LOCUS       NM_008588               1098 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus mesoderm posterior 1 (Mesp1), mRNA.
ACCESSION   NM_008588
VERSION     NM_008588.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Arriagada,C., Lin,E., Schonning,M. and Astrof,S.
  TITLE     Mesodermal fibronectin controls cell shape, polarity, and
            mechanotransduction in the second heart field during cardiac
            outflow tract development
  JOURNAL   Dev Cell 60 (1), 62-84 (2025)
   PUBMED   39413783
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   Eom,T.Y., Schmitt,J.E., Li,Y., Davenport,C.M., Steinberg,J.,
            Bonnan,A., Alam,S., Ryu,Y.S., Paul,L., Hansen,B.S., Khairy,K.,
            Pelletier,S., Pruett-Miller,S.M., Roalf,D.R., Gur,R.E.,
            Emanuel,B.S., McDonald-McGinn,D.M., Smith,J.N., Li,C.,
            Christie,J.M., Northcott,P.A. and Zakharenko,S.S.
  TITLE     Tbx1 haploinsufficiency leads to local skull deformity,
            paraflocculus and flocculus dysplasia, and motor-learning deficit
            in 22q11.2 deletion syndrome
  JOURNAL   Nat Commun 15 (1), 10510 (2024)
   PUBMED   39638997
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1098)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1098)
  AUTHORS   Boulgakoff,L., Sturny,R., Olejnickova,V., Sedmera,D., Kelly,R.G.
            and Miquerol,L.
  TITLE     Participation of ventricular trabeculae in neonatal cardiac
            regeneration leads to ectopic recruitment of Purkinje-like cells
  JOURNAL   Nat Cardiovasc Res 3 (9), 1140-1157 (2024)
   PUBMED   39198628
  REMARK    Erratum:[Nat Cardiovasc Res. 2024 Sep;3(9):1178. doi:
            10.1038/s44161-024-00548-3. PMID: 39261682]
REFERENCE   5  (bases 1 to 1098)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   6  (bases 1 to 1098)
  AUTHORS   Saga,Y., Miyagawa-Tomita,S., Takagi,A., Kitajima,S., Miyazaki,Ji.
            and Inoue,T.
  TITLE     MesP1 is expressed in the heart precursor cells and required for
            the formation of a single heart tube
  JOURNAL   Development 126 (15), 3437-3447 (1999)
   PUBMED   10393122
REFERENCE   7  (bases 1 to 1098)
  AUTHORS   Barrantes,I.B., Elia,A.J., Wunsch,K., Hrabe de Angelis,M.H.,
            Mak,T.W., Rossant,J., Conlon,R.A., Gossler,A. and de la Pompa,J.L.
  TITLE     Interaction between Notch signalling and Lunatic fringe during
            somite boundary formation in the mouse
  JOURNAL   Curr Biol 9 (9), 470-480 (1999)
   PUBMED   10330372
REFERENCE   8  (bases 1 to 1098)
  AUTHORS   Saga,Y.
  TITLE     Genetic rescue of segmentation defect in MesP2-deficient mice by
            MesP1 gene replacement
  JOURNAL   Mech Dev 75 (1-2), 53-66 (1998)
   PUBMED   9739106
REFERENCE   9  (bases 1 to 1098)
  AUTHORS   Saga,Y., Hata,N., Koseki,H. and Taketo,M.M.
  TITLE     Mesp2: a novel mouse gene expressed in the presegmented mesoderm
            and essential for segmentation initiation
  JOURNAL   Genes Dev 11 (14), 1827-1839 (1997)
   PUBMED   9242490
REFERENCE   10 (bases 1 to 1098)
  AUTHORS   Saga,Y., Hata,N., Kobayashi,S., Magnuson,T., Seldin,M.F. and
            Taketo,M.M.
  TITLE     MesP1: a novel basic helix-loop-helix protein expressed in the
            nascent mesodermal cells during mouse gastrulation
  JOURNAL   Development 122 (9), 2769-2778 (1996)
   PUBMED   8787751
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC125505.1 and CF105615.1.
