LOCUS       NM_008584               2360 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus mesenchyme homeobox 2 (Meox2), mRNA.
ACCESSION   NM_008584
VERSION     NM_008584.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2360)
  AUTHORS   Pelaez,M.C., Fiore,F., Larochelle,N., Dabbaghizadeh,A.,
            Comaduran,M.F., Arbour,D., Minotti,S., Marcadet,L., Semaan,M.,
            Robitaille,R., Nalbantoglu,J.N., Sephton,C.F. and Durham,H.D.
  TITLE     Reversal of cognitive deficits in FUSR521G amyotrophic lateral
            sclerosis mice by arimoclomol and a class I histone deacetylase
            inhibitor independent of heat shock protein induction
  JOURNAL   Neurotherapeutics 21 (5), e00388 (2024)
   PUBMED   38972779
REFERENCE   2  (bases 1 to 2360)
  AUTHORS   Sandovici,I., Knee,O., Lopez-Tello,J., Shreeve,N., Fowden,A.L.,
            Sferruzzi-Perri,A.N. and Constancia,M.
  TITLE     A genetically small fetus impairs placental adaptations near term
  JOURNAL   Dis Model Mech 17 (8) (2024)
   PUBMED   39207227
REFERENCE   3  (bases 1 to 2360)
  AUTHORS   Sasner,M., Preuss,C., Pandey,R.S., Uyar,A., Garceau,D.,
            Kotredes,K.P., Williams,H., Oblak,A.L., Lin,P.B., Perkins,B.,
            Soni,D., Ingraham,C., Lee-Gosselin,A., Lamb,B.T., Howell,G.R. and
            Carter,G.W.
  TITLE     In vivo validation of late-onset Alzheimer's disease genetic risk
            factors
  JOURNAL   Alzheimers Dement 20 (7), 4970-4984 (2024)
   PUBMED   38687251
REFERENCE   4  (bases 1 to 2360)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2360)
  AUTHORS   Freie,B., Carroll,P.A., Varnum-Finney,B.J., Ramsey,E.L., Ramani,V.,
            Bernstein,I. and Eisenman,R.N.
  TITLE     A germline point mutation in the MYC-FBW7 phosphodegron initiates
            hematopoietic malignancies
  JOURNAL   Genes Dev 38 (5-6), 253-272 (2024)
   PUBMED   38565249
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2360)
  AUTHORS   Andres,V., Fisher,S., Wearsch,P. and Walsh,K.
  TITLE     Regulation of Gax homeobox gene transcription by a combination of
            positive factors including myocyte-specific enhancer factor 2
  JOURNAL   Mol Cell Biol 15 (8), 4272-4281 (1995)
   PUBMED   7623821
REFERENCE   7  (bases 1 to 2360)
  AUTHORS   Grigoriou,M., Kastrinaki,M.C., Modi,W.S., Theodorakis,K.,
            Mankoo,B., Pachnis,V. and Karagogeos,D.
  TITLE     Isolation of the human MOX2 homeobox gene and localization to
            chromosome 7p22.1-p21.3
  JOURNAL   Genomics 26 (3), 550-555 (1995)
   PUBMED   7607679
REFERENCE   8  (bases 1 to 2360)
  AUTHORS   Weiss,K.M., Ruddle,F.H. and Bollekens,J.
  TITLE     Dlx and other homeobox genes in the morphological development of
            the dentition
  JOURNAL   Connect Tissue Res 32 (1-4), 35-40 (1995)
   PUBMED   7554933
REFERENCE   9  (bases 1 to 2360)
  AUTHORS   Candia,A.F., Kovalik,J.P. and Wright,C.V.
  TITLE     Amino acid sequence of Mox-2 and comparison to its Xenopus and rat
            homologs
  JOURNAL   Nucleic Acids Res 21 (21), 4982 (1993)
   PUBMED   7909944
REFERENCE   10 (bases 1 to 2360)
  AUTHORS   Candia,A.F., Hu,J., Crosby,J., Lalley,P.A., Noden,D., Nadeau,J.H.
            and Wright,C.V.
  TITLE     Mox-1 and Mox-2 define a novel homeobox gene subfamily and are
            differentially expressed during early mesodermal patterning in
            mouse embryos
  JOURNAL   Development 116 (4), 1123-1136 (1992)
   PUBMED   1363541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010456.8 and AC159640.2.
