LOCUS       NM_010825               4621 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 2, mRNA.
ACCESSION   NM_010825
VERSION     NM_010825.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4621)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4621)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4621)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4621)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 4621)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4621)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 4621)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 4621)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 4621)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 4621)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146633.1, KM974644.1 and
            AL929037.3.
            
            On Apr 22, 2009 this sequence version replaced NM_010825.2.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR, and has
            multiple differences in the coding region, compared to variant 9.
            The encoded isoform (2) is shorter and has a distinct N-terminus
            compared to isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ000507.1, BC017375.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1370              AK146633.1         1-1370
            1371-1626           KM974644.1         874-1129
            1627-2816           AK146633.1         1722-2911
            2817-4621           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..4621
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..4621
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..257
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1658
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 2 is encoded by transcript variant 2;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 2"
                     /protein_id="NP_034955.1"
                     /db_xref="CCDS:CCDS16568.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPP
                     LHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCT
                     PREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLE
                     LEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSW
                     RDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKR
                     QKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRI
                     VQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMG
                     MGMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPTHPGMTMSAQSP
                     TMLNSVDPNVGGQVMDIHAQ"
     exon            258..490
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..632
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            633..683
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            684..734
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            735..884
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            885..999
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1145
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1222
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1281
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1371
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..4621
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2792..2797
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      2811
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat
       61 atcactgaaa aaaattcttc gttttcttga ctgggctttc cccacccccc aaaaaataac
      121 attggaaaat tgggagaagt ctccttggtt tggaaaaaaa ggactcttca acctagctca
      181 ctttcttatc cggactggga tattaaatat acgacacatc caggagttta ttggagcgca
      241 gactgatggc gcaaaggtac gatgagctgc cccattacgg cgggatggac ggagtagggg
      301 ttcccgcttc catgtacgga gaccctcacg cgccgcggcc gatccccccg gttcaccacc
      361 taaaccacgg gccgccgctc cacgccacgc agcactacgg cgcgcacgcc ccgcacccca
      421 atgtcatgcc agccagcatg ggatctgctg tcaacgacgc cttgaaaaga gacaaggacg
      481 caatctatgg gcacccgttg tttcctctgt tagctctggt ttttgagaag tgcgagctgg
      541 cgacctgcac tccccgggaa cccggagtgg ccggcggaga cgtctgttcc tctgactcct
      601 tcaacgagga catcgcggtc ttcgccaagc aggttcgcgc cgaaaagcct cttttttcct
      661 caaacccaga gctggataat ttgatgatac aagcaattca agtactaagg tttcatcttc
      721 tggagttaga aaaggtccac gaactatgtg ataacttctg ccaccggtac attagctgtt
      781 tgaagggaaa aatgcccatt gacctcgtga ttgatgagag agatggaagc tccaagtcag
      841 atcatgaaga actttcaggc tcctccacaa atctcgccga ccacaaccct tcatcctggc
      901 gagaccacga tgacgcaacc tcaacgcact ccgcaggcac cccaggaccc tccagtgggg
