LOCUS       NM_023403               3005 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus mesoderm development LRP chaperone (Mesd), transcript
            variant 1, mRNA.
ACCESSION   NM_023403
VERSION     NM_023403.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3005)
  AUTHORS   Moosa,S., Yamamoto,G.L., Garbes,L., Keupp,K., Beleza-Meireles,A.,
            Moreno,C.A., Valadares,E.R., de Sousa,S.B., Maia,S., Saraiva,J.,
            Honjo,R.S., Kim,C.A., Cabral de Menezes,H., Lausch,E., Lorini,P.V.,
            Lamounier,A. Jr., Carniero,T.C.B., Giunta,C., Rohrbach,M.,
            Janner,M., Semler,O., Beleggia,F., Li,Y., Yigit,G., Reintjes,N.,
            Altmuller,J., Nurnberg,P., Cavalcanti,D.P., Zabel,B., Warman,M.L.,
            Bertola,D.R., Wollnik,B. and Netzer,C.
  TITLE     Autosomal-Recessive Mutations in MESD Cause Osteogenesis Imperfecta
  JOURNAL   Am J Hum Genet 105 (4), 836-843 (2019)
   PUBMED   31564437
REFERENCE   2  (bases 1 to 3005)
  AUTHORS   Chen,X., Guo,F., LeBlanc,M.E., Ding,Y., Zhang,C., Shakya,A. and
            Li,W.
  TITLE     Mesd extrinsically promotes phagocytosis by retinal pigment
            epithelial cells
  JOURNAL   Cell Biol Toxicol 32 (4), 347-358 (2016)
   PUBMED   27184668
REFERENCE   3  (bases 1 to 3005)
  AUTHORS   Brommage,R., Liu,J., Hansen,G.M., Kirkpatrick,L.L., Potter,D.G.,
            Sands,A.T., Zambrowicz,B., Powell,D.R. and Vogel,P.
  TITLE     High-throughput screening of mouse gene knockouts identifies
            established and novel skeletal phenotypes
  JOURNAL   Bone Res 2, 14034 (2014)
   PUBMED   26273529
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3005)
  AUTHORS   Hoshi,T., Tezuka,T., Yokoyama,K., Iemura,S., Natsume,T. and
            Yamanashi,Y.
  TITLE     Mesdc2 plays a key role in cell-surface expression of Lrp4 and
            postsynaptic specialization in myotubes
  JOURNAL   FEBS Lett 587 (23), 3749-3754 (2013)
   PUBMED   24140340
  REMARK    GeneRIF: Mescd2 binds to Lrp4 and regulates Lrp4 surface expression
            in myotubes.
REFERENCE   5  (bases 1 to 3005)
  AUTHORS   Taibi,A.V., Lighthouse,J.K., Grady,R.C., Shroyer,K.R. and
            Holdener,B.C.
  TITLE     Development of a conditional Mesd (mesoderm development) allele for
            functional analysis of the low-density lipoprotein receptor-related
            family in defined tissues
  JOURNAL   PLoS One 8 (10), e75782 (2013)
   PUBMED   24124512
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3005)
  AUTHORS   Wines,M.E., Shi,Y., Lindor,M. and Holdener,B.C.
  TITLE     Physical localization of the mesoderm development (mesd) functional
            region
  JOURNAL   Genomics 68 (3), 322-329 (2000)
   PUBMED   10995574
REFERENCE   7  (bases 1 to 3005)
  AUTHORS   Saga,Y., Hata,N., Kobayashi,S., Magnuson,T., Seldin,M.F. and
            Taketo,M.M.
  TITLE     MesP1: a novel basic helix-loop-helix protein expressed in the
            nascent mesodermal cells during mouse gastrulation
  JOURNAL   Development 122 (9), 2769-2778 (1996)
   PUBMED   8787751
REFERENCE   8  (bases 1 to 3005)
  AUTHORS   Holdener,B.C., Faust,C., Rosenthal,N.S. and Magnuson,T.
  TITLE     msd is required for mesoderm induction in mice
  JOURNAL   Development 120 (5), 1335-1346 (1994)
   PUBMED   8026341
REFERENCE   9  (bases 1 to 3005)
  AUTHORS   Klebig,M.L., Russell,L.B. and Rinchik,E.M.
