LOCUS       NM_201638               2625 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus methyltransferase 14, N6-adenosine-methyltransferase
            subunit (Mettl14), mRNA.
ACCESSION   NM_201638 XM_131193
VERSION     NM_201638.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2625)
  AUTHORS   Zhang,F., Fu,Y., Jimenez-Cyrus,D., Zhao,T., Shen,Y., Sun,Y.,
            Zhang,Z., Wang,Q., Kawaguchi,R., Geschwind,D.H., He,C., Ming,G.L.
            and Song,H.
  TITLE     m6A/YTHDF2-mediated mRNA decay targets TGF-beta signaling to
            suppress the quiescence acquisition of early postnatal mouse
            hippocampal NSCs
  JOURNAL   Cell Stem Cell 32 (1), 144-156 (2025)
   PUBMED   39476834
REFERENCE   2  (bases 1 to 2625)
  AUTHORS   Yang,J., Jiang,T., Lu,X., Li,X., Zhou,X., Guo,X., Ma,C., Xie,X.,
            Li,D., Yu,S., An,J., Zhao,B. and Li,H.
  TITLE     METTL14 downregulates GLUT9 through m6A methylation and attenuates
            hyperuricemia-induced fibrosis in mouse renal tubular epithelial
            cells
  JOURNAL   Int Immunopharmacol 143 (Pt 1), 113308 (2024)
   PUBMED   39393275
  REMARK    GeneRIF: METTL14 downregulates GLUT9 through m6A methylation and
            attenuates hyperuricemia-induced fibrosis in mouse renal tubular
            epithelial cells.
REFERENCE   3  (bases 1 to 2625)
  AUTHORS   Mao,Y., Meng,Y., Zou,K., Qin,N., Wang,Y., Yan,J., Chen,P.,
            Cheng,Y., Shi,W., Zhou,C., Chen,H., Sheng,J., Liu,X., Pan,J. and
            Huang,H.
  TITLE     Advanced paternal age exacerbates neuroinflammation in offspring
            via m6A modification-mediated intergenerational inheritance
  JOURNAL   J Neuroinflammation 21 (1), 249 (2024)
   PUBMED   39367406
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2625)
  AUTHORS   Zhang,Z., Mao,H., Li,F., Wang,D. and Liu,Y.
  TITLE     METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis progression
            by up-regulating ADAM8
  JOURNAL   Int J Rheum Dis 27 (9), e15323 (2024)
   PUBMED   39221886
  REMARK    GeneRIF: METTL14-mediated lncRNA-FAS-AS1 promotes osteoarthritis
            progression by up-regulating ADAM8.
REFERENCE   5  (bases 1 to 2625)
  AUTHORS   Liu,D., Ren,L. and Liu,J.
  TITLE     METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A
            modification of GPX4
  JOURNAL   Int J Rheum Dis 27 (8), e15297 (2024)
   PUBMED   39175261
  REMARK    GeneRIF: METTL14 promotes chondrocyte ferroptosis in osteoarthritis
            via m6A modification of GPX4.
REFERENCE   6  (bases 1 to 2625)
  AUTHORS   Wang,Y., Li,Y., Toth,J.I., Petroski,M.D., Zhang,Z. and Zhao,J.C.
  TITLE     N6-methyladenosine modification destabilizes developmental
            regulators in embryonic stem cells
  JOURNAL   Nat Cell Biol 16 (2), 191-198 (2014)
   PUBMED   24394384
REFERENCE   7  (bases 1 to 2625)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   8  (bases 1 to 2625)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   9  (bases 1 to 2625)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   10 (bases 1 to 2625)
  AUTHORS   Huttenhofer,A., Kiefmann,M., Meier-Ewert,S., O'Brien,J.,
            Lehrach,H., Bachellerie,J.P. and Brosius,J.
  TITLE     RNomics: an experimental approach that identifies 201 candidates
            for novel, small, non-messenger RNAs in mouse
  JOURNAL   EMBO J 20 (11), 2943-2953 (2001)
   PUBMED   11387227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE448358.1, AK146881.1, BI990545.1 and BM247306.2.
