LOCUS       NM_001029890            6225 bp    mRNA    linear   ROD 03-SEP-2023
DEFINITION  Mus musculus mex3 RNA binding family member A (Mex3a), mRNA.
ACCESSION   NM_001029890 XM_143297
VERSION     NM_001029890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6225)
  AUTHORS   Chen W, Hu L, Lu X, Wang X, Zhao C, Guo C, Li X, Ding Y, Zhao H,
            Tong D, Wang L and Huang C.
  TITLE     The RNA binding protein MEX3A promotes tumor progression of breast
            cancer by post-transcriptional regulation of IGFBP4
  JOURNAL   Breast Cancer Res Treat 201 (3), 353-366 (2023)
   PUBMED   37433992
  REMARK    GeneRIF: The RNA binding protein MEX3A promotes tumor progression
            of breast cancer by post-transcriptional regulation of IGFBP4.
REFERENCE   2  (bases 1 to 6225)
  AUTHORS   Domingo-Muelas A, Duart-Abadia P, Morante-Redolat JM, Jordan-Pla A,
            Belenguer G, Fabra-Beser J, Paniagua-Herranz L, Perez-Villalba A,
            Alvarez-Varela A, Barriga FM, Gil-Sanz C, Ortega F, Batlle E and
            Farinas I.
  TITLE     Post-transcriptional control of a stemness signature by RNA-binding
            protein MEX3A regulates murine adult neurogenesis
  JOURNAL   Nat Commun 14 (1), 373 (2023)
   PUBMED   36690670
  REMARK    GeneRIF: Post-transcriptional control of a stemness signature by
            RNA-binding protein MEX3A regulates murine adult neurogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6225)
  AUTHORS   Yang X, Li G, Tian Y, Wang X, Xu J, Liu R, Deng M, Shao C, Pan Y,
            Wu X, Li M, Zhang C, Liu R, Qin J, Zhang C, Liu Z, Wu X, Plikus MV,
            Lengner CJ, Zheng Z, Lv C and Yu Z.
  TITLE     Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer
            cells in undifferentiated and proliferative state
  JOURNAL   Theranostics 12 (16), 6865-6882 (2022)
   PUBMED   36276637
  REMARK    GeneRIF: Identifying the E2F3-MEX3A-KLF4 signaling axis that
            sustains cancer cells in undifferentiated and proliferative state.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6225)
  AUTHORS   Li H, Liang J, Wang J, Han J, Li S, Huang K and Liu C.
  TITLE     Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway
            in colorectal cancer and is inhibited by hsa-miR-6887-3p
  JOURNAL   Cancer Commun (Lond) 41 (6), 472-491 (2021)
   PUBMED   33638620
  REMARK    GeneRIF: Mex3a promotes oncogenesis through the RAP1/MAPK signaling
            pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
REFERENCE   5  (bases 1 to 6225)
  AUTHORS   Panzeri V, Manni I, Capone A, Naro C, Sacconi A, Di Agostino S, de
            Latouliere L, Montori A, Pilozzi E, Piaggio G, Capurso G and Sette
            C.
  TITLE     The RNA-binding protein MEX3A is a prognostic factor and regulator
            of resistance to gemcitabine in pancreatic ductal adenocarcinoma
  JOURNAL   Mol Oncol 15 (2), 579-595 (2021)
   PUBMED   33159833
  REMARK    GeneRIF: The RNA-binding protein MEX3A is a prognostic factor and
            regulator of resistance to gemcitabine in pancreatic ductal
            adenocarcinoma.
REFERENCE   6  (bases 1 to 6225)
  AUTHORS   Pereira B, Amaral AL, Dias A, Mendes N, Muncan V, Silva AR, Thibert
            C, Radu AG, David L, Maximo V, van den Brink GR, Billaud M and
            Almeida R.
  TITLE     MEX3A regulates Lgr5+ stem cell maintenance in the developing
            intestinal epithelium
  JOURNAL   EMBO Rep 21 (4), e48938 (2020)
   PUBMED   32052574
  REMARK    GeneRIF: MEX3A regulates Lgr5(+) stem cell maintenance in the
            developing intestinal epithelium.
