LOCUS       NM_010791               2235 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mesenchyme homeobox 1 (Meox1), mRNA.
ACCESSION   NM_010791
VERSION     NM_010791.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2235)
  AUTHORS   El Azhar,Y., Schulthess,P., van Oostrom,M.J., Weterings,S.D.C.,
            Meijer,W.H.M., Tsuchida-Straeten,N., Thomas,W.M., Bauer,M. and
            Sonnen,K.F.
  TITLE     Unravelling differential Hes1 dynamics during axis elongation of
            mouse embryos through single-cell tracking
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39315665
REFERENCE   2  (bases 1 to 2235)
  AUTHORS   Clark,J.F. and Soriano,P.
  TITLE     Diverse Fgfr1 signaling pathways and endocytic trafficking regulate
            mesoderm development
  JOURNAL   Genes Dev 38 (9-10), 393-414 (2024)
   PUBMED   38834239
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2235)
  AUTHORS   Vong,K.I., Lee,S., Au,K.S., Crowley,T.B., Capra,V., Martino,J.,
            Haller,M., Araujo,C., Machado,H.R., George,R., Gerding,B.,
            James,K.N., Stanley,V., Jiang,N., Alu,K., Meave,N., Nidhiry,A.S.,
            Jiwani,F., Tang,I., Nisal,A., Jhamb,I., Patel,A., Patel,A.,
            McEvoy-Venneri,J., Barrows,C., Shen,C., Ha,Y.J., Howarth,R.,
            Strain,M., Ashley-Koch,A.E., Azam,M., Mumtaz,S., Bot,G.M.,
            Finnell,R.H., Kibar,Z., Marwan,A.I., Melikishvili,G., Meltzer,H.S.,
            Mutchinick,O.M., Stevenson,D.A., Mroczkowski,H.J., Ostrander,B.,
            Schindewolf,E., Moldenhauer,J., Zackai,E.H., Emanuel,B.S.,
            Garcia-Minaur,S., Nowakowska,B.A., Stevenson,R.E., Zaki,M.S.,
            Northrup,H., McNamara,H.K., Aldinger,K.A., Phelps,I.G., Deng,M.,
            Glass,I.A., Morrow,B., McDonald-McGinn,D.M., Sanna-Cherchi,S.,
            Lamb,D.J. and Gleeson,J.G.
  CONSRTM   Spina Bifida Sequencing Consortiumdouble dagger
  TITLE     Risk of meningomyelocele mediated by the common 22q11.2 deletion
  JOURNAL   Science 384 (6695), 584-590 (2024)
   PUBMED   38696583
REFERENCE   4  (bases 1 to 2235)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   5  (bases 1 to 2235)
  AUTHORS   Racedo,S.E., Liu,Y., Shi,L., Zheng,D. and Morrow,B.E.
  TITLE     Dgcr8 functions in the secondary heart field for outflow tract and
            right ventricle development in mammals
  JOURNAL   Dev Biol 506, 72-84 (2024)
   PUBMED   38110169
REFERENCE   6  (bases 1 to 2235)
  AUTHORS   Furuta,Y., Ilic,D., Kanazawa,S., Takeda,N., Yamamoto,T. and
            Aizawa,S.
  TITLE     Mesodermal defect in late phase of gastrulation by a targeted
            mutation of focal adhesion kinase, FAK
  JOURNAL   Oncogene 11 (10), 1989-1995 (1995)
   PUBMED   7478517
REFERENCE   7  (bases 1 to 2235)
  AUTHORS   Oka,C., Nakano,T., Wakeham,A., de la Pompa,J.L., Mori,C., Sakai,T.,
            Okazaki,S., Kawaichi,M., Shiota,K., Mak,T.W. and Honjo,T.
  TITLE     Disruption of the mouse RBP-J kappa gene results in early embryonic
            death
  JOURNAL   Development 121 (10), 3291-3301 (1995)
   PUBMED   7588063
REFERENCE   8  (bases 1 to 2235)
  AUTHORS   Shawlot,W. and Behringer,R.R.
  TITLE     Requirement for Lim1 in head-organizer function
  JOURNAL   Nature 374 (6521), 425-430 (1995)
   PUBMED   7700351
REFERENCE   9  (bases 1 to 2235)
  AUTHORS   Conlon,F.L., Wright,C.V. and Robertson,E.J.
  TITLE     Effects of the TWis mutation on notochord formation and mesodermal
            patterning
  JOURNAL   Mech Dev 49 (3), 201-209 (1995)
   PUBMED   7734393
REFERENCE   10 (bases 1 to 2235)
  AUTHORS   Candia,A.F., Hu,J., Crosby,J., Lalley,P.A., Noden,D., Nadeau,J.H.
            and Wright,C.V.
  TITLE     Mox-1 and Mox-2 define a novel homeobox gene subfamily and are
            differentially expressed during early mesodermal patterning in
            mouse embryos
  JOURNAL   Development 116 (4), 1123-1136 (1992)
   PUBMED   1363541
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC011082.1.
