LOCUS       NM_019648               4990 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus methionine aminopeptidase 2 (Metap2), mRNA.
ACCESSION   NM_019648
VERSION     NM_019648.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4990)
  AUTHORS   Zhao,L., Zhang,R., Zhang,S., Zhang,H., Yang,Q. and Xu,Z.
  TITLE     Upregulation of p67phox in response to ischemia/reperfusion is
            cardioprotective by increasing ZIP2 expression via STAT3
  JOURNAL   Free Radic Res 56 (1), 115-126 (2022)
   PUBMED   35296207
  REMARK    GeneRIF: Upregulation of p67(phox) in response to
            ischemia/reperfusion is cardioprotective by increasing ZIP2
            expression via STAT3.
REFERENCE   2  (bases 1 to 4990)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4990)
  AUTHORS   Esa,R., Steinberg,E., Dror,D., Schwob,O., Khajavi,M., Maoz,M.,
            Kinarty,Y., Inbal,A., Zick,A. and Benny,O.
  TITLE     The Role of Methionine Aminopeptidase 2 in Lymphangiogenesis
  JOURNAL   Int J Mol Sci 21 (14), 5148 (2020)
   PUBMED   32708166
  REMARK    GeneRIF: The Role of Methionine Aminopeptidase 2 in
            Lymphangiogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4990)
  AUTHORS   Pottorf,T.S., Fagan,M.P., Burkey,B.F., Cho,D.J., Vath,J.E. and
            Tran,P.V.
  TITLE     MetAP2 inhibition reduces food intake and body weight in a
            ciliopathy mouse model of obesity
  JOURNAL   JCI Insight 5 (2), 134278 (2020)
   PUBMED   31877115
  REMARK    GeneRIF: MetAP2 inhibition reduces food intake and body weight in a
            ciliopathy mouse model of obesity.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4990)
  AUTHORS   Warder,S.E., Tucker,L.A., McLoughlin,S.M., Strelitzer,T.J.,
            Meuth,J.L., Zhang,Q., Sheppard,G.S., Richardson,P.L.,
            Lesniewski,R., Davidsen,S.K., Bell,R.L., Rogers,J.C. and Wang,J.
  TITLE     Discovery, identification, and characterization of candidate
            pharmacodynamic markers of methionine aminopeptidase-2 inhibition
  JOURNAL   J Proteome Res 7 (11), 4807-4820 (2008)
   PUBMED   18828628
  REMARK    GeneRIF: Discovery, identification, and characterization of
            candidate pharmacodynamic markers of Metap2 inhibition are
            reported.
REFERENCE   6  (bases 1 to 4990)
  AUTHORS   Datta,R., Tammali,R. and Datta,B.
  TITLE     Negative regulation of the protection of eIF2alpha phosphorylation
            activity by a unique acidic domain present at the N-terminus of p67
  JOURNAL   Exp Cell Res 283 (2), 237-246 (2003)
   PUBMED   12581743
REFERENCE   7  (bases 1 to 4990)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 4990)
  AUTHORS   Endo,H., Takenaga,K., Kanno,T., Satoh,H. and Mori,S.
  TITLE     Methionine aminopeptidase 2 is a new target for the
            metastasis-associated protein, S100A4
  JOURNAL   J Biol Chem 277 (29), 26396-26402 (2002)
   PUBMED   11994292
  REMARK    GeneRIF: the functional role of S100A4 in regulating endothelial
            cell growth and tumor metastasis involves interaction with the
            N-terminal half of Methionine Aminopeptidase 2.
REFERENCE   9  (bases 1 to 4990)
  AUTHORS   Li,X. and Chang,Y.H.
  TITLE     Molecular cloning of a human complementary DNA encoding an
            initiation factor 2-associated protein (p67)
  JOURNAL   Biochim Biophys Acta 1260 (3), 333-336 (1995)
   PUBMED   7873610
REFERENCE   10 (bases 1 to 4990)
  AUTHORS   Wu,S., Gupta,S., Chatterjee,N., Hileman,R.E., Kinzy,T.G.,
            Denslow,N.D., Merrick,W.C., Chakrabarti,D., Osterman,J.C. and
            Gupta,N.K.
