LOCUS       NM_008587               4456 bp    mRNA    linear   ROD 07-FEB-2023
DEFINITION  Mus musculus MER proto-oncogene tyrosine kinase (Mertk), mRNA.
ACCESSION   NM_008587 XM_917808
VERSION     NM_008587.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4456)
  AUTHORS   Shi J, Gao S, Chen Z, Chen Z, Yun D, Wu X and Sun F.
  TITLE     Absence of MerTK disrupts spermatogenesis in an age-dependent
            manner
  JOURNAL   Mol Cell Endocrinol 560, 111815 (2023)
   PUBMED   36379275
  REMARK    GeneRIF: Absence of MerTK disrupts spermatogenesis in an
            age-dependent manner.
REFERENCE   2  (bases 1 to 4456)
  AUTHORS   Zhang H, Ni M, Wang H, Zhang J, Jin D, Busuttil RW,
            Kupiec-Weglinski JW, Li W, Wang X and Zhai Y.
  TITLE     Gsk3beta regulates the resolution of liver ischemia/reperfusion
            injury via MerTK
  JOURNAL   JCI Insight 8 (1), e151819 (2023)
   PUBMED   36422999
  REMARK    GeneRIF: Gsk3beta regulates the resolution of liver
            ischemia/reperfusion injury via MerTK.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4456)
  AUTHORS   Rigoni TS, Vellozo NS, Guimaraes-Pinto K, Cabral-Piccin M,
            Fabiano-Coelho L, Matos-Silva TC, Filardy AA, Takiya CM and Lopes
            MF.
  TITLE     Axl receptor induces efferocytosis, dampens M1 macrophage responses
            and promotes heart pathology in Trypanosoma cruzi infection
  JOURNAL   Commun Biol 5 (1), 1421 (2022)
   PUBMED   36581764
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4456)
  AUTHORS   Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu TV,
            Beitzen-Heineke A, Vargas-Delgado ME, Pantel K, Bokemeyer C,
            Bhamidipati S, Darwish IS, Masuda E, Burstyn-Cohen T, Alberto EJ,
            Ghosh S, Rothlin C, Hesse E, Taipaleenmaki H, Ben-Batalla I and
            Loges S.
  TITLE     Regulation of bone homeostasis by MERTK and TYRO3
  JOURNAL   Nat Commun 13 (1), 7689 (2022)
   PUBMED   36509738
  REMARK    GeneRIF: Regulation of bone homeostasis by MERTK and TYRO3.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4456)
  AUTHORS   Huang Y and Lemke G.
  TITLE     Early death in a mouse model of Alzheimer's disease exacerbated by
            microglial loss of TAM receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 119 (41), e2204306119 (2022)
   PUBMED   36191221
  REMARK    GeneRIF: Early death in a mouse model of Alzheimer's disease
            exacerbated by microglial loss of TAM receptor signaling.
REFERENCE   6  (bases 1 to 4456)
  AUTHORS   Robinson DR, Wu YM and Lin SF.
  TITLE     The protein tyrosine kinase family of the human genome
  JOURNAL   Oncogene 19 (49), 5548-5557 (2000)
   PUBMED   11114734
  REMARK    Review article
REFERENCE   7  (bases 1 to 4456)
  AUTHORS   Lu Q, Gore M, Zhang Q, Camenisch T, Boast S, Casagranda F, Lai C,
            Skinner MK, Klein R, Matsushima GK, Earp HS, Goff SP and Lemke G.
  TITLE     Tyro-3 family receptors are essential regulators of mammalian
            spermatogenesis
  JOURNAL   Nature 398 (6729), 723-728 (1999)
   PUBMED   10227296
REFERENCE   8  (bases 1 to 4456)
  AUTHORS   Camenisch TD, Koller BH, Earp HS and Matsushima GK.
  TITLE     A novel receptor tyrosine kinase, Mer, inhibits TNF-alpha
            production and lipopolysaccharide-induced endotoxic shock
  JOURNAL   J Immunol 162 (6), 3498-3503 (1999)
   PUBMED   10092806
REFERENCE   9  (bases 1 to 4456)
  AUTHORS   Bork,P.
