LOCUS       NM_175366               3416 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mex3 RNA binding family member B (Mex3b), mRNA.
ACCESSION   NM_175366 XM_620516 XM_912460
VERSION     NM_175366.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3416)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3416)
  AUTHORS   Yamazumi,Y., Sasaki,O., Suyama-Fuchino,S., Kohu,K., Kamoshida,Y.,
            Harada,H., Fujio,K., Oda,T. and Akiyama,T.
  TITLE     The RNA-binding protein Mex-3B plays critical roles in the
            development of steroid-resistant neutrophilic airway inflammation
  JOURNAL   Biochem Biophys Res Commun 519 (2), 220-226 (2019)
   PUBMED   31493864
REFERENCE   3  (bases 1 to 3416)
  AUTHORS   Yamazumi,Y., Sasaki,O., Imamura,M., Oda,T., Ohno,Y.,
            Shiozaki-Sato,Y., Nagai,S., Suyama,S., Kamoshida,Y., Funato,K.,
            Yasui,T., Kikutani,H., Yamamoto,K., Dohi,M., Koyasu,S. and
            Akiyama,T.
  TITLE     The RNA Binding Protein Mex-3B Is Required for IL-33 Induction in
            the Development of Allergic Airway Inflammation
  JOURNAL   Cell Rep 16 (9), 2456-2471 (2016)
   PUBMED   27545879
  REMARK    GeneRIF: Mex-3B facilitates the development of allergic airway
            inflammation by directly upregulating IL-33 expression via
            inhibiting miR-487b-3p mediated repression of IL-33.
REFERENCE   4  (bases 1 to 3416)
  AUTHORS   Yang,Y., Wang,S.Y., Huang,Z.F., Zou,H.M., Yan,B.R., Luo,W.W. and
            Wang,Y.Y.
  TITLE     The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor
            3 in innate antiviral response
  JOURNAL   Cell Res 26 (3), 288-303 (2016)
   PUBMED   26823206
  REMARK    GeneRIF: A study in Mex3b(-/-) mice suggest that Mex3B acts as a
            coreceptor of TLR3 in innate antiviral response.
REFERENCE   5  (bases 1 to 3416)
  AUTHORS   Gao,Z., Lee,P., Stafford,J.M., von Schimmelmann,M., Schaefer,A. and
            Reinberg,D.
  TITLE     An AUTS2-Polycomb complex activates gene expression in the CNS
  JOURNAL   Nature 516 (7531), 349-354 (2014)
   PUBMED   25519132
REFERENCE   6  (bases 1 to 3416)
  AUTHORS   Le Borgne,M., Chartier,N., Buchet-Poyau,K., Destaing,O.,
            Faurobert,E., Thibert,C., Rouault,J.P., Courchet,J., Negre,D.,
            Bouvard,D., Albiges-Rizo,C., Rousseaux,S., Khochbin,S.,
            Segretain,D., Crepieux,P., Guillou,F., Durand,P., Perrard,M.H. and
            Billaud,M.
  TITLE     The RNA-binding protein Mex3b regulates the spatial organization of
            the Rap1 pathway
  JOURNAL   Development 141 (10), 2096-2107 (2014)
   PUBMED   24803656
  REMARK    GeneRIF: Mex3b is involved in the spatial organization of the Rap1
            pathway that orchestrates Sertoli cell functions.
REFERENCE   7  (bases 1 to 3416)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 3416)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   9  (bases 1 to 3416)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 3416)
  AUTHORS   Peissel,B., Zaffaroni,D., Pazzaglia,S., Manenti,G., Zanesi,N.,
            Zedda,I., Rebessi,S., Covelli,V., Dragani,T.A. and Saran,A.
  TITLE     Use of intercross outbred mice and single nucleotide polymorphisms
            to map skin cancer modifier loci
  JOURNAL   Mamm Genome 12 (4), 291-294 (2001)
   PUBMED   11309660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122736.13.