  TITLE     Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a
            neonatally lethal albino deletion that defines the
            hepatocyte-specific developmental regulation 1 (hsdr-1) locus
  JOURNAL   Proc Natl Acad Sci U S A 89 (4), 1363-1367 (1992)
   PUBMED   1741389
REFERENCE   10 (bases 1 to 3005)
  AUTHORS   Klebig,M.L., Kwon,B.S. and Rinchik,E.M.
  TITLE     Physical analysis of murine albino deletions that disrupt
            liver-specific gene regulation or mesoderm development
  JOURNAL   Mamm Genome 2 (1), 51-63 (1992)
   PUBMED   1543902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154141.7.
            
            On Sep 10, 2019 this sequence version replaced NM_023403.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076773.1, AK031949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               AC154141.7         149781-149990       c
            211-443             AC154141.7         146494-146726       c
            444-3005            AC154141.7         141945-144506       c
FEATURES             Location/Qualifiers
     source          1..3005
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 48.35 cM"
     gene            1..3005
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /note="mesoderm development LRP chaperone"
                     /db_xref="GeneID:67943"
                     /db_xref="MGI:MGI:1891421"
     exon            1..210
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..699
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; LDLR chaperone MESD; LRP chaperone MESD;
                     mesoderm development candidate 2"
                     /codon_start=1
                     /product="LRP chaperone MESD isoform 1 precursor"
                     /protein_id="NP_075892.3"
                     /db_xref="CCDS:CCDS21415.1"
                     /db_xref="GeneID:67943"
                     /db_xref="MGI:MGI:1891421"
                     /translation="MAASRWLRAVLLFLCASDLLLLPPPNAYAADTPGEATPPPRKKK
                     DIRDYNDADMARLLEQWEKDDDIEEGDLPEHKRPSAPIDFSKLDPGKPESILKMTKKG
                     KTLMMFVTVSGNPTEKETEEITSLWQGSLFNANYDVQRFIVGSDRAIFMLRDGSYAWE
                     IKDFLVSQDRCAEVTLEGQMYPGKGGGSKEKNKTKPEKAKKKEGDPKPRASKEDNRAG
                     SRREDL"
     exon            211..443
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /inference="alignment:Splign:2.1.0"
     exon            444..3005
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1851..1856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /note="hexamer: AATAAA"
     polyA_site      1875
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /note="major polyA site"
     regulatory      2984..2989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
                     /note="hexamer: ATTAAA"
     polyA_site      3005
                     /gene="Mesd"
                     /gene_synonym="2210015O11Rik; Mesdc2; mKIAA0081; msd"
ORIGIN      
        1 agtccgttac gctaggctgc taacatggct gcctccaggt ggctgcgcgc ggttctactg
       61 tttctgtgtg cctcggacct tctgttgctc cctcctccta atgcctacgc ggcggacact
      121 ccgggcgagg ccaccccacc tccacggaaa aagaaggaca tccgcgatta caacgatgcc
      181 gacatggcgc gacttctgga gcagtgggag aaagatgatg acatagaaga aggagacctt
      241 ccagaacaca agagaccctc agcacctatc gacttctcaa agctagaccc aggcaaacct
      301 gagagcatct tgaaaatgac aaagaaaggg aagactctga tgatgtttgt caccgtgtct
