LOCUS       NM_008591               6716 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus met proto-oncogene (Met), transcript variant 1, mRNA.
ACCESSION   NM_008591
VERSION     NM_008591.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6716)
  AUTHORS   Wan,X., Li,Z. and Zhou,L.
  TITLE     c-MET is an important marker for acid-driven metastasis and
            anti-immune in colorectal cancer
  JOURNAL   Int Immunopharmacol 142 (Pt A), 113153 (2024)
   PUBMED   39278060
  REMARK    GeneRIF: c-MET is an important marker for acid-driven metastasis
            and anti-immune in colorectal cancer.
REFERENCE   2  (bases 1 to 6716)
  AUTHORS   Lanjewar,A.L., Levitt,P. and Eagleson,K.L.
  TITLE     Developmental and molecular contributions to contextual fear memory
            emergence in mice
  JOURNAL   Neuropsychopharmacology 49 (9), 1392-1401 (2024)
   PUBMED   38438594
REFERENCE   3  (bases 1 to 6716)
  AUTHORS   Barbosa-Matos,C., Borges-Pereira,C., Liborio-Ramos,S.,
            Fernandes,R., Oliveira,M., Mendes-Frias,A., Silvestre,R.,
            Osorio,N.S., Bastos,H.N., Santos,R.F., Guimaraes,S., Morais,A.,
            Mazzone,M., Carvalho,A., Cunha,C. and Costa,S.
  TITLE     Deregulated immune cell recruitment orchestrated by c-MET impairs
            pulmonary inflammation and fibrosis
  JOURNAL   Respir Res 25 (1), 257 (2024)
   PUBMED   38909206
  REMARK    GeneRIF: Deregulated immune cell recruitment orchestrated by c-MET
            impairs pulmonary inflammation and fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6716)
  AUTHORS   Fang,Y., Wan,J.P., Wang,Z., Song,S.Y., Zhang,C.X., Yang,L.,
            Zhang,Q.Y., Yan,C.Y., Wu,F.Y., Lu,S.Y., Sun,F., Han,B., Zhao,S.X.,
            Dong,M. and Song,H.D.
  TITLE     Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by
            impeding late thyroid expansion
  JOURNAL   Nat Commun 15 (1), 3165 (2024)
   PUBMED   38605010
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6716)
  AUTHORS   Kaneko,K., Liang,Y., Liu,Q., Zhang,S., Scheiter,A., Song,D. and
            Feng,G.S.
  TITLE     Identification of CD133+ intercellsomes in intercellular
            communication to offset intracellular signal deficit
  JOURNAL   Elife 12, 86824 (2023)
   PUBMED   37846866
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6716)
  AUTHORS   Li,Y.S., Hoffman,R.M., Le Beau,M.M., Espinosa,R. 3rd, Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Deuel,T.F.
  TITLE     Characterization of the human pleiotrophin gene. Promoter region
            and chromosomal localization
  JOURNAL   J Biol Chem 267 (36), 26011-26016 (1992)
   PUBMED   1464612
REFERENCE   7  (bases 1 to 6716)
  AUTHORS   Rong,S., Bodescot,M., Blair,D., Dunn,J., Nakamura,T., Mizuno,K.,
            Park,M., Chan,A., Aaronson,S. and Vande Woude,G.F.
  TITLE     Tumorigenicity of the met proto-oncogene and the gene for
            hepatocyte growth factor
  JOURNAL   Mol Cell Biol 12 (11), 5152-5158 (1992)
   PUBMED   1406687
REFERENCE   8  (bases 1 to 6716)
  AUTHORS   Kelley,K.A., Stamm,S. and Kozak,C.A.
  TITLE     Expression and chromosome localization of the murine cystic
            fibrosis transmembrane conductance regulator
  JOURNAL   Genomics 13 (2), 381-388 (1992)
   PUBMED   1377165
REFERENCE   9  (bases 1 to 6716)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   10 (bases 1 to 6716)
  AUTHORS   Siegel,D., Irving,N.G., Friedman,J.M. and Wainwright,B.J.
  TITLE     Localization of the cystic fibrosis transmembrane conductance
            regulator (Cftr) to mouse chromosome 6
  JOURNAL   Cytogenet Cell Genet 61 (3), 184-185 (1992)
   PUBMED   1385049
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024950.3.
