LOCUS       NM_001039214            4080 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mex3 RNA binding family member C (Mex3c), mRNA.
ACCESSION   NM_001039214 XM_140436 XM_902156 XM_902158 XM_915529
VERSION     NM_001039214.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4080)
  AUTHORS   Wang,K., Zhang,H.N. and Du,Y.
  TITLE     MEX3C induces cognitive impairment in mice through autophagy
            inhibition
  JOURNAL   Brain Behav 13 (11), e3245 (2023)
   PUBMED   37652868
  REMARK    GeneRIF: MEX3C induces cognitive impairment in mice through
            autophagy inhibition.
REFERENCE   2  (bases 1 to 4080)
  AUTHORS   Du,Y., Sun,D. and Li,Y.
  TITLE     Mex3c mutation affects lactation through impairing milk ejection in
            female mice
  JOURNAL   Biosci Rep 40 (12) (2020)
   PUBMED   33180120
  REMARK    GeneRIF: Mex3c mutation affects lactation through impairing milk
            ejection in female mice.
REFERENCE   3  (bases 1 to 4080)
  AUTHORS   Du,Y., Huo,Q., Li,T., Sun,D., Sun,T. and Lu,Z.
  TITLE     Construction of a Mex3c Gene-Deficient Mouse Model to Study C-FOS
            Expression in Hypothalamic Nuclei and Observe Morphological
            Differences in Embryonic Neural Tube Development
  JOURNAL   Med Sci Monit 26, e927334 (2020)
   PUBMED   33191393
  REMARK    GeneRIF: Construction of a Mex3c Gene-Deficient Mouse Model to
            Study C-FOS Expression in Hypothalamic Nuclei and Observe
            Morphological Differences in Embryonic Neural Tube Development.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4080)
  AUTHORS   Lu,P., Li,H., Li,N., Singh,R.N., Bishop,C.E., Chen,X. and Lu,B.
  TITLE     MEX3C interacts with adaptor-related protein complex 2 and involves
            in miR-451a exosomal sorting
  JOURNAL   PLoS One 12 (10), e0185992 (2017)
   PUBMED   28982131
  REMARK    GeneRIF: MEX3C associates with the endolysosomal compartment
            through an endocytosis-like process. siRNA-mediated inhibition of
            the MEX3C or AP-2 complex substantially decreased exosomal but not
            cellular microRNA miR-451a expression
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4080)
  AUTHORS   Li,X., Li,Y., Liu,C., Jin,M. and Lu,B.
  TITLE     Oocyte-Specific Expression of Mouse MEX3C652AA in the Ovary and Its
            Potential Role in Regulating Maternal Fos mRNA
  JOURNAL   Biol Reprod 94 (5), 115 (2016)
   PUBMED   27053362
  REMARK    GeneRIF: The specific expression of this long MEX3C isoform in
            oocytes and its ability to enhance FOS mRNA nuclear export and
            stability all suggest that MEX3C(659AA) is an RNA-binding protein
            that preserves maternal FOS mRNA in oocytes.
REFERENCE   6  (bases 1 to 4080)
  AUTHORS   Han,C., Jiao,Y., Zhao,Q. and Lu,B.
  TITLE     Mex3c mutation reduces adiposity partially through increasing
            physical activity
  JOURNAL   J Endocrinol 221 (3), 457-468 (2014)
   PUBMED   24741071
  REMARK    GeneRIF: Data indicate that Mex3c mutation significantly increases
            physical activity.
REFERENCE   7  (bases 1 to 4080)
  AUTHORS   Kuniyoshi,K., Takeuchi,O., Pandey,S., Satoh,T., Iwasaki,H.,
            Akira,S. and Kawai,T.
  TITLE     Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in
            RIG-I-mediated antiviral innate immunity
  JOURNAL   Proc Natl Acad Sci U S A 111 (15), 5646-5651 (2014)
   PUBMED   24706898
  REMARK    GeneRIF: MEX3C is required for cytokine production after infection
            with RNA viruses that are detected by RIG-I.