            
            On Apr 11, 2018 this sequence version replaced NM_008584.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028352.1, AK031152.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-805               CT010456.8         188163-188967
            806-978             AC159640.2         97514-97686         c
            979-2360            AC159640.2         85468-86849         c
FEATURES             Location/Qualifiers
     source          1..2360
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 16.84 cM"
     gene            1..2360
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="mesenchyme homeobox 2"
                     /db_xref="GeneID:17286"
                     /db_xref="MGI:MGI:103219"
     exon            1..805
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1203
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="growth arrest-specific homeobox"
                     /codon_start=1
                     /product="homeobox protein MOX-2"
                     /protein_id="NP_032610.1"
                     /db_xref="CCDS:CCDS25888.1"
                     /db_xref="GeneID:17286"
                     /db_xref="MGI:MGI:103219"
                     /translation="MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTS
                     SSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHQQQQHQALQSNWHLPQMSSPPSA
                     ARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPADVEK
                     RSGSKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYE
                     IAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGA
                     ATLQQTGDSLANEDSRDSDHSSEHAHL"
     exon            806..978
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /inference="alignment:Splign:2.1.0"
     exon            979..2360
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="hexamer: AATAAA"
     polyA_site      2360
                     /gene="Meox2"
                     /gene_synonym="Gax; Mox-2; Mox2"
                     /note="major polyA site"
ORIGIN      
        1 gaaagcagtt ctctgggacc accttctttt ggcttccacc tctcccacac ttgacatctg
       61 agcagctgcg aaggaagctc ctccaggtcc tagtgtttat acgtgcagga gactggccgc
      121 taaggctcag gactgggatt agccggctct gctcaaatgc aaacgcgcgc ggcttttact
      181 tttggagtga gtgggggaaa gtcttaggat ttccagtgaa aagtgacagc gcttggtgga
      241 cattcggacc gtccgtgaag tcttctgctt ggaagccgaa acttgcatgc catggaacac
      301 cccctctttg gctgcctgcg cagcccccac gccacagcgc aaggcttgca ccccttctcc
      361 cagtcttctc tggccctcca tggaagatct gaccacatgt cctaccccga actctccaca
      421 tcttcctcgt cttgcataat cgcgggatac cccaacgagg agggcatgtt tgccagccag
      481 catcacaggg ggcaccacca ccaccaccac catcaccatc accaccacca gcagcagcag
      541 caccaggctc tgcaaagcaa ctggcacctc ccgcagatgt cctctccacc aagcgcggcc
      601 cggcacagcc tgtgcctgca gcctgattcg ggagggcccc cggagctggg aagcagccct
      661 ccggtcctgt gttccaactc atctagcctg ggctccagca cccctaccgg ggccgcgtgc
      721 gcaccagggg attatggccg tcaagcgctg tcacccgcag acgtagagaa gagaagtggc
      781 agcaaaagga aaagcgacag ctcagattcc caggaaggaa actacaagtc agaagtgaac
      841 agcaaaccta ggaaggaaag aacagctttt accaaagagc aaatcagaga actagaggca
      901 gaatttgccc atcataatta tctgaccaga ctgagaagat atgagatagc agtgaatcta
      961 gacctcactg aaagacaggt gaaagtgtgg ttccagaaca ggagaatgaa gtggaagcgg
     1021 gtcaaagggg gacagcaagg agctgctgcc cgagaaaagg aactggtgaa tgtgaaaaag
     1081 ggaacgcttc ttccgtcaga gctgtcagga atcggtgcag ccaccctcca gcagacaggg
     1141 gactcactag caaacgagga cagccgcgat agtgaccaca gctctgagca cgcacactta
     1201 tgatacctac aaagaccagc tccattctca ggaaagcacc attgtgatgg caaaccttac
     1261 cgaacatcgt ttacatggca gatgtctgtg gcagtgtggc ttagtataat taaatgcagg
     1321 catctcgagt ctgtgtctca tgatggatag acggtttaca ctaagtgcct tttattgaag
     1381 atgcttccac agtgaaattg gagaaagcga acgtattcca aatacacttg ttcctatata
     1441 tgacagagag ggagatggat gtttgctttg gcttgcactg aaaattaaat ttgctaccaa
     1501 gagcaaactt gataagacgt ttttactcaa gatgtctcca gagtgaagat gttaaaaata
     1561 aaaaatgctt tgaacattcc agttgtgcca ggtcatgtgt gtgacactag gcaggtattt
     1621 gcttttgctt gcactgaaaa ttaaactgct atcaagttaa tccatgaaat agtttatctt
     1681 gaacagccac agtgcctgaa atcaccaagt ggatataaaa tgtactgaaa ctctgtatat
     1741 attaccccta agtcattttt cctgtcttca ctaattttag caaatgcatt catattagct
     1801 gattaaaaat aggcttttcc attgacaaac acagccagct tcttgtattt ttatacattt
     1861 gtgtcagaca gagaaaatca gtatgtgctt acttgtgttc aagtagataa aatgcagtag
     1921 agtctgatag gacatatcct tgtaccacag acaaagcaaa tcttctgttg cattgactat
     1981 caactgctgc agatacatta gagaacatac ctagctcccc tccagccttc ttctcttata
     2041 tcttgaaaga cattaggatc ataggcaaat cagttacctt gcagaacgag tcttgtgcgg
     2101 caaatgtctg attttacatc tttaagttgt taatgtttat gggtctgatt caattaacag
     2161 ggaaaagctt tcttcctcct tgtttatgat ataaaaccaa gtgccaaaca aagctaattc
     2221 ttcaagagaa tagttgagaa actgaatgtc tgacaattag actctgaaag tgcattattt
     2281 ttcatatgct ctatattcat gcagaacaag ttcttgtatt ttgtaaaaaa aaaaagataa
     2341 ataaatgatc cttgaaataa
//
