LOCUS       NM_001346045            4905 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 7, mRNA.
ACCESSION   NM_001346045
VERSION     NM_001346045.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4905)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4905)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4905)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4905)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 4905)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4905)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 4905)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 4905)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 4905)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 4905)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK146633.1, AL772135.14,
            BQ572308.1 and AL929037.3.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (7) differs in the 5' and 3' UTRs
            and has multiple differences in the coding region, compared to
            variant 9. The encoded isoform (7) is shorter and has distinct N-
            and C-termini compared to isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.155293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-999               AK146633.1         1-999
            1000-1080           AL772135.14        146473-146553       c
            1081-1189           BQ572308.1         1-109
            1190-3100           AK146633.1         1001-2911
            3101-4905           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..4905
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..4905
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..257
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1619
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 7 is encoded by transcript variant 7;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 7"
                     /protein_id="NP_001332974.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPP
                     LHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCT
                     PREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLE
                     LEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSW
                     RDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGASETEADHLLLWKPMTDRTGCVSV
                     QMSREDREESREGKHSPQPLENIIIPCQPPFRGESEAGGDGLDNSVASPGTGDDDDPD
                     KDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFIN
                     ARRRIVQPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGPMSGMGMNMGM
                     DGQWHYM"
     exon            258..490
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            491..632
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            633..683
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            684..734
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            735..884
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            885..999
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1188
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1334
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1411
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1470
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1560
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1655
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..4905
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3076..3081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      3095
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaggag gaagatcagg aggaggagga agaagaggaa aaaagagaaa aagaagaaat
       61 atcactgaaa aaaattcttc gttttcttga ctgggctttc cccacccccc aaaaaataac
      121 attggaaaat tgggagaagt ctccttggtt tggaaaaaaa ggactcttca acctagctca
      181 ctttcttatc cggactggga tattaaatat acgacacatc caggagttta ttggagcgca
      241 gactgatggc gcaaaggtac gatgagctgc cccattacgg cgggatggac ggagtagggg
      301 ttcccgcttc catgtacgga gaccctcacg cgccgcggcc gatccccccg gttcaccacc
      361 taaaccacgg gccgccgctc cacgccacgc agcactacgg cgcgcacgcc ccgcacccca
      421 atgtcatgcc agccagcatg ggatctgctg tcaacgacgc cttgaaaaga gacaaggacg
      481 caatctatgg gcacccgttg tttcctctgt tagctctggt ttttgagaag tgcgagctgg
      541 cgacctgcac tccccgggaa cccggagtgg ccggcggaga cgtctgttcc tctgactcct
      601 tcaacgagga catcgcggtc ttcgccaagc aggttcgcgc cgaaaagcct cttttttcct
      661 caaacccaga gctggataat ttgatgatac aagcaattca agtactaagg tttcatcttc
      721 tggagttaga aaaggtccac gaactatgtg ataacttctg ccaccggtac attagctgtt
      781 tgaagggaaa aatgcccatt gacctcgtga ttgatgagag agatggaagc tccaagtcag
      841 atcatgaaga actttcaggc tcctccacaa atctcgccga ccacaaccct tcatcctggc
      901 gagaccacga tgacgcaacc tcaacgcact ccgcaggcac cccaggaccc tccagtgggg
      961 gccatgcttc ccagagtgga gacaacagca gtgagcaagg cgcttcggag actgaggctg