  TITLE     Sperm-egg binding protein or proto-oncogene?
  JOURNAL   Science 271 (5254), 1431-1435 (1996)
   PUBMED   8596918
REFERENCE   10 (bases 1 to 4456)
  AUTHORS   Graham DK, Bowman GW, Dawson TL, Stanford WL, Earp HS and Snodgrass
            HR.
  TITLE     Cloning and developmental expression analysis of the murine c-mer
            tyrosine kinase
  JOURNAL   Oncogene 10 (12), 2349-2359 (1995)
   PUBMED   7784083
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK171320.1, U21301.1 and AL808104.14.
            
            [WARNING] On May 2, 2023 this sequence was replaced by NM_008587.3.
            
            On Jan 19, 2017 this sequence version replaced NM_008587.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U21301.1, SRR7974084.5624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AK171320.1         2-83
            83-3637             U21301.1           1-3555
            3638-4456           AL808104.14        85003-85821
FEATURES             Location/Qualifiers
     source          1..4456
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..4456
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /note="MER proto-oncogene tyrosine kinase"
                     /db_xref="GeneID:17289"
                     /db_xref="MGI:MGI:96965"
     exon            1..189
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..3116
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /EC_number="2.7.10.1"
                     /note="proto-oncogene tyrosine-protein kinase Mer;
                     proto-oncogene c-Mer; receptor tyrosine kinase MerTK;
                     c-mer proto-oncogene tyrosine kinase; Tyro 12"
                     /codon_start=1
                     /product="tyrosine-protein kinase Mer precursor"
                     /protein_id="NP_032613.1"
                     /db_xref="CCDS:CCDS16716.1"
                     /db_xref="GeneID:17289"
                     /db_xref="MGI:MGI:96965"
                     /translation="MVLAPLLLGLLLLPALWSGGTAEKWEETELDQLFSGPLPGRLPV
                     NHRPFSAPHSSRDQLPPPQTGRSHPAHTAAPQVTSTASKLLPPVAFNHTIGHIVLSEH
                     KNVKFNCSINIPNTYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSIASV
                     QRSDNGSYFCKMKVNNREIVSDPIYVEVQGLPYFIKQPESVNVTRNTAFNLTCQAVGP
                     PEPVNIFWVQNSSRVNEKPERSPSVLTVPGLTETAVFSCEAHNDKGLTVSKGVHINIK
                     VIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADRLSNGSVMVFNTSA
                     SPHLYEIQQLQALANYSIAVSCRNEIGWSAVSPWILASTTEGAPSVAPLNITVFLNES
                     NNILDIRWTKPPIKRQDGELVGYRISHVWESAGTYKELSEEVSQNGSWAQIPVQIHNA
                     TCTVRIAAITKGGIGPFSEPVNIIIPEHSKVDYAPSSTPAPGNTDSMFIILGCFCGFI
                     LIGLILCISLALRRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSE
                     ELQNKLEDVVIDRNLLVLGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQR
                     EIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSR
                     LNTGPKYIHLQTLLKFMMDIAQGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLS
                     KKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEITTRGMTPYPG
                     VQNHEMYDYLLHGHRLKQPEDCLDELYDIMYSCWSADPLDRPTFSVLRLQLEKLSESL
                     PDAQDKESIIYINTQLLESCEGIANGPSLTGLDMNIDPDSIIASCTPGAAVSVVTAEV
                     HENNLREERYILNGGNEEWEDVSSTPFAAVTPEKDGVLPEDRLTKNGVSWSHHSTLPL
                     GSPSPDELLFVDDSLEDSEVLM"
