LOCUS       NM_133719               1363 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus meteorin, glial cell differentiation regulator
            (Metrn), mRNA.
ACCESSION   NM_133719 XM_128551
VERSION     NM_133719.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Zhou,B., Feng,C., Sun,S., Chen,X., Zhuansun,D., Wang,D., Yu,X.,
            Meng,X., Xiao,J., Wu,L., Wang,J., Wang,J., Chen,K., Li,Z., You,J.,
            Mao,H., Yang,S., Zhang,J., Jiao,C., Li,Z., Yu,D., Wu,X., Zhu,T.,
            Yang,J., Xiang,L., Liu,J., Chai,T., Shen,J., Mao,C.X., Hu,J.,
            Hao,X., Xiong,B., Zheng,S., Liu,Z. and Feng,J.
  TITLE     Identification of signaling pathways that specify a subset of
            migrating enteric neural crest cells at the wavefront in mouse
            embryos
  JOURNAL   Dev Cell 59 (13), 1689-1706 (2024)
   PUBMED   38636517
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1363)
  AUTHORS   Rutledge,E.A., Benazet,J.D. and McMahon,A.P.
  TITLE     Cellular heterogeneity in the ureteric progenitor niche and
            distinct profiles of branching morphogenesis in organ development
  JOURNAL   Development 144 (17), 3177-3188 (2017)
   PUBMED   28705898
REFERENCE   5  (bases 1 to 1363)
  AUTHORS   Heng,X., Guo,Q., Leung,A.W. and Li,J.Y.
  TITLE     Analogous mechanism regulating formation of neocortical basal
            radial glia and cerebellar Bergmann glia
  JOURNAL   Elife 6, e23253 (2017)
   PUBMED   28489004
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1363)
  AUTHORS   Coulpier,F., Le Crom,S., Maro,G.S., Manent,J., Giovannini,M.,
            Maciorowski,Z., Fischer,A., Gessler,M., Charnay,P. and Topilko,P.
  TITLE     Novel features of boundary cap cells revealed by the analysis of
            newly identified molecular markers
  JOURNAL   Glia 57 (13), 1450-1457 (2009)
   PUBMED   19243017
REFERENCE   7  (bases 1 to 1363)
  AUTHORS   Jorgensen,J.R., Thompson,L., Fjord-Larsen,L., Krabbe,C., Torp,M.,
            Kalkkinen,N., Hansen,C. and Wahlberg,L.
  TITLE     Characterization of Meteorin--an evolutionary conserved
            neurotrophic factor
  JOURNAL   J Mol Neurosci 39 (1-2), 104-116 (2009)
   PUBMED   19259827
  REMARK    GeneRIF: Data show that Meteorin is expressed in the central
            nervous system both during development and in adult mice.
REFERENCE   8  (bases 1 to 1363)
  AUTHORS   Park,J.A., Lee,H.S., Ko,K.J., Park,S.Y., Kim,J.H., Choe,G.,
            Kweon,H.S., Song,H.S., Ahn,J.C., Yu,Y.S. and Kim,K.W.
  TITLE     Meteorin regulates angiogenesis at the gliovascular interface
  JOURNAL   Glia 56 (3), 247-258 (2008)
   PUBMED   18059000
REFERENCE   9  (bases 1 to 1363)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 1363)
  AUTHORS   Nishino,J., Yamashita,K., Hashiguchi,H., Fujii,H., Shimazaki,T. and
            Hamada,H.
  TITLE     Meteorin: a secreted protein that regulates glial cell
            differentiation and promotes axonal extension
  JOURNAL   EMBO J 23 (9), 1998-2008 (2004)
   PUBMED   15085178
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087402.1 and BF472326.1.
