LOCUS       NM_001168489            2644 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus multiple endocrine neoplasia 1 (Men1), transcript
            variant 3, mRNA.
ACCESSION   NM_001168489
VERSION     NM_001168489.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2644)
  AUTHORS   Zhu,X., Xu,B., Lian,A., Zhang,X., Wang,Y., Zhang,Y., Zhang,L.,
            Ma,J., Gao,S. and Jin,G.
  TITLE     Menin orchestrates macrophage reprogramming to maintain the
            pulmonary immune homeostasis
  JOURNAL   Cell Rep 44 (1), 115219 (2025)
   PUBMED   39817905
REFERENCE   2  (bases 1 to 2644)
  AUTHORS   Zhuang,K., Leng,L., Su,X., Wang,S., Su,Y., Chen,Y., Yuan,Z., Zi,L.,
            Li,J., Xie,W., Yan,S., Xia,Y., Wang,H., Li,H., Chen,Z., Yuan,T. and
            Zhang,J.
  TITLE     Menin Deficiency Induces Autism-Like Behaviors by Regulating Foxg1
            Transcription and Participates in Foxg1-Related Encephalopathy
  JOURNAL   Adv Sci (Weinh) 11 (24), e2307953 (2024)
   PUBMED   38582517
  REMARK    GeneRIF: Menin Deficiency Induces Autism-Like Behaviors by
            Regulating Foxg1 Transcription and Participates in Foxg1-Related
            Encephalopathy.
REFERENCE   3  (bases 1 to 2644)
  AUTHORS   Fuentes,M.E., Lu,X., Flores,N.M., Hausmann,S. and Mazur,P.K.
  TITLE     Combined deletion of MEN1, ATRX and PTEN triggers development of
            high-grade pancreatic neuroendocrine tumors in mice
  JOURNAL   Sci Rep 14 (1), 8510 (2024)
   PUBMED   38609433
  REMARK    GeneRIF: Combined deletion of MEN1, ATRX and PTEN triggers
            development of high-grade pancreatic neuroendocrine tumors in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2644)
  AUTHORS   Jin,B., Zhu,J., Pan,T., Yang,Y., Liang,L., Zhou,Y., Zhang,T.,
            Teng,Y., Wang,Z., Wang,X., Tian,Q., Guo,B., Li,H. and Chen,T.
  TITLE     MEN1 is a regulator of alternative splicing and prevents
            R-loop-induced genome instability through suppression of RNA
            polymerase II elongation
  JOURNAL   Nucleic Acids Res 51 (15), 7951-7971 (2023)
   PUBMED   37395406
  REMARK    GeneRIF: MEN1 is a regulator of alternative splicing and prevents
            R-loop-induced genome instability through suppression of RNA
            polymerase II elongation.
REFERENCE   5  (bases 1 to 2644)
  AUTHORS   Duan,S., Sheriff,S., Elvis-Offiah,U.B., Witten,B.L., Sawyer,T.W.,
            Sundaresan,S., Cierpicki,T., Grembecka,J. and Merchant,J.L.
  TITLE     Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive
            Function Through Increased Menin Turnover
  JOURNAL   Cancer Res Commun 3 (7), 1318-1334 (2023)
   PUBMED   37492626
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2644)
  AUTHORS   Khodaei,S., O'Brien,K.P., Dumanski,J., Wong,F.K. and Weber,G.
  TITLE     Characterization of the MEN1 ortholog in zebrafish
  JOURNAL   Biochem Biophys Res Commun 264 (2), 404-408 (1999)
   PUBMED   10529376
REFERENCE   7  (bases 1 to 2644)
  AUTHORS   Karges,W., Maier,S., Wissmann,A., Dralle,H., Dosch,H.M. and
            Boehm,B.O.
  TITLE     Primary structure, gene expression and chromosomal mapping of
            rodent homologs of the MEN1 tumor suppressor gene
  JOURNAL   Biochim Biophys Acta 1446 (3), 286-294 (1999)
   PUBMED   10524203
REFERENCE   8  (bases 1 to 2644)
  AUTHORS   Guru,S.C., Crabtree,J.S., Brown,K.D., Dunn,K.J., Manickam,P.,
            Prasad,N.B., Wangsa,D., Burns,A.L., Spiegel,A.M., Marx,S.J.,
            Pavan,W.J., Collins,F.S. and Chandrasekharappa,S.C.