            
            On Jul 27, 2022 this sequence version replaced NM_008591.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.6594.1,
                                           SRR10223969.6316.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-356               AC024950.3         68879-69234
            357-405             AC024950.3         92783-92831
            406-1616            AC024950.3         96213-97423
            1617-1808           AC024950.3         118336-118527
            1809-1943           AC024950.3         131299-131433
            1944-2117           AC024950.3         132062-132235
            2118-2278           AC024950.3         136409-136569
            2279-2381           AC024950.3         138897-138999
            2382-2518           AC024950.3         139108-139244
            2519-2680           AC024950.3         139928-140089
            2681-2780           AC024950.3         140824-140923
            2781-2999           AC024950.3         145424-145642
            3000-3146           AC024950.3         151936-152082
            3147-3300           AC024950.3         153672-153825
            3301-3441           AC024950.3         154018-154158
            3442-3672           AC024950.3         158225-158455
            3673-3753           AC024950.3         160533-160613
            3754-3935           AC024950.3         163695-163876
            3936-4045           AC024950.3         167144-167253
            4046-4211           AC024950.3         168540-168705
            4212-4348           AC024950.3         176358-176494
            4349-6716           AC024950.3         176599-178966
FEATURES             Location/Qualifiers
     source          1..6716
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 7.83 cM"
     gene            1..6716
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /note="met proto-oncogene"
                     /db_xref="GeneID:17295"
                     /db_xref="MGI:MGI:96969"
     exon            1..356
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            357..405
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            406..1616
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..4559
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /EC_number="2.7.10.1"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; hepatocyte growth factor receptor; SF receptor;
                     HGF/SF receptor; proto-oncogene c-Met; scatter factor
                     receptor; met proto-oncogene tyrosine kinase;
                     tyrosine-protein kinase Met; HGF receptor"
                     /codon_start=1
                     /product="hepatocyte growth factor receptor isoform a
                     precursor"
                     /protein_id="NP_032617.2"
                     /db_xref="CCDS:CCDS19925.1"
                     /db_xref="GeneID:17295"
                     /db_xref="MGI:MGI:96969"
                     /translation="MKAPTVLAPGILVLLLSLVQRSHGECKEALVKSEMNVNMKYQLP
                     NFTAETPIQNVVLHGHHIYLGATNYIYVLNDKDLQKVSEFKTGPVLEHPDCLPCRDCS
                     SKANSSGGVWKDNINMALLVDTYYDDQLISCGSVNRGTCQRHVLPPDNSADIQSEVHC
                     MFSPEEESGQCPDCVVSALGAKVLLSEKDRFINFFVGNTINSSYPPGYSLHSISVRRL
                     KETQDGFKFLTDQSYIDVLPEFQDSYPIKYIHAFESNHFIYFLTVQKETLDAQTFHTR
                     IIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGANLAKQIGA
                     SPSDDILFGVFAQSKPDSAEPVNRSAVCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPN
                     HEHCFNRTLLRNSSGCEARSDEYRTEFTTALQRVDLFMGRLNQVLLTSISTFIKGDLT
                     IANLGTSEGRFMQVVLSRTAHLTPHVNFLLDSHPVSPEVIVEHPSNQNGYTLVVTGKK
                     ITKIPLNGLGCGHFQSCSQCLSAPYFIQCGWCHNQCVRFDECPSGTWTQEICLPAVYK
