LOCUS       NM_172567               2619 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus methyltransferase 2, methylcytidine (Mettl2), mRNA.
ACCESSION   NM_172567
VERSION     NM_172567.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2619)
  AUTHORS   Xu,L., Liu,X., Sheng,N., Oo,K.S., Liang,J., Chionh,Y.H., Xu,J.,
            Ye,F., Gao,Y.G., Dedon,P.C. and Fu,X.Y.
  TITLE     Three distinct 3-methylcytidine (m3C) methyltransferases modify
            tRNA and mRNA in mice and humans
  JOURNAL   J Biol Chem 292 (35), 14695-14703 (2017)
   PUBMED   28655767
REFERENCE   2  (bases 1 to 2619)
  AUTHORS   Georgas,K., Rumballe,B., Valerius,M.T., Chiu,H.S.,
            Thiagarajan,R.D., Lesieur,E., Aronow,B.J., Brunskill,E.W.,
            Combes,A.N., Tang,D., Taylor,D., Grimmond,S.M., Potter,S.S.,
            McMahon,A.P. and Little,M.H.
  TITLE     Analysis of early nephron patterning reveals a role for distal RV
            proliferation in fusion to the ureteric tip via a cap
            mesenchyme-derived connecting segment
  JOURNAL   Dev Biol 332 (2), 273-286 (2009)
   PUBMED   19501082
REFERENCE   3  (bases 1 to 2619)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   4  (bases 1 to 2619)
  AUTHORS   Juriloff,D.M., Harris,M.J. and Brown,C.J.
  TITLE     Unravelling the complex genetics of cleft lip in the mouse model
  JOURNAL   Mamm Genome 12 (6), 426-435 (2001)
   PUBMED   11353389
REFERENCE   5  (bases 1 to 2619)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK048040.1, AL627235.12 and BB671561.1.
            
            On Aug 8, 2009 this sequence version replaced NM_172567.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048040.1, BC089591.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1705              AK048040.1         2-1706
            1706-2203           AL627235.12        99825-100322
            2204-2618           BB671561.1         1-415
            2619-2619           AL627235.12        100738-100738
FEATURES             Location/Qualifiers
     source          1..2619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 68.61 cM"
     gene            1..2619
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /note="methyltransferase 2, methylcytidine"
                     /db_xref="GeneID:52686"
                     /db_xref="MGI:MGI:1289171"
     exon            1..182
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1242
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /EC_number="2.1.1.-"
                     /note="methyltransferase-like protein 2; tRNA
                     N(3)-methylcytidine methyltransferase METTL2;
                     methyltransferase like 2"
                     /codon_start=1
                     /product="tRNA N(3)-cytidine methyltransferase METTL2"
                     /protein_id="NP_766155.3"
                     /db_xref="CCDS:CCDS25538.1"
                     /db_xref="GeneID:52686"
                     /db_xref="MGI:MGI:1289171"
                     /translation="MAASFPEGVPETEDGKRPQFGHRFLSDPARVFHHNAWDNVKWSE
                     EQAAAAERKVQENSSPLVCPEKQVDYEVNAHKYWDDFYRIHENGFFKDRHWLFTEFPE
                     LAPSHSHLTGVPLEKQRSDVCEDGPGLTAEQHKCSCASPGCETQVPPLEEPVTQKLGH
                     LEISGEEFPGSSATYRILEVGCGVGNTVFPILQTNNNPNLFVYCCDFSATAIELLKTN
                     SQYDPSRCYAFVHDLCDEDQSYPVPEDSLDVIVLIFVLSAIVPDKMQKAISKLSRLLK
                     PGGVMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQGELDTLFTAAGLEK
                     VQNLVDRRLQVNRGKQLTMYRVWIQCKYSKPLALRSSQHVPIPHATESSSHSGLL"
     exon            183..274
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..609
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            610..659
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            660..720
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            721..860