REFERENCE   7  (bases 1 to 6225)
  AUTHORS   Barriga FM, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X,
            Sevillano M, Guillaumet-Adkins A, Rodriguez-Esteban G, Buczacki
            SJA, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS, Gut I and
            Batlle E.
  TITLE     Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal
            Stem Cells
  JOURNAL   Cell Stem Cell 20 (6), 801-816 (2017)
   PUBMED   28285904
  REMARK    GeneRIF: Mex3a defines a reserve-like intestinal stem cell
            population within the Lgr5+ compartment.
REFERENCE   8  (bases 1 to 6225)
  AUTHORS   Foronda M, Martinez P, Schoeftner S, Gomez-Lopez G, Schneider R,
            Flores JM, Pisano DG and Blasco MA.
  TITLE     Sox4 links tumor suppression to accelerated aging in mice by
            modulating stem cell activation
  JOURNAL   Cell Rep 8 (2), 487-500 (2014)
   PUBMED   25043184
REFERENCE   9  (bases 1 to 6225)
  AUTHORS   Pereira B, Sousa S, Barros R, Carreto L, Oliveira P, Oliveira C,
            Chartier NT, Plateroti M, Rouault JP, Freund JN, Billaud M and
            Almeida R.
  TITLE     CDX2 regulation by the RNA-binding protein MEX3A: impact on
            intestinal differentiation and stemness
  JOURNAL   Nucleic Acids Res 41 (7), 3986-3999 (2013)
   PUBMED   23408853
REFERENCE   10 (bases 1 to 6225)
  AUTHORS   Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER,
            Collins-Racie L, McCoy JM and Curran T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145168.5.
            
            On Jun 19, 2019 this sequence version replaced NM_001029890.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1949026.1,
                                           SRR7652917.752806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-903               AC145168.5         98033-98935
            904-6225            AC145168.5         102160-107481
FEATURES             Location/Qualifiers
     source          1..6225
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.86 cM"
     gene            1..6225
                     /gene="Mex3a"
                     /gene_synonym="2700083E18Rik; Gm411; Rkhd4"
                     /note="mex3 RNA binding family member A"
                     /db_xref="GeneID:72640"
                     /db_xref="MGI:MGI:1919890"
     exon            1..903
                     /gene="Mex3a"
                     /gene_synonym="2700083E18Rik; Gm411; Rkhd4"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..2012
                     /gene="Mex3a"
                     /gene_synonym="2700083E18Rik; Gm411; Rkhd4"
                     /note="ring finger and KH domain containing 4; mex3
                     homolog A"
                     /codon_start=1
                     /product="RNA-binding protein MEX3A"
                     /protein_id="NP_001025061.2"
                     /db_xref="GeneID:72640"
                     /db_xref="MGI:MGI:1919890"