            
            On or before Apr 14, 2009 this sequence version replaced
            XM_912460.3, XM_620516.4, NM_175366.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.328322.1,
                                           SRR7345562.1236845.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-595               AC122736.13        84209-84803
            596-3416            AC122736.13        85632-88452
FEATURES             Location/Qualifiers
     source          1..3416
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 47.35 cM"
     gene            1..3416
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
                     /note="mex3 RNA binding family member B"
                     /db_xref="GeneID:108797"
                     /db_xref="MGI:MGI:1918252"
     exon            1..595
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..2049
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
                     /note="ring finger and KH domain containing 3; RING finger
                     and KH domain-containing protein 3; mex3 homolog B"
                     /codon_start=1
                     /product="RNA-binding protein MEX3B"
                     /protein_id="NP_780575.2"
                     /db_xref="CCDS:CCDS52286.1"
                     /db_xref="GeneID:108797"
                     /db_xref="MGI:MGI:1918252"
                     /translation="MPSSLFADLERNGSGGGGGGGGGGGGGGSGGGETLDDQRALQLA
                     LDQLSLLGLDSDEGASLYDSEPRKKSVNMTECVPVPSSEHVAEIVGRQGCKIKALRAK
                     TNTYIKTPVRGEEPVFVVTGRKEDVAMARREIISAAEHFSMIRASRNKNTALNGAVPG
                     PPNLPGQTTIQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMP
                     ENVDRAREEIEAHIALRTGGIIELTDENDFHANGTDVGFDLHHGSGGSGPGSLWSKPT
                     PSITPTPGRKPFSSYRNDSSSSLGSASTDSYFGGGTSGSAAATSRLADYSPPSPALSF
                     AHNGNNNNNGNGYTYTAGEASVPSPDGGPELQPTFDPAPAPPPGTPLLWAQFERSPGG
                     GSAAPVSSSCSSSASSSASSSSVVFPGGGASSTPSNANLGLLVHRRLHPGTSCPRLSP
                     PLHMATGAGEHHLARRVRSDPGGGGLAYAAYANGLGTQLPGLPSSDTSGSSSSSSSSS
                     SSSSSSSGLRRKGSRDCSVCFESEVIAALVPCGHNLFCMECANRICEKSEPECPVCHT
                     AVTQAIRIFS"
     exon            596..3416
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3337..3342
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
                     /note="hexamer: AATAAA"
     polyA_site      3357
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
     regulatory      3392..3397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
                     /note="hexamer: AATAAA"
     polyA_site      3411
                     /gene="Mex3b"
                     /gene_synonym="4931439A04Rik; M-04814; mKIAA2009; Rkhd3"
                     /note="major polyA site"
ORIGIN      
        1 tgttcgcttt gcgctcggca ttgtggccag ccagccgggc actcgggggg cacgcgcggc
       61 cgccgctcga gctctgcccc caccccaacc gccagcagat ctggggtggg gacccaggcg
      121 ggggctcttg cagccactgc ccggtgcgga ttgcacgcag agacccactc ctccgagcgc
      181 cgaaaaacga gccacggagc cctccgcagc cgaccggcct ccccgcccct gactgccggc
      241 ttcccggctg cctttgtggc tgcaccttct agctgccgag cagagagccg gctggggcgc
      301 ggcgcgcacg gcggagcgat gcccagctcg ctgtttgcag acctggagcg caacggcagc
      361 ggcggcggcg ggggaggcgg cggcggggga ggcggcggtg gcagcggcgg gggagagact
      421 ctggatgacc aaagagccct gcagcttgcg ctcgatcagc tctccctgtt gggactggac
      481 agtgatgagg gcgcctcttt gtacgacagc gaaccgcgca agaagagcgt gaacatgacc
      541 gagtgcgtgc cggtacccag ttccgaacac gtcgcggaga tcgtagggag gcaaggttgt