                     VFPTSAPLEGGTVLTICGWDFGFRKNNKFDLRKTKVLLGNESCTLTLSESTTNTLKCT
                     VGPAMSEHFNVSVIISNSRETTQYSAFSYVDPVITSISPRYGPQAGGTLLTLTGKYLN
                     SGNSRHISIGGKTCTLKSVSDSILECYTPAQTTSDEFPVKLKIDLANRETSSFSYRED
                     PVVYEIHPTKSFISGGSTITGIGKTLNSVSLPKLVIDVHEVGVNYTVACQHRSNSEII
                     CCTTPSLKQLGLQLPLKTKAFFLLDGILSKHFDLTYVHNPVFEPFEKPVMISIGNENV
                     VEIKGNNIDPEAVKGEVLKVGNQSCESLHWHSGAVLCTVPSDLLKLNSELNIEWKQAV
                     SSTVLGKVIVQPDQNFAGLIIGAVSISVVVLLLSGLFLWMRKRKHKDLGSELVRYDAR
                     VHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGACRQVQYPLTDLS
                     PILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFG
                     CVYHGTLLDNDGKKIHCAVKSLNRITDIEEVSQFLTEGIIMKDFSHPNVLSLLGICLR
                     SEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLA
                     ARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKS
                     DVWSFGVLLWELMTRGAPPYPDVNTFDITIYLLQGRRLLQPEYCPDALYEVMLKCWHP
                     KAEMRPSFSELVSRISSIFSTFIGEHYVHVNATYVNVKCVAPYPSLLPSQDNIDGEGN
                     T"
     exon            1617..1808
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1943
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..2117
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2278
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2381
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..2518
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2680
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            2681..2780
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            2781..2999
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            3000..3146
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3300
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            3301..3441
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            3442..3672
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3753
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            3754..3935
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            3936..4045
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4211
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            4212..4348
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     exon            4349..6716
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6685..6690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /note="hexamer: AATAAA"
     polyA_site      6716
                     /gene="Met"
                     /gene_synonym="c-Met; HGF; HGFR; Par4"
                     /note="major polyA site"
ORIGIN      
        1 gttgcccggc tgagtcacgg gccgggcagg gcgcgtgtgg gaaggggcgg agcagtccga
       61 gggcgctcgg cggggttcgg cccgggccgc aggtgacccg gacggcctcg ccgcccgcag
      121 cgtccgagcc cgggtgaccc tgtgcggagc cagatgctgg gcgaccgctg actcgctgga
      181 gaagggcgga gcgcgcgggt ggtccccagc cggctgactt cggcgccgcg cgctccgggc
      241 accccaaggt acaaactcca gccgcgtcga tcaggcaccc agcctctccc agcccctctg
      301 ctttctttgt tccactaagg gaactggcta ctgctctgga ggacaagacc accgaggatg
      361 gctgtggaga gaaagctgac ggtgtagcag aacgcttggc atgtgatcaa ctcctcacaa
      421 tgaaggctcc caccgtgctg gcacctggca ttctggtgct gctgttgtcc ttggtgcaga
      481 ggagccatgg ggagtgcaag gaggccctag tgaagtctga gatgaacgtg aacatgaagt
      541 atcagctccc caacttcacg gcagaaaccc ccatccagaa tgtcgtccta cacggccatc
      601 atatttatct cggagccaca aactacattt atgttttaaa tgacaaagac cttcagaagg
      661 tatccgaatt caagaccggg cccgtgttgg aacacccaga ttgtttacct tgtcgggact
      721 gcagcagcaa agccaattca tcaggagggg tttggaaaga caacatcaac atggctctgc
