acatttggtg agtggggcag catttccttc
      301 tcccactgct gctgagatgg cagaaattag tcgaattcag tatgaaatgg aatacaccga
      361 aggtattagt cagcgaatga gggtcccgga aaaattaaaa gtagcaccac caaatgctga
      421 cctggagcaa gagttccaag atggagttcc aaatgccagt gtgataatgc aagtcccaga
      481 gaggatcgtg gttacaggaa ataatgaaga catttcattt tcaagaccag cagatcttga
      541 ccttatccag tccactccct ttaaacctct ggcactgaaa acaccaccac gcgtgctcac
      601 actgagtgag agaccactag atttcctgga tttagaaaga ccacttccaa ctcctcaaag
      661 cgaagagcag agccgagcag ttggcaggct aaaaagagag cgttctatga gtgaaaatgc
      721 tgttcgccaa aatggacagt tggtcagaaa cgattccatg tatggcattt caaacctaga
      781 tgcagccatt gaaggagctt cagatgacat gactgtggta gatgcagctt cattaagacg
      841 tcagataatc aaattaaata gacgtctcca acttctggaa gaggagaata aagagcgtgc
      901 taaaagagaa atggtcatgt attcaatcac tgtagcgttc tggctgctta acagctggct
      961 ctggtttcga cgctagaggt aacctcagca ttcacatata ttgtctcaac acctggaaat
     1021 ataaaggatt tgcaaacttc attgtttctg tctttgcatc atcgtatgac ggccctgaaa
     1081 atgtatttct ccagagtgca gggaaggccc tgtatctgta gagtgaaggc ctgtggtgct
     1141 gctgatgggc gttcagccag ttgtgcagtg gcacctatac actctccttt tgcatgtctt
     1201 gtaaataggc tctaggtttg ttttgttttt aaagaaaata atttttgtgg cctcaccagt
     1261 ctgtacagct aattctctaa acagaaatgg cagtcataaa gagtgagttt agaaaactgt
     1321 ctgtgaaaga aaagtgtttt gtcctgtttt cagatgatga agcgatttct ttgatagatg
     1381 ctttttgtat ctacatctca actgtaatgc tttctaagtc acagtgctgt gcaggactga
     1441 agtcaaacca cctgactctg cttcatcgcc tacctgcaca ggcggggcta aaaactccta
     1501 acagttcagc agtctgtctg tgtgcaatgc tgttttgact ttcatcttag ttttctatca
     1561 agtatgtttt taccaagtcc atgtgtgaat gatttaaaaa cctaaaaaat aaggtataaa
     1621 tgtagtgtat ttaataaact gtcaaccaaa
//
