LOCUS       NM_207522               1998 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus methyltransferase like 25 (Mettl25), transcript
            variant 1, mRNA.
ACCESSION   NM_207522 XM_125881
VERSION     NM_207522.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1998)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1998)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132471.4 and AC125108.3.
            
            On Apr 28, 2022 this sequence version replaced NM_207522.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus. The use of an alternative upstream start codon, which
            appears to be found only in mouse, would result in a protein that
            is 3 aa longer.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067068.1, AK144620.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-272               AC132471.4         11493-11764         c
            273-437             AC132471.4         3268-3432           c
            438-544             AC125108.3         2716-2822
            545-1138            AC125108.3         6079-6672
            1139-1289           AC125108.3         9360-9510
            1290-1384           AC125108.3         35351-35445
            1385-1414           AC125108.3         38279-38308
            1415-1488           AC125108.3         39257-39330
            1489-1582           AC125108.3         52989-53082
            1583-1657           AC125108.3         66632-66706
            1658-1729           AC125108.3         67379-67450
            1730-1998           AC125108.3         69209-69477
FEATURES             Location/Qualifiers
     source          1..1998
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 55.12 cM"
     gene            1..1998
                     /gene="Mettl25"
                     /note="methyltransferase like 25"
                     /db_xref="GeneID:216292"
                     /db_xref="MGI:MGI:3041259"
     exon            1..272
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1831
                     /gene="Mettl25"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyltransferase-like protein 25; probable
                     methyltransferase-like protein 25"
                     /codon_start=1
                     /product="probable methyltransferase-like protein 25
                     isoform 1"
                     /protein_id="NP_997405.3"
                     /db_xref="CCDS:CCDS36049.2"
                     /db_xref="GeneID:216292"
                     /db_xref="MGI:MGI:3041259"
                     /translation="MAAACPLPRTPDLPTLHDKLQGLLSFLRGALAISSAHTVDFYTK
                     SVWQELVDLPPESVLAALRESAVEAEPREAETGSGFTELPKIFCETSQKLLSVEAFAR
                     TAKHYSVQNLGLCTPSEQLLTALQGNKRQRVDENVKAIEFMNTKKSHEVQAMSELICS
                     IADYCGLKQIIDVGSGKGYLSSFLSLKYGLNVYGIDSSNTNTHGAKERNRKLKKHWSL
                     YHPHSRADANGWASERPRELKVPKGVECKGDAESVQRSRLGNPDLSATDGLPDFSGSA
                     ISVIRKQQKNVLAQPAEEENLYFEDAFSLIDFLPVDAIEPTSSQVQNTEKSGLRKERR
                     NTASKARDSSIYSPLTSFITADSQLHDIIEDLEDCLMVGLHTCGDLAPSTLRIFTSKA
                     EVKAVCSVGCCYHLLSEEFENQHKDRCANENWGFPMCHYLKEERWCCGRNARMSACLA
                     LQRVAVGQGLPTESLFYRAVLQNIIKDYYGISKCEQHVGKIYSKCSSFLEYVRMSLKK
                     LGLDESKVSEEIIMDYYENYKPRMNELEAFNMLKVVLAPCIETLILLDRLCYLKEQDG
                     VAWSALVKLFDPVQSPRCYAVIALKKQCDRG"
     exon            273..437
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            438..544
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            545..1138
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1289
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1384
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1414
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1488
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1582
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1657
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1729
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1998
                     /gene="Mettl25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1923..1928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl25"
                     /note="hexamer: AATAAA"
     polyA_site      1944
                     /gene="Mettl25"
                     /note="major polyA site"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl25"
                     /note="hexamer: AATAAG"
     polyA_site      1998
                     /gene="Mettl25"
ORIGIN      
        1 atgttggcgc cacctgcagc cccggaggat gagcgtcatg gcggcggcct gccctctgcc
       61 caggaccccg gacctgccca cgctgcacga caagttacag ggcttgctga gcttcctcag
      121 gggcgccctg gccatttcca gcgcgcacac ggtggacttc tacaccaagt cggtctggca
      181 ggagctggtc gacctgcccc ctgagagcgt gctggcggcg ctgagggagt cggcggtgga
      241 ggccgagccg cgcgaggcag agacgggatc aggtttcact gagctcccca aaatattttg
      301 tgaaacttct cagaagctgt tgagtgtgga agcttttgcc cgaactgcaa agcactattc
      361 tgtgcaaaac ttgggactgt gcactccttc tgagcagttg ctcacagccc tccaaggaaa
      421 taaaaggcag agagttgatg aaaatgtgaa ggcaattgag tttatgaata caaaaaaatc
      481 tcatgaggtt caggcaatgt cagagctaat ctgcagtatt gctgattact gtggcttaaa
      541 gcagataatt gacgtgggtt ctggtaaagg ctatctaagc tcctttttgt ccttaaaata
      601 tggtttgaac gtttatggca tcgattcctc aaacactaac actcacggcg cgaaggagag
      661 aaacaggaag ttgaagaagc attggagcct gtatcaccct cactcaagag cagacgccaa
      721 cggctgggca tcagaaaggc ccagagagtt gaaagtgcca aagggagtgg agtgtaaggg
      781 ggacgctgag agcgtgcaga ggagcaggct tgggaatcca gacctgtctg ccaccgatgg
      841 tttgcctgat ttctcaggct ctgcaatttc agtcatcaga aaacagcaaa aaaacgtgct
      901 tgctcagcca gctgaggaag aaaatttgta ttttgaagat gccttttctc tcatagactt
      961 tttacctgtt gatgccatcg aacctacttc atcacaggtg cagaacacag aaaagtctgg
     1021 actgagaaaa gagagaagaa atacggcatc caaggcaagg gactcaagca tatattcacc
     1081 actaacctct ttcatcactg ctgattcaca attgcatgac attattgaag atctggagga
     1141 ctgtttaatg gtgggactgc atacctgtgg tgaccttgca cccagtactc tgcggatatt
     1201 tacatccaag gctgaagtca aggcagtttg cagtgtgggt tgttgctacc atctcctatc
     1261 tgaggagttt gaaaaccagc ataaagatag atgtgctaac gaaaactggg ggtttccaat
     1321 gtgccactat ctgaaagagg agagatggtg ctgcggccgt aatgcaagaa tgtcagcatg
     1381 tttggcattg cagcgggttg cagttggcca agggctgcct actgaatcac tcttctatcg
     1441 tgctgttctt cagaatatta ttaaggatta ttatggcatc agcaaatgtg aacagcacgt
     1501 tggtaaaatt tattccaaat gttcctcttt tctggagtat gtcagaatgt ctctaaagaa
     1561 gcttggatta gatgagtcca aggtctctga agaaattata atggactact atgagaatta
     1621 taagcctaga atgaatgagc tagaggcatt taatatgttg aaagttgttc tggctccttg
     1681 catagaaaca ctgattcttc ttgatcgact ttgttacctg aaggaacagg acggtgtagc
     1741 ctggtctgcc ctcgtgaagt tgtttgaccc tgtgcagtcg cccagatgct acgctgtcat
     1801 tgctctgaag aagcagtgtg atcgtggctg aagcagagtg ctagacagcc tggctgggga
     1861 cttactgctt tcttaaacat ttatatcctg ttatgtaaac attttaaatc tatattttaa
     1921 ataataaaat attgcctaac aaaatcatag tgttttcatt ctcaaagcat acagtaataa
     1981 aataagaatt tatgtaaa
//
