LOCUS       NM_175224               2549 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus methionyl aminopeptidase 1 (Metap1), mRNA.
ACCESSION   NM_175224
VERSION     NM_175224.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Weiss,A., Murdoch,C.C., Edmonds,K.A., Jordan,M.R., Monteith,A.J.,
            Perera,Y.R., Rodriguez Nassif,A.M., Petoletti,A.M., Beavers,W.N.,
            Munneke,M.J., Drury,S.L., Krystofiak,E.S., Thalluri,K., Wu,H.,
            Kruse,A.R.S., DiMarchi,R.D., Caprioli,R.M., Spraggins,J.M.,
            Chazin,W.J., Giedroc,D.P. and Skaar,E.P.
  TITLE     Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate
            zinc homeostasis
  JOURNAL   Cell 185 (12), 2148-2163 (2022)
   PUBMED   35584702
  REMARK    GeneRIF: Zn-regulated GTPase metalloprotein activator 1 modulates
            vertebrate zinc homeostasis.
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Pasquini,M., Grosjean,N., Hixson,K.K., Nicora,C.D., Yee,E.F.,
            Lipton,M., Blaby,I.K., Haley,J.D. and Blaby-Haas,C.E.
  TITLE     Zng1 is a GTP-dependent zinc transferase needed for activation of
            methionine aminopeptidase
  JOURNAL   Cell Rep 39 (7), 110834 (2022)
   PUBMED   35584675
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC079845.31.
            
            On May 2, 2007 this sequence version replaced NM_175224.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077694.1, AK153944.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC079845.31        205295-205419       c
            126-177             AC079845.31        199104-199155       c
            178-290             AC079845.31        196725-196837       c
            291-351             AC079845.31        194907-194967       c
            352-443             AC079845.31        191024-191115       c
            444-527             AC079845.31        189941-190024       c
            528-666             AC079845.31        188188-188326       c
            667-798             AC079845.31        184871-185002       c
            799-942             AC079845.31        182261-182404       c
            943-1008            AC079845.31        178402-178467       c
            1009-2549           AC079845.31        174997-176537       c
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 64.27 cM"
     gene            1..2549
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /note="methionyl aminopeptidase 1"
                     /db_xref="GeneID:75624"
                     /db_xref="MGI:MGI:1922874"
     exon            1..125
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1172
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /EC_number="3.4.11.18"
                     /note="MAP 1; metAP 1; peptidase M 1; Putative methionine
                     aminopeptidase 1 (MetAP 1) (Peptidase M 1)"
                     /codon_start=1
                     /product="methionine aminopeptidase 1"
                     /protein_id="NP_780433.1"
                     /db_xref="CCDS:CCDS17869.1"
                     /db_xref="GeneID:75624"
                     /db_xref="MGI:MGI:1922874"
                     /translation="MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGS
                     WATHKLLHKKAKDEKAKREVCSWTVEGDVNTDPWAGYRYTGKLRPHYPLMPTRPVPSY
                     IQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDIAAGMIKAG
                     VTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVN
                     VDITLYRNGYHGDLNETFFVGDVDEGARKLVQTTYECLMQAIDAVKPGVRYRELGNII
                     QKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGG
                     WQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSSRPHFMSQF"
     exon            126..177
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            178..290
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            291..351
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            352..443
