LOCUS       NP_001025061             520 aa            linear   ROD 03-SEP-2023
DEFINITION  RNA-binding protein MEX3A [Mus musculus].
ACCESSION   NP_001025061 XP_143297
VERSION     NP_001025061.2
DBSOURCE    REFSEQ: accession NM_001029890.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 520)
  AUTHORS   Chen W, Hu L, Lu X, Wang X, Zhao C, Guo C, Li X, Ding Y, Zhao H,
            Tong D, Wang L and Huang C.
  TITLE     The RNA binding protein MEX3A promotes tumor progression of breast
            cancer by post-transcriptional regulation of IGFBP4
  JOURNAL   Breast Cancer Res Treat 201 (3), 353-366 (2023)
   PUBMED   37433992
  REMARK    GeneRIF: The RNA binding protein MEX3A promotes tumor progression
            of breast cancer by post-transcriptional regulation of IGFBP4.
REFERENCE   2  (residues 1 to 520)
  AUTHORS   Domingo-Muelas A, Duart-Abadia P, Morante-Redolat JM, Jordan-Pla A,
            Belenguer G, Fabra-Beser J, Paniagua-Herranz L, Perez-Villalba A,
            Alvarez-Varela A, Barriga FM, Gil-Sanz C, Ortega F, Batlle E and
            Farinas I.
  TITLE     Post-transcriptional control of a stemness signature by RNA-binding
            protein MEX3A regulates murine adult neurogenesis
  JOURNAL   Nat Commun 14 (1), 373 (2023)
   PUBMED   36690670
  REMARK    GeneRIF: Post-transcriptional control of a stemness signature by
            RNA-binding protein MEX3A regulates murine adult neurogenesis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 520)
  AUTHORS   Yang X, Li G, Tian Y, Wang X, Xu J, Liu R, Deng M, Shao C, Pan Y,
            Wu X, Li M, Zhang C, Liu R, Qin J, Zhang C, Liu Z, Wu X, Plikus MV,
            Lengner CJ, Zheng Z, Lv C and Yu Z.
  TITLE     Identifying the E2F3-MEX3A-KLF4 signaling axis that sustains cancer
            cells in undifferentiated and proliferative state
  JOURNAL   Theranostics 12 (16), 6865-6882 (2022)
   PUBMED   36276637
  REMARK    GeneRIF: Identifying the E2F3-MEX3A-KLF4 signaling axis that
            sustains cancer cells in undifferentiated and proliferative state.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 520)
  AUTHORS   Li H, Liang J, Wang J, Han J, Li S, Huang K and Liu C.
  TITLE     Mex3a promotes oncogenesis through the RAP1/MAPK signaling pathway
            in colorectal cancer and is inhibited by hsa-miR-6887-3p
  JOURNAL   Cancer Commun (Lond) 41 (6), 472-491 (2021)
   PUBMED   33638620
  REMARK    GeneRIF: Mex3a promotes oncogenesis through the RAP1/MAPK signaling
            pathway in colorectal cancer and is inhibited by hsa-miR-6887-3p.
REFERENCE   5  (residues 1 to 520)
  AUTHORS   Panzeri V, Manni I, Capone A, Naro C, Sacconi A, Di Agostino S, de
            Latouliere L, Montori A, Pilozzi E, Piaggio G, Capurso G and Sette
            C.
  TITLE     The RNA-binding protein MEX3A is a prognostic factor and regulator
            of resistance to gemcitabine in pancreatic ductal adenocarcinoma
  JOURNAL   Mol Oncol 15 (2), 579-595 (2021)
   PUBMED   33159833
  REMARK    GeneRIF: The RNA-binding protein MEX3A is a prognostic factor and
            regulator of resistance to gemcitabine in pancreatic ductal
            adenocarcinoma.
REFERENCE   6  (residues 1 to 520)
  AUTHORS   Pereira B, Amaral AL, Dias A, Mendes N, Muncan V, Silva AR, Thibert
            C, Radu AG, David L, Maximo V, van den Brink GR, Billaud M and
            Almeida R.
  TITLE     MEX3A regulates Lgr5+ stem cell maintenance in the developing
            intestinal epithelium
  JOURNAL   EMBO Rep 21 (4), e48938 (2020)
   PUBMED   32052574
  REMARK    GeneRIF: MEX3A regulates Lgr5(+) stem cell maintenance in the
            developing intestinal epithelium.