  TITLE     Isolation, genomic organization, and expression analysis of Men1,
            the murine homolog of the MEN1 gene
  JOURNAL   Mamm Genome 10 (6), 592-596 (1999)
   PUBMED   10341092
REFERENCE   9  (bases 1 to 2644)
  AUTHORS   Bassett,J.H., Rashbass,P., Harding,B., Forbes,S.A., Pannett,A.A.
            and Thakker,R.V.
  TITLE     Studies of the murine homolog of the multiple endocrine neoplasia
            type 1 (MEN1) gene, men1
  JOURNAL   J Bone Miner Res 14 (1), 3-10 (1999)
   PUBMED   9893060
REFERENCE   10 (bases 1 to 2644)
  AUTHORS   Stewart,C., Parente,F., Piehl,F., Farnebo,F., Quincey,D.,
            Silins,G., Bergman,L., Carle,G.F., Lemmens,I., Grimmond,S.,
            Xian,C.Z., Khodei,S., Teh,B.T., Lagercrantz,J., Siggers,P.,
            Calender,A., Van de Vem,V., Kas,K., Weber,G., Hayward,N.,
            Gaudray,P. and Larsson,C.
  TITLE     Characterization of the mouse Men1 gene and its expression during
            development
  JOURNAL   Oncogene 17 (19), 2485-2493 (1998)
   PUBMED   9824159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127556.4, AF016398.1 and BY619391.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            a downstream start codon, compared to variant 1, resulting in an
            isoform (b) that is shorter at the N-terminus, compared to isoform
            a. Both variants 2 and 3 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF016398.1, AK133984.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC127556.4         177401-177425
            26-2639             AF016398.1         1-2614
            2640-2644           BY619391.1         365-369
FEATURES             Location/Qualifiers
     source          1..2644
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.45 cM"
     gene            1..2644
                     /gene="Men1"
                     /note="multiple endocrine neoplasia 1"
                     /db_xref="GeneID:17283"
                     /db_xref="MGI:MGI:1316736"
     exon            1..70
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            71..531
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1922
                     /gene="Men1"
                     /note="isoform b is encoded by transcript variant 3;
                     menin"
                     /codon_start=1
                     /product="menin isoform b"
                     /protein_id="NP_001161961.1"
                     /db_xref="CCDS:CCDS29502.1"
                     /db_xref="GeneID:17283"
                     /db_xref="MGI:MGI:1316736"
                     /translation="MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFV
                     EHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVD
                     LSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFA
                     VVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAER
                     SWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERY
                     PMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYPYMYLAGYHCRNRNV
                     REALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLETGEERTGE
                     QAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQ
                     VRQKVHIVSREAEAAEAEEPWGDEAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQ
                     SAGSGPPRKTSGTVPGTTRGGQEVGNAAQAPAPAASPPPEGPVLTFQSEKMKGMKELL
                     VATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL"
     exon            532..740
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            741..869
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            870..910
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..998
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1135
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1271
