LOCUS       NM_001302472            1770 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus Meis homeobox 3 (Meis3), transcript variant 5, mRNA.
ACCESSION   NM_001302472 XM_006539604
VERSION     NM_001302472.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1770)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1770)
  AUTHORS   Luo,P.M., Gu,X., Chaney,C., Carroll,T. and Cleaver,O.
  TITLE     Stromal netrin 1 coordinates renal arteriogenesis and mural cell
            differentiation
  JOURNAL   Development 150 (22) (2023)
   PUBMED   37823339
REFERENCE   3  (bases 1 to 1770)
  AUTHORS   Kumar,S., Fan,X., Rasouly,H.M., Sharma,R., Salant,D.J. and Lu,W.
  TITLE     ZEB2 controls kidney stromal progenitor differentiation and
            inhibits abnormal myofibroblast expansion and kidney fibrosis
  JOURNAL   JCI Insight 8 (1), e158418 (2023)
   PUBMED   36445780
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1770)
  AUTHORS   Sonnet,W., Rezsohazy,R. and Donnay,I.
  TITLE     Characterization of TALE genes expression during the first lineage
            segregation in mammalian embryos
  JOURNAL   Dev Dyn 241 (11), 1827-1839 (2012)
   PUBMED   22987645
  REMARK    GeneRIF: Data have demonstrated the presence of Meis, Pbx, and Prep
            proteins during early lineage segregation in mammals: Meis1, Meis3,
            Pbx1, Pbx2, Pbx3, and Prep1 in the mouse.
REFERENCE   5  (bases 1 to 1770)
  AUTHORS   Liu,J., Wang,Y., Birnbaum,M.J. and Stoffers,D.A.
  TITLE     Three-amino-acid-loop-extension homeodomain factor Meis3 regulates
            cell survival via PDK1
  JOURNAL   Proc Natl Acad Sci U S A 107 (47), 20494-20499 (2010)
   PUBMED   21059917
  REMARK    GeneRIF: Meis3 is abundantly expressed in pancreatic islets and
            beta-cells and regulates beta-cell survival through
            3-phosphoinositide-dependent protein kinase 1 (PDK1).
REFERENCE   6  (bases 1 to 1770)
  AUTHORS   Hara,T., Schwieger,M., Kazama,R., Okamoto,S., Minehata,K.,
            Ziegler,M., Lohler,J. and Stocking,C.
  TITLE     Acceleration of chronic myeloproliferation by enforced expression
            of Meis1 or Meis3 in Icsbp-deficient bone marrow cells
  JOURNAL   Oncogene 27 (27), 3865-3869 (2008)
   PUBMED   18223676
  REMARK    GeneRIF: Novel collaboration between Icsbp deficiency and
            Meis1/Meis3 in the acceleration of chronic myeloid leukemia-like
            disease.
REFERENCE   7  (bases 1 to 1770)
  AUTHORS   Qin,P., Cimildoro,R., Kochhar,D.M., Soprano,K.J. and Soprano,D.R.
  TITLE     PBX, MEIS, and IGF-I are potential mediators of retinoic
            acid-induced proximodistal limb reduction defects
  JOURNAL   Teratology 66 (5), 224-234 (2002)
   PUBMED   12397630
  REMARK    GeneRIF: The mRNA level of this protein was elevated in limb buds
            after treatment with ectopic acid.
REFERENCE   8  (bases 1 to 1770)
  AUTHORS   Wagner,K., Mincheva,A., Korn,B., Lichter,P. and Popperl,H.
  TITLE     Pbx4, a new Pbx family member on mouse chromosome 8, is expressed
            during spermatogenesis
  JOURNAL   Mech Dev 103 (1-2), 127-131 (2001)
   PUBMED   11335119
REFERENCE   9  (bases 1 to 1770)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   10 (bases 1 to 1770)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC156630.6.
            
            On Feb 23, 2023 this sequence version replaced NM_001302472.1.
            
            Summary: The protein encoding this gene belongs to the three amino
            acid loop extension family of homeodomain transcription factors,
            which play essential roles in many embryonic processes. These
            proteins are characterized by an atypical homeodomain containing a
            three amino acid loop extension between helices 1 and 2. Expression
            of this gene begins during the compaction stage of embryogenesis
            and continues into the blastocyst stage. This gene is also
            expressed in pancreatic islet cells and beta-cells and regulates
            beta-cell survival. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Nov 2014].
            
