LOCUS       NM_001346047            5188 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 8, mRNA.
ACCESSION   NM_001346047
VERSION     NM_001346047.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5188)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5188)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 5188)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 5188)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 5188)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 5188)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 5188)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 5188)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 5188)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 5188)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY012436.1, AL772135.14,
            AK012325.1, AK146633.1, AK158839.1 and AL929037.3.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (8) differs in the 5' and 3' UTRs
            and has multiple differences in the coding region, compared to
            variant 9. The encoded isoform (8) is shorter and has distinct N-
            and C-termini compared to isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.97443.1,
                                           SRR7345562.2216049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                BY012436.1         1-83
            84-312              AL772135.14        171559-171787       c
            313-667             AK012325.1         231-585
            668-708             AL772135.14        170657-170697       c
            709-1731            AK146633.1         258-1280
            1732-1844           AK158839.1         1553-1665
            1845-3383           AK146633.1         1373-2911
            3384-5188           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..5188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..5188
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..320
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            321..708
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..1902
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 8 is encoded by transcript variant 8;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 8"
                     /protein_id="NP_001332976.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MPNIPNATQLGRSQEEWWGNKREYDELPHYGGMDGVGVPASMYG
                     DPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGH
                     PLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNP
                     ELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSD
                     HEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDN
                     SVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQD
                     TGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDG
                     QQHMGIRPAGPMSGMGMNMGMDGQWHYM"
     exon            709..941
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1083
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1134
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1185
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1335
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1450
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1596
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1673
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1732
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1843
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1844..1938
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..5188
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3359..3364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      3378
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 atgagaaagt ccagtcaaag gcacccttgc aggaggcgct gctttctgtc acgggatggt
       61 tcagagttgg ggagggaggc cgcagttgaa cagcaaaccc ttactctgtt tgctattctc
      121 tgggcctggg gcccggaacc cagggcgagg gtgagaagtt ggggagaggg cgcgctccca
      181 gtgcgtggct gggtcgcgct gccagctgcc tggtggcggc agggtgaacc cggctacgcg
      241 cgccgggtga ccaaagctcc gcccccagct ctcgtctctc ggtgattgac gcgcagccgc
      301 ggggaaacag cagagcagag attgagccca ggacccctag actctcaatg gtggtctaca
      361 ctgtctgcag cgcaccgagg gactatgctc cgagttcagc tgctcatatc ttgtactaga
      421 caaaaatgaa tattgacaaa aagggctctg catctgcacg agaaagaaag taccacttaa
      481 caacaacaac aacaacaaca acaacaaaaa tcctagcctg gcggtggtgc agttggcgga
      541 gcttgctgct ctaggttgta gtggcagagt tcgggaccta gtaatccgcc ggcagaggaa
      601 gggggccgcg gaattaaaac gaacaaaagc tagagcgcca tgccaaacat ccccaacgcg
      661 acccagttag gcaggagcca agaggagtgg tggggaaata aacgagaata cgatgagctg
      721 ccccattacg gcgggatgga cggagtaggg gttcccgctt ccatgtacgg agaccctcac
      781 gcgccgcggc cgatcccccc ggttcaccac ctaaaccacg ggccgccgct ccacgccacg
      841 cagcactacg gcgcgcacgc cccgcacccc aatgtcatgc cagccagcat gggatctgct
      901 gtcaacgacg ccttgaaaag agacaaggac gcaatctatg ggcacccgtt gtttcctctg
      961 ttagctctgg tttttgagaa gtgcgagctg gcgacctgca ctccccggga acccggagtg
     1021 gccggcggag acgtctgttc ctctgactcc ttcaacgagg acatcgcggt cttcgccaag