            
            On Sep 30, 2009 this sequence version replaced NM_201638.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146881.1, BC052204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BE448358.1         119-130
            13-1620             AK146881.1         2-1609
            1621-2048           BI990545.1         173-600
            2049-2625           BM247306.2         1-577               c
FEATURES             Location/Qualifiers
     source          1..2625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 53.96 cM"
     gene            1..2625
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /note="methyltransferase 14,
                     N6-adenosine-methyltransferase subunit"
                     /db_xref="GeneID:210529"
                     /db_xref="MGI:MGI:2442926"
     exon            1..229
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            230..318
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            319..406
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            407..487
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            488..575
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            576..666
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            667..808
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            809..901
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1018
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1229
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..2625
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2602..2607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /note="hexamer: AATAAA"
     polyA_site      2623
                     /gene="Mettl14"
                     /gene_synonym="G430022H21Rik; mKIAA1627"
                     /note="major polyA site"
ORIGIN      
        1 atagcctgtt tcaggcgcgc cggaaacttc ctcctgaggg acgtgaaagt ctccgggtca
       61 gaatctctgc ggggcgggac ccggtgtttc ctggtttggc aggtggattt gcattttggc
      121 gggcgcggag tctgtcgggg tggtgagcag ccgaagctgg ggcatggata gccgcctgca
      181 ggagatccgg gagcggcaga agttacggcg gcagctccta gctcagcagt tgggagctga
      241 gagtgcggat agcattggtg ctgtgttaaa tagcaaagat gaacagaggg agattgctga
      301 aaccagagaa acctgcaggg cttcctatga tacatctgct ccaaactcaa aacggaagtg
      361 tctggatgaa ggagagactg atgaagacaa agtagaagaa tataaggatg aactggaaat
      421 gcagcaggag gaagagaatt tgccatatga agaagagatt tacaaagatt ccagtacctt
      481 tcttaaggga acgcagagct taaatcccca taatgattac tgccaacatt ttgtagacac
      541 tggacacaga cctcagaatt tcatcaggga tgtaggttta gctgacagat ttgaagaata
      601 ccctaaactt agggaactca tcagactaaa ggatgagtta atagctaagt caaacactcc
      661 tcccatgtac ttacaagcag acatagaagc ctttgacatc agagaattga cacccaaatt
      721 tgatgtgatt ctcctggagc cccctctgga agaatactat agagagactg gcatcactgc
      781 gaatgagaaa tgctggacct gggatgatat tatgaagtta gaaatcgatg agattgcagc
      841 acctcggtca tttatatttc tctggtgcgg ttctggggaa ggattggacc ttgggagagt
      901 atgcttgcga aagtggggtt acagaagatg tgaagatatt tgttggatta aaaccaataa
      961 aaacaatcct ggaaagacaa agactctaga tccaaaggca gttttccaga gaacaaagga
     1021 gcattgcctg atggggatca aaggaaccgt gaagcgaagc acagacgggg acttcattca
     1081 tgctaatgtt gacattgact taattatcac agaagaacct gagattggca atatagaaaa
     1141 accagtagaa atttttcata taatagaaca tttttgtctt ggtagaagac gccttcatct
     1201 ctttgggaga gatagcacta tcaggccagg ctggctcaca gttggaccaa cgcttacaaa
     1261 cagtaactac aatgcagaaa catatgcatc gtatttcagt gcccccaact catacttgac
     1321 cggatgtaca gaggaaatcg agaggcttcg accgaagtca cctcctccca agtccaagtc
     1381 tgaccgtggg ggtggagctc ccagaggtgg aggaaggggg ggaacatctg ctggccgtgg
     1441 tcgggaaaga aaccgatcca atttccgagg agagagaggt ggctttaggg ggggccgtgg
     1501 aggcacgcac agaggcggct ttactcctcg gtagctctta cacttgcatc tttatcacag
     1561 tggagacttg cttcagagct cactcccagc ttgtactttg ctttagtttc tcatgctgcc
     1621 agaaagatct tagccacccc accccacccc agggactggc agttgtcaca gactgagctt
     1681 ttgctcaggg tgggtgagtc acgtgtgcgc aacaccccga cctgacttga ctgattccag
     1741 tcaaggcttt ggcttcctgg aaatggctgc gcagaggctt cggcatctca gaggagtggc
     1801 aggagtgggt gctgtgttcc ctgtcatggc tgcacggcag caggaggctg ggaacccggg
     1861 tagaacagaa ttagagaggt ggtcactgtg ttgggccttt aatgttttct tgttgaaaca
     1921 ctaaaaagag aagagttttt ccccttactt ttaaattcta aaaaataaca tgaagtatca
     1981 tttgagttcc cagaactcgg gaggggaaat gaaatctcgt tcttccagat cagaatctga
     2041 ggtggttgca gtcgtcaggg taggtaacgg gagaggcagg cagagcatgg gatatttcaa
     2101 acaaaaccaa gcttatcata atgtaaatta gcggctacag atggctcctg accatgtgtc
     2161 ttcagaagca agacaaggca tgtatgtctc caggtcggag tgtgaacctg atcttgggct
     2221 aacctaagat aattcagatt tcttagcaaa ggcaaaaaca gatttgggga ggggctggtt
     2281 taaacggttg agaaaataaa atcttgatga tgaggaaatg acaaacatct ttaaagttgt
     2341 tactaaagaa aatttaggta aaagcaattc cagaaaaccc ttacgaatac agcgtggaag
     2401 aggacctgca gtgtcctttg attagaacta tgtggtgcag aagtcgccgc agggctgatg
     2461 ggcagatctc ttggctgtgg gaagcttcgt gctgttgcct ttctacacct taagtcctat
     2521 ttgatggatt tggatatgcc agatgagata atgccaatat tgttctgggt aactcctttt
     2581 ttattttgct ataacttttc taataaaaat ttaaaccttt gaatt
//
