LOCUS       NM_019721               2035 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus methyltransferase 3, N6-adenosine-methyltransferase
            complex catalytic subunit (Mettl3), mRNA.
ACCESSION   NM_019721
VERSION     NM_019721.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2035)
  AUTHORS   Jing,H., Song,J., Sun,J., Su,S., Hu,J., Zhang,H., Bi,Y. and Wu,B.
  TITLE     METTL3 governs thymocyte development and thymic involution by
            regulating ferroptosis
  JOURNAL   Nat Aging 4 (12), 1813-1827 (2024)
   PUBMED   39443728
REFERENCE   2  (bases 1 to 2035)
  AUTHORS   Tang,F., Tian,L.H., Zhu,X.H., Yang,S., Zeng,H. and Yang,Y.Y.
  TITLE     METTL3-mediated m6A modification enhances lncRNA H19 stability to
            promote endothelial cell inflammation and pyroptosis to aggravate
            atherosclerosis
  JOURNAL   FASEB J 38 (20), e70090 (2024)
   PUBMED   39432244
  REMARK    GeneRIF: METTL3-mediated m6A modification enhances lncRNA H19
            stability to promote endothelial cell inflammation and pyroptosis
            to aggravate atherosclerosis.
REFERENCE   3  (bases 1 to 2035)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2035)
  AUTHORS   Zhou,B., Luo,Y., Bi,H., Zhang,N., Ma,M., Dong,Z., Ji,N., Zhang,S.,
            Wang,X., Liu,Y., Guo,X., Wei,W., Xie,C., Wu,L., Wan,X., Zheng,M.H.,
            Zhao,B., Li,Y., Hu,C. and Lu,Y.
  TITLE     Amelioration of nonalcoholic fatty liver disease by inhibiting the
            deubiquitylating enzyme RPN11
  JOURNAL   Cell Metab 36 (10), 2228-2244 (2024)
   PUBMED   39146936
REFERENCE   5  (bases 1 to 2035)
  AUTHORS   Sheng,R., Meng,W., Zhang,Z., Yin,Q., Jiang,S., Li,Q., Gan,X.,
            Zhang,D., Zhou,Z., Lin,S., Lyu,M., Yang,X. and Yuan,Q.
  TITLE     METTL3 regulates cartilage development and homeostasis by affecting
            Lats1 mRNA stability in an m6A-YTHDF2-dependent manner
  JOURNAL   Cell Rep 43 (8), 114535 (2024)
   PUBMED   39088322
  REMARK    GeneRIF: METTL3 regulates cartilage development and homeostasis by
            affecting Lats1 mRNA stability in an m[6]A-YTHDF2-dependent manner.
REFERENCE   6  (bases 1 to 2035)
  AUTHORS   Wang,Y., Li,Y., Toth,J.I., Petroski,M.D., Zhang,Z. and Zhao,J.C.
  TITLE     N6-methyladenosine modification destabilizes developmental
            regulators in embryonic stem cells
  JOURNAL   Nat Cell Biol 16 (2), 191-198 (2014)
   PUBMED   24394384
REFERENCE   7  (bases 1 to 2035)
  AUTHORS   Fustin,J.M., Doi,M., Yamaguchi,Y., Hida,H., Nishimura,S.,
            Yoshida,M., Isagawa,T., Morioka,M.S., Kakeya,H., Manabe,I. and
            Okamura,H.
  TITLE     RNA-methylation-dependent RNA processing controls the speed of the
            circadian clock
  JOURNAL   Cell 155 (4), 793-806 (2013)
   PUBMED   24209618
REFERENCE   8  (bases 1 to 2035)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2035)
  AUTHORS   Hwang,S.Y., Oh,B., Knowles,B.B., Solter,D. and Lee,J.S.
  TITLE     Expression of genes involved in mammalian meiosis during the
            transition from egg to embryo
  JOURNAL   Mol Reprod Dev 59 (2), 144-158 (2001)
   PUBMED   11389549
REFERENCE   10 (bases 1 to 2035)
  AUTHORS   Bokar,J.A., Shambaugh,M.E., Polayes,D., Matera,A.G. and
            Rottman,F.M.
  TITLE     Purification and cDNA cloning of the AdoMet-binding subunit of the
            human mRNA (N6-adenosine)-methyltransferase
  JOURNAL   RNA 3 (11), 1233-1247 (1997)
   PUBMED   9409616
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY108113.1, AK085189.1 and BE979768.1.
