LOCUS       NM_001013799            1086 bp    mRNA    linear   ROD 15-JUL-2024
DEFINITION  Mus musculus methyltransferase 21C, AARS1 lysine (Mettl21c), mRNA.
ACCESSION   NM_001013799 XM_484856 XM_899668 XM_904720 XM_918956
VERSION     NM_001013799.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1086)
  AUTHORS   Qu,J., Dang,S., Sun,Y.Y., Zhang,T., Jiang,H. and Lu,H.Z.
  TITLE     METTL21C mediates autophagy and formation of slow-twitch muscle
            fibers in mice after exercise
  JOURNAL   Genes Genet Syst 99 (2024)
   PUBMED   38417894
  REMARK    GeneRIF: METTL21C mediates autophagy and formation of slow-twitch
            muscle fibers in mice after exercise.
REFERENCE   2  (bases 1 to 1086)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1086)
  AUTHORS   Zoabi,M., Zhang,L., Li,T.M., Elias,J.E., Carlson,S.M. and Gozani,O.
  TITLE     Methyltransferase-like 21C (METTL21C) methylates alanine tRNA
            synthetase at Lys-943 in muscle tissue
  JOURNAL   J Biol Chem 295 (33), 11822-11832 (2020)
   PUBMED   32611769
  REMARK    GeneRIF: Methyltransferase-like 21C (METTL21C) methylates alanine
            tRNA synthetase at Lys-943 in muscle tissue.
REFERENCE   4  (bases 1 to 1086)
  AUTHORS   Wang,C., Arrington,J., Ratliff,A.C., Chen,J., Horton,H.E., Nie,Y.,
            Yue,F., Hrycyna,C.A., Tao,W.A. and Kuang,S.
  TITLE     Methyltransferase-like 21c methylates and stabilizes the heat shock
            protein Hspa8 in type I myofibers in mice
  JOURNAL   J Biol Chem 294 (37), 13718-13728 (2019)
   PUBMED   31346037
REFERENCE   5  (bases 1 to 1086)
  AUTHORS   Wiederstein,J.L., Nolte,H., Gunther,S., Piller,T., Baraldo,M.,
            Kostin,S., Bloch,W., Schindler,N., Sandri,M., Blaauw,B., Braun,T.,
            Holper,S. and Kruger,M.
  TITLE     Skeletal Muscle-Specific Methyltransferase METTL21C Trimethylates
            p97 and Regulates Autophagy-Associated Protein Breakdown
  JOURNAL   Cell Rep 23 (5), 1342-1356 (2018)
   PUBMED   29719249
  REMARK    GeneRIF: METTL21C trimethylates p97 on the Lys315 residue and found
            that loss of this modification reduced p97 hexamer formation and
            ATPase activity in vivo.
REFERENCE   6  (bases 1 to 1086)
  AUTHORS   Huang,J., Hsu,Y.H., Mo,C., Abreu,E., Kiel,D.P., Bonewald,L.F.,
            Brotto,M. and Karasik,D.
  TITLE     METTL21C is a potential pleiotropic gene for osteoporosis and
            sarcopenia acting through the modulation of the NF-kappaB signaling
            pathway
  JOURNAL   J Bone Miner Res 29 (7), 1531-1540 (2014)
   PUBMED   24677265
  REMARK    GeneRIF: Mettl21c knockdown modulated only the NF-kappaB signaling
            pathway.
REFERENCE   7  (bases 1 to 1086)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK041301.1.
            
            On or before Jan 26, 2006 this sequence version replaced
            XM_899668.1, XM_484856.3, XM_918956.1, XM_904720.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK041301.1, BC147328.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1086
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 23.52 cM"
     gene            1..1086
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
                     /note="methyltransferase 21C, AARS1 lysine"
                     /db_xref="GeneID:433294"
                     /db_xref="MGI:MGI:3611450"
     exon            1..99
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            100..190
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            191..342
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            343..460
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            461..1086
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      933..938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      955
                     /gene="Mettl21c"
                     /gene_synonym="A530098C11Rik"
ORIGIN      
        1 tggcttttga tcataaagag ctcatcattt caagtgtgga cctatataaa aaacactggg
       61 gacttgaggc cacacaagct gcgatctctg cttcataagg ctctggctat ggatcagcat
      121 ctccacatag cccagcagcc cctactctcg gggactccac aggaagatgg ttttgcagga
      181 ccctcagtag agttcgacag gatagaatca tctcttcgta gcatccagaa atttgttcct
      241 acagactatg ccagctacac acaagagcat tatcagttcg caggcaagaa gatcatcatt
      301 caagaatcca ttgagaacta tggcacagtg gtgtggccag gggctacagc tctgtgtcaa
      361 tatttagaag accatacaga ggaattaaat ctccaagatg ctaaaatact tgaaattggt
      421 gctggagcag gccttgtttc cattgtatcc agtcttttag gagctcaagt cacagcaaca
      481 gacctgcctg atgttctagg aaatcttcaa tacaatattt taaaaaacac actagaatgc
      541 acagctcatc tacctgaagt gagagaactg gtatgggggg aagacctgga gcagagcttc
      601 cctaagtcaa cctgttgtta tgactacgtg ctggcctctg atgttgtcta ccaccactac
      661 ttcctggaca agctgctcgc taccatggtg tacctttccc agccaggcac tgtggtgctg
      721 tgggcaaaca aattcagatt tagtgctgac tatgaatttt taggtaagtt taagcaagcc
      781 tttgatacca ctctcttggc tgaatattca gaatcatctg tcaagctgtt taaagggata
      841 ttaaagtggg agtgaaatgt gaagcgtctt tcaaaccatc agtgtcttgt gaagatattc
      901 gaaggtgcac catgccacac tggtatggct aaaataaatg caattcaata tacaactttc
      961 taagatgata agattatgtg gtcaaagtat ctatagaaag taaatagata catgactttc
     1021 caatgtatta agcacttaaa taagagttta tacaaagaag taaataaaca ggtgggttcc
     1081 tctgtt
//
