LOCUS       NM_001418826            2103 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus methyltransferase like 15 (Mettl15), transcript
            variant 2, mRNA.
ACCESSION   NM_001418826
VERSION     NM_001418826.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Averina,O.A., Laptev,I.G., Emelianova,M.A., Permyakov,O.A.,
            Mariasina,S.S., Nikiforova,A.I., Manskikh,V.N., Grigorieva,O.O.,
            Bolikhova,A.K., Kalabin,G.A., Dontsova,O.A. and Sergiev,P.V.
  TITLE     Mitochondrial rRNA Methylation by Mettl15 Contributes to the
            Exercise and Learning Capability in Mice
  JOURNAL   Int J Mol Sci 23 (11), 6056 (2022)
   PUBMED   35682734
  REMARK    GeneRIF: Mitochondrial rRNA Methylation by Mettl15 Contributes to
            the Exercise and Learning Capability in Mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Hurley,S., Mohan,C., Suetterlin,P., Ellingford,R., Riegman,K.L.H.,
            Ellegood,J., Caruso,A., Michetti,C., Brock,O., Evans,R., Rudari,F.,
            Delogu,A., Scattoni,M.L., Lerch,J.P., Fernandes,C. and Basson,M.A.
  TITLE     Distinct, dosage-sensitive requirements for the autism-associated
            factor CHD8 during cortical development
  JOURNAL   Mol Autism 12 (1), 16 (2021)
   PUBMED   33627187
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Laptev,I., Shvetsova,E., Levitskii,S., Serebryakova,M.,
            Rubtsova,M., Zgoda,V., Bogdanov,A., Kamenski,P., Sergiev,P. and
            Dontsova,O.
  TITLE     METTL15 interacts with the assembly intermediate of murine
            mitochondrial small ribosomal subunit to form m4C840 12S rRNA
            residue
  JOURNAL   Nucleic Acids Res 48 (14), 8022-8034 (2020)
   PUBMED   32573735
  REMARK    GeneRIF: METTL15 interacts with the assembly intermediate of murine
            mitochondrial small ribosomal subunit to form m4C840 12S rRNA
            residue.
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Favor,J., Bradley,A., Conte,N., Janik,D., Pretsch,W., Reitmeir,P.,
            Rosemann,M., Schmahl,W., Wienberg,J. and Zaus,I.
  TITLE     Analysis of Pax6 contiguous gene deletions in the mouse, Mus
            musculus, identifies regions distinct from Pax6 responsible for
            extreme small-eye and belly-spotting phenotypes
  JOURNAL   Genetics 182 (4), 1077-1088 (2009)
   PUBMED   19474196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL691430.6, BX813309.2 and BX813328.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.167519.1,
                                           SRR17784645.122000.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-309               AL691430.6         35533-35841         c
            310-596             AL691430.6         29504-29790         c
            597-733             BX813309.2         63110-63246         c
            734-925             BX813309.2         8899-9090           c
            926-1104            BX813309.2         3043-3221           c
            1105-2103           BX813328.2         92158-93156         c
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 56.52 cM"
     gene            1..2103
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /note="methyltransferase like 15"
                     /db_xref="GeneID:76894"
                     /db_xref="MGI:MGI:1924144"
     exon            1..309
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..596
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..1547
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /EC_number="2.1.1.-"
                     /note="isoform a is encoded by transcript variant 2;
                     methyltransferase 5 domain containing 1; putative
                     S-adenosyl-L-methionine-dependent methyltransferase
                     METT5D1; probable S-adenosyl-L-methionine-dependent
                     methyltransferase METT5D1; probable methyltransferase-like
                     protein 15; methyltransferase 5 domain-containing protein
                     1; 12S rRNA N(4)-cytidine methyltransferase METTL15; 12S
                     rRNA m4C methyltransferase; 12S rRNA N4-methylcytidine