REFERENCE   8  (bases 1 to 4080)
  AUTHORS   Jiao,Y., George,S.K., Zhao,Q., Hulver,M.W., Hutson,S.M.,
            Bishop,C.E. and Lu,B.
  TITLE     Mex3c mutation reduces adiposity and increases energy expenditure
  JOURNAL   Mol Cell Biol 32 (21), 4350-4362 (2012)
   PUBMED   22927639
  REMARK    GeneRIF: Mex3c mutation caused leanness in both heterozygous and
            homozygous transgenic mice, as well as a more beneficial blood
            glucose and lipid profile in homozygous transgenic mice, in both
            sexes; data show Mex3c is involved in energy balance regulation
REFERENCE   9  (bases 1 to 4080)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4080)
  AUTHORS   Jiao,Y., Bishop,C.E. and Lu,B.
  TITLE     Mex3c regulates insulin-like growth factor 1 (IGF1) expression and
            promotes postnatal growth
  JOURNAL   Mol Biol Cell 23 (8), 1404-1413 (2012)
   PUBMED   22357625
  REMARK    GeneRIF: data suggest that MEX3C plays an important role in
            enhancing the translation of Igf1 mRNA directly or indirectly and
            promoting postnatal growth
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ071688.1, BB618103.1, CJ067036.1, BC125427.1, BC108422.1 and
            BY595095.1.
            
            On Oct 19, 2007 this sequence version replaced NM_001039214.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.147669.1, BC035207.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                CJ071688.1         1-83
            84-571              BB618103.1         1-488
            572-718             CJ067036.1         2-148
            719-2900            BC125427.1         1-2182
            2901-4071           BC108422.1         1220-2390
            4072-4080           BY595095.1         430-438
FEATURES             Location/Qualifiers
     source          1..4080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 49.29 cM"
     gene            1..4080
                     /gene="Mex3c"
                     /gene_synonym="A130001D14Rik; BM-013; Rkhd2"
                     /note="mex3 RNA binding family member C"
                     /db_xref="GeneID:240396"
                     /db_xref="MGI:MGI:2652843"
     exon            1..1072
                     /gene="Mex3c"
                     /gene_synonym="A130001D14Rik; BM-013; Rkhd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..2298
                     /gene="Mex3c"
                     /gene_synonym="A130001D14Rik; BM-013; Rkhd2"
                     /EC_number="2.3.2.27"
                     /note="ring finger and KH domain containing 2; RNA-binding
                     protein MEX3C; RING finger and KH domain-containing
                     protein 2; mex3 homolog C; RING-type E3 ubiquitin
                     transferase MEX3C"
                     /codon_start=1
                     /product="RNA-binding E3 ubiquitin-protein ligase MEX3C"
                     /protein_id="NP_001034303.3"
                     /db_xref="CCDS:CCDS50318.1"
                     /db_xref="GeneID:240396"
                     /db_xref="MGI:MGI:2652843"
                     /translation="MPSGSSAALALALAAAPAPLPQPPPLPPPPPAGGPELEGDGLLL
                     RERLAALGLDDPSPAEPGAPALRAAAVAAAAAAQCQARRATGLAPEEPGRLATSETAE
