LOCUS       NM_001346041            4892 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus Meis homeobox 2 (Meis2), transcript variant 11, mRNA.
ACCESSION   NM_001346041
VERSION     NM_001346041.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4892)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4892)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   3  (bases 1 to 4892)
  AUTHORS   Koo,H.Y., Oh,J.H., Duran Alonso,M.B., Hernandez,I.L.,
            Gonzalez-Vallinas,M., Alonso,M.T., Tena,J.J., Gil-Galvez,A.,
            Giraldez,F., Bok,J. and Schimmang,T.
  TITLE     Analysis of Meis2 knockout mice reveals Sonic hedgehog-mediated
            patterning of the cochlear duct
  JOURNAL   Dev Dyn (2024) In press
   PUBMED   39351969
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 4892)
  AUTHORS   Krishnamurthy,A., Lee,A.S., Bayin,N.S., Stephen,D.N., Nasef,O.,
            Lao,Z. and Joyner,A.L.
  TITLE     Engrailed transcription factors direct excitatory cerebellar neuron
            diversity and survival
  JOURNAL   Development 151 (14) (2024)
   PUBMED   38912572
REFERENCE   5  (bases 1 to 4892)
  AUTHORS   Burglin,T.R. and Affolter,M.
  TITLE     Homeodomain proteins: an update
  JOURNAL   Chromosoma 125 (3), 497-521 (2016)
   PUBMED   26464018
  REMARK    Review article
REFERENCE   6  (bases 1 to 4892)
  AUTHORS   Cecconi,F., Proetzel,G., Alvarez-Bolado,G., Jay,D. and Gruss,P.
  TITLE     Expression of Meis2, a Knotted-related murine homeobox gene,
            indicates a role in the differentiation of the forebrain and the
            somitic mesoderm
  JOURNAL   Dev Dyn 210 (2), 184-190 (1997)
   PUBMED   9337138
REFERENCE   7  (bases 1 to 4892)
  AUTHORS   Oulad-Abdelghani,M., Chazaud,C., Bouillet,P., Sapin,V., Chambon,P.
            and Dolle,P.
  TITLE     Meis2, a novel mouse Pbx-related homeobox gene induced by retinoic
            acid during differentiation of P19 embryonal carcinoma cells
  JOURNAL   Dev Dyn 210 (2), 173-183 (1997)
   PUBMED   9337137
REFERENCE   8  (bases 1 to 4892)
  AUTHORS   Steelman,S., Moskow,J.J., Muzynski,K., North,C., Druck,T.,
            Montgomery,J.C., Huebner,K., Daar,I.O. and Buchberg,A.M.
  TITLE     Identification of a conserved family of Meis1-related homeobox
            genes
  JOURNAL   Genome Res 7 (2), 142-156 (1997)
   PUBMED   9049632
REFERENCE   9  (bases 1 to 4892)
  AUTHORS   Nakamura,T., Jenkins,N.A. and Copeland,N.G.
  TITLE     Identification of a new family of Pbx-related homeobox genes
  JOURNAL   Oncogene 13 (10), 2235-2242 (1996)
   PUBMED   8950991
REFERENCE   10 (bases 1 to 4892)
  AUTHORS   Bouillet,P., Oulad-Abdelghani,M., Vicaire,S., Garnier,J.M.,
            Schuhbaur,B., Dolle,P. and Chambon,P.
  TITLE     Efficient cloning of cDNAs of retinoic acid-responsive genes in P19
            embryonal carcinoma cells and characterization of a novel mouse
            gene, Stra1 (mouse LERK-2/Eplg2)
  JOURNAL   Dev Biol 170 (2), 420-433 (1995)
   PUBMED   7649373
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK158839.1, AL772135.14,
            BB612458.1, AK146633.1, KM974644.1 and AL929037.3.
