LOCUS       NM_008586               2286 bp    mRNA    linear   ROD 29-JUL-2024
DEFINITION  Mus musculus meprin 1 beta (Mep1b), mRNA.
ACCESSION   NM_008586
VERSION     NM_008586.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2286)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2286)
  AUTHORS   Bulck,C., Nystrom,E.E.L., Koudelka,T., Mannbar-Frahm,M.,
            Andresen,G., Radhouani,M., Tran,F., Scharfenberg,F., Schrell,F.,
            Armbrust,F., Dahlke,E., Zhao,B., Vervaeke,A., Theilig,F.,
            Rosenstiel,P., Starkl,P., Rosshart,S.P., Fickenscher,H., Tholey,A.,
            Hansson,G.C. and Becker-Pauly,C.
  TITLE     Proteolytic processing of galectin-3 by meprin metalloproteases is
            crucial for host-microbiome homeostasis
  JOURNAL   Sci Adv 9 (13), eadf4055 (2023)
   PUBMED   37000885
REFERENCE   3  (bases 1 to 2286)
  AUTHORS   Abousaad,S., Ahmed,F., Abouzeid,A. and Ongeri,E.M.
  TITLE     Meprin beta expression modulates the interleukin-6 mediated
            JAK2-STAT3 signaling pathway in ischemia/reperfusion-induced kidney
            injury
  JOURNAL   Physiol Rep 10 (18), e15468 (2022)
   PUBMED   36117389
REFERENCE   4  (bases 1 to 2286)
  AUTHORS   Marengo,L., Armbrust,F., Schoenherr,C., Storck,S.E., Schmitt,U.,
            Zampar,S., Wirths,O., Altmeppen,H., Glatzel,M., Kaether,C.,
            Weggen,S., Becker-Pauly,C. and Pietrzik,C.U.
  TITLE     Meprin beta knockout reduces brain Abeta levels and rescues
            learning and memory impairments in the APP/lon mouse model for
            Alzheimer's disease
  JOURNAL   Cell Mol Life Sci 79 (3), 168 (2022)
   PUBMED   35235058
  REMARK    GeneRIF: Meprin beta knockout reduces brain Abeta levels and
            rescues learning and memory impairments in the APP/lon mouse model
            for Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2286)
  AUTHORS   Berner,D.K., Wessolowski,L., Armbrust,F., Schneppenheim,J.,
            Schlepckow,K., Koudelka,T., Scharfenberg,F., Lucius,R., Tholey,A.,
            Kleinberger,G., Haass,C., Arnold,P. and Becker-Pauly,C.
  TITLE     Meprin beta cleaves TREM2 and controls its phagocytic activity on
            macrophages
  JOURNAL   FASEB J 34 (5), 6675-6687 (2020)
   PUBMED   32237095
REFERENCE   6  (bases 1 to 2286)
  AUTHORS   Marchand,P., Tang,J. and Bond,J.S.
  TITLE     Membrane association and oligomeric organization of the alpha and
            beta subunits of mouse meprin A
  JOURNAL   J Biol Chem 269 (21), 15388-15393 (1994)
   PUBMED   8195177
REFERENCE   7  (bases 1 to 2286)
  AUTHORS   Gorbea,C.M., Marchand,P., Jiang,W., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A. and Bond,J.S.
  TITLE     Cloning, expression, and chromosomal localization of the mouse
            meprin beta subunit
  JOURNAL   J Biol Chem 268 (28), 21035-21043 (1993)
   PUBMED   8407940
REFERENCE   8  (bases 1 to 2286)
  AUTHORS   Jiang,W., Gorbea,C.M., Flannery,A.V., Beynon,R.J., Grant,G.A. and
            Bond,J.S.