                     methyltransferase"
                     /codon_start=1
                     /product="12S rRNA N(4)-cytidine methyltransferase METTL15
                     isoform a"
                     /protein_id="NP_001405755.1"
                     /db_xref="GeneID:76894"
                     /db_xref="MGI:MGI:1924144"
                     /translation="MLRYPYFYRTYNRLFSHFVDSGASNLDVCPHTIHTAVALHTESK
                     AVEGTALCGPQKVYSSEEKELEAMAKLHIPVMVDQVVHCLAPQKGQVFLDMTFGSGGH
                     TRAILQKEPDVMVYALDRDPVAYAIAEQLSRLYPTQIQALLGQFSQAEALLMKAGVQP
                     GTIDGILMDLGCSSMQLDAPERGFSLRKDGPLDMRMDGDRYPDTPTASDVVNALDQQA
                     LASILRAYGEEKHAKKIASAIIQARSTYPISRTQQLASIVAGAFPPSAVYARKDLLQR
                     STHIATKTFQALRIFVNNELNELYAGLRTAEKFLKTGGRLVALSFHSLEDRIVKRFLL
                     GISMTERFNLSIRQKVKQTSQLDSDQETEERHSVRAPLKWELIHKKVLTPEDQDVQDN
                     PRGRSAKLRAAIKL"
     exon            597..733
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..925
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1104
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..2103
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2081..2086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /note="hexamer: AATAAA"
     polyA_site      2103
                     /gene="Mettl15"
                     /gene_synonym="0610027B03Rik; Mett5d1"
                     /note="major polyA site"
ORIGIN      
        1 agaggctggg cctcagatgc cggaggagaa gttactttcc tgggcgtcgc cgtggcaacg
       61 cgcgcggtcg tttccggcag ccgtgacgga ggtgggcgga gctcgggcgg cggtgcaggt
      121 gggaagcagc cacctgggat atttagtatt gccacagtcc tagggtctgg ggtgccctgg
      181 gctttgggtg atgtttctct tagggggaga ggcggagtct gcgggcctgt aaaagggcct
      241 gggttatttt gtcctttttc cctttctgat tagtcaagtt cccaaggatt aggactcagg
      301 ctttggaaga tttcttgacc tacaaaatgc ttcgatatcc atatttttac agaacatata
      361 atagactgtt ttcacacttt gtggattctg gtgcatctaa tttggatgtc tgtccccaca
      421 caatccacac tgcagtggca ctgcatactg aatctaaagc tgtggaaggg acagctctgt
      481 gcggccctca gaaggtctac agctctgaag agaaagagtt ggaagccatg gctaaattac
      541 atatcccagt aatggtggat caagttgttc attgcttggc accacaaaag ggacaggttt
      601 tcctagatat gacctttggt tcaggaggac atacaagagc cattctgcag aaggaaccag
      661 atgttatggt ctatgcctta gaccgggacc cagtggctta tgcaatagct gagcagcttt
      721 caagactgta tccgacacag atccaagctc tgttgggcca gttcagccaa gcggaggcat
      781 tgctaatgaa agctggagtg cagccaggaa cgattgatgg aatccttatg gacctggggt
      841 gttcttccat gcaacttgat gctcctgaac gaggtttctc ccttcggaaa gatggcccct
      901 tggacatgag gatggatgga gacaggtacc ctgacacgcc cactgcttct gatgttgtga
      961 atgctttaga tcaacaagca cttgcatcca tcctaagagc atatggagag gaaaaacatg
     1021 ccaaaaaaat tgcttctgcg atcattcaag cacgcagcac ataccctatc tctagaaccc
     1081 agcagcttgc cagcattgtt gcaggtgcct ttcctccctc tgctgtctat gcaagaaaag
     1141 acttgctaca aagatccacc cacatcgcta ccaagacttt ccaagccctt cgcatctttg
     1201 tgaacaatga gctcaatgag ctctatgcag gactgaggac agcagagaag tttctaaaaa
     1261 ctggtggtcg cctggtcgcc ctctccttcc attccttaga agatcgtatt gtcaaacgct
     1321 ttctgcttgg gataagcatg acagaaaggt ttaacctgag cattagacag aaggtgaagc
     1381 agacttccca gctggattca gatcaggaga ctgaggagag acactctgta agagcgcctc
     1441 tgaagtggga gctgatacac aagaaggtac ttactccaga agatcaagat gtccaagata
     1501 accccagagg gcgctcagcc aagctcagag cagccatcaa attatgagga tcttattatt
     1561 tgatccacaa gtttttactc aatatttcta tttttttttt ctaacttaaa actgtgtttc
     1621 tggatgtaat gtaaagtatg gggcatctct atgccctaaa ttcgaaattg atatatttac
     1681 atttgcagtg aacattcaat ggcttatata attcatcatg atcatggaat aaattataat
     1741 ttcccctacc atagctttat caaatgtaag ctttttacaa attttaaatt ctcaacatta
     1801 tttaaaatat accatactgg tggtcttcac tagtgagttc atagttcatt tgaaggcatt
     1861 tttcaatatg atccatattt catacagtgg aaaggaagca tgtagaactg ctctaacaac
     1921 cctcatagaa aatctgaggt ccagaacttc tatttgctgt gggttgtatc aatactctta
     1981 gtaaacaatg taatctcttg tttcatcttg cttttttgtt tccttaaata attttaaatg
     2041 ttatgcaaag tggtaagttt cactatggca ttttcatgaa aataaagcat gatattagta
     2101 cta
//
