LOCUS       NM_144877               4521 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus methyltransferase 13, eEF1A lysine and N-terminal
            methyltransferase (Mettl13), transcript variant 1, mRNA.
ACCESSION   NM_144877
VERSION     NM_144877.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4521)
  AUTHORS   Yu,S., Sun,Z., Wang,X., Ju,T., Wang,C., Liu,Y., Qu,Z., Liu,K.,
            Mei,Z., Li,N., Lu,M., Wu,F., Huang,M., Pang,X., Jia,Y., Li,Y.,
            Zhang,Y., Dou,S., Jiang,J., Li,X., Yang,B. and Du,W.
  TITLE     Mettl13 protects against cardiac contractile dysfunction by
            negatively regulating C-Cbl-mediated ubiquitination of SERCA2a in
            ischemic heart failure
  JOURNAL   Sci China Life Sci 66 (12), 2786-2804 (2023)
   PUBMED   37450238
  REMARK    GeneRIF: Mettl13 protects against cardiac contractile dysfunction
            by negatively regulating C-Cbl-mediated ubiquitination of SERCA2a
            in ischemic heart failure.
REFERENCE   2  (bases 1 to 4521)
  AUTHORS   Li,Y., Kobayashi,K., Murayama,K., Kawahara,K., Shima,Y., Suzuki,A.,
            Tani,K. and Takahashi,A.
  TITLE     FEAT enhances INSL3 expression in testicular Leydig cells
  JOURNAL   Genes Cells 23 (11), 952-962 (2018)
   PUBMED   30178547
  REMARK    GeneRIF: Results suggest that FEAT facilitates the INSL3 production
            in testicular Leydig cells that is essential for transabdominal
            testis migration.
REFERENCE   3  (bases 1 to 4521)
  AUTHORS   Yousaf,R., Ahmed,Z.M., Giese,A.P., Morell,R.J., Lagziel,A.,
            Dabdoub,A., Wilcox,E.R., Riazuddin,S., Friedman,T.B. and
            Riazuddin,S.
  TITLE     Modifier variant of METTL13 suppresses human GAB1-associated
            profound deafness
  JOURNAL   J Clin Invest 128 (4), 1509-1522 (2018)
   PUBMED   29408807
REFERENCE   4  (bases 1 to 4521)
  AUTHORS   Li,Y., Kobayashi,K., Mona,M.M., Satomi,C., Okano,S., Inoue,H.,
            Tani,K. and Takahashi,A.
  TITLE     Immunogenic FEAT protein circulates in the bloodstream of cancer
            patients
  JOURNAL   J Transl Med 14 (1), 275 (2016)
   PUBMED   27659353
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4521)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   6  (bases 1 to 4521)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC138218.15.
            
            On Mar 13, 2023 this sequence version replaced NM_144877.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173044.1, AK146751.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               AC138218.15        95005-95430         c
            427-1186            AC138218.15        92669-93428         c
            1187-1386           AC138218.15        91087-91286         c
            1387-1582           AC138218.15        89159-89354         c
            1583-1750           AC138218.15        85733-85900         c
            1751-1963           AC138218.15        84020-84232         c
            1964-2095           AC138218.15        82743-82874         c
            2096-4521           AC138218.15        79026-81451         c
FEATURES             Location/Qualifiers
     source          1..4521
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 70.29 cM"
     gene            1..4521
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /note="methyltransferase 13, eEF1A lysine and N-terminal
                     methyltransferase"
                     /db_xref="GeneID:71449"
                     /db_xref="MGI:MGI:1918699"
     exon            1..426
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2370
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /note="isoform 1 is encoded by transcript variant 1;
                     methyltransferase-like protein 13; eEF1A-KNMT;
                     methyltransferase like 13; EEF1A lysine and N-terminal
                     methyltransferase"
                     /codon_start=1
