LOCUS       NM_144797               2468 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus meteorin, glial cell differentiation regulator-like
            (Metrnl), mRNA.
ACCESSION   NM_144797
VERSION     NM_144797.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2468)
  AUTHORS   Lin,L., Huang,S., Lin,X., Liu,X., Xu,X., Li,C. and Chen,P.
  TITLE     Upregulation of Metrnl improves diabetic kidney disease by
            inhibiting the TGF-beta1/Smads signaling pathway: A potential
            therapeutic target
  JOURNAL   PLoS One 19 (8), e0309338 (2024)
   PUBMED   39190657
  REMARK    GeneRIF: Upregulation of Metrnl improves diabetic kidney disease by
            inhibiting the TGF-beta1/Smads signaling pathway: A potential
            therapeutic target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2468)
  AUTHORS   Jackson,C.M., Pant,A., Dinalankara,W., Choi,J., Jain,A., Nitta,R.,
            Yazigi,E., Saleh,L., Zhao,L., Nirschl,T.R., Kochel,C.M., Hwa-Lin
            Bergsneider,B., Routkevitch,D., Patel,K., Cho,K.B., Tzeng,S.,
            Neshat,S.Y., Kim,Y.H., Smith,B.J., Ramello,M.C., Sotillo,E.,
            Wang,X., Green,J.J., Bettegowda,C., Li,G., Brem,H., Mackall,C.L.,
            Pardoll,D.M., Drake,C.G., Marchionni,L. and Lim,M.
  TITLE     The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell
            responses by disrupting mitochondrial function
  JOURNAL   Immunity 57 (8), 1864-1877 (2024)
   PUBMED   39111315
REFERENCE   3  (bases 1 to 2468)
  AUTHORS   Zhang,L., Li,Y., Wu,Z., Shen,Q., Zeng,C., Liu,H., Zhang,X.,
            Yang,J., Liu,Q., Tang,D., Ou,K. and Fang,Y.
  TITLE     Metrnl inhibits choroidal neovascularization by attenuating the
            choroidal inflammation via inactivating the UCHL-1/NF-kappaB
            signaling pathway
  JOURNAL   Front Immunol 15, 1379586 (2024)
   PUBMED   38745648
  REMARK    GeneRIF: Metrnl inhibits choroidal neovascularization by
            attenuating the choroidal inflammation via inactivating the
            UCHL-1/NF-kappaB signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2468)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2468)
  AUTHORS   Chen,Z., Li,J., Peng,H., Zhang,M., Wu,X., Gui,F., Li,W., Ai,F.,
            Yu,B. and Liu,Y.
  TITLE     Meteorin-like/Meteorin-beta protects LPS-induced acute lung injury
            by activating SIRT1-P53-SLC7A11 mediated ferroptosis pathway
  JOURNAL   Mol Med 29 (1), 144 (2023)
   PUBMED   37880599
  REMARK    GeneRIF: Meteorin-like/Meteorin-beta protects LPS-induced acute
            lung injury by activating SIRT1-P53-SLC7A11 mediated ferroptosis
            pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2468)
  AUTHORS   Rao,R.R., Long,J.Z., White,J.P., Svensson,K.J., Lou,J.,
            Lokurkar,I., Jedrychowski,M.P., Ruas,J.L., Wrann,C.D., Lo,J.C.,
            Camera,D.M., Lachey,J., Gygi,S., Seehra,J., Hawley,J.A. and
            Spiegelman,B.M.
  TITLE     Meteorin-like is a hormone that regulates immune-adipose
            interactions to increase beige fat thermogenesis
  JOURNAL   Cell 157 (6), 1279-1291 (2014)
   PUBMED   24906147
  REMARK    GeneRIF: Study reports the identification of meteorin-like
            (Metrnl), a circulating factor that is induced in muscle after
            exercise and in adipose tissue upon cold exposure; increasing
            circulating levels of Metrnl stimulates energy expenditure and
            improves glucose tolerance and the expression of genes associated
            with beige fat thermogenesis and anti-inflammatory cytokines.