            Transcript Variant: This variant (5) differs in the 3' UTR compared
            to variant 1. Variants 1 and 5 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3191251.1,
                                           SRR7345562.3241129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-173               AC156630.6         56081-56253
            174-355             AC156630.6         58078-58259
            356-515             AC156630.6         58395-58554
            516-566             AC156630.6         58647-58697
            567-617             AC156630.6         59431-59481
            618-767             AC156630.6         59637-59786
            768-879             AC156630.6         62727-62838
            880-1028            AC156630.6         63006-63154
            1029-1105           AC156630.6         64477-64553
            1106-1164           AC156630.6         64724-64782
            1165-1248           AC156630.6         65321-65404
            1249-1322           AC156630.6         66134-66207
            1323-1770           AC156630.6         66743-67190
FEATURES             Location/Qualifiers
     source          1..1770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.76 cM"
     gene            1..1770
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="Meis homeobox 3"
                     /db_xref="GeneID:17537"
                     /db_xref="MGI:MGI:108519"
     exon            1..173
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1298
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="isoform a is encoded by transcript variant 5;
                     homeobox protein Meis3; meis1-related protein 2; myeloid
                     ecotropic viral integration site-related gene 2"
                     /codon_start=1
                     /product="homeobox protein Meis3 isoform a"
                     /protein_id="NP_001289401.1"
                     /db_xref="CCDS:CCDS39782.1"
                     /db_xref="GeneID:17537"
                     /db_xref="MGI:MGI:108519"
                     /translation="MARRYDELRHYPGITEHTTALASFSEAAPSVPRAPGPYTPHRPP
                     QLQAPGLDSDSLKREKDDIYGHPLFPLLALVFEKCELATCSPRDGASAGLGSPPGGDV
                     CSSDSFNEDIAAFAKQIRSERPLFSSNPELDNLMVQAIQVLRFHLLELEKVHDLCDNF
                     CHRYITCLKGKMPIDLVIEDRDGSCREDLEDYAASCPSLPDQNTTWIRDHEDSGSVHL
                     GTPGPSSGGLASQSGDNSSDQGDGLDTSVASPSSAGEDEDLDLERRRNKKRGIFPKVA
                     TNIMRAWLFQHLSHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRT
                     GQGASFNPEGQPMAGFTETQPQVTVRTPGSMGMNLNLEGEWHYL"
     exon            174..355
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            356..515
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            516..566
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..617
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            618..767
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..879
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1028
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1105
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1164
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1248
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1322
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1770
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1749..1754
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="hexamer: AATAAA"
     polyA_site      1770
                     /gene="Meis3"
                     /gene_synonym="Mrg2"
                     /note="major polyA site"
ORIGIN      
        1 gccgggcccg tgtgagcgga ggagccgccg ccaccctcgg ccgcgatccg cgggtcttgg
       61 ccactcggag accctggcac ccggcgggga cctcggggac ctcctgccgc gatgagctcc
      121 aggccgtgac ctcccgagcc caggacaggc ggcgccggct catggcccgg aggtatgatg
      181 agctgcgcca ctacccaggc attacagagc acacgacagc cctggccagc ttttcagagg
      241 cagcgccttc agtacctaga gcccctgggc cctacacccc acaccggcca ccccagctcc
      301 aagctccagg cttggacagc gacagcttga agagagagaa ggatgacatc tatggacacc
      361 ccctcttccc actcttggcc ctggtctttg agaagtgtga gctggctaca tgctcgcccc
      421 gtgatggggc ctcggctggg ctgggttcac ccccaggtgg tgacgtctgc tcctctgact
      481 ccttcaatga ggatattgct gcctttgcta agcagatccg ctccgagagg ccgctgttct
      541 cttccaaccc ggagctggac aacctgatgg tccaggccat ccaggtactc cggttccacc
      601 tgctggagct ggagaaggtc cacgacctgt gcgacaactt ctgtcaccgc tacatcacct
      661 gcctcaaggg gaagatgccc atagacctgg tgattgagga tcgggatggt agttgcaggg
      721 aggatcttga ggactacgca gcctcctgcc ccagcctccc agaccagaat actacatgga
      781 tcagagacca tgaggacagt gggtctgtac atttggggac cccaggtcca tccagcggag
      841 gcctggcctc ccagagtggg gacaactcaa gtgaccaagg agatgggctg gacacaagcg
      901 tagcctctcc cagctccgca ggagaggatg aggacctgga cctggaacgc agacggaaca
      961 agaagagggg gatctttccc aaagtggcca ccaacatcat gagggcctgg ttgttccagc
     1021 atctctcgca cccgtaccct tcagaagagc aaaagaaaca gctggcccag gacacagggc
     1081 tcaccatcct gcaggtgaac aactggttta ttaatgcccg gagacgaata gtgcagccca
     1141 tgattgacca gtctaatcgc acagggcagg gtgcatcttt caaccctgag ggccagccca
     1201 tggcaggctt cacagagact cagccacaag tgacagtcag gacaccagga tcaatgggga
     1261 tgaacctgaa cttagaagga gagtggcatt acctatagag gctgggttca aagggaaggt
     1321 gggaaggccc cagcctctga ctgtgaccac cagccttgca cctaattggt ccctgctggt
     1381 ccttgggctt caggacttca cctccaaagc tcccacccca ttcaacgcct acctccctgg
     1441 ggtccccagt agcttgagga ccaagagccc acttgagggt ctctcaaggg caaagacaaa
     1501 gcctccaggt cctgcaccct tcttctgccc tcccctttgc ccaggaccta agcagaaaac
     1561 tgggccaagg tctgaagaag atggtggctg gggccccgac ccaggacaga gaagagactg
     1621 gggttggaca aggatggtca aggaagaagg gtcacctgga tccaatgttt ggaagaatcc
     1681 tccatcttcc tgccctctgc ctcccccacc tcccttctct gacattcttc tacttttcct
     1741 tttttaataa taaagtcttt aaaatgcaaa
//
