LOCUS       NM_029280                971 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus methyltransferase 5, N6-adenosine (Mettl5), transcript
            variant 1, mRNA.
ACCESSION   NM_029280 XM_001002094 XM_001002098 XM_001002107 XM_130324
            XM_892172 XM_899988 XM_909519 XM_921352 XM_982540
VERSION     NM_029280.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 971)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 971)
  AUTHORS   Dai,Z., Zhu,W., Hou,Y., Zhang,X., Ren,X., Lei,K., Liao,J., Liu,H.,
            Chen,Z., Peng,S., Li,S., Lin,S. and Kuang,M.
  TITLE     METTL5-mediated 18S rRNA m6A modification promotes oncogenic mRNA
            translation and intrahepatic cholangiocarcinoma progression
  JOURNAL   Mol Ther 31 (11), 3225-3242 (2023)
   PUBMED   37735874
  REMARK    GeneRIF: METTL5-mediated 18S rRNA m[6]A modification promotes
            oncogenic mRNA translation and intrahepatic cholangiocarcinoma
            progression.
REFERENCE   3  (bases 1 to 971)
  AUTHORS   Zhang,L., Yuan,M., Huang,X., Cao,Q., Huang,S., Sun,R. and Lei,L.
  TITLE     Inhibition of METTL5 improves preimplantation development of mouse
            somatic cell nuclear transfer embryos
  JOURNAL   Reproduction 164 (5), 221-230 (2022)
   PUBMED   36111643
  REMARK    GeneRIF: Inhibition of METTL5 improves preimplantation development
            of mouse somatic cell nuclear transfer embryos.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 971)
  AUTHORS   Sepich-Poore,C., Zheng,Z., Schmitt,E., Wen,K., Zhang,Z.S.,
            Cui,X.L., Dai,Q., Zhu,A.C., Zhang,L., Sanchez Castillo,A., Tan,H.,
            Peng,J., Zhuang,X., He,C. and Nachtergaele,S.
  TITLE     The METTL5-TRMT112 N6-methyladenosine methyltransferase complex
            regulates mRNA translation via 18S rRNA methylation
  JOURNAL   J Biol Chem 298 (3), 101590 (2022)
   PUBMED   35033535
REFERENCE   5  (bases 1 to 971)
  AUTHORS   Han,Y., Du,T., Guo,S., Wang,L., Dai,G., Long,T., Xu,T., Zhuang,X.,
            Liu,C., Li,S., Zhang,D., Liao,X., Dong,Y., Lui,K.O., Tan,X.,
            Lin,S., Chen,Y. and Huang,Z.P.
  TITLE     Loss of m6A Methyltransferase METTL5 Promotes Cardiac Hypertrophy
            Through Epitranscriptomic Control of SUZ12 Expression
  JOURNAL   Front Cardiovasc Med 9, 852775 (2022)
   PUBMED   35295259
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 971)
  AUTHORS   Xing,M., Liu,Q., Mao,C., Zeng,H., Zhang,X., Zhao,S., Chen,L.,
            Liu,M., Shen,B., Guo,X., Ma,H., Chen,H. and Zhang,J.
  TITLE     The 18S rRNA m6 A methyltransferase METTL5 promotes mouse embryonic
            stem cell differentiation
  JOURNAL   EMBO Rep 21 (10), e49863 (2020)
   PUBMED   32783360
  REMARK    GeneRIF: The 18S rRNA m(6) A methyltransferase METTL5 promotes
            mouse embryonic stem cell differentiation.
REFERENCE   7  (bases 1 to 971)
  AUTHORS   Ignatova,V.V., Stolz,P., Kaiser,S., Gustafsson,T.H., Lastres,P.R.,
            Sanz-Moreno,A., Cho,Y.L., Amarie,O.V., Aguilar-Pimentel,A.,
            Klein-Rodewald,T., Calzada-Wack,J., Becker,L., Marschall,S.,
            Kraiger,M., Garrett,L., Seisenberger,C., Holter,S.M., Borland,K.,
            Van De Logt,E., Jansen,P.W.T.C., Baltissen,M.P., Valenta,M.,
            Vermeulen,M., Wurst,W., Gailus-Durner,V., Fuchs,H., Hrabe de
            Angelis,M., Rando,O.J., Kellner,S.M., Bultmann,S. and Schneider,R.