                     /translation="MPSLVVSGIMERNGGFGELGCFGGSAKDRGLLEDERALQLALDQ
                     LCLLGLGEPPAPTAGEDGGGGGGGAPAQPAAPPQPAPPPPPAAAPAAPSAAPAAQTPQ
                     PPTAPKGANDAKLCALYKEAELRLKGSSNTTECVPVPTSEHVAEIVGRQGCKIKALRA
                     KTNTYIKTPVRGEEPVFMVTGRREDVATARREIISAAEHFSMIRASRNKSGAAFGVAP
                     ALPGQVTIRVRVPYRVVGLVVGPKGATIKRIQQQTNTYIITPSRDRDPVFEITGAPGN
                     VERAREEIETHIAVRTGKILEYNSDGDFLAGSPDAALDSRYSDAWRVHAPGCKPLSTF
                     RQNSLGCIGECGVDSAFEAPRLSEQGGDFGYSGYLFPGYGVGKQDVYYGVAETSPPLW
                     AGQENATPTSVLFSSASSSSSSAKARAGPPGAHRSPATSAGPEQLTGLPRRPPGEPLQ
                     GFSKLGTGGLRSPGSGRDCMVCFESEVTAALVPCGHNLFCMECAVRICERTDPECPVC
                     HITATQAIRIFS"
     exon            904..6225
                     /gene="Mex3a"
                     /gene_synonym="2700083E18Rik; Gm411; Rkhd4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaagagttt gagcgctgga aggggctggg ctctattggg ggccactgag cgacgctccg
       61 ggactggggc tcggtgcggg aacctaaggg ggcgtctgct cggcggaggg tagagactct
      121 gggtccgagg cggaggggtg ggggctaggg cccgcagccc cccaccccac cccgtcaccc
      181 cggagcgaga ggagatctgc tttcttggtt ttgcttcttt tcccccaccc ccacccgggg
      241 gctggggcga ggggagtcag gttacagggt gcttggggag gggggcttag gggtgggtct
      301 atctttctat ctcgctttct tcccccctcc ccagctcttt gttccccctc cccacacacc
      361 ccctcctctc ctctcccctc ccctcctctc tcctcttctc ccttccacca cctctctctc
      421 tccctctctc ccccagcttt tgtttcgcca tgcctagtct agtggtatct ggaataatgg
      481 aaagaaatgg gggctttgga gaactaggat gtttcggggg aagcgctaag gaccgagggc
      541 tgctggaaga cgagcgcgcc cttcagctgg ctcttgatca actctgcctc ctgggtttgg
      601 gggagccccc cgcccccacg gcgggcgagg acgggggagg tggggggggc ggcgcccccg
      661 cgcagccggc cgcccccccg cagccggccc cgccgccgcc gcccgcggcg gccccggccg
      721 ccccgagcgc ggcccccgcg gcgcagacgc cccagccccc caccgccccc aaaggggcga
      781 acgacgccaa gctctgcgcg ctctacaaag aggccgagct gcgactgaag ggcagcagca
      841 acaccacgga gtgcgttccc gtgcccacct ccgagcacgt ggccgagatc gtgggcaggc
      901 aaggctgcaa gattaaggct ctgagggcca aaaccaacac ctacatcaag acacctgtgc
      961 gaggtgagga gccagtgttc atggtgactg ggaggcggga agacgtggcc acagcccggc
     1021 gggagatcat ctctgcagct gagcacttct ccatgataag agcctcacgc aacaagtctg
     1081 gcgccgcctt tggcgtggcc cctgctctgc caggccaagt gaccatccgt gtacgagtac
     1141 cctaccgcgt ggtgggactg gtggtgggcc ccaagggagc gaccatcaaa cgcatccagc
     1201 agcagaccaa cacgtacatc atcactccca gccgggaccg cgaccccgtg tttgagataa
     1261 ccggcgcacc gggcaacgtg gagcgtgcgc gggaggagat cgagacgcac atcgctgtgc
     1321 gcaccggcaa gattcttgaa tacaacagcg acggcgactt cctggctggc agccctgacg
     1381 ctgccttgga cagccgctac tcagacgcct ggcgggtgca tgctccaggc tgtaagccgc
     1441 tctccacctt caggcagaac agcctgggct gcataggcga atgcggcgtg gactcggcct
     1501 ttgaggcccc gcgcctaagc gagcagggcg gggactttgg ctacagcgga tatctgtttc