     1081 caggttcgcg ccgaaaagcc tcttttttcc tcaaacccag agctggataa tttgatgata
     1141 caagcaattc aagtactaag gtttcatctt ctggagttag aaaaggtcca cgaactatgt
     1201 gataacttct gccaccggta cattagctgt ttgaagggaa aaatgcccat tgacctcgtg
     1261 attgatgaga gagatggaag ctccaagtca gatcatgaag aactttcagg ctcctccaca
     1321 aatctcgccg accacaaccc ttcatcctgg cgagaccacg atgacgcaac ctcaacgcac
     1381 tccgcaggca ccccaggacc ctccagtggg ggccatgctt cccagagtgg agacaacagc
     1441 agtgagcaag gcgatgggtt agacaacagc gtagcttcac ctggcacagg tgatgacgac
     1501 gatccagaca aggacaaaaa acgccagaag aaaagaggca tattccccaa agtcgcgaca
     1561 aatatcatga gagcgtggct cttccagcat ctcacacacc cgtacccttc agaagaacag
     1621 aagaaacagt tagcgcaaga cacgggactg acaattctgc aagtgaacaa ctggtttatc
     1681 aatgccagaa gaagaatagt gcagcccatg attgaccagt caaatcgagc aggttttctt
     1741 cttgatcctt cagtgagcca aggagcagcg tatagtccag agggtcagcc catggggagc
     1801 tttgtgttgg atggtcagca acacatgggg atccggcctg caggacccat gagtggaatg
     1861 ggcatgaata tgggcatgga tgggcagtgg cactatatgt aaccttcgcc atgtaaagca
     1921 atctcaaggc aaggggaagt ttgcagagca tgccagggga ctacgtttct cagggtggtc
     1981 caatgggaat gggtatggcc cagccaagtt acactcctcc ccagatgacc ccacacccta
     2041 ctcagttaag acatggaccc ccaatgcatt catatttgcc aagccatccc caccacccag
     2101 ccatggtgat gcacggagga ccccctaccc accctggaat gactatgtca gcacagagcc
     2161 ccacaatgtt aaattctgta gatcccaatg ttggcggaca ggttatggac attcatgccc
     2221 aatagtataa gggaactcaa ggaagaagga aacacacgca aaaactattt taagactctc
     2281 tgaactttga ccagatgtga cacttaatat gaaactccag acagctgtga ttatttttta
     2341 ctttttgtca tttttcatca agcaacagag gaccaatggg acaagaacac aaatgtgaag
     2401 cgacgggctc atcgagacaa ttttgtccat gcaaagatcc tctggagaaa gactccgaga
     2461 gttataacta ctgtagcata aacataggga ctaagttaaa cttgtacatt tctgttgatc
     2521 actccgttat gttgcctcaa atagttttag aagagaaaaa aaaaatatat ccttgttttc
     2581 cacactatgt gtgttgttcc caaaagaatg actgtcttgg ttcatcagtg aattcactat
     2641 ccagaagaga ctgtggtata ttttaaacct gttgggccaa tgagaaaaga accatgctgc
     2701 ggagcgagat ggacacttgt ctgaacctca tcactaactc cagcggctag aatgtgtttt
     2761 catgcccggc ctttgttccc cccgtccatg tgtcctttag tttcaaacag atctttatag
     2821 tttgtgcttc ataagccaat tcttattatg attttggggg actgttcttc aaagagcttg
     2881 ccagtgaaga tctagagaca gagcgaaggc ttcttcaagt tctgagcctt ggctgtggac
     2941 aaaacaatct taagttgggc agctttcctc aacgcacata cacacacaca cacacacaag
     3001 ttattcatgg tcgttgcacc ataagtagga ttctatcagg aactcaaagc ttgggggata
     3061 aaaaggagca agagaatact gtaacaaact tcgtacagag ttcggtcttt taattgtttc
     3121 atgttagata ttctatgtgt ttacctcaat tgaaaaaaaa aaaaagaatg tttttgctag
     3181 tatcagatct gctgtggaat tggtattgta tgtccatggg gtcctctttt ctcagcacgt
     3241 gttcctcact agaagaaaat gctgttacct ttaagctttg tcaaatttac attaaaatac
     3301 ttgtatgagg actgtgacgt tatgttaaaa aaaaaggtgt taagtcacaa aatgcggtaa
     3361 taaatatttc atttttgatt ttttgttagg ctttggtgtt ttttaatggt ttgaaggttg
     3421 caggaggcca gctcctgggc actgatgaaa gtacctgatg gtctcccacc accccccccc
     3481 ccaaggaagt tgagcatatt taagatgtaa cttagcagca tctgtagctt ttcattgtgt
     3541 gtttggactc ttaggtttca tcaacagaaa acttccaaag gtatgaaatt acttgtgtta
     3601 tatccagctt gagagatcac cttcaaaagg cccagcctat cttattatag ctgcatgatg
     3661 tttttaaaag cagttgcaga ttaaactttt gcctatgtac ccaccagtag aataaagggt
     3721 ttattccatg ttaattttat atcataagaa gttatgtgtg tgctcaaaca tgatttatct
     3781 gtactctatc ttactcaaat actgttgact ctgtacatta aagctcatat atgatgtcta
     3841 tagataagta aacactttct atggagttgg gaattctaag cttaaaagag tgcttaagca
     3901 ttaatattta gtacaaataa tacagtggta tctttctaat aaggttgctt tctccatgtg
     3961 cagggatgca agtatgatag tctggtgcct caaaaatttt tttttcataa aaaaaaagaa
     4021 aagaaaaaaa aaagagatac tttgatagca ttttcaaagc tttacttggt aatctagagc
     4081 cacaagcttg ttgatgttgc agtgtctact aaagtgtgca aaatgtagcc gcttaagata
     4141 gctgcacact caaagagttt ccaaataaac acacagctga ggctttccta actcctaaat
     4201 gttgacgcct ccatctaaag gggaggataa ataggagatg gagagatgat ttgatttggt
     4261 agggaagagc tcactagtca tacaaacttc cacttggaag cactccatag tggcctctca
     4321 ggcaaaccct tccctgtttc cttgttaggc agccttaatg gaagcactac atatgaatga
     4381 gcaaggatat aaattgctat tgttttcttt tatattgtta agtaaaattt ttataagtgc
     4441 atttatcact ttaattagtg cactgctctt taaacctaga aatagcagtg tttgacacaa
     4501 acacactgat cttgtaaaat acatagagcc tccctccctc tcattatccc tgttccatgc
     4561 tacatggaat ctttctgtaa aatttaaata tttgcatatg tttgctttaa atgctctgat
     4621 gtaaactctg acaagttcct catttataaa cttactctca tatcagttga aaggggaaaa
     4681 attatattgg cagcttttct ctcattgctc tccataaggt aattgctgaa gggtttcctt
     4741 ggtcacaagc tcacgtttat aaaaagtatt ttatggagtt attactccag gaagggtaca
     4801 gccagagtgg ttgagccttc gtttgaattc acagactcat cgtgagctta gtatcttggc
     4861 caatctgtat cctatcatgc taattttaac cttagatatt tggagatgag tgataattgt
     4921 ggtaatatct atgtattttc ttaccccacc cccaccccat tctatgacag agggatgatg
     4981 aatttatcca gtttttatag tgctttttat accacctcag aaggcgcttg ctcctatctc
     5041 gggtttacta tttagtataa agagttccga tttgggtata tttaagaaag actcagctgt
     5101 caaacgcaaa gaaactggga atggtgtttt gacaaccata tagtgttaaa ggaaatactg
     5161 tagtctgaat aaaattgctt atgttctc
//