  TITLE     The alpha subunit of meprin A. Molecular cloning and sequencing,
            differential expression in inbred mouse strains, and evidence for
            divergent evolution of the alpha and beta subunits
  JOURNAL   J Biol Chem 267 (13), 9185-9193 (1992)
   PUBMED   1374387
  REMARK    Erratum:[J Biol Chem 1992 Jul 5;267(19):13779]
REFERENCE   9  (bases 1 to 2286)
  AUTHORS   Gorbea,C.M., Flannery,A.V. and Bond,J.S.
  TITLE     Homo- and heterotetrameric forms of the membrane-bound
            metalloendopeptidases meprin A and B
  JOURNAL   Arch Biochem Biophys 290 (2), 549-553 (1991)
   PUBMED   1929422
REFERENCE   10 (bases 1 to 2286)
  AUTHORS   Craig,S.S., Mader,C. and Bond,J.S.
  TITLE     Immunohistochemical localization of the metalloproteinase meprin in
            salivary glands of male and female mice
  JOURNAL   J Histochem Cytochem 39 (1), 123-129 (1991)
   PUBMED   1701182
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK098127.1.
            
            On May 22, 2007 this sequence version replaced NM_008586.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK098127.1, BC145979.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2286              AK098127.1         1-2286
FEATURES             Location/Qualifiers
     source          1..2286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 11.81 cM"
     gene            1..2286
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /note="meprin 1 beta"
                     /db_xref="GeneID:17288"
                     /db_xref="MGI:MGI:96964"
     exon            1..93
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..2145
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /EC_number="3.4.24.63"
                     /note="meprin A subunit beta; endopeptidase-2; meprin B;
                     meprin beta"
                     /codon_start=1
                     /product="meprin A subunit beta precursor"
                     /protein_id="NP_032612.2"
                     /db_xref="CCDS:CCDS37747.1"
                     /db_xref="GeneID:17288"
                     /db_xref="MGI:MGI:96964"
                     /translation="MDARHQPWFLVFATFLLVSGLPAPEKFVKDIDGGIDQDIFDINQ
                     GLGLDLFEGDIKLEANGKNSIIGDHKRWPHTIPYVLEDSLEMNAKGVILNAFERYRLK
                     TCIDFKPWSGEANYISVFKGSGCWSSVGNIHAGKQELSIGTNCDRIATVQHEFLHALG
                     FWHEQSRADRDDYVIIVWDRIQPGKEHNFNIYNDSVSDSLNVPYDYTSVMHYSKTAFQ
                     NGTESTIVTRISEFEDVIGQRMDFSDYDLLKLNQLYNCTSSLSFMDSCDFELENICGM
                     IQSSGDSADWQRVSQVLSGPESDHSKMGQCKDSGFFMHFNTSILNEGATAMLESRLLY
                     PKRGFQCLEFYLYNSGSGNDQLNIYTREYTTGQQGGVLTLQRQIKEVPIGSWQLHYVT
                     LQVTKKFRVVFEGLRGPGTSSGGLSIDDINLSETRCPHHIWHIQNFTQILGGQDTSVY
                     SPPFYSSKGYAFQIYMDLRSSTNVGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPD
                     IRQRMFNQRSITTDPTMTSDNGSYFWDRPSKVGVTDVFPNGTQFSRGIGYGTTVFITR
                     ERLKSREFIKGDDIYILLTVEDISHLNSTSAVPDPVPTLAVHNACSEVVCQNGGICVV
                     QDGRAECKCPAGEDWWYMGKRCEKRGSTRDTVIIAVSSTVTVFAVMLIITLVSVYCTR
                     RKYRKKARANTAAMTLENQHAF"
     exon            94..112
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            113..163
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            164..204
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            205..283
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            284..401
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            402..580
