LOCUS       NM_028865               1055 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus methyltransferase like 23 (Mettl23), mRNA.
ACCESSION   NM_028865
VERSION     NM_028865.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1055)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1055)
  AUTHORS   Pan,Y., Suga,A., Kimura,I., Kimura,C., Minegishi,Y., Nakayama,M.,
            Yoshitake,K., Iejima,D., Minematsu,N., Yamamoto,M., Mabuchi,F.,
            Takamoto,M., Shiga,Y., Araie,M., Kashiwagi,K., Aihara,M.,
            Nakazawa,T. and Iwata,T.
  TITLE     METTL23 mutation alters histone H3R17 methylation in normal-tension
            glaucoma
  JOURNAL   J Clin Invest 132 (21), e153589 (2022)
   PUBMED   36099048
  REMARK    GeneRIF: METTL23 mutation alters histone H3R17 methylation in
            normal-tension glaucoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1055)
  AUTHORS   Hatanaka,Y., Tsusaka,T., Shimizu,N., Morita,K., Suzuki,T.,
            Machida,S., Satoh,M., Honda,A., Hirose,M., Kamimura,S., Ogonuki,N.,
            Nakamura,T., Inoue,K., Hosoi,Y., Dohmae,N., Nakano,T.,
            Kurumizaka,H., Matsumoto,K., Shinkai,Y. and Ogura,A.
  TITLE     Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming
            the Paternal Genome in Zygotes
  JOURNAL   Cell Rep 20 (12), 2756-2765 (2017)
   PUBMED   28930672
REFERENCE   4  (bases 1 to 1055)
  AUTHORS   Hahn,P., Bose,J., Edler,S. and Lengeling,A.
  TITLE     Genomic structure and expression of Jmjd6 and evolutionary analysis
            in the context of related JmjC domain containing proteins
  JOURNAL   BMC Genomics 9, 293 (2008)
   PUBMED   18564434
  REMARK    GeneRIF: Located immediately downstream of Jmjd6, with a
            bi-directionar promoter between the two.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1055)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY122329.1, AK003450.1 and AW490033.1.
            
            On Jun 6, 2009 this sequence version replaced NM_028865.2.
            
            CCDS Note: The coding region has been updated to extend the
            N-terminus to one that is more supported by the available
            transcript data, and by conservation in rat and opossum.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026936.1, AK003450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               BY122329.1         1-155
            156-852             AK003450.1         2-698
            853-1055            AW490033.1         1-203               c
FEATURES             Location/Qualifiers
     source          1..1055
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 81.49 cM"
     gene            1..1055
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /note="methyltransferase like 23"
                     /db_xref="GeneID:74319"
                     /db_xref="MGI:MGI:1921569"
     exon            1..260
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..854
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /EC_number="2.1.1.319"
                     /note="methyltransferase-like protein 23; probable
                     methyltransferase-like protein 23"
                     /codon_start=1
                     /product="histone-arginine methyltransferase METTL23"
                     /protein_id="NP_083141.3"
                     /db_xref="CCDS:CCDS25679.2"
                     /db_xref="GeneID:74319"
                     /db_xref="MGI:MGI:1921569"
                     /translation="MDSVRPRAPWAPPPDPASLDSPTCEPGLMAGTQLFRFREEPVPG
                     GNRAVLEVRVPQVLHVQYGMYVWPCAVVLAQYLWFHRRSLPGKAVLEVGAGVSLPGIL
                     AAKCGAKVILSDSSEFPHCLDICRQSCQMNNLPQVEVVGLTWGHISKDILSLPPQDII
                     LGSDVFFEPEDFESILATVYFLMQKNPKVQFWSTYQVRSADWSLEGLLYKWDMKCVHI
                     PLESFDADKEDIAESTLPGRHTVEMLIISFAKDSF"
     exon            261..365
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            366..603
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            604..688
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            689..1039
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      907..912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /note="hexamer: CATAAA"
     polyA_site      931
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /note="major polyA site"
     regulatory      1018..1023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1035
                     /gene="Mettl23"
                     /gene_synonym="1110005A03Rik; 1500035B17Rik;
                     4933424L15Rik"
                     /note="major polyA site"
ORIGIN      
        1 tttggcctac gcaacacttc cgtctgcgcg tcgcttccct gcggtctcct tccggccggg
       61 cccgctgcgg cctccggctt cctgtgtttg ccatggacag tgtccggccc cgcgctcctt
      121 gggcaccgcc tcctgacccg gcgtccctgg actcccctac gtgcgagccc ggcctcatgg
      181 ccgggaccca gctctttcgg ttccgggagg agccagttcc cggaggcaat cgggcggtgc
      241 tggaggtccg cgtcccgcag gtcctgcatg tccagtatgg aatgtatgtt tggccctgtg
      301 ctgtagtcct ggcccaatac ctgtggtttc acagaagatc tctaccaggc aaagctgtct
      361 tagaggttgg cgctggagtg agccttcctg ggattttggc tgccaaatgt ggtgctaaag
      421 taatactatc tgacagctca gagtttcctc actgtctgga tatctgcagg caaagttgcc
      481 agatgaataa cctgccacag gtcgaagttg taggactgac atggggccac atatcaaagg
      541 acattctgtc tttgccacca caagacatca ttcttggatc tgatgtgttc tttgaaccag
      601 aagactttga aagcatttta gccacagtat acttcctgat gcagaagaat ccaaaagttc
      661 aattttggtc tacataccag gtccgaagtg ctgactggtc acttgaaggc ttgctctaca
      721 agtgggatat gaaatgtgtg catattcctc tggagtcttt tgatgccgac aaggaagaca
      781 tagcagagtc tacccttcca ggaagacata ctgttgaaat gctgatcatc tcctttgcaa
      841 aggacagttt ctgaatgaat tgtacctcaa tatgttctgg gacagtgtca aaatggaata
      901 acctggcata aagctgaatt atctgaggaa actcaatggg tatgaagatg atcaattctg
      961 taagccttgt ggctgtgctg tcatgcctag gatagcattc aacataactt taacaaaatt
     1021 aaacattcaa aaaggcttaa aaaaaaaaaa aaaaa
//
