LOCUS       NM_008589               1936 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus mesoderm posterior 2 (Mesp2), mRNA.
ACCESSION   NM_008589
VERSION     NM_008589.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1936)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   2  (bases 1 to 1936)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   3  (bases 1 to 1936)
  AUTHORS   Chen,X., Liu,F., Li,B., Wang,Y., Yuan,L., Yin,A., Chen,Q., Hu,W.,
            Yao,Y., Zhang,M., Wu,Y. and Chen,K.
  TITLE     Neuropathy-associated Fars2 deficiency affects neuronal development
            and potentiates neuronal apoptosis by impairing mitochondrial
            function
  JOURNAL   Cell Biosci 12 (1), 103 (2022)
   PUBMED   35794642
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1936)
  AUTHORS   Zhao,T., McMahon,M., Reynolds,K., Saha,S.K., Stokes,A. and
            Zhou,C.J.
  TITLE     The role of Lrp6-mediated Wnt/beta-catenin signaling in the
            development and intervention of spinal neural tube defects in mice
  JOURNAL   Dis Model Mech 15 (6) (2022)
   PUBMED   35514236
REFERENCE   5  (bases 1 to 1936)
  AUTHORS   Okada,H. and Saga,Y.
  TITLE     Repurposing of the enhancer-promoter communication underlies the
            compensation of Mesp2 by Mesp1
  JOURNAL   PLoS Genet 18 (1), e1010000 (2022)
   PUBMED   35025872
  REMARK    GeneRIF: Repurposing of the enhancer-promoter communication
            underlies the compensation of Mesp2 by Mesp1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1936)
  AUTHORS   Yoon,J.K., Moon,R.T. and Wold,B.
  TITLE     The bHLH class protein pMesogenin1 can specify paraxial mesoderm
            phenotypes
  JOURNAL   Dev Biol 222 (2), 376-391 (2000)
   PUBMED   10837126
REFERENCE   7  (bases 1 to 1936)
  AUTHORS   Saga,Y., Miyagawa-Tomita,S., Takagi,A., Kitajima,S., Miyazaki,Ji.
            and Inoue,T.
  TITLE     MesP1 is expressed in the heart precursor cells and required for
            the formation of a single heart tube
  JOURNAL   Development 126 (15), 3437-3447 (1999)
   PUBMED   10393122
REFERENCE   8  (bases 1 to 1936)
  AUTHORS   Barrantes,I.B., Elia,A.J., Wunsch,K., Hrabe de Angelis,M.H.,
            Mak,T.W., Rossant,J., Conlon,R.A., Gossler,A. and de la Pompa,J.L.
  TITLE     Interaction between Notch signalling and Lunatic fringe during
            somite boundary formation in the mouse
  JOURNAL   Curr Biol 9 (9), 470-480 (1999)
   PUBMED   10330372
REFERENCE   9  (bases 1 to 1936)
  AUTHORS   Saga,Y.
  TITLE     Genetic rescue of segmentation defect in MesP2-deficient mice by
            MesP1 gene replacement
  JOURNAL   Mech Dev 75 (1-2), 53-66 (1998)
   PUBMED   9739106
REFERENCE   10 (bases 1 to 1936)
  AUTHORS   Saga,Y., Hata,N., Koseki,H. and Taketo,M.M.
  TITLE     Mesp2: a novel mouse gene expressed in the presegmented mesoderm
            and essential for segmentation initiation
  JOURNAL   Genes Dev 11 (14), 1827-1839 (1997)
   PUBMED   9242490
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109221.32 and AK146740.1.
