LOCUS       NM_133771               1499 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mediator of cell motility 1 (Memo1), mRNA.
ACCESSION   NM_133771 XM_980096
VERSION     NM_133771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1499)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1499)
  AUTHORS   Bartos,K. and Moor,M.B.
  TITLE     FGFR regulator Memo1 is dispensable for FGF23 expression by
            osteoblasts during folic acid-driven kidney injury
  JOURNAL   Physiol Rep 11 (6), e15650 (2023)
   PUBMED   36967231
  REMARK    GeneRIF: FGFR regulator Memo1 is dispensable for FGF23 expression
            by osteoblasts during folic acid-driven kidney injury.
REFERENCE   3  (bases 1 to 1499)
  AUTHORS   Moor,M.B., Ramakrishnan,S.K., Legrand,F., Bachtler,M., Koesters,R.,
            Hynes,N.E., Pasch,A. and Bonny,O.
  TITLE     Elevated serum magnesium lowers calcification propensity in
            Memo1-deficient mice
  JOURNAL   PLoS One 15 (7), e0236361 (2020)
   PUBMED   32706793
  REMARK    GeneRIF: Elevated serum magnesium lowers calcification propensity
            in Memo1-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1499)
  AUTHORS   Moor,M.B. and Bonny,O.
  TITLE     Memo1 gene expression in kidney and bone is unaffected by dietary
            mineral load and calciotropic hormones
  JOURNAL   Physiol Rep 8 (7), e14410 (2020)
   PUBMED   32291966
  REMARK    GeneRIF: Memo1 gene expression in kidney and bone is unaffected by
            dietary mineral load and calciotropic hormones.
REFERENCE   5  (bases 1 to 1499)
  AUTHORS   Nakagawa,N., Plestant,C., Yabuno-Nakagawa,K., Li,J., Lee,J.,
            Huang,C.W., Lee,A., Krupa,O., Adhikari,A., Thompson,S., Rhynes,T.,
            Arevalo,V., Stein,J.L., Molnar,Z., Badache,A. and Anton,E.S.
  TITLE     Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral
            Cortical Development
  JOURNAL   Neuron 103 (5), 836-852 (2019)
   PUBMED   31277925
  REMARK    GeneRIF: Memo1 is a mediator of radial glial cell scaffold tiling,
            necessary to generate and organize neurons into functional
            ensembles in the developing cerebral cortex.
REFERENCE   6  (bases 1 to 1499)
  AUTHORS   Ning,K., Zhang,H., Han,J.Q., Fan,H.X., Li,J.Z., Li,R. and Ye,Q.N.
  TITLE     [Preparation of antibody against Memo protein and analysis of
            expression profile of Memo in mouse tissues]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 22 (6), 794-796 (2006)
   PUBMED   17077023
  REMARK    GeneRIF: tissue distribution of Memo in mice.
REFERENCE   7  (bases 1 to 1499)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1499)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (bases 1 to 1499)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (bases 1 to 1499)
  AUTHORS   Reymond,A., Friedli,M., Henrichsen,C.N., Chapot,F., Deutsch,S.,
            Ucla,C., Rossier,C., Lyle,R., Guipponi,M. and Antonarakis,S.E.
  TITLE     From PREDs and open reading frames to cDNA isolation: revisiting
            the human chromosome 21 transcription map
  JOURNAL   Genomics 78 (1-2), 46-54 (2001)
   PUBMED   11707072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF466279.1, AF363447.1 and CT010445.12.
            
            On Apr 6, 2010 this sequence version replaced NM_133771.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013819.1, SRR5189673.80622.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164143 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-80                BF466279.1         1-80
            81-1493             AF363447.1         143-1555
            1494-1499           CT010445.12        95411-95416
FEATURES             Location/Qualifiers
     source          1..1499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 45.63 cM"
     gene            1..1499
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /note="mediator of cell motility 1"
                     /db_xref="GeneID:76890"
                     /db_xref="MGI:MGI:1924140"
     exon            1..172
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1005
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /note="protein memo; mediator of ErbB2-driven cell
                     motility 1; memo-1"
                     /codon_start=1
                     /product="protein MEMO1"
                     /protein_id="NP_598532.1"
                     /db_xref="CCDS:CCDS28969.1"
                     /db_xref="GeneID:76890"
                     /db_xref="MGI:MGI:1924140"
                     /translation="MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARA
                     IIAPHAGYTYCGSCAAHAYKQVDPSVTRRIFILGPSHHVPLSRCALSSVDIYRTPLYD
                     LRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGA
                     LSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDK
                     MGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQS
                     SQCRSWQDSSVSYAAGALTVH"
     exon            173..254
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            255..323
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            324..436
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            437..548
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            549..691
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            692..768
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            769..873
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1499
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1497
                     /gene="Memo1"
                     /gene_synonym="0610016J10Rik; D930048L02Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcggccgcct cctcctgggc tgggcccgcg gcgtctcgtc ccctcgcgga gccgccgccg
       61 ccgccgcctc ctcattcatc ctcgtgcacc ataggcggca caggcaccaa gatgtccaac
      121 cgagtggtct gccgggaagc cagccacgcc gggagctggt acaccgcctc aggacctcag
      181 ctgaacgctc agctggaagg ttggctttca caagtacagt ctacgaaaag acctgctaga
      241 gccattattg caccccatgc gggatacaca tactgtgggt cctgtgctgc ccatgcttac
      301 aaacaagtgg atccatctgt tacccggaga attttcatcc ttgggccttc ccatcatgtg
      361 cccctgtctc gatgtgcact ctccagtgtg gatatatata ggactcctct gtatgatctt
      421 cgtattgacc aaaagattta cggagagcta tggaagacag gaatgtttga acgaatgtct
      481 ctgcagacag atgaagatga acacagtatt gaaatgcatt tgccttatac agctaaagcc
      541 atggaaagcc ataaagatga gtttaccatt attcctgtac tggttggagc tctgagtgag
      601 tcaaaagaac aggaattcgg aaaactcttc agtaaatatc tagcggatcc tagtaatctc
      661 tttgtggttt cttctgattt ctgccactgg ggtcaaaggt tccgttacag ttactatgat
      721 gaatcccagg gggagattta tagatccatt gaacatctag ataaaatggg tatgagtatt
      781 atagaacaat tagatcctgt atcttttagc aattatttga agaaatatca taatactata
      841 tgtggaagac atcccattgg ggtgttatta aatgctatca cagagcttca gaagaatgga
      901 atgaatatga gcttttcctt tttgaattat gcccagtcga gccagtgtag aagctggcaa
      961 gacagttcag tcagttacgc agctggagca ctcacggtcc actgaagctc cgatcctcag
     1021 ggacaccacc tgcacagact cgtactctgt ccagggtcca gcctagcctt taccaagatg
     1081 ttggttctgg tgtgggggga ttctgaaacc tcagactaat agaactctct tcttcttttc
     1141 tagtaggtgt agtcctcctt aatttcaact cattttaaaa atgctttcta gtttgaggca
     1201 gtggaaggaa ggctggaatc aaaatatttg cccaaattgg cacacagtga cttgtaaagc
     1261 atttagcata tctgaaattt gcactctttg cagactcatg cacatatatt ccgctttcag
     1321 aatagttttg caaattgtac acagacaaag ggtggaagct ttttaataaa agaaactgca
     1381 tttataaatg atctgtatta gaatataaga aatctccagt tatagacaat tactacccat
     1441 gttgtacaac agataccttc tattttagtt gctaataaag ggctacacaa ctcaaaata
//
