LOCUS       NM_029568               1527 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus microfibrillar-associated protein 4 (Mfap4),
            transcript variant 2, mRNA.
ACCESSION   NM_029568
VERSION     NM_029568.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1527)
  AUTHORS   Christensen,K.B., Unsal,S., Ebbesen,M.F., Hemstra,L., Schlosser,A.,
            Rosenstand,K., Hansen,P.B.L., Jensen,B.L., Bloksgaard,M.,
            Simonsen,U. and Sorensen,G.L.
  TITLE     MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance
            Artery Structure, While Ameliorating Hypertension
  JOURNAL   Hypertension 81 (6), 1308-1319 (2024)
   PUBMED   38563153
  REMARK    GeneRIF: MFAP4-Deficiency Aggravates Age-Induced Changes in
            Resistance Artery Structure, While Ameliorating Hypertension.
REFERENCE   2  (bases 1 to 1527)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1527)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   4  (bases 1 to 1527)
  AUTHORS   Kurz,J., Weiss,A.C., Thiesler,H., Qasrawi,F., Deuper,L., Kaur,J.,
            Rudat,C., Ludtke,T.H., Wojahn,I., Hildebrandt,H., Trowe,M.O. and
            Kispert,A.
  TITLE     Notch signaling is a novel regulator of visceral smooth muscle cell
            differentiation in the murine ureter
  JOURNAL   Development 149 (4) (2022)
   PUBMED   35103284
REFERENCE   5  (bases 1 to 1527)
  AUTHORS   Pilecki,B., de Carvalho,P.V.S.D., Kirketerp-Moller,K.L.,
            Schlosser,A., Kejling,K., Dubik,M., Madsen,N.P., Stubbe,J.,
            Hansen,P.B.L., Andersen,T.L., Moeller,J.B., Marcussen,N.,
            Azevedo,V., Hvidsten,S., Baun,C., Shi,G.P., Lindholt,J.S. and
            Sorensen,G.L.
  TITLE     MFAP4 Deficiency Attenuates Angiotensin II-Induced Abdominal Aortic
            Aneurysm Formation Through Regulation of Macrophage Infiltration
            and Activity
  JOURNAL   Front Cardiovasc Med 8, 764337 (2021)
   PUBMED   34805319
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1527)
  AUTHORS   Holm,A.T., Wulf-Johansson,H., Hvidsten,S., Jorgensen,P.T.,
            Schlosser,A., Pilecki,B., Ormhoj,M., Moeller,J.B., Johannsen,C.,
            Baun,C., Andersen,T., Schneider,J.P., Hegermann,J., Ochs,M.,
            Gotz,A.A., Schulz,H., de Angelis,M.H., Vestbo,J., Holmskov,U. and
            Sorensen,G.L.
  TITLE     Characterization of spontaneous air space enlargement in mice
            lacking microfibrillar-associated protein 4
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 308 (11), L1114-L1124 (2015)
   PUBMED   26033354
  REMARK    GeneRIF: Mfap4 knockout mice develop a spontaneous loss of lung
            function.
REFERENCE   7  (bases 1 to 1527)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   8  (bases 1 to 1527)
  AUTHORS   Naba,A., Clauser,K.R., Hoersch,S., Liu,H., Carr,S.A. and Hynes,R.O.
  TITLE     The matrisome: in silico definition and in vivo characterization by
            proteomics of normal and tumor extracellular matrices
  JOURNAL   Mol Cell Proteomics 11 (4), M111.014647 (2012)
   PUBMED   22159717
REFERENCE   9  (bases 1 to 1527)
  AUTHORS   Yan,J., Bi,W. and Lupski,J.R.
  TITLE     Penetrance of craniofacial anomalies in mouse models of
            Smith-Magenis syndrome is modified by genomic sequence surrounding
            Rai1: not all null alleles are alike
  JOURNAL   Am J Hum Genet 80 (3), 518-525 (2007)
   PUBMED   17273973
REFERENCE   10 (bases 1 to 1527)
  AUTHORS   Probst,F.J., Chen,K.S., Zhao,Q., Wang,A., Friedman,T.B.,
            Lupski,J.R. and Camper,S.A.