REFERENCE   7  (bases 1 to 2468)
  AUTHORS   Li,Z.Y., Zheng,S.L., Wang,P., Xu,T.Y., Guan,Y.F., Zhang,Y.J. and
            Miao,C.Y.
  TITLE     Subfatin is a novel adipokine and unlike Meteorin in adipose and
            brain expression
  JOURNAL   CNS Neurosci Ther 20 (4), 344-354 (2014)
   PUBMED   24393292
  REMARK    GeneRIF: Results show that Subfatin is a novel adipokine regulated
            by adipogenesis and obesity, with tissue distribution different
            from its homologue Meteorin
REFERENCE   8  (bases 1 to 2468)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   9  (bases 1 to 2468)
  AUTHORS   Jorgensen,J.R., Fransson,A., Fjord-Larsen,L., Thompson,L.H.,
            Houchins,J.P., Andrade,N., Torp,M., Kalkkinen,N., Andersson,E.,
            Lindvall,O., Ulfendahl,M., Brunak,S., Johansen,T.E. and
            Wahlberg,L.U.
  TITLE     Cometin is a novel neurotrophic factor that promotes neurite
            outgrowth and neuroblast migration in vitro and supports survival
            of spiral ganglion neurons in vivo
  JOURNAL   Exp Neurol 233 (1), 172-181 (2012)
   PUBMED   21985865
  REMARK    GeneRIF: Cometin is a novel neurotrophic factor(meteorin protein
            family) that promotes neurite outgrowth and neuroblast migration in
            vitro and supports survival of spiral ganglion neurons in vivo.
REFERENCE   10 (bases 1 to 2468)
  AUTHORS   Ono,Y., Nakatani,T., Minaki,Y. and Kumai,M.
  TITLE     The basic helix-loop-helix transcription factor Nato3 controls
            neurogenic activity in mesencephalic floor plate cells
  JOURNAL   Development 137 (11), 1897-1906 (2010)
   PUBMED   20460368
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK034855.1.
            
            On Apr 5, 2007 this sequence version replaced NM_144797.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK034855.1, BC024445.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2468              AK034855.1         2-2469
FEATURES             Location/Qualifiers
     source          1..2468
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 86.89 cM"
     gene            1..2468
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /note="meteorin, glial cell differentiation
                     regulator-like"
                     /db_xref="GeneID:210029"
                     /db_xref="MGI:MGI:2384806"
     exon            1..369
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1135
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /note="meteorin-like protein; cometin; subfatin"
                     /codon_start=1
                     /product="meteorin-like protein precursor"
                     /protein_id="NP_659046.1"
                     /db_xref="CCDS:CCDS25781.1"
                     /db_xref="GeneID:210029"
                     /db_xref="MGI:MGI:2384806"
                     /translation="MRGAVWAARRRAGQQWPRSPGPGPGPPPPPPLLLLLLLLLGGAS
                     AQYSSDLCSWKGSGLTREARSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQ
                     NLTVCIKPFRDSSGANIYLEKTGELRLLVRDIRGEPGQVQCFSLEQGGLFVEATPQQD
                     ISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVP
                     EQQVSVIYLRVNRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVH
                     FGEAQLGCAPRFSDFQRMYRKAEEMGINPCEINME"
     exon            370..755
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            756..815
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            816..2468
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1344..1349
