LOCUS       NM_027279               1531 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus methyltransferase like 18 (Mettl18), transcript
            variant 1, mRNA.
ACCESSION   NM_027279
VERSION     NM_027279.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK139786.1, BC050143.1 and AC110499.19.
            
            On Sep 20, 2017 this sequence version replaced NM_027279.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052693.1, AK139786.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AK139786.1         3-58
            57-205              BC050143.1         1-149
            206-206             AC110499.19        169806-169806       c
            207-1531            BC050143.1         151-1475
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.3 cM"
     gene            1..1531
                     /gene="Mettl18"
                     /gene_synonym="2810422O20Rik"
                     /note="methyltransferase like 18"
                     /db_xref="GeneID:69962"
                     /db_xref="MGI:MGI:1917212"
     exon            1..183
                     /gene="Mettl18"
                     /gene_synonym="2810422O20Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            184..1513
                     /gene="Mettl18"
                     /gene_synonym="2810422O20Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..1470
                     /gene="Mettl18"
                     /gene_synonym="2810422O20Rik"
                     /EC_number="2.1.1.85"
                     /note="methyltransferase-like protein 18"
                     /codon_start=1
                     /product="histidine protein methyltransferase 1 homolog"
                     /protein_id="NP_081555.2"
                     /db_xref="CCDS:CCDS15431.1"
                     /db_xref="GeneID:69962"
                     /db_xref="MGI:MGI:1917212"
                     /translation="MAFQFNFSIEEDLENKLTSLDDGTCVLESQKGKQDKRQSTERPG
                     LPRDHSWKCSSLGNAASSEDTGSPPPIADRSDDPEACKHQPSWKPAKEHVMPKDVNHV
                     LENTVLEMLPGPQHANTAVVKTVSLKEKFPGENIVSKSFSSHSDLIPGVYEGGLKIWE
                     CTFDLLTYFTKAKVKFAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTL
                     PNVVANVPLQDDSNGKNEPDGKRQRKSEVGREICKCRLFSGEWAEFCKLVLREKLFVK
                     YDLILTSETIYNPDYYSTLHETFLRLLSRSGRVLLASKAHYFGVGGGVHLFQKFVEEK
                     GVFETRTLEVIDEGLKRFLMEMTFKHPS"
     regulatory      1493..1498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl18"
                     /gene_synonym="2810422O20Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1513
                     /gene="Mettl18"
                     /gene_synonym="2810422O20Rik"
                     /note="major polyA site"
ORIGIN      
        1 ggtgttcgcc gtaggctgaa ggcgagtttc tccggtagtt tgttcgccct ggcgtctgac
       61 tttccaatgc tgagaccaga agtcctcagg tttgctatcc tcagtccggg gggactttga
      121 gacgacgcgt agtttcaagg gtgacctggg ctgaggccag gaatgactct actcccctgt
      181 gagggctgaa ctgaaaaagg atcaaaggcg tctaaaacgt ctttggagcc ccctctgaat
      241 acatctgatg gtgtatacgc agctaacaga cattgggcgc aacagaacta atcgactgtg
      301 tgatcggtta tgccattaaa ttctttctag aagctgaagc atcatccttt ggtaaaaaaa
      361 cggtgtgcat agaaaaagag gatggccttt caattcaatt tcagcataga agaagatctg
      421 gaaaataaat taacatccct cgatgatgga acttgtgtct tagaaagtca gaaaggaaag
      481 caggacaaaa ggcaatctac agaacgtccg ggcttgcctc gggatcactc ttggaaatgc
      541 tcctcactgg gaaatgcagc ttcctctgaa gacactggca gcccaccccc tattgctgac
      601 aggtcagatg acccagaagc ttgtaaacac cagccctcct ggaaacctgc taaagaacat
      661 gtgatgccta aagatgtgaa tcacgtctta gaaaatacgg ttttggaaat gttgccaggt
      721 ccccagcatg ctaacacagc agtagtgaaa accgtctctt tgaaagagaa attccctgga
      781 gaaaacatcg tttcaaagag cttttcttct cattctgatc tgatcccagg tgtttatgaa
      841 ggaggcttga aaatctggga atgcaccttt gacctcttga cttacttcac aaaagccaaa
      901 gtgaaatttg ctgggcagaa agtgttagac cttggctgtg ggtctgggct gcttgggata
      961 actgcatcca aaggaggggc tagggaagtt cattttcaag attacaacgg tttggtgatc
     1021 gatgaggtga ccttacctaa tgtagttgct aatgtccctt tgcaagatga cagcaatggc
     1081 aaaaatgagc cagatgggaa aagacaaagg aagtcagaag taggccgaga aatctgtaaa
     1141 tgtcgcttgt tctctgggga gtgggctgag ttttgcaagc ttgtattacg tgaaaaactg
     1201 tttgtgaaat atgacctcat tctcacttca gaaaccattt ataatccgga ttattacagc
     1261 actttgcatg aaacattcct caggctatta agtaggagtg gccgggtgct tctggccagc
     1321 aaagcacatt attttggtgt tggtggtggc gttcatctct tccagaagtt tgtagaagaa
     1381 aagggtgtat ttgagactcg aacacttgaa gtaattgatg aaggtctaaa gagatttcta
     1441 atggagatga cttttaagca ccccagttaa tatgcaccga atggcgtaat gaaataaaaa
     1501 gaatacccca gaaaaaaaaa aaaaaaaaaa a
//