      781 ttgttgacac atactatgat gatcaactca ttagctgtgg cagtgtcaac agagggactt
      841 gccagcggca tgtccttcct cctgacaatt ctgctgacat ccagtctgag gtccactgca
      901 tgttctcccc agaagaggag tcagggcagt gtcctgactg tgtagtgagt gccctcggag
      961 ccaaagtcct cctgtcggaa aaggaccggt tcatcaattt ctttgtgggg aatacgatca
     1021 attcctccta tcctcctggt tattcactgc attcgatatc ggtgagacgg ctgaaggaaa
     1081 cccaagatgg ttttaagttt ttgacagacc agtcctatat tgatgtctta ccagaattcc
     1141 aagattccta ccccataaag tacatacatg ccttcgaaag caaccatttt atttactttc
     1201 tgactgtcca aaaggaaact ctagatgctc agacttttca tacaagaata atcaggttct
     1261 gttccgtaga ctctgggttg cactcctaca tggaaatgcc cctggaatgc atcctgacag
     1321 aaaaaagaag gaagagatcc acaagggaag aagtgtttaa tatcctccaa gccgcgtatg
     1381 tcagtaaacc aggggccaat cttgctaagc aaataggagc tagcccttct gatgacattc
     1441 tcttcggggt gtttgcacaa agcaagccag attctgctga acctgtgaat cgatcagcag
     1501 tctgtgcatt ccccatcaaa tatgtcaatg acttcttcaa caagattgtc aacaaaaaca
     1561 acgtgagatg tctccagcat ttttacggac ccaaccatga gcactgtttc aataggaccc
     1621 tgctgagaaa ctcttccggc tgtgaagcgc gcagtgacga gtatcggaca gagtttacca
     1681 cggctttgca gcgcgtcgac ttattcatgg gccggcttaa ccaagtgctc ctgacatcca
     1741 tctccacctt catcaaaggt gacctcacca ttgctaatct agggacgtca gaaggtcgct
     1801 tcatgcaggt ggtgctctct cgaacagcac acctcactcc tcatgtgaac ttcctcctgg
     1861 actcccatcc tgtatctcca gaagttattg ttgagcatcc atcaaatcaa aatggctata
     1921 cattggttgt cacaggaaag aagatcacca agattccatt gaatggcctg ggctgtggac
     1981 atttccaatc ctgcagtcag tgcctctctg ccccttactt tatacagtgt ggctggtgcc
     2041 acaatcaatg tgtgcgtttt gatgaatgcc ccagcggtac atggactcaa gagatctgtc
     2101 tgccggcggt ttataaggtg ttccccacca gcgcgcccct tgaaggagga acagtgttga
     2161 ccatatgtgg ctgggacttt ggattcagga agaataataa atttgattta aggaaaacca
     2221 aagttctgct tggcaacgag agctgtacct tgaccttaag cgagagcacg acaaatacgt
     2281 tgaaatgcac agttggtccc gcgatgagtg agcacttcaa tgtgtctgta attatctcaa
     2341 acagtcgaga gacgacgcaa tacagtgcat tctcctatgt agatcctgta ataacaagca
     2401 tttctccgag gtacggccct caggctggag gcaccttact cactcttact gggaaatacc
     2461 tcaacagtgg caattctaga cacatttcaa ttggagggaa aacatgtact ttaaaaagtg
     2521 tatcagatag tattcttgaa tgctacaccc cagcccaaac tacctctgat gagtttcctg
     2581 tgaaattgaa gattgacttg gctaaccgag agaccagcag cttcagttac cgggaagacc
     2641 ccgttgtcta tgaaatccac ccgaccaaat cttttattag tggtggaagc acaataacgg
     2701 gtattgggaa gaccctgaac tcggttagcc tcccaaagct ggtaatagat gtgcatgaag
     2761 tgggtgtgaa ctacacagtg gcatgtcagc atcgctcaaa ttcagagatc atctgctgca
     2821 ctactccttc actgaaacag ctgggcctgc aactccccct gaagaccaaa gccttcttcc
     2881 tgttagacgg gattctttcc aaacactttg atctcactta tgtgcataat cctgtgtttg
     2941 agccttttga aaagccagta atgatctcaa taggcaatga aaatgtagtg gaaattaagg
     3001 gaaacaatat tgaccctgaa gcagttaaag gtgaagtgtt aaaagttgga aatcagagct
     3061 gcgagagtct ccactggcac tctggagctg tgttgtgtac agtccccagt gacctgctca
     3121 aactgaacag cgagctaaat atagagtgga agcaagcagt ctcttcaact gttcttggaa
     3181 aagtgatcgt tcaaccggat cagaattttg caggattgat cattggtgcg gtctcaatat
     3241 cagtagtagt tttgttatta tccgggctct tcctgtggat gagaaagaga aagcataaag
     3301 atctgggcag tgaattagtt cgctatgacg caagagtaca cactcctcat ttggataggc
     3361 ttgtaagtgc ccgaagtgta agtccaacta cagagatggt ttcaaatgag tctgtagact
     3421 acagagctac ttttccagaa gaccagtttc ccaactcctc tcagaatgga gcatgcagac
     3481 aagtgcaata ccctctgaca gacctgtccc ctatcctgac aagtggagac tctgatatat
     3541 ccagcccatt actacaaaat actgttcaca ttgacctcag tgctctaaat ccagagctgg
     3601 tccaagcagt tcagcacgta gtgattggac ccagcagcct gattgtgcat ttcaatgaag
     3661 tcataggaag agggcatttt ggctgtgtct atcatgggac tttgctggac aatgacggaa
     3721 agaaaattca ctgtgctgtg aaatccttaa atagaatcac agatatagaa gaggtctccc