     1021 accatttact attgtggaag cccatgactg atcgcacagg atgcgtttca gtgcaaatgt
     1081 caagagaaga tagagaagaa agcagagagg gaaaacactc tccacaacca cttgaaaaca
     1141 tcatcattcc ctgtcagccg ccctttcgtg gggaaagcga agctggaggc gatgggttag
     1201 acaacagcgt agcttcacct ggcacaggtg atgacgacga tccagacaag gacaaaaaac
     1261 gccagaagaa aagaggcata ttccccaaag tcgcgacaaa tatcatgaga gcgtggctct
     1321 tccagcatct cacacacccg tacccttcag aagaacagaa gaaacagtta gcgcaagaca
     1381 cgggactgac aattctgcaa gtgaacaact ggtttatcaa tgccagaaga agaatagtgc
     1441 agcccatgat tgaccagtca aatcgagcag tgagccaagg agcagcgtat agtccagagg
     1501 gtcagcccat ggggagcttt gtgttggatg gtcagcaaca catggggatc cggcctgcag
     1561 gacccatgag tggaatgggc atgaatatgg gcatggatgg gcagtggcac tatatgtaac
     1621 cttcgccatg taaagcaatc tcaaggcaag gggaagtttg cagagcatgc caggggacta
     1681 cgtttctcag ggtggtccaa tgggaatggg tatggcccag ccaagttaca ctcctcccca
     1741 gatgacccca caccctactc agttaagaca tggaccccca atgcattcat atttgccaag
     1801 ccatccccac cacccagcca tggtgatgca cggaggaccc cctacccacc ctggaatgac
     1861 tatgtcagca cagagcccca caatgttaaa ttctgtagat cccaatgttg gcggacaggt
     1921 tatggacatt catgcccaat agtataaggg aactcaagga agaaggaaac acacgcaaaa
     1981 actattttaa gactctctga actttgacca gatgtgacac ttaatatgaa actccagaca
     2041 gctgtgatta ttttttactt tttgtcattt ttcatcaagc aacagaggac caatgggaca
     2101 agaacacaaa tgtgaagcga cgggctcatc gagacaattt tgtccatgca aagatcctct
     2161 ggagaaagac tccgagagtt ataactactg tagcataaac atagggacta agttaaactt
     2221 gtacatttct gttgatcact ccgttatgtt gcctcaaata gttttagaag agaaaaaaaa
     2281 aatatatcct tgttttccac actatgtgtg ttgttcccaa aagaatgact gtcttggttc
     2341 atcagtgaat tcactatcca gaagagactg tggtatattt taaacctgtt gggccaatga
     2401 gaaaagaacc atgctgcgga gcgagatgga cacttgtctg aacctcatca ctaactccag
     2461 cggctagaat gtgttttcat gcccggcctt tgttcccccc gtccatgtgt cctttagttt
     2521 caaacagatc tttatagttt gtgcttcata agccaattct tattatgatt ttgggggact
     2581 gttcttcaaa gagcttgcca gtgaagatct agagacagag cgaaggcttc ttcaagttct
     2641 gagccttggc tgtggacaaa acaatcttaa gttgggcagc tttcctcaac gcacatacac
     2701 acacacacac acacaagtta ttcatggtcg ttgcaccata agtaggattc tatcaggaac
     2761 tcaaagcttg ggggataaaa aggagcaaga gaatactgta acaaacttcg tacagagttc
     2821 ggtcttttaa ttgtttcatg ttagatattc tatgtgttta cctcaattga aaaaaaaaaa
     2881 aagaatgttt ttgctagtat cagatctgct gtggaattgg tattgtatgt ccatggggtc
     2941 ctcttttctc agcacgtgtt cctcactaga agaaaatgct gttaccttta agctttgtca
     3001 aatttacatt aaaatacttg tatgaggact gtgacgttat gttaaaaaaa aaggtgttaa
     3061 gtcacaaaat gcggtaataa atatttcatt tttgattttt tgttaggctt tggtgttttt
     3121 taatggtttg aaggttgcag gaggccagct cctgggcact gatgaaagta cctgatggtc
     3181 tcccaccacc ccccccccca aggaagttga gcatatttaa gatgtaactt agcagcatct
     3241 gtagcttttc attgtgtgtt tggactctta ggtttcatca acagaaaact tccaaaggta
     3301 tgaaattact tgtgttatat ccagcttgag agatcacctt caaaaggccc agcctatctt
     3361 attatagctg catgatgttt ttaaaagcag ttgcagatta aacttttgcc tatgtaccca
     3421 ccagtagaat aaagggttta ttccatgtta attttatatc ataagaagtt atgtgtgtgc
     3481 tcaaacatga tttatctgta ctctatctta ctcaaatact gttgactctg tacattaaag
     3541 ctcatatatg atgtctatag ataagtaaac actttctatg gagttgggaa ttctaagctt
     3601 aaaagagtgc ttaagcatta atatttagta caaataatac agtggtatct ttctaataag
     3661 gttgctttct ccatgtgcag ggatgcaagt atgatagtct ggtgcctcaa aaattttttt
     3721 ttcataaaaa aaaagaaaag aaaaaaaaaa gagatacttt gatagcattt tcaaagcttt
     3781 acttggtaat ctagagccac aagcttgttg atgttgcagt gtctactaaa gtgtgcaaaa
     3841 tgtagccgct taagatagct gcacactcaa agagtttcca aataaacaca cagctgaggc
     3901 tttcctaact cctaaatgtt gacgcctcca tctaaagggg aggataaata ggagatggag
     3961 agatgatttg atttggtagg gaagagctca ctagtcatac aaacttccac ttggaagcac
     4021 tccatagtgg cctctcaggc aaacccttcc ctgtttcctt gttaggcagc cttaatggaa
     4081 gcactacata tgaatgagca aggatataaa ttgctattgt tttcttttat attgttaagt
     4141 aaaattttta taagtgcatt tatcacttta attagtgcac tgctctttaa acctagaaat
     4201 agcagtgttt gacacaaaca cactgatctt gtaaaataca tagagcctcc ctccctctca
     4261 ttatccctgt tccatgctac atggaatctt tctgtaaaat ttaaatattt gcatatgttt
     4321 gctttaaatg ctctgatgta aactctgaca agttcctcat ttataaactt actctcatat
     4381 cagttgaaag gggaaaaatt atattggcag cttttctctc attgctctcc ataaggtaat
     4441 tgctgaaggg tttccttggt cacaagctca cgtttataaa aagtatttta tggagttatt
     4501 actccaggaa gggtacagcc agagtggttg agccttcgtt tgaattcaca gactcatcgt
     4561 gagcttagta tcttggccaa tctgtatcct atcatgctaa ttttaacctt agatatttgg
     4621 agatgagtga taattgtggt aatatctatg tattttctta ccccaccccc accccattct
     4681 atgacagagg gatgatgaat ttatccagtt tttatagtgc tttttatacc acctcagaag
     4741 gcgcttgctc ctatctcggg tttactattt agtataaaga gttccgattt gggtatattt
     4801 aagaaagact cagctgtcaa acgcaaagaa actgggaatg gtgttttgac aaccatatag
     4861 tgttaaagga aatactgtag tctgaataaa attgcttatg ttctc
//