                     LELEVDEEEGEEAELDGELLEEEELEEAEEEDRPSLLLLSPPAATASQTQPIPGGPLG
                     SVLLPAAGFDAREAAAAGVLYGGDDAQGMMAAMLSHAYGPGGGGAAAAALNGEQAALL
                     RRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRK
                     EDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLV
                     VGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYI
                     ELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMMSNYRNDSSSSLGSGSTDS
                     YFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLTVDSPAFDSLPTSAQTIWTPFEP
                     VNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGL
                     PIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCME
                     CANKICEKRTPSCPVCQTAVTQAIQIHS"
     exon            1073..4080
                     /gene="Mex3c"
                     /gene_synonym="A130001D14Rik; BM-013; Rkhd2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4050..4055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mex3c"
                     /gene_synonym="A130001D14Rik; BM-013; Rkhd2"
                     /note="hexamer: AATAAA"
     polyA_site      4077
                     /gene="Mex3c"
                     /gene_synonym="A130001D14Rik; BM-013; Rkhd2"
                     /note="major polyA site"
ORIGIN      
        1 attcggagag cggcgtgggg cgtcgccgcc gccgccgcgc gcgccggggg ctggttaagg
       61 ccatgaaaca aaagaaaccc tgagagggga gccgctgccg tccccaccca cccacctagt
      121 tccctacctc ggctccgttc ccggcccctc caccccgccc tcgcgcgctc cggcggccct
      181 ggcgctcctc agcccggggc gcgggcgccg ccgcctcccc cgaggaaagg tgtttgcgcg
      241 ctgagcaggg ccggggccct gtccgccatg gggccggctg ctcgccgcgc ctgacgctcc
      301 cgccgccgcc gccgccgcca ttgacagcgc gccgccgcga tgccaagcgg cagctccgcg
      361 gccctggccc tggccctggc ggcggccccg gcccccctgc cgcagccgcc tccgctgccg
      421 ccgccgccgc ccgcgggagg cccagagctc gaaggggacg ggctgctgct gagggagcgc
      481 ctggccgcgc taggcctcga cgaccccagc ccggcggagc ccggcgcccc ggcgctcagg
      541 gccgcggcgg tggcggcggc ggcggcggcg cagtgccagg cccggcgggc gaccgggctg
      601 gctccggagg agcctggccg cctcgcgacc tccgagacgg cggagctgga gctggaggtg
      661 gacgaagagg agggggagga agcggagctg gacggagaac tgctggagga ggaggagctg
      721 gaggaggcag aggaggagga ccggccgtcg ctgctgctgt tgtcgccgcc cgcggccacc
      781 gcctcccaga ctcagccgat cccgggcggg cccctggggt cggtgctgct gccggccgcg
      841 ggcttcgatg cccgggaggc cgcggcggca ggggtgctgt acggagggga cgatgcccag
      901 ggcatgatgg cggcgatgct gtcccacgcc tacggccccg gcggcggcgg ggccgccgct
      961 gccgccctga acggagagca agcggccctg ctgagaagga agagcgtcaa caccaccgag
     1021 tgcgtccccg tgcccagttc cgagcatgtc gctgagattg tcggacgcca gggttgtaaa
     1081 attaaagcac tgagagccaa gacaaacacg tatatcaaga cacctgttcg tggtgaagaa
     1141 cccatttttg ttgtcactgg acggaaagaa gatgttgcca tggccaaaag agaaatcctc
     1201 tcggctgcag agcacttttc tatgattcgt gcatctcgaa acaaaaatgg tcctgcacta
     1261 ggagggttat cgtgtagtcc taatctgcct ggtcaaacca cagtccaagt cagggtcccc
     1321 tatcgtgtgg tagggctagt ggttggacca aaaggagcaa caattaagag aattcagcaa
     1381 cagacccaca cgtacatagt tactccgagc agagataagg agccagtctt tgaagtcaca
     1441 gggatgcccg aaaatgttga tcgagcacga gaagagatag aaatgcatat cgccatgcgt