            
            On Aug 11, 2006 this sequence version replaced NM_008589.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146740.1, U71125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-522               AC109221.32        84472-84993
            523-1936            AK146740.1         3-1416
FEATURES             Location/Qualifiers
     source          1..1936
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.18 cM"
     gene            1..1936
                     /gene="Mesp2"
                     /gene_synonym="bHLHc6"
                     /note="mesoderm posterior 2"
                     /db_xref="GeneID:17293"
                     /db_xref="MGI:MGI:1096325"
     exon            1..1033
                     /gene="Mesp2"
                     /gene_synonym="bHLHc6"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..1315
                     /gene="Mesp2"
                     /gene_synonym="bHLHc6"
                     /codon_start=1
                     /product="mesoderm posterior protein 2"
                     /protein_id="NP_032615.2"
                     /db_xref="CCDS:CCDS39993.1"
                     /db_xref="GeneID:17293"
                     /db_xref="MGI:MGI:1096325"
                     /translation="MAQSPPPQSLQGLDHWVFSQGWGWAQQSDSTSPASSSDSSGSCP
                     CYATRRPSQPAGPARSTRTTQATAPRRTRPAPAGGQRQSASEREKLRMRTLARALQEL
                     RRFLPPSVAPAGQSLTKIETLRLAIRYIGHLSALLGLSEDSLRRRRRRSADAAFSHRC
                     PQCPDGGSPSQAQMLGPSLGSAMSSGVSWGCPPACPGPLISPENLGNRISNVDPWVTP
                     PYCPQIQSPLHQSLERAADSSPWAPPQACPGMQMSPEPRNKTGHWTQSTEPAELTKVY
                     QSLSVSPEPCLSLGSPLLLPRPSCQRLQPQPQPQPQWGCWGHDAEVLSTSEDQGSSPA
                     LQLPVASPTPSSGLQLSGCPELWQEDLEGPPLNIFY"
     exon            1034..1936
                     /gene="Mesp2"
                     /gene_synonym="bHLHc6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1919..1924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mesp2"
                     /gene_synonym="bHLHc6"
                     /note="putative"
     polyA_site      1936
                     /gene="Mesp2"
                     /gene_synonym="bHLHc6"
                     /note="putative"
ORIGIN      
        1 ccattagagc cttcgagggg tcagaatcca cacctctgca aatgggcccg ctttcccagg
       61 gcccccctgc ccagaccttc cctgggctct gtgggttttg acacctctct gcaacctggc
      121 aggggaccac ctcacacctt tagtccagat aaaagctagg acctggaggt gaccggtcca
      181 gcttcccaga gtcacaccag ccatggccca gtcgcctcct cctcagagcc tccagggtct
      241 cgaccactgg gtcttctccc agggctgggg ctgggctcag caatcggact ccacgtctcc
      301 ggcctcgtcc tcagattcgt ccggttcctg cccttgctac gccacccgtc ggccctcgca
      361 gcccgccggc ccggcccgta gcacgcgcac tacccaggcg acggcgcccc gacgaacgcg
      421 cccagcgccc gcaggcggac agcggcagag cgccagcgag cgcgagaagc tgcgcatgcg
      481 cacactcgcc cgcgcgctgc aagaactgcg ccgcttcctg ccgccgtcgg tggcacctgc
      541 aggccagagc ctgaccaaga tcgagacgct gcgcctggcc atccgctaca tcggccacct
      601 gtcagccctg ctgggcctca gcgaggacag tctgcggcgc aggcgccgac ggagtgcgga
      661 cgcggcgttc tctcaccgat gccctcaatg ccccgacggt ggcagcccct cacaggctca
      721 gatgcttggt cctagcctgg gatcagccat gagtagtggg gtgtcctggg ggtgcccgcc
      781 tgcttgtcct ggacctctga tctcacctga aaaccttggg aacaggatct ccaacgtgga
      841 tccctgggtg acacctcctt attgtcccca aatacagtca cccttacacc agtccctaga
      901 aagagccgct gactcctctc cctgggcacc acctcaagca tgtcctggca tgcagatgtc
      961 cccagagcct aggaacaaga ctggacactg gacacaatcc actgaacctg cagagctgac
     1021 taaagtgtat cagagtcttt ctgtgtctcc agaaccctgc ctgtccctgg gaagcccact
     1081 tctcctgccc cgcccatcat gccagagact acagcctcag cctcagcctc agcctcagtg
     1141 gggctgctgg ggccacgatg cagaggtgct ctccacctct gaggatcagg gttccagccc
     1201 tgccctccag cttcctgtgg ccagccccac ccccagctca ggcctgcagc tcagtggctg
     1261 tcctgaactt tggcaggaag acctggaagg acccccactg aatattttct actaatatgg
     1321 ccttacctgc accctgcggt gtggatttgg gctgccttgg aagtgccttt atctgcctct
     1381 tctgtgacat tttgaggtct gcttagctat ggcccccctt tcccagatga cccctttcat
     1441 ggaaacggtg tctggggcag ataaacattg ggtaccttca ctgttttgag gggggctgag
     1501 acaagacacc cccgcttcta ggtatcttct agagcagtga ttctcaacct tgctaatgct
     1561 gtgacccttt aatacataca gttcctcatg gtgtggtgac cccccccaac cataaaatta
     1621 tcttattgct acttcataac tgtaattttg ctactgttat aaatcataat gtaaatctct
     1681 gtgttttctg gtagttttag gtaacccctg tgagagggtc gttccatact ccacccccca
     1741 ggggtcacaa cctacaggtt gagaactact attctaaagg ctcagcactc tgcagagcac
     1801 aggctgagct gctctgagta cggggtggcc tgagtgtgga ggacaaagga ggtccatgtc
     1861 ctgcttgctg gagacagctg gccagaatcg tatatgctgg ttttataact gttttattat
     1921 taaagagaag aaaacc
//