            
            On Oct 13, 2005 this sequence version replaced NM_019721.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085189.1, BC012526.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY108113.1         6-19
            15-1999             AK085189.1         2-1986
            2000-2035           BE979768.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..2035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 26.88 cM"
     gene            1..2035
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /note="methyltransferase 3, N6-adenosine-methyltransferase
                     complex catalytic subunit"
                     /db_xref="GeneID:56335"
                     /db_xref="MGI:MGI:1927165"
     exon            1..237
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1880
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /EC_number="2.1.1.348"
                     /note="N6-adenosine-methyltransferase 70 kDa subunit;
                     MT-A70; methyltransferase-like protein 3; m6a
                     methyltransferase; N6-adenosine-methyltransferase subunit
                     METTL3; methyltransferase like 3;
                     N(6)-adenosine-methyltransferase 70 kDa subunit"
                     /codon_start=1
                     /product="N(6)-adenosine-methyltransferase catalytic
                     subunit METTL3"
                     /protein_id="NP_062695.2"
                     /db_xref="CCDS:CCDS27053.1"
                     /db_xref="GeneID:56335"
                     /db_xref="MGI:MGI:1927165"
                     /translation="MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSP
                     TFRSDSPVPTAPTSSGPKPSTTSVAPELATDPELEKKLLHHLSDLALTLPTDAVSIRL
                     AISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAV
                     AEKKGLGEVAGTIAGQKRRAEQDLTTVTTFASSLASGLASSASEPAKEPAKKSRKHAA
                     SDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFC
                     DYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEID
                     ACVDSESPGSKEHMPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVV
                     MADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYE
                     RVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVR
                     STSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFK
                     QRYPDGIISKPKNL"
     exon            238..455
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            456..860
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1036
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1253
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1441
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1480
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1589
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1655
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1768
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..2021
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1982..1987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /note="hexamer: AATAAA"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /note="hexamer: ATTATA"
     polyA_site      2007
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
                     /note="major polyA site"
     polyA_site      2021
                     /gene="Mettl3"
                     /gene_synonym="2310024F18Rik; M6A; Spo8"
ORIGIN      
        1 ggaagtggct tttcatcttg gctctatccg gctggccttc gggcgtcctc gtgagaatta
       61 gatgtttctt agttctaggc tggggaggtg ctagtccgcc gcgcctgatt cgagccgagt
      121 ccgcgctggg agctaggatg tcggacacgt ggagctctat ccaggcccat aagaaacagc
      181 tggactcgct tcgcgagaga ttgcagcggc gacggaagca ggactctggg cacttggatt
      241 taaggaaccc agaagcggca ctgtccccaa ccttccgtag tgatagtccc gtgcctactg
      301 cccctacctc tagcggccct aagcccagca caacatctgt ggcccctgaa ctagctacag
      361 accctgagtt agagaagaag ttgctacacc acctctcaga tctggccttg accttgccca
      421 ctgatgctgt ttccatccgt cttgccatct ctacgccaga tgcacctgcc actcaagatg
      481 gggtagaaag ccttctccag aaatttgccg cccaggagtt gattgaggta aagcgaggtc
      541 tcctccaaga tgatgcacat cctactcttg taacttacgc tgaccactcc aagctgtctg
      601 ccatgatggg ggctgtggca gaaaagaaag gtcttggaga ggtagcaggg accatcgcag
      661 ggcagaaacg gcgtgcagaa caggatttga ctacagtgac cacctttgcc agctctttag
      721 catctggtct ggcctcttca gcatcagaac cagctaagga gccggctaag aagtcaagga
      781 agcacgctgc ctccgatgtt gatctggaga tagaaagcct tttgaaccaa cagtcaacga
      841 aagaacagca gagcaagaag gtcagtcagg agatcctaga gctattaaat accacaacag
      901 ccaaggaaca gtccattgtt gaaaagtttc gctctcgagg tcgggcccag gtgcaagaat
      961 tttgtgatta tgggaccaag gaagagtgca tgaaagccag tgacgctgac cggccttgtc
     1021 gcaagctgca cttcagacga attatcaata agcacactga tgaatcttta ggtgactgct
     1081 ctttccttaa cacatgtttc cacatggaca cctgcaaata tgttcactat gaaattgatg
     1141 cttgtgttga ttctgagagt cctggcagca aggagcatat gccaagccag gagcttgctc
     1201 ttacacagag tgttgggggt gactccagtg ctgatcgact ctttccacct cagtggatct
     1261 gttgtgatat ccgctacctg gacgtcagta tcttgggcaa atttgcagtt gtgatggctg
     1321 acccaccttg ggatattcac atggagctac cgtatgggac attaacagat gatgagatgc
     1381 gcaggctcaa tataccagtg ctacaggatg acggctttct tttcctctgg gtcacaggaa
     1441 gggccatgga attgggcaga gaatgtctga acctctgggg ttatgaacgg gtggatgaaa
     1501 tcatctgggt gaagactaat cagctgcagc gcatcattag gacgggccgg acgggtcact
     1561 ggttaaacca cgggaaggaa cactgcttgg ttggtgttaa gggaaatcct caaggattca
     1621 accagggcct ggactgcgat gtgattgtag ctgaggttcg ttccaccagt cataaaccag
     1681 atgaaatata tggcatgatt gagagactgt cccctggcac ccgcaagatt gagttatttg
     1741 gacgaccaca caatgtgcag cccaactgga ttactcttgg aaaccaactg gatgggatac
     1801 acctactaga cccagatgtg gttgccaggt ttaagcaaag gtatccggac ggcatcatct
     1861 ctaaacctaa gaatttatag acgcacttcc ttacaaagct aagcgttcag agccatgggc
     1921 tacaggccac accttaagag gactgtttac gcaatagtgt cccctaccct gtatataaat
     1981 aaataaaagt ttgtattata attggaattt ctgaagtgaa aaaaaaaaaa aaaaa
//