            
            On Dec 10, 2004 this sequence version replaced NM_133719.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK087402.1, SRR1660817.472242.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143, SAMN02415130
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-866               AK087402.1         2-867
            867-1305            AK087402.1         869-1307
            1306-1363           BF472326.1         215-272
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.89 cM"
     gene            1..1363
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
                     /note="meteorin, glial cell differentiation regulator"
                     /db_xref="GeneID:70083"
                     /db_xref="MGI:MGI:1917333"
     exon            1..181
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..959
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
                     /note="hypoxia/reoxygenation regulatory factor in
                     astrocytes"
                     /codon_start=1
                     /product="meteorin precursor"
                     /protein_id="NP_598480.1"
                     /db_xref="CCDS:CCDS28529.1"
                     /db_xref="GeneID:70083"
                     /db_xref="MGI:MGI:1917333"
                     /translation="MLVATLLCALCCGLLAASAHAGYSEDRCSWRGSGLTQEPGSVGQ
                     LTLDCTEGAIEWLYPAGALRLTLGGPDPGTRPSIVCLRPERPFAGAQVFAERMTGNLE
                     LLLAEGPDLAGGRCMRWGPRERRALFLQATPHRDISRRVAAFRFELHEDQRAEMSPQA
                     QGLGVDGACRPCSDAELLLAACTSDFVIHGTIHGVAHDTELQESVITVVVARVIRQTL
                     PLFKEGSSEGQGRASIRTLLRCGVRPGPGSFLFMGWSRFGEAWLGCAPRFQEFSRVYS
                     AALTTHLNPCEMALD"
     exon            182..582
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
                     /inference="alignment:Splign:2.1.0"
     exon            583..642
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
                     /inference="alignment:Splign:2.1.0"
     exon            643..1363
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1109
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
                     /note="major polyA site"
     polyA_site      1307
                     /gene="Metrn"
                     /gene_synonym="1810034B16Rik; EyeLinc16; Hyrac"
ORIGIN      
        1 gggcagccgc gccgcgggct gctcgcgctg cggccccgac cctcccgggg cagcagtccg
       61 aggccccggc gcgtccccta accatgctgg tagccacgct tctttgcgcg ctctgttgcg
      121 gcctcctggc cgcgtccgct cacgctggct actcggaaga ccgctgcagc tggaggggca
      181 gcggtttgac ccaggagcct ggcagcgtgg ggcagctgac cctggactgt actgagggcg
      241 ctatcgagtg gctgtaccca gctggggcgc tgcgcctgac cctgggcggc cccgatccgg
      301 gcacacggcc cagcatcgtc tgtctgcgcc cagagcggcc cttcgctggt gcccaggtct
      361 tcgctgaacg tatgaccggc aatctagagt tgctactggc cgagggcccg gacctggctg
      421 ggggccgctg catgcgctgg ggtccccgcg agcgccgagc ccttttcctg caggccacac
      481 cacaccgcga catcagccgc agagttgctg ccttccgttt tgaactgcac gaggaccaac
      541 gtgcagaaat gtctccccag gctcaaggtc ttggtgtgga tggtgcctgc aggccctgca
      601 gtgatgccga gctcctcctg gctgcatgca ccagtgattt tgtgatccac gggaccatcc
      661 atggggtcgc ccatgacaca gagctgcaag aatcagtcat cactgtggtg gttgctcgtg
      721 tcatccgcca gacactgcca ctgttcaagg aagggagctc ggagggccaa ggccgggcct
      781 ccattcgtac cttgctgcgc tgtggtgtgc gtcctggccc aggctccttc ctcttcatgg
      841 gctggagccg atttggcgaa gcttggctgg gctgtgctcc ccgcttccaa gagttcagcc
      901 gtgtctattc agctgctctc acgacccatc tcaacccatg tgagatggca ctggactgag
      961 agacctggga gcaagccctg gatggacctt cttctggaga tggggtgttg gggagggtga
     1021 tgggagggtg ggtgagaagg gtgtggctcg gatggcatcc tggtacccac agtgagctgg
     1081 tagaatacta agtaatctgg accataccag ccactgtagt catggtcttc tgtggcaggc
     1141 agcataccca gctctgtgcc tgcctcactt tgtctactct ccagtctgct gcccttctaa
     1201 cccttcttag cctgctgacc agtgagctca tgttttcctc gaattccagg gtgctgctgg
     1261 ggttcagagc aaccgtgccg tagtttggaa gacttgagct aattgttttt tttttgtttg
     1321 tttttttgtt tgtttaaagg tggcctgggg ggggcggcaa aca
//