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /note="hexamer: ATTATA"
     polyA_site      1365
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
                     /note="major polyA site"
     polyA_site      1524
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
     polyA_site      1573
                     /gene="Metrnl"
                     /gene_synonym="9430048M07Rik"
ORIGIN      
        1 agaggttcta ggggcagccg gcgcgcttct ctagttgcag cttgggcggc tcctgtggtg
       61 ggcggctagg ggcgagccgg gatgggctat agacgcgcga cgtgatcagt tcgcacgcgg
      121 acccacgcct cccatcgctc tgcctcaaga gcctattctg tgggtgcagg cacgcaccgg
      181 acgcagaccc ggccggagca tgcggggtgc ggtgtgggcg gcccggaggc gcgcggggca
      241 gcagtggcct cggtccccgg gccctgggcc gggtccgccc ccgccgccac cgctgctgtt
      301 gctgctacta ctgctgctgg gcggcgcgag cgctcagtac tccagcgacc tgtgcagctg
      361 gaaggggagt gggctcaccc gagaggcacg cagcaaggag gtggagcagg tgtacctgcg
      421 ctgctccgca ggctctgtgg agtggatgta cccaactggg gcgctcattg ttaacctacg
      481 gcccaacacc ttctcacctg cccagaactt gactgtgtgc atcaagcctt tcagggactc
      541 ctctggagcc aatatttatt tggaaaaaac tggagaacta agactgttgg tgcgggacat
      601 cagaggtgag cctggccaag tgcagtgctt cagcctggag cagggaggct tatttgtgga
      661 ggcgacaccc caacaggaca tcagcagaag gaccacaggc ttccagtatg agctgatgag
      721 tgggcagagg ggactggacc tgcacgtgct gtctgccccc tgtcggcctt gcagtgacac
      781 tgaggtcctc cttgccatct gtaccagtga ctttgttgtc cgaggcttca ttgaggacgt
      841 cacacatgta ccagaacagc aagtgtcagt catctacctg cgggtgaaca ggcttcacag
      901 gcagaagagc agggtcttcc agccagctcc tgaggacagt ggccactggc tgggccatgt
      961 cacaacactg ctgcagtgtg gagtacgacc agggcatggg gaattcctct tcactggaca
     1021 tgtgcacttt ggggaggcac aacttggatg tgccccacgc tttagtgact ttcaaaggat
     1081 gtacaggaaa gcagaagaaa tgggcataaa cccctgtgaa atcaatatgg agtgacttgc
     1141 agggtgacac agtactgttg tccttcagat gagccatgtt ttgtgggctc agtcgctcta
     1201 tcatatcctg atagagattg cagactggtg gcatgggccc agcctggtgc tagaactggg
     1261 aaggtacatg ctgctctgac cccttaggtc ccagccaagg atgccctgac ccattggaac
     1321 tgctgtaaaa tgcaaactaa gttattatat tttttttgta aaagatgcct tggtgtgcca
     1381 tttaatagtg tttttacaaa gttattttca ggcattggat ttggcctggt atattggtgg
     1441 gagctaggtt atggtgtgca gtgatggcta tggctcagcc ttgttattcc tgtgatggaa
     1501 atgtatggag caaatacttt ctaatttccc cttcatttta ttttctattt taaaagacca
     1561 tctttgccgt tgagaacctt tccagactgt atggaggctg ctcccattcc agggagtaaa
     1621 gaccaggatc tgagactagt attacatcca tcttaaccca tcagatgggt acctgcattg
     1681 aaccttctct gctcagctat ggcctgctgt cccaaagacc ttttgctctc tggacagttc
     1741 cagatggtgc tgcctggctt aagggacttg ttcctccctt gctcctacca ggccactgtt
     1801 gctttctgca tctgtcccac tgaaccagtc ttgtcctttg accctgagtt tccccaaatg
     1861 cacacatcaa atccctgaat accaagggac taacctactt aatggcccat ttcttcagag
     1921 ggtgtgggtt ttccctatag taagaaaatc tccacaagtt gaagcttaaa cagtaggctt
     1981 tcgttcatac agtcctggaa gccagaatgg gtgtgagcag aatcacattt cctccggaga
     2041 ctccaggagg gactttatag cttctggtga ctccaggaat ccttggcttg taacaatttc
     2101 actctggcat tgctttccct gccatgtgac ttctgccttg tatgtgaggg cctgtatcaa
     2161 atctctgtct tgggaggata cagatcattg acttagggcc cactccggtg acctcacctt
     2221 cacctgaaat ttactcgatt tccatttagg tcagaggcaa aggctacaaa aaatatcaaa
     2281 tccggagaaa gattcaatgg ttaggcactt gctactctta caaaggacct gtgttcgatt
     2341 cccatgttgg gaactcatgt taggtggctt aaaattgcct ataactacaa ttccagggga
     2401 tctagcaacc tcttctcgcc acacacaagc acacacacac acacacacac acacacacaa
     2461 ttaaaaac
//
