LOCUS       NM_053172               1682 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus matrix extracellular phosphoglycoprotein with ASARM
            motif (bone) (Mepe), mRNA.
ACCESSION   NM_053172
VERSION     NM_053172.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1682)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   2  (bases 1 to 1682)
  AUTHORS   Hai,Q., Ritchey,B., Robinet,P., Alzayed,A.M., Brubaker,G., Zhang,J.
            and Smith,J.D.
  TITLE     Quantitative Trait Locus Mapping of Macrophage Cholesterol
            Metabolism and CRISPR/Cas9 Editing Implicate an ACAT1 Truncation as
            a Causal Modifier Variant
  JOURNAL   Arterioscler Thromb Vasc Biol 38 (1), 83-91 (2018)
   PUBMED   29097366
REFERENCE   3  (bases 1 to 1682)
  AUTHORS   Bouleftour,W., Juignet,L., Bouet,G., Granito,R.N.,
            Vanden-Bossche,A., Laroche,N., Aubin,J.E., Lafage-Proust,M.H.,
            Vico,L. and Malaval,L.
  TITLE     The role of the SIBLING, Bone Sialoprotein in skeletal biology -
            Contribution of mouse experimental genetics
  JOURNAL   Matrix Biol 52-54, 60-77 (2016)
   PUBMED   26763578
  REMARK    Review article
REFERENCE   4  (bases 1 to 1682)
  AUTHORS   Gullard,A., Gluhak-Heinrich,J., Papagerakis,S., Sohn,P.,
            Unterbrink,A., Chen,S. and MacDougall,M.
  TITLE     MEPE Localization in the Craniofacial Complex and Function in Tooth
            Dentin Formation
  JOURNAL   J Histochem Cytochem 64 (4), 224-236 (2016)
   PUBMED   26927967
  REMARK    GeneRIF: Mepe(-/-) molars exhibited increased thickness of
            predentin, dentin, and enamel over controls and decreased gene
            expression of Enam, Bsp, Dmp1, Dspp, and Opn by RT-PCR.
REFERENCE   5  (bases 1 to 1682)
  AUTHORS   Fujikawa,K., Yokohama-Tamaki,T., Morita,T., Baba,O., Qin,C. and
            Shibata,S.
  TITLE     An in situ hybridization study of perlecan, DMP1, and MEPE in
            developing condylar cartilage of the fetal mouse mandible and limb
            bud cartilage
  JOURNAL   Eur J Histochem 59 (3), 2553 (2015)
   PUBMED   26428891
  REMARK    GeneRIF: An in situ hybridization study of perlecan, DMP1, and MEPE
            in developing condylar cartilage of the fetal mouse mandible and
            limb bud cartilage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1682)
  AUTHORS   Lu,C., Huang,S., Miclau,T., Helms,J.A. and Colnot,C.
  TITLE     Mepe is expressed during skeletal development and regeneration
  JOURNAL   Histochem Cell Biol 121 (6), 493-499 (2004)
   PUBMED   15221418
  REMARK    GeneRIF: Mepe appears to play a role in both long bone regeneration
            and the latter stages of skeletogenesis.
REFERENCE   7  (bases 1 to 1682)
  AUTHORS   Quarles,L.D.
  TITLE     FGF23, PHEX, and MEPE regulation of phosphate homeostasis and
            skeletal mineralization
  JOURNAL   Am J Physiol Endocrinol Metab 285 (1), E1-E9 (2003)
   PUBMED   12791601
  REMARK    Review article
REFERENCE   8  (bases 1 to 1682)
  AUTHORS   Gowen,L.C., Petersen,D.N., Mansolf,A.L., Qi,H., Stock,J.L.,
            Tkalcevic,G.T., Simmons,H.A., Crawford,D.T., Chidsey-Frink,K.L.,
            Ke,H.Z., McNeish,J.D. and Brown,T.A.
  TITLE     Targeted disruption of the osteoblast/osteocyte factor 45 gene
            (OF45) results in increased bone formation and bone mass
  JOURNAL   J Biol Chem 278 (3), 1998-2007 (2003)
   PUBMED   12421822
REFERENCE   9  (bases 1 to 1682)
  AUTHORS   Guo,R., Rowe,P.S., Liu,S., Simpson,L.G., Xiao,Z.S. and Quarles,L.D.
  TITLE     Inhibition of MEPE cleavage by Phex
  JOURNAL   Biochem Biophys Res Commun 297 (1), 38-45 (2002)
   PUBMED   12220505
  REMARK    GeneRIF: MEPE may be involved in the pathogenesis defective
            mineralization due to Phex deficiency in X-linked hypophosphatemia
            (XLH) and the Hyp-mouse.
REFERENCE   10 (bases 1 to 1682)
  AUTHORS   Argiro,L., Desbarats,M., Glorieux,F.H. and Ecarot,B.
  TITLE     Mepe, the gene encoding a tumor-secreted protein in oncogenic
            hypophosphatemic osteomalacia, is expressed in bone
  JOURNAL   Genomics 74 (3), 342-351 (2001)
   PUBMED   11414762
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF298661.1.