            
            Summary: This gene encodes a homeobox protein belonging to the TALE
            ('three amino acid loop extension') family of
            homeodomain-containing proteins. TALE homeobox proteins are highly
            conserved transcriptional regulators and several members have been
            shown to be essential contributors to developmental programs. In
            mice, a knock-out of this gene leads to lethality at embryonic day
            14, accompanied with hemorrhaging. Embryos lacking this gene show
            defects in tissues derived from the neural crest, suggesting a
            critical role of this gene during cranial and cardiac neural crest
            cell development. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Sep 2016].
            
            Transcript Variant: This variant (11) has multiple differences in
            the coding region, compared to variant 9. The encoded isoform (11)
            is shorter than isoform 9.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.273384.1,
                                           SRR9219381.13010.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AK158839.1         3-285
            284-285             AL772135.14        168761-168762       c
            286-377             AK158839.1         286-377
            378-529             BB612458.1         1-152
            530-1641            AK146633.1         259-1370
            1642-1897           KM974644.1         874-1129
            1898-3087           AK146633.1         1722-2911
            3088-4892           AL929037.3         120395-122199       c
FEATURES             Location/Qualifiers
     source          1..4892
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 58.28 cM"
     gene            1..4892
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="Meis homeobox 2"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
     exon            1..528
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     CDS             520..1929
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="isoform 11 is encoded by transcript variant 11;
                     homeobox protein Meis2; meis1-related protein 1;
                     Cbp/p300-interacting transactivator with Glu/Asp-rich
                     carboxy-terminal domain 2; myeloid ecotropic viral
                     integration site-related gene 1"
                     /codon_start=1
                     /product="homeobox protein Meis2 isoform 11"
                     /protein_id="NP_001332970.1"
                     /db_xref="GeneID:17536"
                     /db_xref="MGI:MGI:108564"
                     /translation="MFLYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPL
                     HATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTP
                     REPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLEL
                     EKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWR
                     DHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQ
                     KKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIV
                     QPMIDQSNRAVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGM
                     GMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMVMHGGPPTHPGMTMSAQSPT
                     MLNSVDPNVGGQVMDIHAQ"
     exon            529..761
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            762..903