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            861..967
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1033
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..2619
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2601..2606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /note="hexamer: AATAAA"
     polyA_site      2619
                     /gene="Mettl2"
                     /gene_synonym="2810438F06Rik; C130031G21Rik; D11Ertd768e;
                     METL; PSENIP1"
                     /note="major polyA site"
ORIGIN      
        1 acttccggaa ggggcgtggc ccacaggaag tcctcgcctt cgggaagaga aggcgtttcc
       61 gtctccggtg tcatggcggc ctccttccct gaaggcgtgc cggagaccga ggacgggaag
      121 agaccgcagt tcgggcaccg gttcctgagc gacccggcgc gcgtcttcca tcacaatgcc
      181 tgggacaacg tgaagtggtc cgaggagcag gccgcggcgg cggagaggaa agtgcaggag
      241 aacagctccc cgctggtgtg cccggagaag caagttgatt atgaagtcaa tgcccataaa
      301 tactgggatg acttctacag aatccatgaa aatgggtttt tcaaggatag acactggctt
      361 tttactgagt tccctgaatt ggcacctagc cacagtcacc tgacgggtgt acccttggag
      421 aagcagagga gtgacgtctg tgaggacgga cctggcttga cagcagaaca gcacaagtgt
      481 tcttgtgcca gccctggatg tgagactcag gtgcctccct tggaagagcc agtgactcag
      541 aagctcggtc acctagaaat tagtggtgag gaatttcctg gctcctctgc cacctaccga
      601 atacttgagg ttggttgtgg tgtaggaaac acagtctttc caattttaca aactaacaat
      661 aacccaaacc tcttcgttta ctgttgtgac ttttctgcca cggctattga actgctcaag
      721 acaaattcac aatatgatcc ttctcgctgt tatgcctttg ttcatgatct ctgtgatgaa
      781 gatcagagtt acccagtgcc tgaggacagt cttgatgtca tcgttcttat atttgttctt
      841 tcagcaattg ttccagacaa gatgcagaaa gcgatcagca agctaagccg actcctgaag
      901 cctggagggg tgatgcttct tcgagactat ggccgctatg acatggctca acttcggttt
      961 aagaaaggtc agtgtctatc tggaaacttc tatgtgagag gtgatggcac cagagtttac
     1021 ttcttcacac aaggtgagct ggatacgctc ttcaccgctg ctggcctgga gaaggtgcag
     1081 aacctggtgg atcgccgctt gcaggtgaat cgagggaaac agctgaccat gtaccgcgtc
     1141 tggattcagt gcaaatacag caagcctcta gcactccgct ccagccaaca tgtgcccatt
     1201 ccccacgcca cagaaagttc ttcacattcg gggcttttgt aagaagacat ctgtagacag
     1261 cggcttgttg atgatggaca gtctggggat tcaaggagct ctaactttga gcctaagaac
     1321 aactactttc cggtttttag ccaggtgcaa tgacacatgc ctttaaaccc agcactcagg
     1381 aggcagaggc agacagatct ctgagtttga tgacagccag tgatacacag agaaatcctg
     1441 tctccaaaag caaaccaaaa aagtgtggtt ttatttctaa agcccattaa tgcgtatttt
     1501 ctggagttcg ttttattaat atcattggtc gaggcaatgc cctggtgaat gtggggagtt
     1561 caaagggcaa cttgcaggag tcagttctct cctacaggct ggtcctagaa ttcagactca
     1621 ggcttgacag caaacacctt gagctttttg actgccctca aattttttaa tgactagagt
     1681 tttatataaa actcattctg tgaccaaaaa tgaccttgaa gtttagatcc tcttgccatc
     1741 atattgcaag atgatgatgg tccacacctt taatcctagc actcagaagc cagagacagg
     1801 cgatctctga gttcagggcc tgcctagtct acagagtgag ttccaggaca cccagggcta
     1861 cacagacaaa aaaagaaaaa taagaaagga aaaagaatgc taacacattt gagagttaag
     1921 aatttaaaat ccaagcctgg ccaagtgtgg tggctcacag cagaaatccc tgcgggtaaa
     1981 aagctgagtt aggccgggcg tggtagcgca cgcctttgat cccagcactc aggaggcaga
     2041 ggcaggcaga tttctgagtt cgaggccagc ctggtctaca aagtgagttc caggacagcc
     2101 agggctatac agagaaaccc tgtctcgaaa aaccaaaaaa aaaaaaaaaa aaaaggctga
     2161 gtcagcacag ggatcccgtt aagatcaagg ctagcctgga ctgcactgta aaaccatctc
     2221 acagatggtg aatatggctc agtggcatga gccctggagc cagccaggta cggggtgtta
     2281 gcttaatcta aattggcatg gggggtctga gataggagaa ctgccttcaa ttccaggcca
     2341 gcccaagcta catggtgaaa gcctgcctgg cttgtttgat cctggggcag gatggaggtg
     2401 atgctgtgct ccgctgcaag gtgctggatt atgagggcct tttactgtct ccagtattag
     2461 cactagaacg aaggctcagc aggtttaggc acttgctgcc gagcgtgaca gcctgaattc
     2521 atgtccccaa aacccacatg gtggaaggag agagccatca tgtgctgtag catgtctgtg
     2581 tcctcagaca tacgtaccaa aataaaataa ttttctata
//