     1561 cgggctacgg tgtgggcaag caggacgtgt actatggcgt ggcagagaca agccccccgc
     1621 tgtgggcggg tcaggagaat gccacgccca cctcggtgct cttctcctct gcctcctcct
     1681 cctcctcttc agccaaggca cgcgcgggcc ccccaggcgc gcatcgctct cctgccacct
     1741 ctgcggggcc agagcagctg accgggctcc ctcggaggcc acccggagag ccactgcagg
     1801 gtttctctaa actggggaca ggcgggctgc ggagccccgg cagcgggcgg gactgcatgg
     1861 tgtgctttga gagtgaagtg acagcagccc tggtgccctg tggacacaac cttttctgca
     1921 tggagtgtgc agtacgcatc tgcgagagga cggacccaga gtgtcctgtc tgccacatca
     1981 ccgccacaca agccatccga atattttcct aagctccatg tccctggtct cctgggcccg
     2041 ctccctcggg tgctgccctg gacctgtagg gctttttgaa aaatcagtga ctacagggca
     2101 aggtgcttgg aaatattcac tcgctggggt ggggacaagg aggcctgagt ggctgggggc
     2161 ggggccattt tcagagcctc tggttaccct ttgggagggg ccataagttt tactagagtt
     2221 acaactctga tacctcaaca cacccttaaa tctggaagca gctaagagaa gcttttgttt
     2281 agccagaagt ggccaccagg acacacatcc tgacctttcc cttctcccta tccacatgtc
     2341 attttgcccc ttctctggag gggtaagaac agggagactt gccatctgta gttagaggtg
     2401 ctcttcctga ttcgctagcc ctctggtcct gacctcccat ctcctaacat gaccctttag
     2461 cccacacaca cacacacaca cacacacaca cacacactca ctcactcact catatcctga
     2521 gttcccaaca gtatagggag atgggggcct attaaagatc tgcatagatc ttccagggtg
     2581 atggaggatg tcgataaagg gctcacaact tacccatctt acaaagctgg gctagagatc
     2641 tggaaagggg cttctcttcc cccttcaatt gtttgcttgg cttttccccc aatttttttt
     2701 tgtttgtttg tttctggatc tgccctttgg tttctgttgt tgttgttgtt gttttcccta
     2761 ttctgtcccc ctctccctca gcccccagcc acatgtttct ttccatcctc ttacctcttc
     2821 tagcccagct ttggggatat cattttcttg ggagagaagt ctggagagtg ttttgatagc
     2881 ccccacctcc agttcctctt catgtagagg acagcccttt tcccccactc ctccaaagaa
     2941 tcagtttgag acgggaaact agtaatgggg tacatgaaag gttggaaccc tgcctttatc
     3001 atctatgggc attatactta gggagcatct tatcctgggt cttctgccca aggcaaggga
     3061 aagccaaaag taggaaaagt cctggggcaa gagagatgtg tctggacggg ctcccctccc
     3121 cctcacctgc agtggcctac ccccgacctc tctctgcacc tagctgaacc attattgagt
     3181 ccttattagc cacaaatcat gaattctctg tcttacccac tggctgagga gagaggccag
     3241 atctttggtg aggggtcagg ccagggcaaa gcaggattgg ggtgcggtgg agcctgttac
     3301 aggaatcagg tattgtgata ggtctagcac cccttcacta ctcctcttgc tcacttgtgt
     3361 ctgtcagcag cctcctactc tcccgggttc cgctggtcgg gccaggagag gatgggtgac
     3421 caggaggccc aggagatgct tgtatataat tgggtgggat attctgagct ctagctcagg
     3481 agtcccactc ttcctggatg gggaaaggat gtgggatgag ggcagaggga ggtctctctc
     3541 tctcctgcct cttgtgaatt aacttgcctc tcctcagcct tcccctccag accaccagcc
     3601 tgggagggga gaggaaggag gtcacagccc agaaaactgg cctgtggcag cttccctcct
     3661 ttccatcaat gtgagccatc ttgagatgtc tgtacaatag aaaccaaacc aaatgggcac
     3721 cctgggttgc ccaggggcag gggatgggag gggggtggga agaagggatg tctgtctgtc
     3781 agtcccctcc ccctctccac tccttaccca caaaggcaaa agactgttac actaggggct
     3841 ccacagatcc aatcccaccc ttgctgagtg agcctttcct agaaacaagc gcaaaagtga