  TITLE     Cloning and characterization of complementary DNA encoding the
            eukaryotic initiation factor 2-associated 67-kDa protein (p67)
  JOURNAL   J Biol Chem 268 (15), 10796-10801 (1993)
   PUBMED   8496145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165301.1, AF434712.1 and AC124686.3.
            
            On Dec 21, 2005 this sequence version replaced NM_019648.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK165301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-611               AK165301.1         2-612
            612-2550            AF434712.1         2-1940
            2551-4990           AC124686.3         112932-115371       c
FEATURES             Location/Qualifiers
     source          1..4990
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 48.69 cM"
     gene            1..4990
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /note="methionine aminopeptidase 2"
                     /db_xref="GeneID:56307"
                     /db_xref="MGI:MGI:1929701"
     exon            1..106
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            107..843
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             693..2129
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /EC_number="3.4.11.18"
                     /note="initiation factor 2-associated protein (p67);
                     peptidase M 2; MAP 2; metAP 2; initiation factor
                     2-associated 67 kDa glycoprotein; eIF-2-associated p67"
                     /codon_start=1
                     /product="methionine aminopeptidase 2"
                     /protein_id="NP_062622.1"
                     /db_xref="CCDS:CCDS48673.1"
                     /db_xref="GeneID:56307"
                     /db_xref="MGI:MGI:1929701"
                     /translation="MAGVEQAASFGGHLNGDLDPDDREEGTSSTAEEAAKKKRRKKKK
                     GKGAVSAVQQELDKESGALVDEVAKQLESQALEEKERDDDDEDGDGDADGATGKKKKK
                     KKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQ
                     ASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLA
                     FPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDIL
                     LTAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIG
                     PYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHV
                     PIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDI
                     KGSYTAQFEHTILLRPTCKEVVSRGDDY"
     exon            844..951
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1017
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1120
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1282
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1464
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1559
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1656
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1760
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1876
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..4990
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2125..2130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /note="hexamer: ATTAAA"
     polyA_site      2147
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
     regulatory      2531..2536
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /note="hexamer: AATAAA"
     polyA_site      2559
