LOCUS       NM_021554               1709 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus methyltransferase like 9 (Mettl9), transcript variant
            1, mRNA.
ACCESSION   NM_021554
VERSION     NM_021554.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1709)
  AUTHORS   Lv,M., Cao,D., Zhang,L., Hu,C., Li,S., Zhang,P., Zhu,L., Yi,X.,
            Li,C., Yang,A., Yang,Z., Zhu,Y., Zhang,K. and Pan,W.
  TITLE     METTL9 mediated N1-histidine methylation of zinc transporters is
            required for tumor growth
  JOURNAL   Protein Cell 12 (12), 965-970 (2021)
   PUBMED   34218407
  REMARK    Review article
REFERENCE   2  (bases 1 to 1709)
  AUTHORS   Daitoku,H., Someya,M., Kako,K., Hayashi,T., Tajima,T., Haruki,H.,
            Sekiguchi,N., Uetake,T., Akimoto,Y. and Fukamizu,A.
  TITLE     siRNA screening identifies METTL9 as a histidine
            Npi-methyltransferase that targets the proinflammatory protein
            S100A9
  JOURNAL   J Biol Chem 297 (5), 101230 (2021)
   PUBMED   34562450
  REMARK    GeneRIF: siRNA screening identifies METTL9 as a histidine
            Npi-methyltransferase that targets the proinflammatory protein
            S100A9.
REFERENCE   3  (bases 1 to 1709)
  AUTHORS   Davydova,E., Shimazu,T., Schuhmacher,M.K., Jakobsson,M.E.,
            Willemen,H.L.D.M., Liu,T., Moen,A., Ho,A.Y.Y., Malecki,J.,
            Schroer,L., Pinto,R., Suzuki,T., Gronsberg,I.A., Sohtome,Y.,
            Akakabe,M., Weirich,S., Kikuchi,M., Olsen,J.V., Dohmae,N.,
            Umehara,T., Sodeoka,M., Siino,V., McDonough,M.A., Eijkelkamp,N.,
            Schofield,C.J., Jeltsch,A., Shinkai,Y. and Falnes,P.O.
  TITLE     The methyltransferase METTL9 mediates pervasive 1-methylhistidine
            modification in mammalian proteomes
  JOURNAL   Nat Commun 12 (1), 891 (2021)
   PUBMED   33563959
  REMARK    GeneRIF: The methyltransferase METTL9 mediates pervasive
            1-methylhistidine modification in mammalian proteomes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1709)
  AUTHORS   Shu,K.X., Wu,L.X., Xie,Y.F., Zhao,J.F., Liang,Y.L. and Li,B.
  TITLE     Characterization of the human PAP1 gene and its homologue possible
            involvement in mouse embryonic development
  JOURNAL   Colloids Surf B Biointerfaces 52 (1), 22-30 (2006)
   PUBMED   16837177
REFERENCE   5  (bases 1 to 1709)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   6  (bases 1 to 1709)
  AUTHORS   Bates,E.E., Kissenpfennig,A., Peronne,C., Mattei,M.G., Fossiez,F.,
            Malissen,B. and Lebecque,S.
  TITLE     The mouse and human IGSF6 (DORA) genes map to the inflammatory
            bowel disease 1 locus and are embedded in an intron of a gene of
            unknown function
  JOURNAL   Immunogenetics 52 (1-2), 112-120 (2000)
   PUBMED   11132146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140782.4.
            
            On Mar 22, 2023 this sequence version replaced NM_021554.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ278576.1, BC068124.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-417               AC140782.4         184591-185007       c
            418-608             AC140782.4         171538-171728       c
            609-818             AC140782.4         167270-167479       c
            819-1003            AC140782.4         162167-162351       c
            1004-1709           AC140782.4         142731-143436       c
FEATURES             Location/Qualifiers
     source          1..1709
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 65.07 cM"
     gene            1..1709
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /note="methyltransferase like 9"
                     /db_xref="GeneID:59052"
                     /db_xref="MGI:MGI:1914862"
     exon            1..417
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /inference="alignment:Splign:2.1.0"
     exon            418..608
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /inference="alignment:Splign:2.1.0"
     exon            609..818
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1003
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1709
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1689..1694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /note="hexamer: AATAAA"
     polyA_site      1709
                     /gene="Mettl9"
                     /gene_synonym="0610012D09Rik; Drev; mMETTL9; MNCb-5680"
                     /note="major polyA site"
ORIGIN      
        1 gttggcgttc cgggctggga agggccgcgg gggacgtgag aaggccgcgc gcctgccgct
       61 cctcccccgc cccccctccc gcgccatctc cccctccctc tgcctcggcc ccgaaggggg
      121 ctgcacgggc gacttggcgg cgatggctcg agctccggcg gcgacgacgg tggccggagg
      181 cggcggctcc tcctcctcct cctcctgggc ttgggcccgg cggtgatccg agctggcggc
      241 cgcggccccc cgatgagact gttggcgggc tggctgtgcc tgagcctggc gtccgtgtgg
      301 ctggcgcgga ggatgtggac gctgcggagc ccgctctccc gctccctgta cgtgaacatg
      361 actagcggcc ccggcgggcc agcggcggcc gcgggcggcg ggaaggacac gcaccagtgg
      421 tatgtgtgca acagagagaa attatgcgaa tcacttcagt ctgtctttgt tcagagttat
      481 cttgaccaag gaacacagat cttcttaaac aacagcattg agaaatctgg ctggctattt
      541 atccaactct atcattcttt tgtatcatct gtttttagcc tgtttatgtc tagaacatct
      601 attaacgggt tgctaggaag aggctccatg tttgtgttct caccagatca gtttcagaga
      661 ctgcttagaa ttaatccgga ctggaaaacc catagacttc ttgatttagg tgctggagat
      721 ggagaagtca cgaaaatcat gagccctcat tttgaagaaa tttacgccac tgagctttct
      781 gaaacaatga tctggcagct ccagaagaag aaatacagag tgcttggtat aaatgaatgg
      841 cagaatacag ggttccagta tgatgtcatc agctgcttaa atttgctgga tcgctgtgat
      901 cagcccctga cattgttaaa agatatcaga agtgtcttgg agcccaccca aggcagggtc
      961 atcctggcat tggttttgcc ctttcatccc tatgtagaaa acgtaggtgg caagtgggag
     1021 aaaccatcag aaattctgga aatcaaggga cagaattggg aagagcaagt gaatagcctg
     1081 cctgaggtgt tcagaaaagc cggctttgtc gtcgaagctt tcactagact gccatacctg
     1141 tgtgaaggcg acatgtacaa tgactactat gttctggacg atgctgtctt tgttctcaga
     1201 ccagtataaa cacgtggagg cccaagtcct cagagtcacc cctgcaaccg accctccaga
     1261 agaggagatg catccagtga tgtgaggggg acctctgggg actgtcattc tcagtatcat
     1321 gtaggaattt aaaaagccaa aatactaatt ctttctttgt agtgtgtaag ggagtgtttt
     1381 taaaaacaaa acccaactct ttgtgtattt ttaatcaact ctttactcag aatcacgctc
     1441 caatgcaggt cactctccaa ttatgatgga agatattttt tatacttaat tgctgtaggg
     1501 actcattccc agacaaagca atagtcatga tgtcatggaa ccgatcaatg gattgttttt
     1561 aataaatgaa gactggcaat aaagctgtcc attcaattcc aaatattggt tataaagtag
     1621 aaccattgat aactttcatg tttagaaact ccttctctta ctattcaaaa aatgttttta
     1681 atcatgctaa taaacgtttt tggagatga
//
