LOCUS       NM_013900               4133 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus melanotransferrin (Meltf), mRNA.
ACCESSION   NM_013900 XM_358818
VERSION     NM_013900.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4133)
  AUTHORS   Tan,Z., Chen,P., Dong,X., Guo,S., Leung,V.Y.L., Cheung,J.P.Y.,
            Chan,D., Richardson,S.M., Hoyland,J.A., To,M.K.T. and Cheah,K.S.E.
  TITLE     Progenitor-like cells contributing to cellular heterogeneity in the
            nucleus pulposus are lost in intervertebral disc degeneration
  JOURNAL   Cell Rep 43 (6), 114342 (2024)
   PUBMED   38865240
REFERENCE   2  (bases 1 to 4133)
  AUTHORS   Rutkowski,T.P., Purcell,R.H., Pollak,R.M., Grewenow,S.M.,
            Gafford,G.M., Malone,T., Khan,U.A., Schroeder,J.P., Epstein,M.P.,
            Bassell,G.J., Warren,S.T., Weinshenker,D., Caspary,T. and
            Mulle,J.G.
  TITLE     Behavioral changes and growth deficits in a CRISPR engineered mouse
            model of the schizophrenia-associated 3q29 deletion
  JOURNAL   Mol Psychiatry 26 (3), 772-783 (2021)
   PUBMED   30976085
REFERENCE   3  (bases 1 to 4133)
  AUTHORS   Suryo Rahmanto,Y., Dunn,L.L. and Richardson,D.R.
  TITLE     Identification of distinct changes in gene expression after
            modulation of melanoma tumor antigen p97 (melanotransferrin) in
            multiple models in vitro and in vivo
  JOURNAL   Carcinogenesis 28 (10), 2172-2183 (2007)
   PUBMED   17449903
REFERENCE   4  (bases 1 to 4133)
  AUTHORS   Dunn,L.L., Sekyere,E.O., Suryo Rahmanto,Y. and Richardson,D.R.
  TITLE     The function of melanotransferrin: a role in melanoma cell
            proliferation and tumorigenesis
  JOURNAL   Carcinogenesis 27 (11), 2157-2169 (2006)
   PUBMED   16704991
  REMARK    GeneRIF: melanotransferrin has a role in cell proliferation and
            tumorigenesis
REFERENCE   5  (bases 1 to 4133)
  AUTHORS   Sekyere,E.O., Dunn,L.L., Suryo Rahmanto,Y. and Richardson,D.R.
  TITLE     Role of melanotransferrin in iron metabolism: studies using
            targeted gene disruption in vivo
  JOURNAL   Blood 107 (7), 2599-2601 (2006)
   PUBMED   16291590
  REMARK    GeneRIF: Iron indices, tissue levels, hematology, and serum
            chemistry parameters demonstrated no differences between
            metallototransferrin deficient and wild-type mice, suggesting MTf
            was not essential for iron metabolism.
REFERENCE   6  (bases 1 to 4133)
  AUTHORS   Sekyere,E.O., Dunn,L.L. and Richardson,D.R.
  TITLE     Examination of the distribution of the transferrin homologue,
            melanotransferrin (tumour antigen p97), in mouse and human
  JOURNAL   Biochim Biophys Acta 1722 (2), 131-142 (2005)
   PUBMED   15716025
  REMARK    GeneRIF: The distribution of MTf and its splice variants may
            provide clues to their possible biological roles in melanoma and
            other tumors.
REFERENCE   7  (bases 1 to 4133)
  AUTHORS   Oda,R., Suardita,K., Fujimoto,K., Pan,H., Yan,W., Shimazu,A.,
            Shintani,H. and Kato,Y.
  TITLE     Anti-membrane-bound transferrin-like protein antibodies induce
            cell-shape change and chondrocyte differentiation in the presence
            or absence of concanavalin A
  JOURNAL   J Cell Sci 116 (Pt 10), 2029-2038 (2003)
   PUBMED   12679380
  REMARK    GeneRIF: MTf represents the first identification of a plant lectin
            receptor involved in cell-shape changes and the differentiation of
            animal cells
REFERENCE   8  (bases 1 to 4133)
  AUTHORS   Nakamasu,K., Kawamoto,T., Yoshida,E., Noshiro,M., Matsuda,Y. and
            Kato,Y.