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1436
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..2644
                     /gene="Men1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2631..2636
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Men1"
                     /note="hexamer: AAGAAA"
     polyA_site      2639
                     /gene="Men1"
                     /note="major polyA site"
ORIGIN      
        1 gggacttcat ttcccagcag gcttcaggcg gcgggcgccg cggtgccttg tgtgggatgt
       61 aagcgcggag gccaccgccc gccgccatgg ggctgaaggc cgcccagaag acgctgttcc
      121 ctctgcgctc tatcgacgac gtggtgcgcc tgtttgctgc agagctgggc cgagaggagc
      181 ctgacctggt gctcctgtcc ttggtcctgg gcttcgtgga gcatttcctg gctgtcaacc
      241 gtgtcatccc caccaacgtg ccggagctca ccttccagcc cagccccgca cccgaccctc
      301 ctggtggcct cacctacttc ccggtggccg acctatccat cattgctgcc ctctatgccc
      361 gattcaccgc tcagatccgc ggcgctgtgg acctctccct ctatcctcga gagggaggtg
      421 tttctagtcg cgaactggta aaaaaggtct cggatgtcat atggaacagc ctcagccgct
      481 cctacttcaa ggaccgggcc cacatccagt ccctcttcag cttcatcaca ggcaccaaac
      541 tggacagctc gggcgtggcc tttgcagtgg taggggcctg ccaggctctg ggtctcagag
      601 atgtccatct ggccctgtct gaagatcatg cttgggtggt gtttgggccc aacggggagc
      661 agacagctga ggtgacgtgg cacggcaaag gcaacgagga ccgcagaggc cagacagtca
      721 atgccggtgt ggctgagcgg agctggctgt acctgaaggg gtcgtacatg cgctgcgacc
      781 gtaagatgga ggtggcgttc atggtgtgtg ccatcaaccc ttccatcgat cttcacactg
      841 actctttgga actgttgcaa ctacagcaga agctgctctg gctgctgtat gacctcggac
      901 atctggaaag ataccccatg gcgctaggga acttggcaga cctggaggag ctggagccta
      961 ccccgggccg gccagaccca ctcacccttt atcacaaggg aattgcctca gctaagacct
     1021 actaccagga tgaacacatc tacccctaca tgtacctggc tggctaccac tgtcgcaacc
     1081 gaaatgtgcg cgaagccctg caggcctggg ccgacactgc cactgttatc caagactaca
     1141 actactgccg ggaggatgag gagatctaca aggaattctt tgaagtggcc aatgacgtca
     1201 tccccaacct gctgaaggag gcggccagcc tgctagaaac aggcgaagag cggactgggg
     1261 agcaagccca gggcacccag ggccaaggtt ctgctctcca ggacccagaa tgctttgccc
     1321 acctgctgcg attttatgat ggcatctgca aatgggagga gggtagcccc acaccagtac
     1381 tgcacgtagg ctgggcaact ttccttgtgc agtccctagg ccgcttcgag ggacaggtgc
     1441 ggcagaaggt gcacatagtt agccgggaag cagaggcggc cgaggctgaa gaaccatggg
     1501 gggatgaagc ccgagaaggc cgtcggcgtg gtccccgaag agagtccaag cctgaggagc
     1561 caccaccacc caagaagcct gcattggaca agggcccggg ctcaggacaa agtgcagggt
     1621 cgggaccacc taggaaaacg tcagggactg tcccaggtac tacccgcggt ggccaggaag
     1681 tcggcaatgc tgctcaggct ccagcacctg cagcatcgcc acccccagag ggcccagtgc
     1741 tcactttcca gagtgagaag atgaaaggca tgaaggagct actggtggcc accaagatca
     1801 actcgagcgc catcaagctg caactcacgg cacagtcgca agtgcagatg aagaaacaga
     1861 aagtgtccac acccagcgac tacacactct ctttcctaaa gcggcagcgc aagggcctct
     1921 gaactctgat tctgtggcaa ggccccaggc ctgccctcac tcccagcagg cttcaccctc
     1981 atcctctaat tcaagcctag actccgccct cagtcctagg ggacccagag ctgtcctgca
     2041 gtgactagga gccttcattt agcccctctt caggccccag agccctggct cagttcttag
     2101 aatgtaggtg tcatccccac cagccggcca attggaacct cattgtaggt ccaatccccc
     2161 gaaattcagt ggaccatgac aggagcccaa gtcacgcctg aacagtaggg cattcctccc
     2221 acttgggggc tagattgacc ttagccccag agcacagttg ctacctggaa accaaggacc
     2281 attcagtccc taggggtaga tttccgcact ttatatagag ttccatcctt tgggaatcca
     2341 aatcccttac cccaaagaac ttacatattg ctgcccgaat ttggaaatct tcctcgtctc
     2401 cctagcccct gagtacagga catgaagctc cgactcttat ctgtgaatac tgagcctcgc
     2461 ccccttcctg accaaactgg cgcaagaaca gagcaggacc tcttccagcc ctctgggaac
     2521 ctccctgagg tcccaggagg aaatctgcac ggggtggggg agggccagcc tcttcctgtt
     2581 ttgtacatag atttattttt cagttccaag aaagataaat gcattttgtt aagaaaaaag
     2641 agag
//
