LOCUS       NM_010792                887 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus methyltransferase 1, tRNA methylguanosine (Mettl1),
            mRNA.
ACCESSION   NM_010792
VERSION     NM_010792.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 887)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 887)
  AUTHORS   Yu,S., Sun,Z., Ju,T., Liu,Y., Mei,Z., Wang,C., Qu,Z., Li,N., Wu,F.,
            Liu,K., Lu,M., Huang,M., Pang,X., Jia,Y., Li,Y., Zhang,Y., Dou,S.,
            Jiang,J., Dong,X., Huang,C., Li,W., Zhang,Y., Yuan,Y., Yang,B. and
            Du,W.
  TITLE     The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by
            Regulating SRSF9-Mediated Splicing of NFATc4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2308769 (2024)
   PUBMED   38810124
  REMARK    GeneRIF: The m7G Methyltransferase Mettl1 Drives Cardiac
            Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
REFERENCE   3  (bases 1 to 887)
  AUTHORS   Zeng,X., Liao,G., Li,S., Liu,H., Zhao,X., Li,S., Lei,K., Zhu,S.,
            Chen,Z., Zhao,Y., Ren,X., Su,T., Cheng,A.S., Peng,S., Lin,S.,
            Wang,J., Chen,S. and Kuang,M.
  TITLE     Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents
            hepatocellular carcinoma recurrence after radiofrequency ablation
  JOURNAL   Hepatology 77 (4), 1122-1138 (2023)
   PUBMED   35598182
  REMARK    GeneRIF: Eliminating METTL1-mediated accumulation of PMN-MDSCs
            prevents hepatocellular carcinoma recurrence after radiofrequency
            ablation.
REFERENCE   4  (bases 1 to 887)
  AUTHORS   Han,H., Yang,C., Ma,J., Zhang,S., Zheng,S., Ling,R., Sun,K.,
            Guo,S., Huang,B., Liang,Y., Wang,L., Chen,S., Wang,Z., Wei,W.,
            Huang,Y., Peng,H., Jiang,Y.Z., Choe,J. and Lin,S.
  TITLE     N7-methylguanosine tRNA modification promotes esophageal squamous
            cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis
  JOURNAL   Nat Commun 13 (1), 1478 (2022)
   PUBMED   35304469
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 887)
  AUTHORS   Dai,Z., Liu,H., Liao,J., Huang,C., Ren,X., Zhu,W., Zhu,S., Peng,B.,
            Li,S., Lai,J., Liang,L., Xu,L., Peng,S., Lin,S. and Kuang,M.
  TITLE     N7-Methylguanosine tRNA modification enhances oncogenic mRNA
            translation and promotes intrahepatic cholangiocarcinoma
            progression
  JOURNAL   Mol Cell 81 (16), 3339-3355 (2021)
   PUBMED   34352206
REFERENCE   6  (bases 1 to 887)
  AUTHORS   Zhang,L.S., Liu,C., Ma,H., Dai,Q., Sun,H.L., Luo,G., Zhang,Z.,
            Zhang,L., Hu,L., Dong,X. and He,C.
  TITLE     Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome
            in Mammalian mRNA
  JOURNAL   Mol Cell 74 (6), 1304-1316 (2019)
   PUBMED   31031084
  REMARK    GeneRIF: METTL1 acts as a methyltransferase for a subset of
            internal N(7)-methylguanosine sites in mRNA.
REFERENCE   7  (bases 1 to 887)
  AUTHORS   Jung,H., Park,H., Choi,Y., Kang,H., Lee,E., Kweon,H., Roh,J.D.,
            Ellegood,J., Choi,W., Kang,J., Rhim,I., Choi,S.Y., Bae,M.,
            Kim,S.G., Lee,J., Chung,C., Yoo,T., Park,H., Kim,Y., Ha,S.,
            Um,S.M., Mo,S., Kwon,Y., Mah,W., Bae,Y.C., Kim,H., Lerch,J.P.,
            Paik,S.B. and Kim,E.
  TITLE     Sexually dimorphic behavior, neuronal activity, and gene expression
            in Chd8-mutant mice
  JOURNAL   Nat Neurosci 21 (9), 1218-1228 (2018)
   PUBMED   30104731
REFERENCE   8  (bases 1 to 887)
  AUTHORS   Bahr,A., Hankeln,T., Fiedler,T., Hegemann,J. and Schmidt,E.R.
  TITLE     Molecular analysis of METTL1, a novel human methyltransferase-like
            gene with a high degree of phylogenetic conservation
  JOURNAL   Genomics 57 (3), 424-428 (1999)
   PUBMED   10329009
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB023619.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB023619.1, AK160914.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..887
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /note="methyltransferase 1, tRNA methylguanosine"
                     /db_xref="GeneID:17299"
                     /db_xref="MGI:MGI:1339986"
     exon            1..139
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..854
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /EC_number="2.1.1.33"
                     /note="mRNA (guanine-N(7)-)-methyltransferase; miRNA
                     (guanine-N(7)-)-methyltransferase; methyltransferase like
                     1"
                     /codon_start=1
                     /product="tRNA (guanine-N(7)-)-methyltransferase"
                     /protein_id="NP_034922.1"
                     /db_xref="CCDS:CCDS24223.1"
                     /db_xref="GeneID:17299"
                     /db_xref="MGI:MGI:1339986"
                     /translation="MMAGAEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELY
                     PEFFAPLIQNKSHDDPKDEKEKHSGAQVEFADIGCGYGGLLVALSPLFPDTLILGLEI
                     RVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFRKGQLAKMFFLFPDPHF
                     KRTKHKWRIISPTLLAEYAYVLRVGGLVYTVTDVPELHEWMCTHFEEHPLFERVPLEE
                     LSEDPIVEHLGSSTEEGKKVLRNGGKNFPAVFRRIQDPLLQAVTPNPTLP"
     exon            140..303
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            304..488
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            489..602
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            603..704
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            705..887
                     /gene="Mettl1"
                     /gene_synonym="2810012D02Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcatcacctc gcgccgcgag ctcggctctc cacgtggact gcgtggcatg atggcgggag
       61 ccgaagcccc ccagccgcag aagcgctact accggcagcg cgcccactcc aaccccatgg
      121 cagaccacac actgcgctac cctgtgaagc cagaggaaat ggactggtct gagctttacc
      181 cagagttctt tgctccgctt attcaaaata agagccatga tgatccaaag gatgagaaag
      241 aaaagcactc tggggcccaa gtggagtttg cagacatagg ctgtggctat ggtggcttgt
      301 tagtggcact gtcaccgctc ttcccagata ccctgattct gggtctggag attcgggtga
      361 aggtgtcgga ctatgtgcag gacaggattc gggccctccg tgcagctccc gggggcggat
      421 tccagaacat cgcctgtctc cgaagtaacg ccatgaaaca ccttcctaat ttcttccgca
      481 agggccagct ggcaaagatg ttcttcctct tcccggaccc acactttaag cgaacgaagc
      541 ataaatggag aatcatcagc cctacgcttc tggcagagta tgcctacgtg ctgagagtcg
      601 ggggcctggt gtacaccgtc accgacgtgc cggagctgca tgagtggatg tgcacccact
      661 ttgaagaaca cccactgttt gagcgtgtgc ctcttgaaga gctaagtgaa gaccccattg
      721 tggaacatct aggcagttca actgaggaag gaaagaaagt tctacgcaat gggggaaaga
      781 atttcccagc cgtcttccga agaatacagg atcccctcct ccaggcagtg acccccaacc
      841 ccaccctgcc ttagccagac cccctagaag gtgactggaa aaaagat
//