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            444..527
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            528..666
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            667..798
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            799..942
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1008
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..2549
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1346..1351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
                     /note="hexamer: AATAAA"
     polyA_site      1375
                     /gene="Metap1"
                     /gene_synonym="1700029C17Rik; mKIAA0094"
ORIGIN      
        1 agccaggcag catggcggcg gtggagacgc gggtgtgcga gacggacggc tgcagcagcg
       61 aggccaagct ccagtgtccc acctgcatca agctgggcat ccagggctcg tacttctgct
      121 cgcaggaatg ctttaaagga agctgggcca ctcacaagtt actacataag aaagcaaaag
      181 atgaaaaggc aaagcgagaa gtgtgttcct ggactgtaga aggtgatgtc aacactgacc
      241 catgggcagg ctatcggtac actggtaaac tcaggccaca ttatccactg atgccaacac
      301 ggccagtgcc cagttacatt cagaggccgg actatgctga ccatccctta ggaatgtctg
      361 aatcggagca ggctcttaaa ggtacctctc agattaagtt actctcatct gaagatatag
      421 aagggatgcg actcgtgtgt aggcttgcca gagaagtttt ggacattgct gctgggatga
      481 ttaaagcggg tgtaactact gaagagatcg accacgctgt acacttagca tgcattgcaa
      541 gaaattgcta tccttctccc ctgaattact ataacttccc aaagtcttgt tgtacctcag
      601 tgaatgaagt catctgccat gggattccag acaggcggcc tttgcaagaa ggtgatattg
      661 ttaatgtgga catcactctt tatcgaaatg gttaccatgg ggatctaaat gagacctttt
      721 tcgttggcga tgtggatgaa ggagcacgga aacttgttca gactacatat gagtgcctga
      781 tgcaagccat cgatgcagtg aagcctggtg ttcgatacag agaactggga aacatcattc
      841 agaaacacgc ccaagcaaat ggattctcag ttgttcgaag ctattgtggg catgggatcc
      901 acaaactttt ccatacagcc cccaatgtcc cgcactatgc caaaaataaa gcagttggtg
      961 tgatgaagtc gggtcatgtg tttacaattg agccaatgat ttgtgaaggt ggatggcagg
     1021 atgagacttg gccagatggc tggactgcag tgacgaggga cgggaagcga tctgctcagt
     1081 ttgagcacac cctgctggtc acggacactg gctgtgaaat tctcacccgg agactcgata
     1141 gctctcggcc tcatttcatg tcccagtttt aatttctctc aagatgccta acatacgaac
     1201 accatctcgt actgtgcatt ttattgaaag tatggaaatg aagttttttt tttttaatca
     1261 ctcgttttgt tttgactgtg gataagaatg gactacagca tttggtgtgt gtcctcaaga
     1321 gcttttgggt ctgaaagctg agaagaataa aggaaacatt gcttacttcc ttccaccact
     1381 ggcctcaccc cctcagtttt ctgtactgtg ttttcttctt tgccccttga gcactttgac
     1441 ttcaacctgc actcactgct ttgtcactgc cagaccagcc accaagggcc agctgcttcc
     1501 caacagaagg ttggagatga gaaatcttga aactttagca acatgttgct ccagattttt
     1561 actatatatt gatatatatg gaaatatata tatgcataca ttttaaattc catatacacg
     1621 attactgaac actatatgac cttcggtctg ggttgattct gctttgacag gatatctgct
     1681 ctcagaaacg gatccataac tcgttagtga gtgactccta gttaggacct ggtctcctct
     1741 cacccccatg ctgttcattt atcttgtctg tctgcaggga agactccgcg cagtgtggac
     1801 tgtgtgtcag tgagtgagac gttgtcagac tttaaggtct ggtgtgtgct gcaggaagtg
     1861 gccggcagct gcggggtggc tttacagagc actgctgctt tagacctctc tttggtcagg
     1921 tgtgaagccc ccttttttca gacccttctg atgtgaggct gcacctctgg agcactcaag
     1981 agaagaggca gttgtcctgt ggcagaggat gggggagtta aaaaatgtcc ccaggtgtgt
     2041 gcacagtcac gggtggctgt ggctttacca ttagtaaaca taacagaatg agaaaggagc
     2101 ctgttgcggt actgtaaaca ctcagtatgc tgctgctatc ctgtattgca aatgcacctc
     2161 tcctcggtcg agttgagagt ctcatcagaa atgactaggt tgcccggaat ctgtgctcct
     2221 cggtggtggt tcaaacacca gaggataaag ttgtcacaag agtatccttg attgctgggt
     2281 gtctcatgac ttttatagta taatttgata ccactgacac atacttcaag acatctttcc
     2341 cagagtgcct cagaccttat tgctttaaga gaatgatgat aatgttttca tgactttatt
     2401 ttaatgattt agtaaagtga ttgaatctgg tgtagacttc tgggtgtgtg tgtgtttaaa
     2461 gtttttatca aactgtaata tttgtgaatg gaatgccttg taatatgaat gttaatataa
     2521 tatgtaaagg gagattaaac gtttgaatg
//