REFERENCE   7  (residues 1 to 520)
  AUTHORS   Barriga FM, Montagni E, Mana M, Mendez-Lago M, Hernando-Momblona X,
            Sevillano M, Guillaumet-Adkins A, Rodriguez-Esteban G, Buczacki
            SJA, Gut M, Heyn H, Winton DJ, Yilmaz OH, Attolini CS, Gut I and
            Batlle E.
  TITLE     Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+ Intestinal
            Stem Cells
  JOURNAL   Cell Stem Cell 20 (6), 801-816 (2017)
   PUBMED   28285904
  REMARK    GeneRIF: Mex3a defines a reserve-like intestinal stem cell
            population within the Lgr5+ compartment.
REFERENCE   8  (residues 1 to 520)
  AUTHORS   Foronda M, Martinez P, Schoeftner S, Gomez-Lopez G, Schneider R,
            Flores JM, Pisano DG and Blasco MA.
  TITLE     Sox4 links tumor suppression to accelerated aging in mice by
            modulating stem cell activation
  JOURNAL   Cell Rep 8 (2), 487-500 (2014)
   PUBMED   25043184
REFERENCE   9  (residues 1 to 520)
  AUTHORS   Pereira B, Sousa S, Barros R, Carreto L, Oliveira P, Oliveira C,
            Chartier NT, Plateroti M, Rouault JP, Freund JN, Billaud M and
            Almeida R.
  TITLE     CDX2 regulation by the RNA-binding protein MEX3A: impact on
            intestinal differentiation and stemness
  JOURNAL   Nucleic Acids Res 41 (7), 3986-3999 (2013)
   PUBMED   23408853
REFERENCE   10 (residues 1 to 520)
  AUTHORS   Jensen P, Magdaleno S, Lehman KM, Rice DS, Lavallie ER,
            Collins-Racie L, McCoy JM and Curran T.
  TITLE     A neurogenomics approach to gene expression analysis in the
            developing brain
  JOURNAL   Brain Res Mol Brain Res 132 (2), 116-127 (2004)
   PUBMED   15582152
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC145168.5.
            
            On Oct 6, 2010 this sequence version replaced NP_001025061.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1949026.1,
                                           SRR7652917.752806.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..520
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.86 cM"
     Protein         1..520
                     /product="RNA-binding protein MEX3A"
                     /note="ring finger and KH domain containing 4; mex3
                     homolog A"
                     /calculated_mol_wt=54093
     Region          132..204
                     /region_name="KH-I_MEX3_rpt1"
                     /note="first type I K homology (KH) RNA-binding domain
                     found in the family of MEX-3 RNA-binding proteins;
                     cd22423"
                     /db_xref="CDD:411851"
     Site            order(141..142,144..146,148..152,154..156,159,165..171,
                     199..200,203..204)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411851"
     Region          221..292
                     /region_name="KH-I_MEX3_rpt2"
                     /note="second type I K homology (KH) RNA-binding domain
                     found in the family of MEX-3 RNA-binding proteins;
                     cd22424"
                     /db_xref="CDD:411852"
     Site            order(233,235..237,239..243,246..247,250,256..262,291)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:411852"
     Region          465..520
                     /region_name="RING-HC_MEX3A"
                     /note="RING finger, HC subclass, found in RNA-binding
                     protein MEX3A; cd16720"
                     /db_xref="CDD:438380"
     CDS             1..520
                     /gene="Mex3a"
                     /gene_synonym="2700083E18Rik; Gm411; Rkhd4"
                     /coded_by="NM_001029890.3:450..2012"
                     /db_xref="GeneID:72640"
                     /db_xref="MGI:MGI:1919890"
ORIGIN      
        1 mpslvvsgim ernggfgelg cfggsakdrg llederalql aldqlcllgl geppaptage
       61 dgggggggap aqpaappqpa pppppaaapa apsaapaaqt pqpptapkga ndaklcalyk
      121 eaelrlkgss nttecvpvpt sehvaeivgr qgckikalra ktntyiktpv rgeepvfmvt
      181 grredvatar reiisaaehf smirasrnks gaafgvapal pgqvtirvrv pyrvvglvvg
      241 pkgatikriq qqtntyiitp srdrdpvfei tgapgnvera reeiethiav rtgkileyns
      301 dgdflagspd aaldsrysda wrvhapgckp lstfrqnslg cigecgvdsa feaprlseqg
      361 gdfgysgylf pgygvgkqdv yygvaetspp lwagqenatp tsvlfssass ssssakarag
      421 ppgahrspat sagpeqltgl prrppgeplq gfsklgtggl rspgsgrdcm vcfesevtaa
      481 lvpcghnlfc mecavricer tdpecpvchi tatqairifs
//