                     /product="eEF1A lysine and N-terminal methyltransferase
                     isoform 1"
                     /protein_id="NP_659126.1"
                     /db_xref="CCDS:CCDS15420.1"
                     /db_xref="GeneID:71449"
                     /db_xref="MGI:MGI:1918699"
                     /translation="MNLLPKSSKEFGSADYWEKFFQQRGKTAFEWYGTYLELCEVLHK
                     YIKPKEKVLVIGCGNSELSEQLYDVGYQDIVNIDISEVVIKQMKERNGSRRPHMSFLK
                     MDMTQLEFPDATFQVVLDKGTLDAVLTDEEEVTLRQVDRMLAEVGRVLQVGGRYLCIS
                     LAQAHILKKAVGHFSREGWMVRAHQVASSQDRVSEAEPRFSLPVFAFVMTKFRPVPGS
                     ALQIFELCTQEQGKPVRLESADQLAEAVRERQYYAWLCSQLRRKAGLGSVSLDLCSGD
                     TGEPRYTLHVVDNPAVKPSRDNHFAIFIIPQGRETEWLFGMEEGRKQLAASAGFRRLV
                     TVALHRGQRYAGMESIQAELSARVMELAPAGLPPQQQVPFLSVGGDIGVRTVQHQDHS
                     ALSGDYVIEDVQGEDRWYFRRLIFLSNRNVVQSEARLLKDTSHRAQKKRKKDRKKQRP
                     ADTSEDFPPAPGQSIDKSYLCCEHHKAMVAGLALLRNPELLLETPLTLLVVGLGGGSL
                     PLFVHDHFPKSRIDAVEIDPTMLEVATQWFGFSQSDRMKVHIADGLDYITSLAGEAPP
                     HYDVIMFDVDSKDPTLGMSCPPPAFVDQVFLQKVKSILCHDGVFILNLVCRDVRLKDS
                     VLAGLKAAFPLLYVRRIEGEVNEILFCQLHPEQKLATPELLEMAQVLERTLRKPGQGW
                     DDTYVLSDMLKTVKIV"
     exon            427..1186
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1386
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1582
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1750
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1963
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2095
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..4521
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2955..2960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /note="hexamer: AATAAA"
     polyA_site      2975
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /note="major polyA site"
     regulatory      4501..4506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
                     /note="hexamer: AATAAA"
     polyA_site      4521
                     /gene="Mettl13"
                     /gene_synonym="5630401D24Rik; Eef1aknmt"
ORIGIN      
        1 aggttctgag tgtagctgcg ggagtgtgtg gctgctgcac gtggggcgcg gaccgagggt
       61 gaagaaaaac aaggggggcg gcagcggcgc gtggccagct cagtggttcg tccgcgcgtc
      121 tgctgcacag ggcccggttc ggttgggttt tgcgtgcaga acaaatctat ggtgcctgta
      181 gtggctaaga ttcccgccgc tgctgcctcc cggtgcttcc cggggtgatc tgtcaccagg
      241 agcagtgtcg aagacgccgc tcacggtggg aacatgaatc tcctacctaa aagctccaag
      301 gagtttggct ctgccgacta ctgggagaag ttcttccagc agcgagggaa gacagctttc
      361 gagtggtatg ggacctatct ggagctgtgc gaggtgctgc acaaatacat aaagcccaag
      421 gaaaaggtgc ttgtgatcgg atgtggcaac tcagagctca gtgaacaact ctatgatgtg
      481 ggctatcagg atatcgtgaa catcgacatc agcgaggttg tcatcaagca gatgaaggaa
      541 cgcaatggca gccgacggcc ccacatgagt ttcctgaaga tggacatgac ccagctggag
      601 tttcctgacg ccacattcca ggtggtgttg gacaagggca cgctggatgc tgtcctgaca
      661 gatgaggagg aggtgaccct gcgtcaggtg gacaggatgc tagctgaggt tggccgtgtc
      721 ctgcaggtgg gcggtcgcta cctctgcatc tccctggctc aggctcacat cctgaagaaa
      781 gcagtgggcc acttctctcg ggaggggtgg atggtgaggg cacaccaagt ggccagcagc
      841 caggaccggg tgtctgaagc cgagccccgc ttctccctgc ccgtctttgc cttcgtcatg
      901 actaagttca ggccagtccc tggctctgcc cttcagatct ttgagctgtg tactcaggag
      961 cagggcaagc ccgtaaggct ggagagtgct gatcagctgg cggaggctgt gcgggagcgc
     1021 cagtactatg cttggctgtg tagtcagctg cgccgcaaag ccgggctggg gagtgtgtcc
     1081 ctggacttgt gcagtgggga cacgggggag ccacgctaca ccctccacgt ggtggacaac
     1141 cccgctgtga aaccatcgcg ggacaatcat tttgccattt tcatcatccc ccagggtcgc
     1201 gagaccgagt ggctctttgg catggaggag ggccggaagc agctggcagc cagtgcgggc
     1261 ttcaggaggt tggtcacagt ggctctccac cgaggccagc ggtatgctgg catggaaagc
     1321 attcaagcag agttgtcagc cagagtcatg gagctggccc cggctgggtt gcctccccag