  TITLE     The rRNA m6A methyltransferase METTL5 is involved in pluripotency
            and developmental programs
  JOURNAL   Genes Dev 34 (9-10), 715-729 (2020)
   PUBMED   32217665
  REMARK    GeneRIF: The rRNA m(6)A methyltransferase METTL5 is involved in
            pluripotency and developmental programs.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA466649.1, AK133594.1, AK013063.1 and AA175151.1.
            
            On Mar 19, 2014 this sequence version replaced NM_029280.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027547.1, BE995710.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AA466649.1         1-32
            33-747              AK133594.1         23-737
            748-952             AK013063.1         648-852
            953-971             AA175151.1         99-117
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 40.95 cM"
     gene            1..971
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /note="methyltransferase 5, N6-adenosine"
                     /db_xref="GeneID:75422"
                     /db_xref="MGI:MGI:1922672"
     exon            1..367
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..888
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /note="methyltransferase-like protein 5; rRNA
                     N6-adenosine-methyltransferase METTL5; methyltransferase
                     like 5"
                     /codon_start=1
                     /product="rRNA N(6)-adenosine-methyltransferase METTL5"
                     /protein_id="NP_083556.2"
                     /db_xref="CCDS:CCDS16103.2"
                     /db_xref="GeneID:75422"
                     /db_xref="MGI:MGI:1922672"
                     /translation="MKKLKLKELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIH
                     NTYDDIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNV
                     DMIQCDVYSLSNRMSKLFDTVIMNPPFGTKNNKGTDMAFLKTALGMARTAVYSLHKSS
                     TREHIQKKAAEWKVKIEIIAELRYDLPALYNFHKKKSVDIEVDLIRFSF"
     exon            368..482
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            483..664
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            665..747
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            748..799
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            800..849
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            850..971
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      930..935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /note="hexamer: AATAAA"
     regulatory      950..955
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /note="hexamer: AATAAA"
     polyA_site      955
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
                     /note="major polyA site"
     polyA_site      971
                     /gene="Mettl5"
                     /gene_synonym="2810410A08Rik"
ORIGIN      
        1 gtacttccgg cactgcgggg agggaccgcg aggaccagct agaggcatac gagtgctttc
       61 ctggagcgtc tgggttccac gggcggcgat ccccgcgagg ctcgtgggat cccctcgctg
      121 agtcctaaat agtctgtccc cgaccctcca ccccaccccc accctgcacc gctggggagt
      181 ttcgggttag gtagacttcc ctgcagctcc cgtgctgtga agccccagga gcccaaactt
      241 taaaatacag agaaaacgat gaagaagtta aagcttaagg aactagagag tcgcctgcaa
      301 gaagtggatg gattcgaaaa gcccaagtta cttctagaac agtatcccac caggccgcac
      361 attgcagcat gcatgcttta tacaatccat aacacatacg atgacattga aaacaaagcg
      421 gttgcagatc taggatgtgg ctgtggagta cttagcatcg gagcggcaat gctaggagca
      481 gggttgtgtg ttggatttga catagatgaa gatgcactgg aaatatttaa taagaatgtg
      541 gaagagtttg agctaacaaa tgttgatatg attcagtgtg atgtgtactc attatctaac
      601 agaatgtcca agttatttga tacagtaatt atgaatcctc cctttgggac caaaaataat
      661 aaagggacag atatggcttt tctgaagact gctttgggaa tggcaagaac agcagtatat
      721 tctttacaca agtcctcaac tagggaacat attcaaaaga aagctgctga atggaaagtc
      781 aagatagaaa ttattgcaga gcttcgatat gatctaccag cattatacaa ctttcataaa
      841 aagaaatctg tggacatcga agtggaccta attcgctttt ctttttaaaa gcttctgaag
      901 acaaaaagca gcttaaaatc taactaagga ataaaaacac tgcttactaa ataaactact
      961 tgtctctagc a
//