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            904..954
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1005
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1155
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1270
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1416
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1493
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1552
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1642
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..4892
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="hexamer: AATAAA"
     polyA_site      3082
                     /gene="Meis2"
                     /gene_synonym="A430109D20Rik; Mrg1; Stra10"
                     /note="major polyA site"
ORIGIN      
        1 gagagtgtgt gtgcgtgcgt gtgtgcgtgt ctggccgcgc gtgtcccagc gctgagcgag
       61 cgggcgggcg gcgagagcgt gtgagtggtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
      121 tgtgtgtgtg tgtgtgtgtg tgtgtacttg tgtgcaattg ttacacgctt tcgcctcgct
      181 ccagctttta ccccggcagc gtgattcccc gggttctctg cgggcggcga gagcgtgtga
      241 gtggtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtacttg tgtgcaattg
      301 ttacacgctt tcgcctcgct ccagctttta ccccggcagc gtgattcccc gggttctcct
      361 gccgccgccg ctgcgcctct ttcgccgcta ctcgcgcggc tccgggcggg cgcgggctgc
      421 gtaggagccg ccggcgtggg gccgcgctgc ctagactagc cccggctgct tgttttgtct
      481 ctgaaattga caaggacgca gggaatccgc tgctaaataa tgtttctgta cgatgagctg
      541 ccccattacg gcgggatgga cggagtaggg gttcccgctt ccatgtacgg agaccctcac
      601 gcgccgcggc cgatcccccc ggttcaccac ctaaaccacg ggccgccgct ccacgccacg
      661 cagcactacg gcgcgcacgc cccgcacccc aatgtcatgc cagccagcat gggatctgct
      721 gtcaacgacg ccttgaaaag agacaaggac gcaatctatg ggcacccgtt gtttcctctg
      781 ttagctctgg tttttgagaa gtgcgagctg gcgacctgca ctccccggga acccggagtg
      841 gccggcggag acgtctgttc ctctgactcc ttcaacgagg acatcgcggt cttcgccaag
      901 caggttcgcg ccgaaaagcc tcttttttcc tcaaacccag agctggataa tttgatgata
      961 caagcaattc aagtactaag gtttcatctt ctggagttag aaaaggtcca cgaactatgt
     1021 gataacttct gccaccggta cattagctgt ttgaagggaa aaatgcccat tgacctcgtg
     1081 attgatgaga gagatggaag ctccaagtca gatcatgaag aactttcagg ctcctccaca
     1141 aatctcgccg accacaaccc ttcatcctgg cgagaccacg atgacgcaac ctcaacgcac
     1201 tccgcaggca ccccaggacc ctccagtggg ggccatgctt cccagagtgg agacaacagc
     1261 agtgagcaag gcgatgggtt agacaacagc gtagcttcac ctggcacagg tgatgacgac
     1321 gatccagaca aggacaaaaa acgccagaag aaaagaggca tattccccaa agtcgcgaca
     1381 aatatcatga gagcgtggct cttccagcat ctcacacacc cgtacccttc agaagaacag
     1441 aagaaacagt tagcgcaaga cacgggactg acaattctgc aagtgaacaa ctggtttatc
     1501 aatgccagaa gaagaatagt gcagcccatg attgaccagt caaatcgagc agtgagccaa
     1561 ggagcagcgt atagtccaga gggtcagccc atggggagct ttgtgttgga tggtcagcaa
     1621 cacatgggga tccggcctgc aggtttgcag agcatgccag gggactacgt ttctcagggt
     1681 ggtccaatgg gaatgggtat ggcccagcca agttacactc ctccccagat gaccccacac
     1741 cctactcagt taagacatgg acccccaatg cattcatatt tgccaagcca tccccaccac
     1801 ccagccatgg tgatgcacgg aggaccccct acccaccctg gaatgactat gtcagcacag
     1861 agccccacaa tgttaaattc tgtagatccc aatgttggcg gacaggttat ggacattcat
     1921 gcccaatagt ataagggaac tcaaggaaga aggaaacaca cgcaaaaact attttaagac
     1981 tctctgaact ttgaccagat gtgacactta atatgaaact ccagacagct gtgattattt
     2041 tttacttttt gtcatttttc atcaagcaac agaggaccaa tgggacaaga acacaaatgt
     2101 gaagcgacgg gctcatcgag acaattttgt ccatgcaaag atcctctgga gaaagactcc