  TITLE     A physical map of the mouse shaker-2 region contains many of the
            genes commonly deleted in Smith-Magenis syndrome (del17p11.2p11.2)
  JOURNAL   Genomics 55 (3), 348-352 (1999)
   PUBMED   10049592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL604029.12.
            
            On Mar 19, 2018 this sequence version replaced NM_029568.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022666.1, AK003537.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                AL604029.12        72498-72552
            56-140              AL604029.12        72788-72872
            141-295             AL604029.12        73105-73259
            296-392             AL604029.12        73977-74073
            393-575             AL604029.12        74146-74328
            576-1527            AL604029.12        74821-75772
FEATURES             Location/Qualifiers
     source          1..1527
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..1527
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /note="microfibrillar-associated protein 4"
                     /db_xref="GeneID:76293"
                     /db_xref="MGI:MGI:1342276"
     exon            1..55
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            56..140
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            141..295
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            296..392
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            393..575
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1527
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1527
                     /gene="Mfap4"
                     /gene_synonym="1110007F23Rik"
                     /note="major polyA site"
ORIGIN      
        1 tgcagtctgg ggccccagac agccagcctc tctcaactga gctgacacca tgaaggccct
       61 cccagccctg ccactgatgc tgatgctgct ctccatgcct cccccctgcg ccccgcaagc
      121 ctctgggatc cggggagatg ctctggagaa gtcctgtctt cagcaacccc tggactgtga
      181 tgatatctac gcccagggct atcaggaaga cggcgtgtat ctcatctacc cctatggccc
      241 cagtgtgccg gtgcccgtct tctgcgacat gacaactgag ggcggcaagt ggacggtttt
      301 ccagaaaaga ttcaacggct cagtgagttt cttccggggc tggagcgact acaagctggg
      361 ctttggccgt gctgacgggg agtactggct ggggctgcag aacctgcacc tcctgacact
      421 gaagcagaag tatgagctgc gcgtggactt ggaagacttt gagaacaaca cagcctatgc
      481 caagtacatt gacttctcca tctcccccaa cgccatcagt gctgaggagg atggctatac
      541 cctctacgtg gctggcttcg aggatggcgg ggcaggtgac tcactgtcct accacagtgg
      601 ccagaagttc tccacctttg atcgggacca ggacctcttc gtgcagaact gtgcagccct
      661 ctcctcagga gccttctggt tccgaagctg ccatttcgcc aatctcaacg gtttctacct
      721 gggtggttcc catctctcct atgccaatgg catcaattgg gcccaatgga aaggcttcta
      781 ttactccctc aagcgcacgg agatgaaaat tcgtcgggcc tgaggggctg gcccaagcag
      841 gccccatctt tcccctgaag tcccaagggt ccatgttctc cctccacgct ttacccacaa
      901 ttcctgagca ccagccatgc cctggcaaat ccctgtccca catacagcca cgccctgatg
      961 cattccacct gaggctaggc tgtcagcagc cctccaggcc tttctgtggc tgagccatcc
     1021 tagcctggat ctggctgaaa tccattaaaa actccaagtt gcttctaccc cttcacgaca
     1081 gctgaaagcc agaagctacc ttctagctgc cagcttttgc accccacctc agcagtttcc
     1141 ttactgcaga gccttctgtt tggggctacc ctcgacagag tcatgcagca cctgtggcat
     1201 tgccaatcag ctcttgcaca ctgccacacc ccagcactca catagctctc ctcagaatac
     1261 ttcctacctt ggcctcatca ctttactccc tacgtgagca tcatggagcc caatcccatc
     1321 tgccttcact catccctcaa aattcaccac caaaacaata ctcaccacgg ctactgctca
     1381 actctgaagt cgtcatggca aagataggct tgttgacttg gtcccctact tgccctagcg
     1441 atcgtcatga gaggcagcag ggatcaatat gtggggctgg aagtgggtgg gtagcagagg
     1501 tctcaataaa cttcaggatc tgatgga
//