     exon            190..598
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            599..699
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            700..873
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            874..960
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1076
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1260
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1412
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1566
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1720
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1806
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1902
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..1983
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2076
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            2077..2195
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2305
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            2306..2465
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            2466..2602
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..4456
                     /gene="Mertk"
                     /gene_synonym="Eyk; Mer; nmf12; Nyk"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactctggcg cctgctgccc gggcggccgg gactgaggcg cttcgcacgc gccctcggcg
       61 actggcgagt ttgggacgtt ggtggatacg tgcatctgtc cggagagaac tgccagatcc
      121 gcggccccgc gatggttctg gccccactgc tactggggct gctgctgcta cccgcgctct
      181 ggagtggagg cactgccgag aagtgggaag agaccgagct agatcagcta ttttcagggc
      241 ctttaccagg gagactccca gtcaaccaca ggccattctc tgctcctcac tccagccggg
      301 accagctgcc accaccccag actggaagat cacatccagc acacacagcc gctccccagg
      361 tgacctccac agcatcaaag ctcctacctc ctgttgcgtt taatcacacc attggacaca
      421 tagtactgtc ggaacataaa aatgtcaaat ttaattgctc catcaatatt cctaacacat
      481 accaagaaac agctggcatt tcatggtgga aagatggaaa ggaattgctc ggggcacatc
      541 attcaatcac acagttttat cctgatgagg aaggggtatc aataattgca ttgttcagca
      601 tagccagtgt gcagcgctca gacaatgggt cgtacttctg taagatgaag gtgaacaata
      661 gagagattgt atctgatccc atatacgtgg aagttcaagg actcccttac tttattaagc
      721 agcctgagag tgtgaatgtc accagaaaca cagccttcaa cctcacctgc caggccgtgg
      781 gccctcctga gcccgtcaat atcttctggg ttcaaaatag cagccgtgtt aatgaaaaac
      841 cggaaaggtc cccgtctgtc ctaaccgtac ctggtctgac agagacagca gtcttcagct
      901 gtgaggccca caatgacaaa ggactgacgg tgtccaaggg tgtacatatc aacatcaaag
      961 taatcccctc cccgcccact gaagtccata tcctcaacag tacagcacac agcatcctgg
     1021 tctcctgggt ccctggtttt gatggctact ccccacttca gaactgcagc attcaggtca
     1081 aggaagctga ccggctgagt aatggctcag tcatggtttt taatacctct gcttcgccac
     1141 atctgtatga gatccagcag ctgcaagccc tggctaatta cagcatcgct gtgtcctgtc
     1201 ggaatgagat tggctggtct gcagtaagcc cttggattct ggccagcaca acagaaggag
     1261 ctccatctgt agcaccttta aacatcactg tgtttctgaa cgaatctaac aatatcctgg
     1321 atattagatg gacgaagcct ccaattaagc ggcaggatgg ggaactggtg ggctaccgga
     1381 tatctcacgt gtgggaaagc gcagggactt acaaagagct ttctgaagaa gtcagccaga
     1441 atggcagctg ggctcagatt cctgtccaaa tccacaatgc cacctgcaca gtgagaatcg
     1501 cggccattac taaagggggc atcgggccct tcagtgagcc agtgaatatc atcattcctg
     1561 aacacagtaa ggtagattac gcaccctcgt caaccccagc ccctggcaac accgactcta
     1621 tgttcatcat cctcggctgc ttctgtggat tcattttaat cgggttaatt ttgtgtattt
     1681 ctctggccct cagaaggaga gtccaggaaa caaagtttgg gggagcattc tctgaggagg