            
            On Jun 19, 2003 this sequence version replaced NM_010791.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011082.1, AK052370.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2235
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11"
     gene            1..2235
                     /gene="Meox1"
                     /gene_synonym="D330041M02Rik; Mox-1; Mox1; squig"
                     /note="mesenchyme homeobox 1"
                     /db_xref="GeneID:17285"
                     /db_xref="MGI:MGI:103220"
     exon            1..812
                     /gene="Meox1"
                     /gene_synonym="D330041M02Rik; Mox-1; Mox1; squig"
                     /inference="alignment:Splign:2.1.0"
     CDS             350..1111
                     /gene="Meox1"
                     /gene_synonym="D330041M02Rik; Mox-1; Mox1; squig"
                     /codon_start=1
                     /product="homeobox protein MOX-1"
                     /protein_id="NP_034921.1"
                     /db_xref="CCDS:CCDS25480.1"
                     /db_xref="GeneID:17285"
                     /db_xref="MGI:MGI:103220"
                     /translation="MDPVANSCVRNPQPPAPVWGCLRNPHSEDSSASGLSHYPPTPFS
                     FHQKSDFPATAAYPDFSASCLAATPHSLPRTERIFNEQHPAFPQTPDWHFPISEAGQR
                     LNLGPAGSAREMGAGSPGLVDGTAGLGEDCMVLGTIANETEKKSSRRKKERSDNQENG
                     GGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWF
                     QNRRMKWKRVKGGQPVSPQEQDREDGDSAASPSSE"
     exon            813..988
                     /gene="Meox1"
                     /gene_synonym="D330041M02Rik; Mox-1; Mox1; squig"
                     /inference="alignment:Splign:2.1.0"
     exon            989..2208
                     /gene="Meox1"
                     /gene_synonym="D330041M02Rik; Mox-1; Mox1; squig"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meox1"
                     /gene_synonym="D330041M02Rik; Mox-1; Mox1; squig"
                     /note="hexamer: AATAAA"
     polyA_site      2208
                     /gene="Meox1"
                     /gene_synonym="D330041M02Rik; Mox-1; Mox1; squig"
                     /note="major polyA site"
ORIGIN      
        1 cactcattca ctcagggtcc ccgggaaggg cttgtcagta tgggtgggtc caaggtagga
       61 cagtcaaaat gttcagcatg gtaggaaaca actccgtgcc cgatagtcag cgtgtgtcgg
      121 gggcaggaag gcagacgtga agcctagaca ggtgtggaca cgcacatgtg tgttcctggc
      181 cacgtgtttg tggaatttga ggcaaaattt ttgttttggt tcctggggta aagtttccat
      241 tcaacatttt cctctactgt ttaatttttt ttttaatttt aaattacaaa actctgacta
      301 gaaaaagcgc aatacctttg aaaggactgg ggcaggcagt ggacagcaga tggatccagt
      361 ggccaacagc tgtgtgagga acccccagcc cccagcccct gtctggggct gccttcgaaa
      421 cccccactca gaagatagca gcgcctcagg gctgtcccat tatcccccaa ccccgttttc
      481 cttccaccaa aaatcagact tcccagcgac agcagcatac cccgacttct ctgcttcctg
      541 cctggcagcc accccacaca gcctgccccg gactgagcga atcttcaacg agcagcatcc
      601 tgccttccca cagacccctg actggcactt ccctatctca gaagccgggc agaggctcaa
      661 cctaggccca gctgggagcg ccagggagat gggagccggc agccccggcc tggtggatgg
      721 cacagcagga ttgggggagg attgcatggt acttgggacg atcgccaatg agacggagaa
      781 gaaatcatcc agaaggaaaa aagagaggtc agacaaccag gagaacggag gagggaagcc
      841 agaaggcagc agcaaagccc ggaaggagag gacagccttc accaaggagc agctacggga
      901 gctggaggca gagtttgccc accacaacta cctgacccgg ctccggagat atgagattgc
      961 agtcaacctg gacctttctg agcggcaggt caaagtctgg ttccagaacc ggaggatgaa
     1021 gtggaaacgt gtgaaggggg gtcagcctgt gtccccacag gagcaggacc gagaggatgg
     1081 ggactctgca gcttctccaa gttcagagtg agatgctcca aagaccaaaa ccaagaaaga
     1141 ctgaaggaac cccctctcca gttcccacca cccggtccca ccctctcaca tctctggacc
     1201 cacccagggc agcctgcaca cactctaagg tgtgaagttg cccagtatgt gggagccttg
     1261 aatttcccag aaggcttagc tcagcgtcct tacatctcag cagccccttc cccaggcctt
     1321 caacttccca ctctctcttg aactccaaag gactgggaaa ctatagaaac agagcctggg
     1381 gccctctttt ctgggtctct tggctactac ccacacctag catccccctc ttacatcagg
     1441 gtctcctctg ggtctggccc catctggcct atgcagaatc cattccttgg taccagctgg
     1501 tgacttgtaa aagcaaacct ctctccagat gttcacaccg ttgagttgaa ggttaggaag
     1561 tggctcctgt gtctaaggac ggagaggata gcacaagagc tgatggatga ggactgagat
     1621 acgtggacct tggaagtaga acgttctcag gctgcagcgt cttgtgttct ccaaggactc
     1681 tgactgcaga taaggacagg aaaacaaccc atcttcctcc atgggatgca tttggaccta
     1741 tcctgcgtgt tccggaaaaa gctttgtggg aagacctccc aggttcacac acatgcgcag
     1801 ctcagatctc agacccaact tctgaggatg ctcctgtgag gactggtggg aaaacagcct
     1861 caggcaacag tctccttgga agagacccct gtgtgcctca gtattagatg gtggatctcc
     1921 cagatcctgc tgatgttgca gaaggagggt cagcaagtat ttgaatttct tgcatggaga
     1981 tctgattgtg agtgtttaaa aataacccca gttcccttcc ccaccccatc aagacagaag
     2041 ctgtggaaaa tgattgtcaa atgagatggc aagttagagc atgtatcagt tttcccctac
     2101 agcatatttc atatgttttt ttttcctaag attacatcaa gctaattgtg caaggtcaat
     2161 tcactttgta agaaaactct cagagaaata aatcaacaaa aaaatgcaaa aaaaaaaaaa
     2221 aaaaaaaaaa aaaaa
//