  TITLE     Structure and promoter analysis of the mouse membrane-bound
            transferrin-like protein (MTf) gene
  JOURNAL   Eur J Biochem 268 (5), 1468-1476 (2001)
   PUBMED   11231300
REFERENCE   9  (bases 1 to 4133)
  AUTHORS   Nakamasu,K., Kawamoto,T., Shen,M., Gotoh,O., Teramoto,M.,
            Noshiro,M. and Kato,Y.
  TITLE     Membrane-bound transferrin-like protein (MTf): structure, evolution
            and selective expression during chondrogenic differentiation of
            mouse embryonic cells
  JOURNAL   Biochim Biophys Acta 1447 (2-3), 258-264 (1999)
   PUBMED   10542324
REFERENCE   10 (bases 1 to 4133)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC129214.5.
            
            On Nov 17, 2006 this sequence version replaced NM_013900.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB024336.1, BC040347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164132, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               AC129214.5         166572-166737
            167-321             AC129214.5         167885-168039
            322-421             AC129214.5         169630-169729
            422-604             AC129214.5         171523-171705
            605-761             AC129214.5         172706-172862
            762-829             AC129214.5         173962-174029
            830-1017            AC129214.5         175174-175361
            1018-1198           AC129214.5         175872-176052
            1199-1350           AC129214.5         176640-176791
            1351-1447           AC129214.5         178478-178574
            1448-1642           AC129214.5         179329-179523
            1643-1799           AC129214.5         180248-180404
            1800-1867           AC129214.5         180502-180569
            1868-2055           AC129214.5         182453-182640
            2056-2254           AC129214.5         184191-184389
            2255-4133           AC129214.5         184904-186782
FEATURES             Location/Qualifiers
     source          1..4133
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.4 cM"
     gene            1..4133
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /note="melanotransferrin"
                     /db_xref="GeneID:30060"
                     /db_xref="MGI:MGI:1353421"
     exon            1..166
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2334
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /note="membrane-bound transferrin-like protein p97;
                     antigen p97 (melanoma associated) identified by monoclonal
                     antibodies 133.2 and 96.5"
                     /codon_start=1
                     /product="melanotransferrin precursor"
                     /protein_id="NP_038928.1"
                     /db_xref="CCDS:CCDS28108.1"
                     /db_xref="GeneID:30060"
                     /db_xref="MGI:MGI:1353421"
                     /translation="MRLLSVTFWLLLSLRTVVCVMEVQWCTISDAEQQKCKDMSEAFQ
                     GAGIRPSLLCVQGNSADHCVQLIKEQKADAITLDGGAIYEAGKEHGLKPVVGEVYDQD
                     IGTSYYAVAVVRRNSNVTINTLKGVKSCHTGINRTVGWNVPVGYLVESGHLSVMGCDV
                     LKAVGDYFGGSCVPGTGETSHSESLCRLCRGDSSGHNVCDKSPLERYYDYSGAFRCLA
                     EGAGDVAFVKHSTVLENTDGNTLPSWGKSLMSEDFQLLCRDGSRADITEWRRCHLAKV
                     PAHAVVVRGDMDGGLIFQLLNEGQLLFSHEDSSFQMFSSKAYSQKNLLFKDSTLELVP
                     IATQNYEAWLGQEYLQAMKGLLCDPNRLPHYLRWCVLSAPEIQKCGDMAVAFSRQNLK