      961 gccatgcttc ccagagtgga gacaacagca gtgagcaagg cgatgggtta gacaacagcg
     1021 tagcttcacc tggcacaggt gatgacgacg atccagacaa ggacaaaaaa cgccagaaga
     1081 aaagaggcat attccccaaa gtcgcgacaa atatcatgag agcgtggctc ttccagcatc
     1141 tcacacaccc gtacccttca gaagaacaga agaaacagtt agcgcaagac acgggactga
     1201 caattctgca agtgaacaac tggtttatca atgccagaag aagaatagtg cagcccatga
     1261 ttgaccagtc aaatcgagca gtgagccaag gagcagcgta tagtccagag ggtcagccca
     1321 tggggagctt tgtgttggat ggtcagcaac acatggggat ccggcctgca ggtttgcaga
     1381 gcatgccagg ggactacgtt tctcagggtg gtccaatggg aatgggtatg gcccagccaa
     1441 gttacactcc tccccagatg accccacacc ctactcagtt aagacatgga cccccaatgc
     1501 attcatattt gccaagccat ccccaccacc cagccatggt gatgcacgga ggacccccta
     1561 cccaccctgg aatgactatg tcagcacaga gccccacaat gttaaattct gtagatccca
     1621 atgttggcgg acaggttatg gacattcatg cccaatagta taagggaact caaggaagaa
     1681 ggaaacacac gcaaaaacta ttttaagact ctctgaactt tgaccagatg tgacacttaa
     1741 tatgaaactc cagacagctg tgattatttt ttactttttg tcatttttca tcaagcaaca
     1801 gaggaccaat gggacaagaa cacaaatgtg aagcgacggg ctcatcgaga caattttgtc
     1861 catgcaaaga tcctctggag aaagactccg agagttataa ctactgtagc ataaacatag
     1921 ggactaagtt aaacttgtac atttctgttg atcactccgt tatgttgcct caaatagttt
     1981 tagaagagaa aaaaaaaata tatccttgtt ttccacacta tgtgtgttgt tcccaaaaga
     2041 atgactgtct tggttcatca gtgaattcac tatccagaag agactgtggt atattttaaa
     2101 cctgttgggc caatgagaaa agaaccatgc tgcggagcga gatggacact tgtctgaacc
     2161 tcatcactaa ctccagcggc tagaatgtgt tttcatgccc ggcctttgtt ccccccgtcc
     2221 atgtgtcctt tagtttcaaa cagatcttta tagtttgtgc ttcataagcc aattcttatt
     2281 atgattttgg gggactgttc ttcaaagagc ttgccagtga agatctagag acagagcgaa
     2341 ggcttcttca agttctgagc cttggctgtg gacaaaacaa tcttaagttg ggcagctttc
     2401 ctcaacgcac atacacacac acacacacac aagttattca tggtcgttgc accataagta
     2461 ggattctatc aggaactcaa agcttggggg ataaaaagga gcaagagaat actgtaacaa
     2521 acttcgtaca gagttcggtc ttttaattgt ttcatgttag atattctatg tgtttacctc
     2581 aattgaaaaa aaaaaaaaga atgtttttgc tagtatcaga tctgctgtgg aattggtatt
     2641 gtatgtccat ggggtcctct tttctcagca cgtgttcctc actagaagaa aatgctgtta
     2701 cctttaagct ttgtcaaatt tacattaaaa tacttgtatg aggactgtga cgttatgtta
     2761 aaaaaaaagg tgttaagtca caaaatgcgg taataaatat ttcatttttg attttttgtt
     2821 aggctttggt gttttttaat ggtttgaagg ttgcaggagg ccagctcctg ggcactgatg
     2881 aaagtacctg atggtctccc accacccccc cccccaagga agttgagcat atttaagatg
     2941 taacttagca gcatctgtag cttttcattg tgtgtttgga ctcttaggtt tcatcaacag
     3001 aaaacttcca aaggtatgaa attacttgtg ttatatccag cttgagagat caccttcaaa
     3061 aggcccagcc tatcttatta tagctgcatg atgtttttaa aagcagttgc agattaaact
     3121 tttgcctatg tacccaccag tagaataaag ggtttattcc atgttaattt tatatcataa
     3181 gaagttatgt gtgtgctcaa acatgattta tctgtactct atcttactca aatactgttg
     3241 actctgtaca ttaaagctca tatatgatgt ctatagataa gtaaacactt tctatggagt
     3301 tgggaattct aagcttaaaa gagtgcttaa gcattaatat ttagtacaaa taatacagtg
     3361 gtatctttct aataaggttg ctttctccat gtgcagggat gcaagtatga tagtctggtg
     3421 cctcaaaaat ttttttttca taaaaaaaaa gaaaagaaaa aaaaaagaga tactttgata
     3481 gcattttcaa agctttactt ggtaatctag agccacaagc ttgttgatgt tgcagtgtct
     3541 actaaagtgt gcaaaatgta gccgcttaag atagctgcac actcaaagag tttccaaata
     3601 aacacacagc tgaggctttc ctaactccta aatgttgacg cctccatcta aaggggagga
     3661 taaataggag atggagagat gatttgattt ggtagggaag agctcactag tcatacaaac
     3721 ttccacttgg aagcactcca tagtggcctc tcaggcaaac ccttccctgt ttccttgtta
     3781 ggcagcctta atggaagcac tacatatgaa tgagcaagga tataaattgc tattgttttc
     3841 ttttatattg ttaagtaaaa tttttataag tgcatttatc actttaatta gtgcactgct
     3901 ctttaaacct agaaatagca gtgtttgaca caaacacact gatcttgtaa aatacataga
     3961 gcctccctcc ctctcattat ccctgttcca tgctacatgg aatctttctg taaaatttaa
     4021 atatttgcat atgtttgctt taaatgctct gatgtaaact ctgacaagtt cctcatttat
     4081 aaacttactc tcatatcagt tgaaagggga aaaattatat tggcagcttt tctctcattg
     4141 ctctccataa ggtaattgct gaagggtttc cttggtcaca agctcacgtt tataaaaagt
     4201 attttatgga gttattactc caggaagggt acagccagag tggttgagcc ttcgtttgaa
     4261 ttcacagact catcgtgagc ttagtatctt ggccaatctg tatcctatca tgctaatttt
     4321 aaccttagat atttggagat gagtgataat tgtggtaata tctatgtatt ttcttacccc
     4381 acccccaccc cattctatga cagagggatg atgaatttat ccagttttta tagtgctttt
     4441 tataccacct cagaaggcgc ttgctcctat ctcgggttta ctatttagta taaagagttc
     4501 cgatttgggt atatttaaga aagactcagc tgtcaaacgc aaagaaactg ggaatggtgt
     4561 tttgacaacc atatagtgtt aaaggaaata ctgtagtctg aataaaattg cttatgttct
     4621 c
//