      601 aaaatcaaag ctttgagggc gaagaccaac acttacatca agaccccagt tcgcggggag
      661 gagcctgtct ttgttgtgac gggcaggaag gaggatgtgg ctatggctcg gagggagatc
      721 atctctgccg cagagcactt ctccatgatc cgagcctctc gtaacaagaa cacggctctc
      781 aacggagctg tgcccggacc gcccaacctg ccgggacaga ccactatcca agtgagggtg
      841 ccataccgcg tggtagggct cgtggtgggt ccaaagggcg ccacgatcaa gcgcattcaa
      901 cagcagacac atacatatat tgtgacaccc agccgagaca aggagccagt tttcgaggtg
      961 actggcatgc cagagaacgt ggatcgcgct agagaggaga tcgaagctca catcgcgctg
     1021 cgcaccggtg gcatcatcga gctgacagac gagaacgact tccatgccaa tggcacagac
     1081 gtgggctttg atctgcatca cgggtccggc gggtccgggc cgggcagcct ctggagcaag
     1141 cccaccccaa gcatcactcc tacacctggc cgcaagccct tctccagcta tcgcaacgac
     1201 agctccagct cgcttggcag cgcatccaca gactcttact tcggtggtgg gaccagcggc
     1261 agcgcagctg ctacttcacg cctggcggac tatagccctc ccagccctgc actcagcttt
     1321 gctcacaatg ggaacaacaa caataacggc aatggttaca cctacacagc gggggaagcc
     1381 tcagtacctt ccccagatgg gggtcctgag ctgcagccta ctttcgaccc agctcccgcc
     1441 ccaccacctg ggacacccct tctctgggcc cagttcgagc gctctccagg aggtggatct
     1501 gcagcaccag tatcctcttc ctgctcttct tcggcatcct catctgcctc gtcgtcctct
     1561 gtggtctttc ccgggggtgg cgccagcagc acaccctcca atgccaatct ggggctgctg
     1621 gtgcaccgtc gactgcaccc gggcaccagc tgcccgcgcc tgtctccgcc cttgcacatg
     1681 gccacggggg cgggagagca ccaccttgct cgccgcgtgc gcagcgaccc gggcggtgga
     1741 ggcctggcct acgctgccta tgctaatggg ctagggacgc agctccctgg cctgccctcg
     1801 tcggacactt cgggctcctc ctcgtcctct agctcctcct ccagctcttc ctcctcttcc
     1861 tctgggctga ggcgcaaagg cagccgcgac tgctctgtgt gcttcgagag tgaagtgatc
     1921 gccgcgctgg tgccctgtgg ccacaacctc ttctgcatgg agtgtgccaa ccgcatttgt
     1981 gagaagagcg agcccgagtg tcccgtctgc cacacggcgg tcactcaggc catccgcatt
     2041 ttttcctgaa ggcagtgcgc gcgcgcgcac tgcagggaag gagggtcctc tctcgaccct
     2101 cattccctag ggtctacctg cccagacgcc tctggtgccc acctctttcc accccaccct
     2161 catcactctc agagatccca gaggagcttg gaaagctgta gtatccgctc atttttaaaa
     2221 tgtcattttt aaacaaagga acttgccagg atctctgcat caggagtact gtagcctccg
     2281 aaccacctga attgcatgct ctataaataa taggaacggc gacattctag taacgatagt
     2341 ttttacactg tacttaatag gaagcttcca aaagaaaacc ccacaagttt tccattttct
     2401 tgaagtagaa aaatgaacag taattatgaa gatgattaat aattgtgcta tgggatgtgt
     2461 ggactgtttt gtgtgtttcc ctttgtgggt gggttcctac agcgctcgtt ctagaacaca
     2521 agtggatcct ttttgaatgt tcatggaagg gccaggagtt ctgtacagcc aggaccctgc
     2581 agctttatta aagttaaaac tgtaacatat ctcttatata ttaaaaaaaa aaacctttaa
     2641 aagttttaaa gagaaattgc attaatacag attgaagtat tttattcttt ttttgacttg
     2701 aaaaattata tttcatattg caaagatgtt tacaagtatt ttaatttaag ttcagtgaac
     2761 ttttttgtag ctgggttaaa tctttttatt tttagtatgg ccttatggca aagaacactg
     2821 tattatttta ataatcacac gattgtgacg gattacaaac cataaaatgt ataacgtttt
     2881 gagcagtatt ctgttgggat ggagatttta taggttcaga caaatcttct agatctgctt
     2941 cacccagcat attttctatt cagtgatata aagcatattt tattctatat tattacaaaa
     3001 aatggaaatg tataaacatg tcaaaaggaa cagttgatgc tttctaacat ttgtataaat
     3061 agaattcagt gcaaattaca gaaattctgt tgcaccgcta tagttttagt gtttctattt
     3121 taatacattt gtttaccact cgtttatgta tatgtaggtg acgttacttg agcttaaatg
     3181 tactttactg agcaaagttt aaaaaaaaac aaagtatatt ttattttatg ataaagggcc
     3241 tttaacctca tggtcaaata ctaatattat atttgctgag acaagatttg aaattgtatc
     3301 aagagtttta tttttctgac atttaaagtt ctacataata aaggtaaact taagtaatgg
     3361 tgctacttca ttttttaagt atttctatat aaataaaaca ttgaagaaaa atcact
//