            
            On Mar 27, 2009 this sequence version replaced NM_053172.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF298661.1, AK158330.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1682              AF298661.1         1-1682
FEATURES             Location/Qualifiers
     source          1..1682
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 50.68 cM"
     gene            1..1682
                     /gene="Mepe"
                     /gene_synonym="Of45"
                     /note="matrix extracellular phosphoglycoprotein with ASARM
                     motif (bone)"
                     /db_xref="GeneID:94111"
                     /db_xref="MGI:MGI:2137384"
     exon            1..76
                     /gene="Mepe"
                     /gene_synonym="Of45"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1392
                     /gene="Mepe"
                     /gene_synonym="Of45"
                     /note="osteoregulin; osteoblast/osteocyte factor 45"
                     /codon_start=1
                     /product="matrix extracellular phosphoglycoprotein
                     precursor"
                     /protein_id="NP_444402.2"
                     /db_xref="CCDS:CCDS51578.1"
                     /db_xref="GeneID:94111"
                     /db_xref="MGI:MGI:2137384"
                     /translation="MTPEGLMKMQAVSVGLLLFSMTWAAPMPNEDRSSCGNQDSIHKD
                     LAASVYPDPTVDEGTEDGQGALLHPPGQDRYGAALLRNITQPVKSLVTGAELRREGNQ
                     EKRPQSVLSVIPADVNDAKVSLKDIKNQESYLLTQSSPVKSKHTKHTRQTRRSTHYLT
                     HLPQIKKTPSDLEGSGSPDLLVRGDNDVPPFSGDGQHFMHIPGKGGAGSGPESSTSRP
                     LSGSSKAEVIDPHMSGLGSNEIPGREGHGGSAYATRDKAAQGAGSAGGSLVGGSNEIT
                     GSTNFRELPGKEGNRINAGSQNAHQGKVEFHYPQVASREKVKGGVEHAGRAGYNEIPK
                     SSKGSSSKDAEESKGNQLTLTASQRFPGKGKSQGPALPSHSLSNEVKSEENHYVFHGQ
                     NNLTPNKGMSQRRGSWPSRRPNSHRRASTRQRDSSESSSSGSSSESHGD"
     exon            77..144
                     /gene="Mepe"
                     /gene_synonym="Of45"
                     /inference="alignment:Splign:2.1.0"
     exon            145..1682
                     /gene="Mepe"
                     /gene_synonym="Of45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaactttaa atttcagcaa atgcccagag actaagcccg aagaagccaa gctttcctga
       61 aggtgaatga cgccagaggg cctcatgaag atgcaggctg tgtctgttgg actgctcctc
      121 ttcagtatga cctgggcggc accaatgccg aatgaagaca ggagcagctg cggcaatcaa
      181 gacagcattc acaaggactt ggcagcatct gtgtatcctg atcccacggt ggatgaaggc
      241 acagaggatg ggcaaggtgc tctccttcac ccgcctggcc aggacaggta tggtgctgcc
      301 ctcctcagaa atatcacgca gcctgtaaag agtctagtga ctggggccga actacggagg
      361 gaaggaaacc aggagaagag acctcagagt gttctaagcg taattccagc agatgtcaat
      421 gatgctaaag tctccttaaa agacataaag aatcaagaga gttatctgct aacccagagc
      481 agcccggtca aaagcaaaca caccaaacac acccgccaga cccgacggag cactcactac
      541 ctgacacatc tcccacagat caagaagact cccagtgacc ttgaaggcag tggctcccca
      601 gatcttctag tgaggggaga taatgatgtc ccccctttca gtggagatgg gcaacatttt
      661 atgcacattc ctggcaaagg aggtgctggg tctggtcctg aaagctcaac tagtcgcccc
      721 ctctcaggct ccagcaaagc tgaagttatt gacccacata tgagtggact aggctctaat
      781 gagatcccgg ggagagaagg acatggtggc agtgcctatg caaccagaga caaagctgca
      841 cagggggcag gctctgcagg tgggagcctt gtggggggca gcaatgaaat cacaggcagc
      901 accaatttca gggaactccc cggaaaagaa ggaaacagaa ttaatgccgg cagccaaaat
      961 gctcatcaag ggaaagtaga atttcactat ccacaagtgg cctcgagaga aaaggtaaag
     1021 gggggcgtgg agcatgcagg gagagctggt tacaacgaaa tccccaagag cagcaaaggt
     1081 agctctagca aagatgcaga agagtccaaa gggaaccaat taaccttgac tgcaagccaa
     1141 agatttccag gtaaaggcaa aagccagggc cctgctctgc cctctcacag tcttagtaat
     1201 gaggttaaaa gtgaagaaaa ccattatgtg ttccatggac aaaataatct tacaccgaat
     1261 aaagggatgt cacagcggag aggctcctgg ccttcgagaa gacccaattc ccacaggcgc
     1321 gctagcaccc gccaaagaga cagcagcgag tcgtcatcca gtgggagttc tagtgagagt
     1381 catggtgact agtccctggg attgaaccag tcccctgctc tagtcctgga ggaagagagg
     1441 gcacagcagg aactgagcaa gccaacagac ctggtcccct ccaggacatt gtgctatttt
     1501 aatggtggtt ataagaattt ctactcaaag ttctaatgct tttttcaata aaaactttca
     1561 taagaatttg tataataggt aatatttgga caggcgacac attaaaatag tctgtgaatg
     1621 tcacaagtgc cttgatacgt catcatttgc tcttcagaca tgaaaataaa tatgcttgct
     1681 ct
//