     1381 cagcaggtgc ccttcctgtc tgtgggtggg gacattgggg tccggactgt gcagcaccaa
     1441 gaccacagtg ccttgagtgg tgactatgtt attgaggatg tgcaagggga agacagatgg
     1501 tactttcggc ggctcatctt cctcagcaac aggaacgtgg tgcagtcgga agccaggctg
     1561 ctgaaggata cgtctcacag agcccagaag aaacggaaaa aggacaggaa aaaacagcga
     1621 cctgctgata cttctgagga cttcccgcct gccccagggc agtccatcga taagagttac
     1681 ctgtgctgtg aacaccataa agccatggtt gctggccttg ccctgctgag aaaccccgag
     1741 ctactcttag agactccact gacattgctg gtggtgggtc tgggtggagg tagcctccct
     1801 ctcttcgttc acgatcattt cccgaagtcc cgcatcgatg ctgttgagat tgaccccaca
     1861 atgttggaag tggccactca gtggtttggc ttctcacaga gcgaccggat gaaggttcac
     1921 attgcagatg gtcttgacta cattaccagc ctggcaggag aagcgccgcc tcactatgat
     1981 gtgataatgt ttgatgtaga cagtaaggat ccgacgctgg ggatgagctg tcctccccca
     2041 gcatttgtgg accaagtttt cctgcagaag gtcaaaagca tcctgtgtca cgacggcgtc
     2101 ttcatcctta acctcgtgtg tcgggacgtg aggttaaagg actcagtgct ggctggactc
     2161 aaggcagcct tccctctcct ctatgtccgg cggattgaag gcgaggtgaa tgaaatcctg
     2221 ttttgtcagc tgcatccaga acagaaactt gctacaccag agctcctgga aatggcccag
     2281 gttttggagc ggaccctgcg gaagcctggg cagggttggg atgacacgta tgttctgtca
     2341 gatatgctga agactgtgaa gattgtgtga gccctggggc caggcaactc agctttctgt
     2401 ccaaactgac ttgaactcct gggctgctgg gagctaaagc atgacgcaca ggacttttag
     2461 acctcatgct tttgttggtc acataatcag ctacatgctt cccacctttt gggatgggag
     2521 gcagcatggg ggtgatgatg aaagccgggt ggtggtagca caggccttaa tcccggcact
     2581 tgagaggcag aggcaaatgg atctttataa gttcaaggcc agtctgaact tacaaagtga
     2641 gttcaggaca gccaaggcta cacagatatt taatgtcttc tcaaaggtca tatgttgaaa
     2701 gctggctccc cagcccccat ggctcctttg gatgatggta gaacttggga ggaactttgt
     2761 agaaggaaat tgggtcactg gtgtgccctt gaagggccct tgggacactg gcccgcctct
     2821 ttgccttttg gctgctgtca agtgaagaac tcatcccctc atatcttccc cttcatgatg
     2881 ccctgcctta ccacaggcac aaggacagtg actgggtctg gtcactgcta gcctggaacc
     2941 tccacactaa gccaaataaa ctttctttct tgaaagttgg tttatctcaa gtatttttat
     3001 agtaactgaa agaggcagtt ttcagcttca tttcccacac aacggacatt tgtatcactg
     3061 gggacccatg ctccccagct gctggccttg tgctcagtcc ctcctctgag tcctcggaca
     3121 ctcactagct tttgcagagg ttttatgtac acagagccac ttcctgtgtc ccatctttcc
     3181 cactaaagaa tggtttggtg ctgggtatgg ggtgccacac gcctttagtc ccagtgcttg
     3241 ggaggcagag gcaggtggat ctccatgagt ctgaggccag ccaaggcaca gagaaacgtt
     3301 tgtctcaaca aataaaacaa gaatgatttg tttttgtatt aatgtcaggc aaatgactat
     3361 gcaaaattta aagaacacga ttctttacat acacatataa tgttctcaga ttatatttcc
     3421 ccaccccatt attctctcat ctttcctctc aacaaacccg tttttcctac caaaactttc
     3481 ttcttttttg gtaggccact gcatttaatt agtgttgctt gtatgaccat gagtggagtt
     3541 tatttactca agcaacagca acttagagtg ggcacagccc tgtggagcct tatttctacc
     3601 accaacccca caaacattaa ccatacagct tcttgggagg ggtgggtcct tgtgagccct
     3661 tctttgtaag agttgtgcct aactttgggc ataacaggca ctggggaagg aaagttgtga
     3721 acttaagacc actaacagat tttgaagtga tttaggcata acacatgcta agggaaacac
     3781 catgcagtgg cccctgtggt tcttggagcc ctgtagatcc acagaaaggt atccctagtg
     3841 tgcctaggtt tttatgatga gtcctataat tcagaaatcg aaagatggac ctcactggct
     3901 aaaactgagt tgttaacaga gttgcataca gcagtgctgg agaccgaaga gcagagagcc
     3961 tcattctggt gaccacctgc ctcgttttct aacatttcct agcttctaca ggccaactga
     4021 actataggac tgtatggtaa tgtctgagtt catctaagct cagagtagca tgccacaagc
     4081 agtcctagga agctaatctg ggctggttta aaggccactg aggttgaagt ctactctgat
     4141 tggacacact ctgggaacca ggaacgagtt gctatcagtg gtcagcattt ttactgcctg
     4201 gtcgtatgtc aacttgacat aagctaagag tcatcagaaa ggagcctttg ttgagggaat
     4261 gcctcaatga aattcagctg gaaagcattt tctcaattag tggtcaatag ggcccattgt
     4321 aggtggtgcc atccctaggt tggttgtcct gggttctata agaaagcaag ccgagcaagc
     4381 catttcaagc aagccagtaa acacccctcc atgttagctt ctgcctccaa attcctgccc
     4441 tgtttgagtt cctgtcctga cttcctttgg tgatgaacag caatgtggaa gtttaagctg
     4501 aataaaccct tttctcctca a
//