     3901 gcgagcagca aaacaaagca atgggggagt gagatgggcg accaacagag gagaggaaac
     3961 aaaaatagca aaaaaagaaa aaaaagcagt tctttataat ttaatattct attttaataa
     4021 aggcatttat taccgtataa atgtagcaaa gaacctgggc taatatgaaa aaaagacttt
     4081 ttattaggta atttattata tgaaaaggat attttatttt atgataaagt gatccttaaa
     4141 aaaaaaaact ttagaaggtt tagaatatat gtagggagag aagaaaaaaa atacatttgt
     4201 attcagagtt aaatcttaaa aaaagttttt aatatatgtt cgggtttatg ttcttttttt
     4261 tcccccactt ctttttgggg agaaatgtca tttgcttttc ttgggggagc atcctggggt
     4321 ggatggtgga gaggggatag ggagttggtc ccttctgggg cccccaccag tagattggat
     4381 ttcattctgt gggctcccct ccccctcccc ctcaggggag ccggcagagc caaacaaagg
     4441 aagggattaa ccagaaagga agcagctttg ggactaagga ctgagggtcc tggagtgtcc
     4501 ctccttcccc taccctgtgc caggggcagt caggagggaa aaccagaact gaggcctagt
     4561 tggccgactg aaaccctcag aggtgtgaga tttaagagaa atagattttt tttaaccaaa
     4621 aaattaaaaa aaaaaatgag aaagaaaaac cgaggggttt aaaagaagag aatactacaa
     4681 aataattcaa atttatttca tataatccta gagaaagaaa aagaattact agttacttag
     4741 tagacgatac tcaagatagc ttaaagttta gtagcattgt gggcccctga gcccggtaga
     4801 atgtataaaa gtatggggga agaaaaagaa tagaggccag tggctgagct gccctatccc
     4861 tggggacagg gctagagcag gctgctagct gagattggga gcttccagtc tgctggggtt
     4921 gattctgaga atccttgggt ttaagtgtgg gataagtaca ggagaggctc tgtcccaggg
     4981 tctttgcaag ggtacacact ggtcatccga agctcagtgc agctcggctg agcctggcca
     5041 tctgttagga agcccctact cctaatgtcc aaccctccca ggccaccctg aggaagtcct
     5101 tgaagtcacc tcggtccatc ttgctaccag tgggttcaag agccaggtgg agctattctg
     5161 tgaatgagcc agcaactgct gatcagctta gcctccagca cccatgcagt atgagagcgg
     5221 cattgcagtt tctagcgctg tttcccttca catctgtagt ggggattttg ttcatttgtt
     5281 gttttttgac acagggtctg tagctcagtc tggccttaaa ctagcagcca tcttgctgcc
     5341 tttagttgct gggcctacaa ggttcgcacc actactcctg gcttcatgga gtctcaaaga
     5401 agttaacatt ccacgaaaga cttccgactc aggaagtaga gtgcaagtat tgtccttatg
     5461 agcctgggag aactccccca ccccatccca cccccaagaa cagataaaag tgcaggaact
     5521 tgggtggcct ctgtgcaacc cttgtgtcac agctcccagc tgtgttcaga taagaatcac
     5581 ccattagggc cacatcacat catcttcccc acagaaatcc ggaagcctgg ctttgcatgt
     5641 gagaaatagg catttttaag cacttgcctt ctttccatca gccccagcta gcaatcagat
     5701 cgggaatggg agaggcctct tggctttagc ttaagcaagc gggacaccag tgattgacat
     5761 tgccacttct tgaccctaga gcccaaacac ttctccctct ccgcagttta ctcttctcac
     5821 cccatctaga gactagaagt ccccctgccc tttttgccct aggaccctca gtagttggag
     5881 atggtagcat ctgggaatgg ggaggatttc cctagcatgc tcgagggtga gtgctcagag
     5941 ggtcgagtgg ttgggtggag acagccctgg ggcagggaag atggtctctc cactgtagaa
     6001 agtagagtag gatcgtggtc agacttaatt tgaggcatcc agtgactcat acaaatcacc
     6061 aaggaagatt tcaaatgcaa agtaaaggtg ggaaataaaa cagacccatg aattaatcaa
     6121 gtcaaagtga tgttgcacac aatgcagaga aaccaagaag ggggagggtt aatgtattaa
     6181 atgtgctatt gagaagttaa ttttattaaa agtattatta cttaa
//