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /note="major polyA site"
     regulatory      4963..4968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
                     /note="hexamer: AATAAA"
     polyA_site      4990
                     /gene="Metap2"
                     /gene_synonym="4930584B20Rik; A930035J23Rik; Amp2; Mnpep;
                     p67; p67eIF2"
ORIGIN      
        1 aacctttgga tgtaggcagt ttatctttga ctccacctca tccacagcct cctgggccag
       61 aaacctgggt gccattctta ccttctcccc cgcctccaag atcaagagat tctcccgctt
      121 ctctgcggag tgctgggatt aaacggatta accgcctcca agcgatgatc ctatcttgaa
      181 ccatcggagg tttggagtgc agcatacgaa acgcggaatt ccggcttcca aaattatccc
      241 acgcttctcg acagcttccc cgcgagctgt gacagtgagt ttaacgcggt ctttgagtca
      301 tcaagaatgt gtgtgataaa tacattattt taaccctctc tcatcactgc ctgtaggatt
      361 ttttttttta aatagggaac actaaattcc tcgtgttagt ggcatctcct gcgcactctg
      421 gagcgaagcc cccctgcttt ttcccaggct gggaagatgc gcacaggggg tgcagaagct
      481 tagggtcaga gtaagcgctg agccaggaga gggggcgggc acttagaccg cgtgctgcag
      541 agtcctccgc cgtcccagca ttccctgcgt ccggaccatc gagcgcggct tccggcgtcg
      601 ctggtggagg tgggtgaaga aggagcgggc cctcgccgct cgttctcgct ccctctctct
      661 ctctctctct ccctctctct ttctcgggca acatggcggg cgtggagcag gcagcgtcct
      721 tcgggggcca cctgaatggc gacctggatc cagacgacag ggaagaggga acctccagca
      781 cggccgagga agccgccaag aagaaaagac ggaagaagaa gaagggcaaa ggggctgtgt
      841 cagcagtgca acaagaactt gataaagaat ccggagcctt ggtggatgaa gtagcaaaac
      901 agctggagag ccaagcactg gaggagaagg agagagatga cgacgatgaa gatggagatg
      961 gtgatgctga tggtgcaact gggaagaaga agaaaaagaa gaagaagaag agaggaccaa
     1021 aagttcaaac agaccctccc tcagttccaa tatgtgacct gtatcctaat ggtgtatttc
     1081 ccaaaggaca agagtgtgaa tacccaccca cacaagatgg gcggacagct gcttggagaa
     1141 ccacaagtga ggaaaaaaag gccctagacc aggccagtga ggagatctgg aacgacttcc
     1201 gagaagctgc ggaggcacat cggcaagtta ggaaatatgt catgagctgg atcaagcctg
     1261 ggatgacgat gatagaaatc tgtgagaagt tggaagactg ttcccgaaag ctaataaagg
     1321 aaaatgggtt aaatgcaggc ctggcgttcc ccactgggtg ttctctcaac aactgtgctg
     1381 cccattacac tcccaatgct ggtgacacga cagtcttgca gtatgatgac atctgtaaga
     1441 tagactttgg aacacatata agtggtagaa taatcgattg tgcttttact gttactttta
     1501 atcccaaata tgacatacta ttaacagctg taaaggatgc cactaatact ggaataaagt
     1561 gtgctgggat tgacgttcgt ctctgcgatg tcggtgaggc cattcaagaa gttatggaat
     1621 cctatgaagt agaaatagat gggaagacat accaagtgaa acccatacgt aacttaaatg
     1681 gacattcaat tgggccatat agaattcacg ctggaaaaac ggtgcccatt gtgaaaggag
     1741 gggaagctac aagaatggag gaaggagagg tgtatgccat tgagaccttt gggagcacgg
     1801 ggaagggcgt ggttcatgac gacatggaat gttcacacta catgaaaaat tttgatgtgg
     1861 ggcacgtgcc aataaggctt ccaagaacaa aacacttgtt aaatgtcatc aacgaaaact
     1921 tcggtaccct tgccttctgc cgaaggtggc tggatcgctt gggagaaagt aaatacttga
     1981 tggctctgaa gaatctgtgt gacttgggca ttgtagatcc atacccacca ctgtgtgaca
     2041 ttaaagggtc atatacagca cagtttgaac acactatact gttgcgtcca acctgtaaag
     2101 aagttgtcag cagaggagat gactattaaa acttagtcca aagccaactc aacgtcttta
     2161 ttttctaagc tttgttggaa cacattatac cacaagtaat ttgcaacatg ttgtctgttt
     2221 tagcagtgga cctgtgtaat accgttattc atgtttaaag gagtttgatc aaaggcaaac
     2281 tgtctacatg taattaacca aggaaaaggc tttcaagact ttaatgttaa ctgtttctcc