     3781 agtttctgac tgagggaatc atcatgaaag acttcagcca tcccaatgtt ctctcactct
     3841 tgggaatctg cctgaggagt gaagggtctc ctctggtggt cctgccctat atgaagcatg
     3901 gagatctgcg aaatttcatt cgaaacgaga ctcataatcc aactgtgaaa gatcttatag
     3961 gatttggcct tcaagtagcc aaaggcatga aatatcttgc cagcaaaaag tttgtccaca
     4021 gagacttagc tgcaagaaac tgcatgttgg atgaaaaatt cactgtcaag gttgctgatt
     4081 tcggtcttgc cagagacatg tacgataaag agtactatag tgtccacaac aagacgggtg
     4141 ccaagctacc agtaaagtgg atggctttag agagtctgca aacgcagaag ttcaccacca
     4201 agtcagatgt gtggtccttt ggtgtgctcc tctgggagct catgacgaga ggagcccctc
     4261 cttatcccga cgtgaacaca tttgatatca ctatctacct gttgcaaggc agaagactct
     4321 tgcaaccaga atactgtcca gacgccttgt acgaagtgat gctaaaatgc tggcacccca
     4381 aagcggaaat gcgcccgtcc ttttccgaac tggtctccag gatatcctca atcttctcca
     4441 cgttcattgg ggaacactac gtccacgtga acgctactta tgtgaatgta aaatgtgttg
     4501 ctccatatcc ttctctgttg ccatcccaag acaacattga tggcgagggg aacacatgat
     4561 gaatgagagg tccaccagcc cacttccaag aaacagttct ggcccaaacc agactatccc
     4621 ttccccaaca gttctcactg cctggccttt ggaaggtcac ttaacatttg ttgttgtttt
     4681 gttttgtttt ttgttttgct tttgcggtaa ctgcaccact atgaaacatt gacttgctat
     4741 ttcaaattcc tggattctaa ggaatttctc atctgacaat ggaacagaaa tagaagcatg
     4801 gcccccacag gctggggacc agtggcaacc tgcagctaca acactcctat ctcagcggaa
     4861 ttctaaatct cagttctggc ttaaaagttt taaaaataag atatatatac atatatatat
     4921 ccaatacaat gaactttgaa gatttctcag aaaactcaga agaaacgccc tctttcagga
     4981 taaatgtggt gttcctagca ggctgcttgt tgaaattcca gtgttttaaa aatatttttg
     5041 ttgtgttgca gtcgtgaaca ttttccattt ctgatgttgt ctgcccatca ggcaaacatt
     5101 cccttttaaa tgcttatata cacattcctt aggttggaag aatatccacg gacaatgcac
     5161 ttatttttaa acgagcatga catgaggtgt gtttataaat tatcagggat tttatgtatt
     5221 gtacatagat gacaatagga aattgtttat ttcaagaaat agctttgtta cagtaaaata
     5281 tttgtcattt aaaacccagc tgtttagcaa ggagtgttgg ctcacaccta caatcccagc
     5341 atttgggaag ctgaggcaag cagattacca caagtttgaa accaaccttg gctgcataca
     5401 gatgatgtat atataggcca gcatgggtta cactgtctgt cttagcaaac aaaatttcaa
     5461 ctgtttgaga aagattttgt tctgatctaa tgaatgtgga catttaaatt ttttatctgt
     5521 tttttaatgg caactttgga aataagtaac ttgcggtgat aaatcttttt aaaggcaact
     5581 cagtattttt taaaggacaa aataaactga ctgaagggtt cgctacttcc agtcacaacc
     5641 tgtgtataga agaaagaaag ggtcagtgat cgagaatcag acactctcgt tcaggaggag
     5701 gcttctcgcc tgaaacaatt gcacccaaca cttttgggga agtctcattt ttgcattagg
     5761 acatatttta ggttaaacaa aagcatattt tagaaacaga caaaagccaa ctgaaaatcg
     5821 tggatgaata gttactctgg acaggacttt tgacatgtct tgctctgtgg aattttgtgc
     5881 ttactactgt atagtgcatg tggcttaggt taccctagct ggttttgtcc gtgtaaacat
     5941 tgaaagtatt atatttttat agaaatgttt atttttaatg atgtaagaaa aattttcctt
     6001 aggccgcaga aatcctgcac tgtgagcatt tcagaagagg tatgtgagac ccagttcaac
     6061 gacagcatga ttttttaaat ggctgtaagt tatgataagg aaatgtactg attgccagtg
     6121 cactccaccc tcattacgtc accaggactt gaagccaagg gttaagaggg caagctatga
     6181 catgggtgtg tggtctgctg aaacccaatc gttgaacttg gctgttgtta caggaaaatg
     6241 atggcatcaa caggtctttg atggtggtgg agcatatcag aacacataag gaactgtagc
     6301 ccagatttat ttcaattcaa atattactgc ttcgtaatta tgaagagtag tgcaaattta
     6361 cagagcactg tcaaagactg acagaaaaaa aaaagatctg ctctgtagaa agaattgtct
     6421 gccattacag ggtcaagaaa atgaatgcgc caataacagt aagagctgtg gaagacaccc
     6481 atacctgtat atacatgctc gagaaagctg taatgtgaaa atcatgttct ctatttatga
     6541 ctcttcctag ggcaatgtgt ctggacagat tgtaagagta agtcattttc ctaaagaatt
     6601 agatatttgt cactgcctat acctgcagtt gagctgaatg gtactccatg tgttaataat
     6661 tgttctgatg aatcatacag ttgaaataaa gtgacgtaac atcttgtata ctgtga
//