            
            On Jul 23, 2009 this sequence version replaced NM_008588.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012689.1, BU946310.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-901               BC125505.1         1-901
            902-1098            CF105615.1         377-573
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.16 cM"
     gene            1..1098
                     /gene="Mesp1"
                     /gene_synonym="bHLHc5"
                     /note="mesoderm posterior 1"
                     /db_xref="GeneID:17292"
                     /db_xref="MGI:MGI:107785"
     exon            1..726
                     /gene="Mesp1"
                     /gene_synonym="bHLHc5"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..795
                     /gene="Mesp1"
                     /gene_synonym="bHLHc5"
                     /codon_start=1
                     /product="mesoderm posterior protein 1"
                     /protein_id="NP_032614.2"
                     /db_xref="CCDS:CCDS21387.1"
                     /db_xref="GeneID:17292"
                     /db_xref="MGI:MGI:107785"
                     /translation="MAQPLCEPRSESWILSPAGRQPPMPSDGNSVCSPAWSSDPWDGA
                     QASSPAPPCARPARRAGTPGRRGTHGSRLGSGQRQSASEREKLRMRTLARALHELRRF
                     LPPSVAPTGQNLTKIETLRLAIRYIGHLSAVLGLSEDNLRRQRHAVSPRGCPLCPDSD
                     LAQSQSLGPRLSPAVCSGVSWGSPPAYPRPRVAAESWDPSFLYAETASQERQEMEPSP
                     SSPLFSSDMLALLETWTPPQEWPPA"
     exon            727..1077
                     /gene="Mesp1"
                     /gene_synonym="bHLHc5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1054..1059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mesp1"
                     /gene_synonym="bHLHc5"
                     /note="hexamer: AATAAA"
     polyA_site      1077
                     /gene="Mesp1"
                     /gene_synonym="bHLHc5"
                     /note="major polyA site"
ORIGIN      
        1 ccgcttcaca cctagggctc aggataaagc tacagcggac ccaatggtca ggcctccgct
       61 gccatggccc agcccctgtg cgagccgcgc tccgagtcct ggatcctgag tcccgctggt
      121 cggcagccac cgatgccttc cgatgggaac agcgtctgct ccccagcctg gtcctcggac
      181 ccgtgggacg gtgcccaggc cagcagccct gcaccaccct gcgcccgccc ggcccggcgt
      241 gctgggaccc cgggtaggcg cgggacgcac ggtagccgcc tgggtagcgg acagcggcag
      301 agcgccagcg agcgggagaa gctacgtatg cgcacactcg cccgcgcgct gcacgagctg
      361 cgccgcttct tgccgccatc cgtggcacca accggccaga acctgaccaa gatcgagacg
      421 ctgcgcctgg ccatccgcta cattggccac ctgtcggctg tgctgggact cagcgaggac
      481 aacctccggc gacagcggca cgcggtgtca cctcgaggct gcccgctgtg ccccgacagc
      541 gacctggcgc agtcgcagtc gctcggtccc cgtttaagcc cggccgtctg cagcggggtg
      601 tcgtggggat ccccgcctgc ctaccctaga ccccgagtcg ccgcagaatc gtgggaccca
      661 tcgttcctgt acgcagaaac agcatcccag gaaaggcagg aaatggagcc cagtccctca
      721 tctccgctct tcagcagcga catgctggct cttctagaaa cctggacgcc gccgcaggag
      781 tggccgcctg cctgaagagt ggaggggaca atgcaacgga tgattgtcac cctgtctgag
      841 cacagacact tttcctttgg tcttggcacc ttcggaggga gtagatcctg gaagaggcgg
      901 cagtgatacc aacatgggca tcccggggtg ggagctggcc ctcatccaga ctgtaccatt
      961 ccaaccctcc ttggaaggag gcgcccaata gggtacacgc tctaaagatg aagcaggcac
     1021 aagctttgcc tggtgtgtat ttatttattt gtgaataaac cgattgtgct agtgtcaaaa
     1081 aaaaaaaaaa aaaaaaaa
//