     1501 accggaaact acatagagct caatgaagaa aatgatttcc attataacgg taccgatgtg
     1561 agctttgaag gtggcactct tggctctgca tggctctctt ccaatccagt tcctccaagc
     1621 cgagcaagaa tgatgtctaa ctatcgcaat gatagttcta gctctctagg aagtggctcc
     1681 actgattcct attttgggag caataggcta gctgacttta gtccaacaag cccatttagc
     1741 acagggaact tttggtttgg agatacacta ccatctgtag gctcagaaga tcttacagta
     1801 gactctcctg cctttgactc tttaccaaca tctgctcaaa ctatctggac tccatttgaa
     1861 ccagttaacc cactctctgg ctttgggagt gatccttctg gtaacatgaa gactcagcgt
     1921 agaggaagtc agccatcaac tcctcgtctg tctcctacat ttcctgagag catagaacac
     1981 ccacttgctc gaagggtgag gagtgaccca cctagtacag gcaaccatgt tggccttcca
     2041 atatacatcc ctgctttttc taatggtacc aatagttact cctcttccaa tggtggttcc
     2101 acctctagct cacctccaga atcaagaaga aagcacgact gtgtgatttg ctttgagaat
     2161 gaagttattg ctgccctagt tccatgtggc cacaacctct tctgcatgga atgtgccaac
     2221 aagatctgtg aaaagagaac gccgtcatgt ccagtttgcc agacagctgt tactcaggca
     2281 atccaaattc actcttaact atatatatat acataaatac tatatctcta tatggactca
     2341 taaaggcatg ggtataatgg tacccccagt aaacttccta atgaattctt atgactgtta
     2401 tcaggcttta ttgggattag gctaaagttg ttagtacact tataaaaggc tgctatggta
     2461 acactaacct aagtggtctc ttgtctatta gtttggtttg aattattaat actatcttgt
     2521 agactcagag acatagcttg tataggaatt gttaaagtgg aagttgtact tggctgtgta
     2581 acctaagagc aaaatgtatc catctgagat tgtagtcagt gggtcccaga gcctagccgc
     2641 actaagagtt tatggagggt gcctggcatc tcagatgact gacacttcca gtgctgcctt
     2701 cttcacactg ccagttttga caaaaacagg tttgtttttt tattttacaa caacttctgc
     2761 ctaattctgc aggattgcaa gtaacttttt aaagcattga ttacttacta gtaataatag
     2821 ggctgatggc agtttactag atcactggtt ataatttggg acaaaaactg ctacattgac
     2881 tctcatctcg cccagagtgc tcaaggctgg tatgttcagt ggatcaggaa tacagttgtc
     2941 tttgattgtg aattcctacc cattgcctct ctcagtgaat gtggaaatgg ccgcctgggt
     3001 tttcccattt caggatgggc ttttggaagc acctatattg gctgaaaatt tgagaatgcg
     3061 aacattccat tcattagtct gatcaagcta ttaattaata tttagactgt agctcaaaat
     3121 gtgaaacatt ttttgttcaa tccatatttg tcttgcacat tataaatata tttttatttt
     3181 ttagtaatgt aggggatggg gagggagata ataatgccct tggcatgatt catgaaagca
     3241 gctgtgacaa cctccaatca gtttacttca tttcaaacct atttccaatc acaaggaaag
     3301 atttctttaa gacacacttg tacatttcac ctgtggatgt tttaacgtca tcctcagtat
     3361 gtccccaaat ttgctggtat ggaaaggaca aaacattata gtggtgggtt tttctactaa
     3421 ttattttttg aagcgttatt ttcccaacac aaaagagctt tttttctcag tataacaaaa
     3481 attgaaatct tatgtgtatt caatagtaaa tagacaaaat tttatttttt atttccactt
     3541 gaagagttac atttcgtata aagtttacaa ataacggttt ttattttgat ttttttcagt
     3601 ataaaaaagt tgccttgatg gcatattatg atgtaatgct aactgcttgt aggatagttg
     3661 attgtcagta ttgaatccta atctctagct gccgtcttgt agatatggac gaatgccacc
     3721 aagcatgtgt ttcctatttt gttgcatcgt acactgcaac taataagcca aggaatcgac
     3781 atatattagg tgcgtgtact gtttctaaaa accacaaact aagaatgata aattatcaat
     3841 atagtttagt atttgctaat tttactacac tcttttgtta tgtatatgta gggaagtcat
     3901 agggattata aattcaattt gagtaaagtt taaaaccata tattttatga taaagggcct
     3961 ttaacttaag atggccaaag cactgatatt atatatttgc tgtaaagaga attataagag
     4021 ttttattttt ctgatattaa aagttactta ataaagactt gtttccatta acttgaatgt
//