     2161 gagagttata actactgtag cataaacata gggactaagt taaacttgta catttctgtt
     2221 gatcactccg ttatgttgcc tcaaatagtt ttagaagaga aaaaaaaaat atatccttgt
     2281 tttccacact atgtgtgttg ttcccaaaag aatgactgtc ttggttcatc agtgaattca
     2341 ctatccagaa gagactgtgg tatattttaa acctgttggg ccaatgagaa aagaaccatg
     2401 ctgcggagcg agatggacac ttgtctgaac ctcatcacta actccagcgg ctagaatgtg
     2461 ttttcatgcc cggcctttgt tccccccgtc catgtgtcct ttagtttcaa acagatcttt
     2521 atagtttgtg cttcataagc caattcttat tatgattttg ggggactgtt cttcaaagag
     2581 cttgccagtg aagatctaga gacagagcga aggcttcttc aagttctgag ccttggctgt
     2641 ggacaaaaca atcttaagtt gggcagcttt cctcaacgca catacacaca cacacacaca
     2701 caagttattc atggtcgttg caccataagt aggattctat caggaactca aagcttgggg
     2761 gataaaaagg agcaagagaa tactgtaaca aacttcgtac agagttcggt cttttaattg
     2821 tttcatgtta gatattctat gtgtttacct caattgaaaa aaaaaaaaag aatgtttttg
     2881 ctagtatcag atctgctgtg gaattggtat tgtatgtcca tggggtcctc ttttctcagc
     2941 acgtgttcct cactagaaga aaatgctgtt acctttaagc tttgtcaaat ttacattaaa
     3001 atacttgtat gaggactgtg acgttatgtt aaaaaaaaag gtgttaagtc acaaaatgcg
     3061 gtaataaata tttcattttt gattttttgt taggctttgg tgttttttaa tggtttgaag
     3121 gttgcaggag gccagctcct gggcactgat gaaagtacct gatggtctcc caccaccccc
     3181 ccccccaagg aagttgagca tatttaagat gtaacttagc agcatctgta gcttttcatt
     3241 gtgtgtttgg actcttaggt ttcatcaaca gaaaacttcc aaaggtatga aattacttgt
     3301 gttatatcca gcttgagaga tcaccttcaa aaggcccagc ctatcttatt atagctgcat
     3361 gatgttttta aaagcagttg cagattaaac ttttgcctat gtacccacca gtagaataaa
     3421 gggtttattc catgttaatt ttatatcata agaagttatg tgtgtgctca aacatgattt
     3481 atctgtactc tatcttactc aaatactgtt gactctgtac attaaagctc atatatgatg
     3541 tctatagata agtaaacact ttctatggag ttgggaattc taagcttaaa agagtgctta
     3601 agcattaata tttagtacaa ataatacagt ggtatctttc taataaggtt gctttctcca
     3661 tgtgcaggga tgcaagtatg atagtctggt gcctcaaaaa tttttttttc ataaaaaaaa
     3721 agaaaagaaa aaaaaaagag atactttgat agcattttca aagctttact tggtaatcta
     3781 gagccacaag cttgttgatg ttgcagtgtc tactaaagtg tgcaaaatgt agccgcttaa
     3841 gatagctgca cactcaaaga gtttccaaat aaacacacag ctgaggcttt cctaactcct
     3901 aaatgttgac gcctccatct aaaggggagg ataaatagga gatggagaga tgatttgatt
     3961 tggtagggaa gagctcacta gtcatacaaa cttccacttg gaagcactcc atagtggcct
     4021 ctcaggcaaa cccttccctg tttccttgtt aggcagcctt aatggaagca ctacatatga
     4081 atgagcaagg atataaattg ctattgtttt cttttatatt gttaagtaaa atttttataa
     4141 gtgcatttat cactttaatt agtgcactgc tctttaaacc tagaaatagc agtgtttgac
     4201 acaaacacac tgatcttgta aaatacatag agcctccctc cctctcatta tccctgttcc
     4261 atgctacatg gaatctttct gtaaaattta aatatttgca tatgtttgct ttaaatgctc
     4321 tgatgtaaac tctgacaagt tcctcattta taaacttact ctcatatcag ttgaaagggg
     4381 aaaaattata ttggcagctt ttctctcatt gctctccata aggtaattgc tgaagggttt
     4441 ccttggtcac aagctcacgt ttataaaaag tattttatgg agttattact ccaggaaggg
     4501 tacagccaga gtggttgagc cttcgtttga attcacagac tcatcgtgag cttagtatct
     4561 tggccaatct gtatcctatc atgctaattt taaccttaga tatttggaga tgagtgataa
     4621 ttgtggtaat atctatgtat tttcttaccc cacccccacc ccattctatg acagagggat
     4681 gatgaattta tccagttttt atagtgcttt ttataccacc tcagaaggcg cttgctccta
     4741 tctcgggttt actatttagt ataaagagtt ccgatttggg tatatttaag aaagactcag
     4801 ctgtcaaacg caaagaaact gggaatggtg ttttgacaac catatagtgt taaaggaaat
     4861 actgtagtct gaataaaatt gcttatgttc tc
//