     2341 cgtctaggaa atgctgtact gctcactagt taggaattac tcacacgttt tgttttgaag
     2401 acctaagaga tgctttttgg atatttatat tgccatattc ttacttggat gctttgaatg
     2461 acttcattca gttctgcacc tgtgccctct ggtattgctt tttaacctcc ctggaatcca
     2521 ttttctaaaa aataaagaca ttttcagatc tgagagatac attttaatgt gtatggttgt
     2581 aattctaagc agaaagaggc aaaagtatgg ataatgttct ttatctgtct ttatctggac
     2641 tgtagatacg acagataacc tcagattctc ttcatggtgg ctacaagctc ttcatgtgtg
     2701 tgaagcaggc agaaaggagt atagttgagg aaggttttgc tttttttttt tttttttttg
     2761 ttaaaagcat atttaaaatg atttaagcat catggaaaaa ccttgtgcca actggaaaaa
     2821 ccttgctgta gtaaatgtcc ctcaagggtt catatttaca ggatatgtgt tccatattag
     2881 aaaaccaaat caacagtaaa gccacaagca aaagaagttt caatcttgtc ctaattagaa
     2941 caattatctt gggattgggc tttttccttc ctgagccaag cactgaacat cacggcctcc
     3001 agtaagttag agatcccagc atcaggttac tcaaggagat gaggttcgag acctttcata
     3061 aactgtgtgt taatttgaac ataaagacac attcgacttt aggctgggcc caataatcat
     3121 ttagctgctt aaaatctttg tatgatttgc tagaaatggt ccatcttagt tccaaattcg
     3181 tcccttgccc aggtaaagcc ttaatttgtg tataccttga cacagtaatg ctgtattgct
     3241 tccggaatgc taaatcaatt tttattttgc ttgacattgt ctctgaagga aaggtagact
     3301 tagggccctg gaccacgggc tgcttgaagt tttccgggaa ggctactttt gactttgtga
     3361 gctgtgtctt cctggtgctg aggggctcca cgtgaactca cacactcaca ggccctccag
     3421 ctgcctcctt gggttctgca ttcatggtct tggtttttga gcagcttgac ctctaagccc
     3481 aggatattga aaactgaccc ctaaataaac tttagggttt tctaagacct ttcctgcagt
     3541 ctccctcttt gtaaggtcca aacttatctc agagtactac tgttgggagc agacatcctt
     3601 gtgtcctgag tggccggaag gagtatggcc ttataaagga aagccaaaac aacacaaagc
     3661 caaaaccaac acttgttgtt tgcttagtag ttatgtagcc cttaaagtca ttgttacatt
     3721 tagtgatgtg tcttcctgtg atggttaaca atagtgcctt tagtaaatta ttttacagcc
     3781 taaactgttg gttttttgcg tgggtgtcca ccttgcagat ctgaggtatt taataagaaa
     3841 ctgaagtttc tttgcatcat ttgggttttg tttagttttt ttttttttca gtgtaatctt
     3901 agattcacaa caaaatctag tgggaagtac aacagtctgc tgtgtgctag tttaatgttt
     3961 tgtttctttt aaatgccagt aaaaaaaaaa aaggtgctac aatgtgttgg tctagaaaaa
     4021 aaaaaggttc ttgaaattaa aggctagatt tggtaacttt tatcacatga atctttaatg
     4081 aggtatattt aacagctgat gcaacaattt gtatacgctt tgggtaagtg acctaatatc
     4141 actccaaata ttactccagc tgtatttttg gcacatagga ttctgtcttc ggttgatgtg
     4201 tttttgttgc ggtttgttaa taagctgccc caggcgacac tcctttcaga agtctgtgct
     4261 aaagataact cttcctggct tagatataag ctgtaaatta agtcactttc tttaggaaga
     4321 agggggaaaa aaaaacctct cccagtggct cacaggttcc ttgggatctg tgggttggtg
     4381 gagccccatt tctgagcagg ttgggtggcg gtggccatgg ccatggccat ggcagcagca
     4441 gagctccatc cataagacct ggaaagcttt ctttagaaca cagcgaaagg aatctctctt
     4501 gcttttagtt aattcaagtt tagaccactt ctagtgtttt taaaaagggg ccagggccct
     4561 gagaaattcc cagtggtcac ataatcctag caagagtcag gcttagggta cttcgagaaa
     4621 aacaagatct tagatgtaac agcccaggtg ccatgctcga actgtcttct ctctgcctta
     4681 aacatctgcc cctatgcatt tgcccctatg catttgtctt actcctttga actaaaaata
     4741 aaaaataaag aaataaatct caactactta agatatctaa aattaaacgt aaaaactcat
     4801 tctcaagata aactacattt gtgtatcata atatattggt ttgctaaatt caaaattttg
     4861 tgactgcctt attagaacta ttttttcatt gcccatagtt ccaaagttca ttgaagtata
     4921 taccatgtgt aaatctgcta ttttcatttt gaatttgtgc tcaataaagg acagttatgg
     4981 aagcaataaa
//