                     PEIQCVSAESPEHCMEQIQAGHTDAVTLRGEDIYRAGKVYGLVPAAGELYAEEDRSNS
                     YFVVAVARRDSSYSFTLDELRGKRSCHPYLGSPAGWEVPIGSLIQRGFIRPKDCDVLT
                     AVSQFFNASCVPVNNPKNYPSALCALCVGDEKGRNKCVGSSQERYYGYSGAFRCLVEH
                     AGDVAFVKHTTVFENTNGHNPEPWASHLRWQDYELLCPNGARAEVDQFQACNLAQMPS
                     HAVMVRPDTNIFTVYGLLDKAQDLFGDDHNKNGFQMFDSSKYHSQDLLFKDATVRAVP
                     VREKTTYLDWLGPDYVVALEGMLSQQCSGAGAAVQRVPLLALLLLTLAAGLLPRVL"
     exon            167..321
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            322..421
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            422..604
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            605..761
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            762..829
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1017
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1198
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1350
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1447
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1642
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1799
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1867
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..2055
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2254
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..4133
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4084..4089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /note="hexamer: AATAAA"
     polyA_site      4121
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /note="major polyA site"
     polyA_site      4133
                     /gene="Meltf"
                     /gene_synonym="CD228; Mfi2; MTf"
                     /note="major polyA site"
ORIGIN      
        1 ggtgtgttga ggggcgtgga ctctccccgg gctgcgctta aatagtgaag gccagagaga
       61 ccagggaaga ggaagccagg acagacccgc cagcacccca gccaacccaa cgttgccatg
      121 aggctcctga gcgtgacttt ttggctactc ctgtccctgc gcactgtcgt ctgtgtgatg
      181 gaggtgcagt ggtgtaccat ctcagacgca gagcagcaga agtgcaaaga catgagcgag
      241 gccttccagg gagctggcat tcgtccttcc cttctctgcg tccagggcaa ctccgctgac
      301 cactgtgtcc agctcatcaa ggaacaaaaa gcagatgcca tcaccctgga tggaggggcc
      361 atctatgagg cagggaagga gcacggcctg aagccagtgg tgggggaagt ctatgaccaa
      421 gacattggga cttcctatta tgccgtggct gtggtcagga ggaattccaa tgttaccatc
      481 aacaccctga agggcgtcaa gtcctgccac acaggcatta accggactgt gggctggaac
      541 gtgcctgtcg gttacctcgt agagagcggc catctgtcag tgatgggctg tgatgtgctc
      601 aaagccgttg gtgattattt tggaggcagc tgtgtccctg gaacaggaga aaccagccat
      661 tccgagtccc tctgtcgcct ctgccgtggc gactcttctg ggcacaatgt gtgtgacaag
      721 agtcccctag agagatacta cgactacagt ggagccttcc ggtgcctggc ggaaggagcc
      781 ggtgacgtgg ccttcgtgaa gcacagcaca gtgctggaaa atactgatgg aaacaccctg
      841 ccttcctggg gcaagtccct gatgtcagag gacttccagc tactatgcag ggatggcagc
      901 cgagccgaca tcactgagtg gagacgttgc cacctggcca aggtgcctgc tcatgctgtg
      961 gtggtcaggg gtgacatgga tggcggtctc atattccaac tgctcaacga aggccagctt
     1021 ctgttcagcc atgaagacag cagcttccag atgttcagct ccaaagccta cagccagaag
     1081 aacttgctgt tcaaagactc caccttggag cttgtgccca ttgccacaca gaactatgag
     1141 gcctggctgg gccaggaata cctgcaggcc atgaaggggc tcctctgtga tcccaaccgg
     1201 ctgccccact acctgcgctg gtgtgtgctg tcagcgcccg agatccagaa gtgtggagat
     1261 atggctgtgg ccttcagccg ccagaatctc aagccggaaa ttcagtgtgt gtcggccgag
     1321 tcccctgagc actgcatgga gcagatccag gctgggcaca ctgacgctgt gactctgagg