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            581..799
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            800..952
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1168
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1612
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1792
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1793..1925
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..2130
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2286
                     /gene="Mep1b"
                     /gene_synonym="Mep-1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcttgcagc tttcatctgg aagccacagt atggatgccc ggcatcagcc ttggtttctg
       61 gtttttgcca catttctcct ggtttctggt ttgccagctc cggaaaagtt tgtcaaagac
      121 atagatggag gaattgacca agacatattt gatattaacc aaggtttggg tctggacctt
      181 tttgagggag acatcaaact cgaggcaaat gggaagaatt ccatcattgg agaccacaag
      241 agatggccac ataccattcc atatgttcta gaggacagct tggaaatgaa tgctaaagga
      301 gttatcctca atgcttttga gcgctatcgc cttaaaacat gcattgactt caagccttgg
      361 tccggagaag ctaactatat ctcagtgttc aagggcagtg ggtgctggtc ttcagtggga
      421 aacattcatg ctgggaagca ggagttgtcc attgggacaa actgtgacag aatagcaaca
      481 gttcagcatg agttcctcca cgccctggga ttctggcatg agcagtcacg tgctgaccgg
      541 gatgattacg tcattatagt ttgggacagg attcagccag gcaaggaaca caacttcaac
      601 atctacaatg acagtgtgtc tgattccctg aatgtcccat atgactacac ctcagtaatg
      661 cactacagta aaaccgcttt ccagaacggg acagagtcta ccatcgtcac gagaatctca
      721 gagttcgagg acgtgattgg ccaacgaatg gacttcagtg actatgacct tctgaagcta
      781 aatcagctgt ataactgcac ttcttccttg agttttatgg actcctgtga ttttgaattg
      841 gaaaatatct gtggcatgat ccaaagttcg ggggatagtg ctgactggca gcgggtttca
      901 caggttctca gtggcccaga gagcgaccac tccaagatgg gccagtgcaa agactctggc
      961 ttcttcatgc atttcaacac tagcattttg aatgaggggg ccacggcgat gttggagagc
     1021 agactgttgt accccaagag agggtttcag tgcttggagt tttatctgta caacagtgga
     1081 agtggaaatg accaactgaa catttacacc cgggagtaca ctacaggcca gcagggtggt
     1141 gttttaaccc ttcagagaca aataaaagag gtacccattg ggagctggca acttcactat
     1201 gtaacactgc aagtgactaa aaagtttcga gtggtgtttg aaggactcag aggccctggc
     1261 acgtcatcag gtggtctgtc tatcgatgac atcaatctct cagaaacaag gtgtcctcac
     1321 catatctggc acatacagaa tttcacacag attctaggcg gccaggacac atctgtatac
     1381 agtcctccat tttattcttc taaaggttac gcttttcaga tctacatgga tctaagatcc
     1441 tcaacaaatg taggaattta tttccacctg atctccggtg ccaatgatga tcaattacag
     1501 tggccatgtc cttggcaaca agctacaatg acactcttgg atcaaaatcc tgacatccga
     1561 cagcgtatgt tcaaccagcg gagtataacc acagacccaa cgatgaccag tgataatgga
     1621 agctactttt gggacaggcc ttccaaggtg ggagtgacgg atgttttccc taacggaact
     1681 cagtttagca gaggtatagg ctatggaacg actgtcttca taacccgaga gaggctgaag
     1741 agcagagagt tcataaaagg agatgacatt tacatcttac tgactgttga agacatatct
     1801 cacctcaatt ctacatcagc tgtccccgac ccagtcccca ccttggctgt ccataatgcc
     1861 tgctctgagg ttgtatgtca gaacggtggc atctgtgttg tccaagatgg cagagctgag
     1921 tgcaagtgtc ctgcaggaga agactggtgg tacatgggca aaaggtgtga gaagagaggg
     1981 tccacccgag acactgttat catcgctgtt tcttccacgg tcaccgtgtt tgctgtgatg
     2041 ctaatcatca ctctcgtcag tgtctactgc accaggagga aatatcgtaa gaaggctaga
     2101 gcaaatacgg cagccatgac tctagaaaac caacatgcgt tttgaatatt aactcacgcc
     2161 agcaggtgaa atgaaaagag accttccatc atagaagaat attttaccca agccatgtga
     2221 catttccaac cagatcatct ttgtaaatag ctgaaggcgt aataaatcat tattttggta
     2281 aaagtc
//