     1741 attcccaact ggtcgtaaat tatagagcga agaagtcctt ctgccggcga gccatcgagc
     1801 ttaccttgca gagcctggga gtgagcgagg agctgcagaa taagctggaa gatgttgtga
     1861 ttgacagaaa ccttctggtt ctcggcaaag ttctgggtga aggagagttt gggtctgtaa
     1921 tggaaggaaa tttgaagcaa gaagatggga cttctcagaa ggtggcagtg aagaccatga
     1981 agttggacaa cttttctcaa cgggagatcg aggagtttct cagcgaagca gcatgcatga
     2041 aagacttcaa ccacccaaat gtcatccgac ttctaggcgt gtgtatagaa ctgagctctc
     2101 aaggcatccc gaagcccatg gtgattttac ccttcatgaa atacggagac ctccacacct
     2161 tcctgttata ttcccgatta aacacaggac ccaagtacat tcacctgcag acactactga
     2221 agttcatgat ggacattgcc cagggaatgg agtatctgag caacaggaat tttcttcata
     2281 gggatttggc agctcgaaac tgcatgttgc gggatgacat gactgtctgc gtggcagact
     2341 ttggcctctc aaagaagatt tacagtggtg attattaccg ccaaggccgc attgccaaaa
     2401 tgcctgtgaa gtggatcgcc atcgagagcc tggcggaccg agtctacaca agcaaaagtg
     2461 acgtgtgggc ttttggcgtg accatgtggg aaataacaac acggggaatg actccctatc
     2521 ccggagttca gaaccatgag atgtacgact accttctcca cggccacagg ctgaagcagc
     2581 ctgaggactg cttggatgaa ctgtatgaca tcatgtactc ttgctggagt gctgatccct
     2641 tggatcgacc caccttctct gtgttgaggc tgcagctgga aaagctctcc gagagtttgc
     2701 ctgatgcgca ggacaaagaa tccatcatct acatcaatac ccagttgcta gagagctgcg
     2761 agggcatagc caatgggccc tcactcacgg ggctagacat gaacattgac cctgactcca
     2821 tcattgcctc ttgcacacca ggcgctgccg tcagcgtggt cacggcagaa gttcacgaga
     2881 acaaccttcg tgaggaaaga tacatcttga atgggggcaa tgaggaatgg gaagatgtgt
     2941 cctccactcc ttttgctgca gtcacacctg aaaaggatgg tgtcttaccg gaggacagac
     3001 tcaccaaaaa tggcgtctcc tggtctcacc atagtacact acccttgggg agcccatcac
     3061 cagatgaact tttatttgta gatgactcct tggaagactc tgaagttctg atgtgaagcc
     3121 agctgagagg aggcatgaga gaaccaagca aatacagctt cctgggatct ggtggtctta
     3181 gatactttgt tattgctctg ataaaacatc atgaccaagg caatcttcaa gagaaagtgt
     3241 ttaactaggt ttactgtttc agggggttag agtctatgat tgcagaagga agttatgatg
     3301 gcaggaacag ctgagtgctt atatctttaa gagcaagcag gagacagaga gcactctggg
     3361 aaatggcacc tatcttttga aacctcaaag cctgctccca gtgacaaaag tccttcaaca
     3421 ggccatacct cctaatcctt cccaaacaat tccaccaact ggagaccaaa cattcaaatg
     3481 tatgcgcgta ttggggccat tcttaagcaa accactacac tggttatacc tgaggttttg
     3541 gtacttgttt tccttaccaa gtagagttca tggccggaca gcaccaggtg aaagctgtca
     3601 agtcaggttt gcaaatacat aaccaaggtc ttgagagaca actttttata gagatttctt
     3661 ttatacagtt gcctgcaact aaatcagaag gctcacaacc acctgtaact ccagttctag
     3721 aagactgata ctctcttctg gcctctgagg gcatctgcac acacgaggca tactctcacg
     3781 cagtcatatg aatcaaaata aatctaaaaa taagtaaatc aatagcaagg ctaggcgtgt
     3841 ggctcagcaa ctctgtgctt aacctgtgaa ctgtcctata tttcatccca agaccccaaa
     3901 gcagtacaga ataaaaatac agaggcgagg ggagatagct tagttggtaa agtccttgac
     3961 ttgtaagtgt caggatatga gtctgatccc cagagccaac atagcacaac tttgaatgtg
     4021 atagcacaca cttgtgatct cagtgctggg gaggtggtct caggtggatt tctgaggctc
     4081 actggccagc tacccaggtg agttccaggc caagtaaggc ctgtctcaaa aaaaaaaaaa
     4141 aaaaaaaagg tggacagcac ctgaggagtg atatttgatg ctgttctctg tacacacaca
     4201 cacacacaca cacacgaaca tgcattcaca agaaaaatat aaataaaata cataatatat
     4261 ttatttaaag agagaatata tatgtatatg gtggaaagag ccaaggagat tatattttaa
     4321 taaaagatga cttatttcac tgaccttgca gaactcaaaa tgtatccctc agtgttaaca
     4381 tttgtacaga atcaatgttg ctttttaaaa gttgttttct tttccacagt attaaatgta
     4441 aaagtgtttg ttaagt
//