     1381 ggcgaggaca tttacagggc aggaaaggtg tacggcctgg ttccggcggc cggggagctg
     1441 tatgctgagg aggacaggag caattcctac tttgtggtgg ctgtggcaag aagggacagc
     1501 tcctactcct tcaccctgga cgagcttcgc ggcaagcgtt cctgccaccc ctacttgggc
     1561 agcccagcgg gctgggaggt gcccatcggc tccctcatcc agcggggctt catccggccc
     1621 aaggactgtg atgtcctcac agcggtgagc cagttcttca atgccagctg cgtgcctgtc
     1681 aacaacccta agaactaccc ttccgcacta tgtgcgctct gcgtgggaga cgagaagggc
     1741 cgcaacaaat gtgtggggag cagccaggag agatactacg gctacagcgg ggccttcagg
     1801 tgccttgtgg agcatgcagg ggacgtggct ttcgtcaagc acacgactgt ctttgagaac
     1861 acaaatggtc acaatcctga gccttgggct tctcacctca ggtggcaaga ctatgaacta
     1921 ctgtgcccca atggggcacg ggctgaggta gaccagttcc aagcttgcaa cctggcacaa
     1981 atgccatccc acgctgtcat ggtccgtcca gacaccaaca tcttcactgt gtatggactt
     2041 ctggacaagg cccaggacct gtttggagac gaccataaca agaacggttt ccaaatgttt
     2101 gactcctcca aatatcacag ccaagacctg cttttcaaag atgctacagt ccgagcggtg
     2161 ccagtccggg agaaaaccac atacctggac tggctgggtc ctgactatgt ggttgcgctg
     2221 gaggggatgt tgtctcagca gtgctccggt gcaggggccg cggtgcagcg agtccccctg
     2281 ctggccctgc tcctgctgac cctggctgca ggcctccttc ctcgcgttct ctgaagaccg
     2341 ctgcttcagg ccacgcccag agcagggaaa gctacagagc tcaaccggaa gaaaccagga
     2401 catcagctaa ccctgcagga gagcgcgggg cgggatgagg agaggcaagg tgagaactca
     2461 cacacacaca caagcctccg aggtgcgatt ctaacccaaa gagaaatttc tagaatcagg
     2521 atgattgtta aggccaagtc ttcccacttg ctggagccct caatacctga ggcgactggc
     2581 gagtagccca gtcactcctc ccacaccggt ggcgccagca gcgaacctgt gcctcccacc
     2641 tggagcctcc tggctggctg gggtggttaa gggggggggg gggagagtga agatgctggt
     2701 tgccatggca accgtggagc agcttccagc ctctgtaccg gccacctggt gagatgccaa
     2761 ggaaggagca caccaccaac ctagggaacc tgtgcgacac actaccaccc agcagcccct
     2821 gctctcgctg ccccaccgct ctctcctatg ggcacttgtc caccaaggcc acaccgtcgg
     2881 aggggcaagg ctgctgagca catcagcctt ctgatgtgac accaaccaag gagcccagcc
     2941 ctctggacag caagattttg ctagactggg atgggaggaa ggccagagct gtactgtggg
     3001 gatgaagtcc tccaaaaccc tcagaggaag gaagtgcccc caccttccca ttaagaatgt
     3061 tagtgtgtga gaaacttgat gcagggtgga aactatcctg tttaacggct cccgtggcaa
     3121 gcaggacttg cgctgtctgc gctgcctgga cctcactgca caatgaaact gttgccgaga
     3181 ttctattgtt tgctctcctg gtctcagtct caacattagt tttctccctg ccttcatata
     3241 ccccttccca catcaccacg caagcacgca cgcgcacacg cacacgcaca caccttatcc
     3301 gtgtgaacat atctgaacat atctgcttgt ctgaagaagt aggagctaac ccaaaataac
     3361 ttcctgtcat gagctgggcc ttgggatata ccacgagcca ggggattggg gagagccctg
     3421 tcttcccttc accctgcacc tgttgggcag ttgcatcttt cgagaggatc cctggttctc
     3481 tcgaactgtg agagccaagg cctaggctgc cattttgcca ttgttctctc gagaaccaga
     3541 aaaagttttc caaagctacc agctcttacc ccagatcttg ttcccttaaa aaaaagtaat
     3601 aaataaaaag gagaagaaac aggagcaaac agccatcgtc agcacactgg aagcagcgtg
     3661 ggccgggagc tatttgtgtc ttggtctgtg tggggggcct cagatcccaa tgacaggcca
     3721 ggttcccagt ggctcgcccc cacctgtggg cgacgacggg acagatcctt tccatggctc
     3781 accagtagag aaggtcctgg cagtgtccca gccagagtca cacaatcctg aggaaaatcg
     3841 gtcaccatgg tgcttgggag agcaagcccc tcctcctccc agtacacagc catccattct
     3901 tctctgagct ggggacttca cagtgagaag tgtactctgt gtgggcgact gtgctgccca
     3961 aagtgtgatg tctgtgccgt gtgcctttca ggtgtgactt tgaagagcgt tgtgtaaatg
     4021 acgtctgatt gccatgggcc actgctgtgt ttgtgctaaa gaaagacatt ggtttctttt
     4081 taaaataaag ccatatatcc ctgcatacgc agaggcttgg atcctggtgg aaa
//