      361 gggaacccca ccgagaagga gacagaggag atcaccagcc tgtggcaggg tagcctgttc
      421 aacgccaact atgacgttca gaggttcatc gtgggatccg accgcgccat cttcatgctc
      481 cgggatggga gctatgcctg ggagatcaag gactttttgg tcagtcaaga ccggtgtgct
      541 gaagtcactc tagagggaca gatgtatcct ggcaaaggag gaggaagcaa ggagaaaaat
      601 aaaacaaagc cagagaaggc taaaaagaag gagggagatc ccaaaccacg tgcttccaag
      661 gaagacaatc gagctgggag cagaagagaa gacctttagc aggtggcaag cttcccgcca
      721 ggtaggcagg accagatagc ccctcgcaga ctggtggggc aggtggtgca ggaaactgca
      781 tagcagatga cattctcatg tcctctagaa atggtctgtg tatgaccatc tggtcaatat
      841 cacagttacc gtataaaagg cttcccatgt gaaggcagga tttgtgattg gtagtggact
      901 ggcaagtcat gtctactgtg gcttcacctg actttggaaa cttgatgttt tgtacctttt
      961 atttctcttg agtccatgac acccccagag taccactccc tcctcagtgc acctgctgtg
     1021 gtcccatggc ctgttgtatc tgtgtattac aagctcaagt cagacaagcc ttgagaagct
     1081 tcaacttgac tgaagcgcgg gtattgattg ttcagtgagt gaagataact gtgccgtatg
     1141 ggcagtgctg tgttcagtga gtgaagataa ctgtgccgta tgagcagtgc tgtgttcagt
     1201 gagtgaagat aactgtgtcg tatgagcagt gctgtgttca gtgagtgaag ataactgtgc
     1261 cgtatgagca gtgctgtgcg cccaggatct ggacagcaaa ctcgttatgc agagtgggca
     1321 gattcacgac agtgccgtcc agaacttctc atcggttctg gggaatcttt gtctccccgt
     1381 ctcctggagt tgaagaggga atgcgcttgt tcatcgtgtg aggaaagaag gatgcttcca
     1441 ctgagggccc acgttctgca tagcccaaca actataaagt tggcgaggag ggaccagcag
     1501 agtcttgcat aggagtggac ctcatctaca gtatttctaa gcggtttcct ttgatgaagt
     1561 gcctaaactt gtgcttttgt atggtactct catgatgtgc tgctgttcac atctgtttct
     1621 gctgttcata ggttgaagct tcgctaaaag aacatttcta tgaggatgcc atttttaaga
     1681 actcacattc ttttaaaacc tcagttgtgg tttgaaattc gaaatagtac atgtacacgt
     1741 acccggctag aaattgtcac tgttaagagt gtcacagtgt gaagaattgc cctaccctgc
     1801 tgccagtact ttgtcccagt gaagctactg ttggtcattg gtttttcaaa aataaagtac
     1861 aattaccagc ttccagtgat aggtatattc tgtcctccag tgatgggtat attctgtcct
     1921 ccagttggtt tccgttcatg tttctcttac caagccacac ctccctcccc agctcagggc
     1981 gtcctggaca caacctgctg agcctcttca aaaagaagct ttttttggtc ctcgcacctt
     2041 gtgacttgtg atgatctgct gctgtcctgt ttgagggtgc tgccaatcta ggagaagctg
     2101 ggacagggca ctcatccttt tggtatctgt gggcccagca aatctgaaac aagccccgtt
     2161 cctggggttt ttctgttttc acatggggca gttgattggc tactgtcatg tctagccatg
     2221 atgctctttt ctcagggctg ccgtttcctt ctggaagcct tcatgatgct gacacgggac
     2281 tgtcatggct ttgagtgtgg tgtgcagcct cttcaccagg ttcatgcatc acctgtgatg
     2341 tagttgtcac tggtgggttc tgaggacagt gcaggcatgg caggaatgac tgactgtgag
     2401 gagaaaggaa gaaatgcata atgcagtgaa ctgaatgggc agagctttgt tgggaggtca
     2461 agggagttcc ctttgcaaag gccctgaggc tagaagtagt agacaagggt gctcttggag
     2521 gcccctgagg agtctggact ggggagtgag gactctagga ggctgttgga attttgagtg
     2581 cctcagggat tttgcgtagt actgacagga gagcttctcc ggactcaggc ctttagtcag
     2641 tctctcgggt ttacaggcag agaggcttga agcagccttc ggttcatgct ttctgctgtt
     2701 tctgatttct ggctgtgtat tctgagctgg gataaacaga ttctcctctc caaacactta
     2761 tttgctacta gaaacgaaat tggcacatta agcctccttt tattacagtt caagaatttg
     2821 aactccagat tgatcgattt accctccctg atttttgaca gtccctaaac tgcctcgtgt
     2881 tgtcacattt cttcaaattc ttgggttcga gtttctaaag cacaagaagc caggaggccc
     2941 tactgctgct ttttatgagt caaatcaagt agaatgaaag tctattaaag tcacttgtac
     3001 ccaga
//
